LOCUS       NM_207525               2260 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus optic atrophy 3 (Opa3), mRNA.
ACCESSION   NM_207525
VERSION     NM_207525.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2260)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2260)
  AUTHORS   Navein,A.E., Cooke,E.J., Davies,J.R., Smith,T.G., Wells,L.H.,
            Ohazama,A., Healy,C., Sharpe,P.T., Evans,S.L., Evans,B.A.,
            Votruba,M. and Wells,T.
  TITLE     Disrupted mitochondrial function in the Opa3L122P mouse model for
            Costeff Syndrome impairs skeletal integrity
  JOURNAL   Hum Mol Genet 25 (12), 2404-2416 (2016)
   PUBMED   27106103
  REMARK    GeneRIF: Opa3(L122P) mice displayed craniofacial abnormalities,
            including undergrowth of the lower mandible, accompanied in some
            individuals by cranial asymmetry and incisor malocclusion
REFERENCE   3  (bases 1 to 2260)
  AUTHORS   Wells,T., Davies,J.R., Guschina,I.A., Ball,D.J., Davies,J.S.,
            Davies,V.J., Evans,B.A. and Votruba,M.
  TITLE     Opa3, a novel regulator of mitochondrial function, controls
            thermogenesis and abdominal fat mass in a mouse model for Costeff
            syndrome
  JOURNAL   Hum Mol Genet 21 (22), 4836-4844 (2012)
   PUBMED   22869679
  REMARK    GeneRIF: Opa3, a novel regulator of mitochondrial function,
            controls thermogenesis and abdominal fat mass in a mouse model for
            Costeff syndrome.
REFERENCE   4  (bases 1 to 2260)
  AUTHORS   Powell,K.A., Davies,J.R., Taylor,E., Wride,M.A. and Votruba,M.
  TITLE     Mitochondrial localization and ocular expression of mutant Opa3 in
            a mouse model of 3-methylglutaconicaciduria type III
  JOURNAL   Invest Ophthalmol Vis Sci 52 (7), 4369-4380 (2011)
   PUBMED   21613372
  REMARK    GeneRIF: Mutant Opa3 protein retains its mitochondrial localization
            and induces disrupted mitochondrial morphology. Opa3 accumulates in
            the lens. The results may reflect a slow turnover of Opa3 protein
            in vivo and may be important in normal lens physiology.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2260)
  AUTHORS   Davies,V.J., Powell,K.A., White,K.E., Yip,W., Hogan,V.,
            Hollins,A.J., Davies,J.R., Piechota,M., Brownstein,D.G., Moat,S.J.,
            Nichols,P.P., Wride,M.A., Boulton,M.E. and Votruba,M.
  TITLE     A missense mutation in the murine Opa3 gene models human Costeff
            syndrome
  JOURNAL   Brain 131 (Pt 2), 368-380 (2008)
   PUBMED   18222992
  REMARK    GeneRIF: to investigate the OPA3 function we have generated a novel
            ENU-induced mutant mouse carrying a missense mutation in the OPA3
            gene. In the heterozygous state, the mice appear uncompromised. In
            the homozygous state mice display some of the features of MGA.
REFERENCE   6  (bases 1 to 2260)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK164755.1.
            
            [WARNING] On Feb 3, 2025 this sequence was replaced by NM_207525.4.
            
            On Apr 5, 2007 this sequence version replaced NM_207525.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164755.1, AK154917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18614015, 12865426;
                                                  reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2260              AK164755.1         2-2261
FEATURES             Location/Qualifiers
     source          1..2260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.48 cM"
     gene            1..2260
                     /gene="Opa3"
                     /gene_synonym="D630048P19Rik; Gm1425; Gm472"
                     /note="optic atrophy 3"
                     /db_xref="GeneID:403187"
                     /db_xref="MGI:MGI:2686271"
     exon            1..196
                     /gene="Opa3"
                     /gene_synonym="D630048P19Rik; Gm1425; Gm472"
                     /inference="alignment:Splign:2.1.0"
     exon            197..2260
                     /gene="Opa3"
                     /gene_synonym="D630048P19Rik; Gm1425; Gm472"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcgccc cgcccagtca gcaaggttgc gcgtgcccca gggcggccgc cgagatggtg
       61 gtgggcgcgt tccccatggc gaagctgttc tacttgggca tccggcaggt tagcaagccg
      121 ctggccaacc gtatcaagga tgctgcccgc cgcagcgagt tcttcaagac ctacatctgc
      181 ctaccgccag cccagctgta ccactgggtg gagatgcgga cgaagatgcg cataatgggt
      241 ttccggggca ctaccatcaa gccactgaat gaggaggcag cagcagagct gggtgctgag
      301 ctgctgggcg aggccaccat cttcattgtg ggcggaggct gcctggtcct ggagtactgg
      361 cgccaccaga ctcagcagcg caataaggag gaggaacagc gggcagcctg gaacgctctg
      421 caggatgagg tgggccgcct ggcactggcc ttagaggcgc tgcaggctca ggcacaagcg
      481 atgccctcct tgagtgccct ggaggagctg cgggaggagc tgcaggaggt gcgtggtcag
      541 gtctgcaatg ctcactgtac ttccaagtgc caggcagcat cttccaagaa atagccagct
      601 gctaaggcct ggacttgttt gtgaccatgt ggcctccaat agagccttct cctcacacct
      661 cctggcccgg gatgctctgg cctagcagaa accacgagga ccttgatgta gctgtgacat
      721 gtggtcaccc cttactgaca ggttctgggc atttccccag ggagcactca gcagaagcct
      781 tcagagccca tccagtctct gactcagagc cctcagcccc tcattggact ttcaaggtct
      841 cagacacctg actctccact gctctggcaa aggcaaaaga tggaaccagg gctcaagtct
      901 gatcatgaca tagacaaggt cacctgccca tcattggagc gcctccttcc ttcggtgaac
      961 acaggccacc ttgagccttg cctcaggtca atgtagctcc catggaggca gcagagtgca
     1021 attgatgttc ccgttctctc tcctcattct ccctctgagg tccccagggg atcacgcctg
     1081 tatagatccc cttactcctc agcctgtggc attaccccat ttcctcccta ggcacagacg
     1141 gatcctagct ggctcgattc tgacctgtct cagtcgcagc cccgctgccc tatcctgaaa
     1201 tgtccctgaa ccttgtttcg ggtggcacat atttcctcct gtccttctgt ggtatttttc
     1261 agttgggtgg gttagatgtc acacacacac ctgtctgacc cttcataccc cttaggtctg
     1321 ggtccctcta ccctttctgt tgccccacct tccttgctcg atccccccag acatgactta
     1381 ctgctgggaa tgtgatggag gaaacagagt aacctgttct cccaccgttc tggaagccag
     1441 cggcagaggt cagggtgttt gggccccact ttcttctggc ttcaggggcc ccagatctcc
     1501 tagactctgt gtcctgtctt catgtggctt tctcttcccc cacctgtctc ttgcaaggac
     1561 acctgccctg aatacaagac ccaccctaaa tttaggatga ccatattgaa agagccttta
     1621 ttacatctct gaagaccctt tttctaaatg gagacacaca ggccccagga ttcagacatg
     1681 gagttttctt ttgaaggccc tctattcagc ttgctgcctt ctgccatttt aaaatgcaag
     1741 gcccctacta tgctgtttgg ctcttccggc agcctactca tggcttctgg ggttgggcta
     1801 accactatag ctccagaagg attgtgggtg cagcagtcac tgtcatggtt gtccagttcc
     1861 tgatggagct gcagaataag gaggcctcct aaggatatat gaggggcata attaatacgg
     1921 accttcaaac tgggccagtg atcattaaca atagagaaat ccgggcttgg tagctcatat
     1981 ctgaaattcc agcactctga ggctgaggca ggaatgagcc tgggtcccat cgtgagttcc
     2041 tggacagcct gctgaaccac agggagagac cctgtcttta aaaaaaaaaa aaaaggcaaa
     2101 aagtaaaaaa gacaaccaag ccagacagtg gtgatacacg ccattaatcc cagcacttgg
     2161 gaagcagagg caggtggatt ctgatcgaga ccagcctggt ctacagagtg agttccagga
     2221 tagccagggc tacacagaga aaccctgtct ccaaaaaaac
//
