LOCUS       NM_194268              13728 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus one cut domain, family member 2 (Onecut2), mRNA.
ACCESSION   NM_194268 XM_001000005 XM_982987
VERSION     NM_194268.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 13728)
  AUTHORS   Renaux,E., Baudouin,C., Schakman,O., Gay,O., Martin,M.,
            Marchese,D., Achouri,Y., Rezsohazy,R., Gofflot,F. and Clotman,F.
  TITLE     Arid3c identifies an uncharacterized subpopulation of V2
            interneurons during embryonic spinal cord development
  JOURNAL   Front Cell Neurosci 18, 1466056 (2024)
   PUBMED   39479525
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13728)
  AUTHORS   Zupancic,M., Keimpema,E., Tretiakov,E.O., Eder,S.J., Lev,I.,
            Englmaier,L., Bhandari,P., Fietz,S.A., Hartig,W., Renaux,E.,
            Villunger,A., Hokfelt,T., Zimmer,M., Clotman,F. and Harkany,T.
  TITLE     Concerted transcriptional regulation of the morphogenesis of
            hypothalamic neurons by ONECUT3
  JOURNAL   Nat Commun 15 (1), 8631 (2024)
   PUBMED   39366958
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13728)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13728)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   5  (bases 1 to 13728)
  AUTHORS   Mehta,K., Daghsni,M., Raeisossadati,R., Xu,Z., Davis,E.,
            Naidich,A., Wang,B., Tao,S., Pi,S., Chen,W., Kostka,D., Liu,S.,
            Gross,J.M., Kuwajima,T. and Aldiri,I.
  TITLE     A cis-regulatory module underlies retinal ganglion cell genesis and
            axonogenesis
  JOURNAL   Cell Rep 43 (6), 114291 (2024)
   PUBMED   38823017
REFERENCE   6  (bases 1 to 13728)
  AUTHORS   Briancon,N., Bailly,A., Clotman,F., Jacquemin,P., Lemaigre,F.P. and
            Weiss,M.C.
  TITLE     Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF)
            4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in
            the liver
  JOURNAL   J Biol Chem 279 (32), 33398-33408 (2004)
   PUBMED   15159395
  REMARK    GeneRIF: although hepatocyte nuclear factor (HNF)6/onecut(OC)-2 and
            perhaps HNF1 activate the P2 promoter in the embryo, increasing
            HNF4alpha1 expression throughout development causes a switch to
            essentially exclusive P1 promoter activity in the adult liver
REFERENCE   7  (bases 1 to 13728)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   8  (bases 1 to 13728)
  AUTHORS   Jacquemin,P., Pierreux,C.E., Fierens,S., van Eyll,J.M.,
            Lemaigre,F.P. and Rousseau,G.G.
  TITLE     Cloning and embryonic expression pattern of the mouse Onecut
            transcription factor OC-2
  JOURNAL   Gene Expr Patterns 3 (5), 639-644 (2003)
   PUBMED   12971999
  REMARK    GeneRIF: We describe here the cloning of mouse (m) OC-2 and its
            expression pattern in the mouse embryo.
REFERENCE   9  (bases 1 to 13728)
  AUTHORS   Jacquemin,P., Lemaigre,F.P. and Rousseau,G.G.
  TITLE     The Onecut transcription factor HNF-6 (OC-1) is required for timely
            specification of the pancreas and acts upstream of Pdx-1 in the
            specification cascade
  JOURNAL   Dev Biol 258 (1), 105-116 (2003)
   PUBMED   12781686
REFERENCE   10 (bases 1 to 13728)
  AUTHORS   Vanhorenbeeck,V., Jacquemin,P., Lemaigre,F.P. and Rousseau,G.G.
  TITLE     OC-3, a novel mammalian member of the ONECUT class of transcription
            factors
  JOURNAL   Biochem Biophys Res Commun 292 (4), 848-854 (2002)
   PUBMED   11944891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102106.14.
            
            On Jan 26, 2022 this sequence version replaced NM_194268.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY242995.1, BB657009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1584              AC102106.14        135450-137033       c
            1585-13728          AC102106.14        78572-90715         c
FEATURES             Location/Qualifiers
     source          1..13728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 37.33 cM"
     gene            1..13728
                     /gene="Onecut2"
                     /gene_synonym="C730009D12; OC-2; Oc2"
                     /note="one cut domain, family member 2"
                     /db_xref="GeneID:225631"
                     /db_xref="MGI:MGI:1891408"
     exon            1..1584
                     /gene="Onecut2"
                     /gene_synonym="C730009D12; OC-2; Oc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1871
                     /gene="Onecut2"
                     /gene_synonym="C730009D12; OC-2; Oc2"
                     /note="transcription factor ONECUT2; one cut homeobox 2;
                     transcription factor ONECUT-2"
                     /codon_start=1
                     /product="one cut domain family member 2"
                     /protein_id="NP_919244.2"
                     /db_xref="CCDS:CCDS29302.2"
                     /db_xref="GeneID:225631"
                     /db_xref="MGI:MGI:1891408"
                     /translation="MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPVGGGSGGGG
                     GGGGGGGGGGPGHEQELLASPSPHHAGRGAAGSLRGPPPPTAHQELGTAAAAAAAASR
                     SAMVTSMASILDGSDYRPELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPIS
                     TVSDKFHHPHPHHHPHHHHHHHHHHQRLSGNVSGSFTLMRDERGLPSMNNLYSPYKEM
                     PSMSQSLSPLAATPLGNGLGGLHNAQQSLPNYGPPGHDKMLSPNFDAHHTAMLTRGEQ
                     HLSRGLGTPPAAMMSHLNGLHHPGHTQSHGPVLAPSRERPPSSSSGSQVATSGQLEEI
                     NTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRM
                     WKWLQEPEFQRMSALRLAACKRKEQEPNKDRNNSQKKSRLVFTDLQRRTLFAIFKENK
                     RPSKEMQITISQQLGLELTTVSNFFMNARRRSLEKWQDDLGTGGSSSTSSTCTKA"
     exon            1585..13728
                     /gene="Onecut2"
                     /gene_synonym="C730009D12; OC-2; Oc2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1968
                     /gene="Onecut2"
                     /gene_synonym="C730009D12; OC-2; Oc2"
     regulatory      13709..13714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Onecut2"
                     /gene_synonym="C730009D12; OC-2; Oc2"
                     /note="hexamer: ATTAAA"
     polyA_site      13728
                     /gene="Onecut2"
                     /gene_synonym="C730009D12; OC-2; Oc2"
                     /note="major polyA site"
ORIGIN      
        1 agagcccttc tggacagctc ccgctcaccc aaacagaaga cgtcggcgcc agagtgggct
       61 cggacatggc gaggcagcgc gcccgcacaa ccggcggggc ccggtgatcc ctccctcctt
      121 ccccaccccc tcccctctcc cgcacgcacg ccctgtccgc ccccacccca cccccacccc
      181 gggcgcgccc gcccgcagcc cggggcacac acccgcacgc acgctccccc agcacacact
      241 cccgcactcc cacgcccgcc ccccgagccc gtggccgaac cacgccacgc gtgcctagcc
      301 agcccgccgg catcccccgc cgctcccacc gcccccgggc cccgatggac tgaatgaagg
      361 ctgcctacac cgcctatcga tgcctcacca aagacctaga aggctgcgcc atgaacccgg
      421 agctgacaat ggaaagtctg ggcactttgc acgggccggt cggcggcggc agcggcgggg
      481 gaggcggcgg gggcggaggg ggcgggggcg ggggcccggg ccatgagcag gagctgctgg
      541 ccagccccag cccccaccac gcgggccgcg gtgctgccgg ctcgctgcgc ggcccgccgc
      601 cgccaaccgc gcatcaggag ctgggcaccg cagcggcggc ggcagccgcg gcgtcgcgct
      661 cggccatggt caccagtatg gcctcgatct tggacggcag cgactaccga ccagagctct
      721 ccatcccgct acaccacgcc atgagtatgt cctgcgactc gtcgccgcca ggcatgggca
      781 tgagcaacac ctacactacg ctgacgccgc tccagccgct gccacccatc tctacggtct
      841 cagacaagtt ccaccacccg caccctcacc accaccctca ccaccaccat caccaccacc
      901 atcaccatca gcgtctgtcc ggcaacgtca gtggcagctt cactctcatg cgggacgagc
      961 gcgggcttcc gtccatgaac aacctttaca gcccttacaa ggagatgcct agtatgagcc
     1021 agagcctgtc tccattggct gccacgccgc tgggcaacgg gctgggtggc cttcacaatg
     1081 ctcagcagag cctgcccaac tacggtccgc cgggccatga caaaatgctc agccccaatt
     1141 tcgacgcgca ccacactgcc atgctgaccc gcggtgagca acacctgtcc cgaggcctgg
     1201 gcaccccgcc tgcggccatg atgtctcacc tcaatggctt acaccaccct ggccacactc
     1261 agtcccacgg gccagtgctg gctcctagcc gtgagcggcc cccttcgtcc tcctcgggtt
     1321 ctcaggtggc cacgtccggg cagctggaag agatcaacac caaagaggtg gcccagcgta
     1381 tcaccgccga gctgaagcgc tacagcatcc cgcaggcgat cttcgcacag agggttctat
     1441 gccggtctca ggggactctc tccgacctgc tccggaatcc caaaccctgg agtaaactca
     1501 aatctggcag ggagaccttc cgcaggatgt ggaagtggct gcaggagccc gagttccagc
     1561 gcatgtctgc cttacgcctg gcagcatgca aacgcaaaga gcaagaacca aacaaagaca
     1621 ggaacaactc gcagaagaaa tcccgcctgg tgttcacgga cctccaacgc cgaacactct
     1681 tcgccatctt caaggaaaat aagcgccctt cgaaggagat gcagatcacc atttcccagc
     1741 aacttgggct ggagctgacc actgtcagta acttcttcat gaatgcccgg cgtcgcagcc
     1801 tggagaaatg gcaagatgac ctaggcacag ggggttcttc atccacctcc agcacttgta
     1861 ccaaagcatg atgcaaggac tctccacctg ggcacaagtc atctccaaat gaggacaaca
     1921 cataccaaaa accaaaacca aaaaccaaaa ccaaaaccaa aaccaaaacc aaaaccaaaa
     1981 aaaaaaaaaa aaaaaaatca caaagacatc agattcttag ctggggccct tcactggtga
     2041 cttgaaagca caattctctt gaaacttcta atctagctgt aatcataggc caggtgtcca
     2101 ttttcttttg tttcatttta aatggctaca gagtccaagt acacgctgaa agttaatctc
     2161 tttgaaccag acactatcct ctgagtatgc taagcatccc agagacccaa atggggcctt
     2221 cttggagtga gttaatcaca gcacaatgtc aaccaagttc agtgcagctg taagcatcaa
     2281 tagccctatt caggccctgt caacctcttg ctaacactag tttcctgcaa gtcatagtgg
     2341 atatttggcc tgagtataga cacaggattc caaaacacta cagaagaatt taacaagaaa
     2401 ggcctcattt gctccccaag tgcttagcct ctttatatca cagtacatta aaaattctca
     2461 gccataacat tacaaaaaaa aatcagaatg gtaattactg agcacaagtt ttaaatatgg
     2521 aaatcaataa aaaaaatcca aggacatgtt tttccaactc aggcatcttt tcattggata
     2581 gtttagaaaa ctttgatttc agtttacgat ttttcttttc tttacctcct ggaaatctca
     2641 tgtggtcttc tggatccgtc aaaaaaaagt caattcactt gagctcaaag tatcaagcac
     2701 aacgaagata tacagaaata aggaaggctc tggtttcaac gcatccagtt tgacaaggcc
     2761 gtttacatca gtctttactg ttgtgaagtc attagggaat tattgggaat atggcttcaa
     2821 gcacattttg caggttgtta caaactctgt ttgtacattg cgcagatgca cactcaggag
     2881 gccaatttaa ctgctacagt acaggagcaa atgcatcatt taagaagatc tagatttttt
     2941 tagatcatta ctgtgccctt gatttacaag tcacccaggt cctcctatgt gcattacaag
     3001 tgtggtttgt tcttgttctt gctgatccgt gttgttccct atcgcatccc attagttggg
     3061 atgtctctat tgttttctac aaagaaacag tttaataagc cacttcctgt cgtctcttcc
     3121 taactctctt ccattgctga ttcatcctta taatacagct gacagaacct ggagagaaca
     3181 cagcacacca aagaagcaga atactgcaaa ccaaagacat ttgttacctg ccattttcta
     3241 gcctacaaat actgtgatta cttttagaga tcagagcacc tctgtaactc cgagtggcat
     3301 tcggctcttg tcttgggctc accacctggc tgagcagacc agctacatca atgacattag
     3361 ccaaatatcc gggcagtgac ttcgccacgc cagccctggt tggtcacctt cccatagcaa
     3421 gtgaaagagg gcccacagaa ctctgggaga ttacaaaggt cactatgtgc atatttacca
     3481 gtgaatggcc ccaggtgggc accaaggggt gttcggagca agccaaaagc ttcgatgact
     3541 ctttacagac acttgagact gacttttgta tgaattgctt aattgaaacc aaagaaactt
     3601 tttttctgca cctacttctg caacaaacag aactgtccca ttgaatgagt aaatggttcc
     3661 accaatcact ggaaatcacc atcaacagaa aaagcacgct agaatgaaag aaacaacaaa
     3721 accaccgaag acacactgtg ttcaaacaga ccttttggga cgctcttatt ttttattttt
     3781 ttattttttg gaagcagatt tgaaagaaag ggttgagaca caaatcaaca gacgagcctc
     3841 aatggctgct gcttcatatg acaactcact cggtaatctt aacgttgaag attgtcttta
     3901 atttgtgcct atgcagtttt tcaaaagaac atggaaacag agcaacagaa acctcaacag
     3961 ctacaatacc aaagatgagg attctcacac ctttttgtct cagttcatta ccttcttttg
     4021 cctggctaaa atacttatag cgtcattgat ctgtacaaag gtaatcgatt ttgtttcttt
     4081 aagcaacaaa aggaaagggt catttgtttg attttattgt ttccctttag ttttgtttta
     4141 tggcttttac ccaacatgga atctcccccc tacacataaa gttccatgga ctccaaactt
     4201 gagatgtcgg gatactgaaa ggtgtccctt tctctcctca gcagagcatg ggaaatacga
     4261 ttgtcgcttg aatgtctgtg gcttaaccct tagacttggt tgcttctgtg ttcagtgttg
     4321 tcattagggg agggaagggg agcaaggatc aggggtagga gtctaggtga tccgcccttt
     4381 ccagaaccaa agaatttata gagaaattta caacctcatc ttcatgtgat tgccacatgt
     4441 taacagggct tcatttgggg gtggggaaac atgtaaaaag aatcgccagt ttctactttt
     4501 ctattagctt tttaaaaaaa aaagatcagc tgtaaagttg catttctaaa gaaagatata
     4561 tagatatata tatattaaat gtacgagtac acgtatagat taacccgcat tggtgacaac
     4621 ccaaaatttt tgttgtccaa ctatttgttt tctcgtatgc accatttgtt aagcattcat
     4681 ttcacaactg tgctcatttc tcatgccatt ccagagttaa atagccactg tggttgtctg
     4741 gcagtattca tagttctatg taagtttatg gtaaaagttg aaagtccatt taagcatttc
     4801 tacatgtaac ctgttgatga atggattcat gatgtaagtg ggttttattt gtagtcatct
     4861 ctatcctatg cctcaaccat gataagcaag gtttatccat cagactagct cagagctgtg
     4921 ctgctggcag tagggaactt accatctatc atcattggga aggcttggtg attcattccc
     4981 atctgttgtg gagcaaaaca ccagaaatcc attttccagt agataccatt atccaccaga
     5041 gtattctaga ttcctctcag tgagtagatc caaccgaggc ttctcctggg gaaatccaac
     5101 ttctattgca ataggtcgat caggtctcct cgaggtagta attaccagtt tgcactgaca
     5161 agcttgagtg caaccatagc tggcactggg gtcgatcggg attgttgaag ggaggtatct
     5221 cagtcctgga gaaaaggcat tcagtagact gtgaggagag ttccagattc ctgtccctgg
     5281 agagccgcat cctctgcctt gcctctttat tcacccaatg tgggcagttc tgtggtgggc
     5341 acatcatatc tagagctgag agaataggac cctgtgttat ttttctaatt tgtcctatct
     5401 agggagtgct cctttcactt tccccttgtt ccttgcttat aatccatgaa cttatggtca
     5461 aatgaccaag aaaaagcgta tttcctcaga ggcttgctcc catttcagct gggtcagatg
     5521 aatattaact tggatcttac taaatgagtc tttgtgactt gtggacaatg gaatgggtgg
     5581 ttctgcttga gtacagactg cagaacaaag catcttgctt tggttagtga ctgacactaa
     5641 ttagcagcat ttgaggcttt gcatccttgg aagatgatgg catgaaggaa aaaggcaaga
     5701 aatcccctct aggaactctt gataaatgtc ttttctatct cagagaatac ttgtgttcaa
     5761 aagttgctta tacacacaca tacacatata atgtgtatac acattatatg tgtatgtgca
     5821 tctgtacaca tatgtatcca aatttcaggt catacaaagt atcgttttgc taggtagctg
     5881 aaagaaaaag tagtatactg aaaggttata gaatttaatc cactgtcttt tctcaaagcc
     5941 tttaaatttt ttattttaaa taacagtctc agagaaaata accatttgga cttgaatata
     6001 gcctacagtc tacattctta atccaaaaaa agttccaggc ttctgccacc atcaccaaca
     6061 gtgggatgct gggaaagaat agttcacaag caaattttat cttcataggg tgacagaaac
     6121 ccaaagaata ttgagtgaaa gatatatttt tccttaagcc ttcttataac taagctctat
     6181 ttttgtttcc catgtgattt taatgattct aagattcaat tccctcattc ttagaattct
     6241 tttaaaggac agctaatata ttaaaagtac aatgacaaca ataaaattga attccagtat
     6301 ttaaaagatt tccccataaa aaaaagagta tttggtttgt accacatagc ggtacaggct
     6361 attctgaggc aggaaggaaa gatcagaatt ggatacgtgg tttctgtttt tacaaaggct
     6421 cttagcagct tcagctttgg gaacccaatc tcgttgtccc ttcaaactaa agcataacaa
     6481 aacctaggaa ggtaaattga atacacacag gcatgaacac acaaatgtac acatgcgcac
     6541 acacattttc ctaaggcaag cagtgagttt caaagtcaaa tattagcaat taaaatctaa
     6601 gtaatcaaac attatgttgg gcattcatgt cttaatgcca ggaaattaaa attgaataat
     6661 tttcaaacaa atagtcacta ttcagtaggt acagaaagta acctttcctc tatcaaaaat
     6721 gttaatggat gtgtctgtta gcttgataat atcaaaatat ggaaatacac ttttggagga
     6781 aatgggtctt tgggagcttg tctaattgga atttttcaaa atctataaac aaagtaagtt
     6841 ccaaggtcat taaaaaataa ataggggcat taaaaacagg gaaaagtagg aatctgtggt
     6901 taatgttgac cacatggcac agacactact ttgtcaatat cttttctaga ttcctaccca
     6961 atcggggcta acttttactg tcctgtagca atattaggag agtaatgctc tgattcaaac
     7021 ttgctagtct taccaggtga gtgagcaggg agcaggtgaa gaagaaagga tagagcattt
     7081 ctgatggtta tttgcaaagc tgaagagttt aacagttctg tgtcatttgc taaccgcaga
     7141 gaccacagtt gtggggaaaa aaaaagtccc acttaagaag agcagtttcc ccaggtggtt
     7201 acttgaactg tggatgtcct aagtcctttt tttctatcaa tgctttgttt ctttgcgagg
     7261 taggaggtaa gggtagatgg atggttaatt tatcttagaa agtcccaagt acttatgaaa
     7321 caaaacttag tcttaaaata acataggatc atacacacac acacacacac acacacacac
     7381 acatatatat atatatatat gcaaaccttt tcattagtgc ccatgggttt tgctataagt
     7441 ccacaggtcc tgaagtgccc attgacctca agttactctc ataacagcca cagggaagtg
     7501 aaagataaga ctccgagctc tatatctctg gactttgagt taggttagtt gacattaccc
     7561 agcctataca ttttttagtg gaaaaaaaat gtatgtaggg gaaaagaatc accaaaggtt
     7621 agtcattcca tgggaatctt ccatctggct ccatttttag cagcagtcat ttttacatgg
     7681 catagacctt gtccttgtta gataagtttg cctgtcattt atacagtctg tgagcttgaa
     7741 tgtatacaga tctagatact tatttcaaca tataccctca gagttgactt tacatccacg
     7801 tccattgcct agaggtatct agactgtgta cacacaagtg tgtacagacg tgcttaatac
     7861 atacataaat tgtaatctgt tacaataaat aaatttaaaa tcatcatgca acatgtatgt
     7921 gatattttga caatgtacct tgtctttgtt gtttcttgta atgctgaaaa ccaaagtgtg
     7981 gagatgtaag cgaaggatcc cccccatctt catccatcac gatacttgaa atcactttta
     8041 gttgggtgca gccacgacaa acaactttag gtggaatgtt ggatattatt tcactgtctg
     8101 tgttagatgt ttaatgactt tggttgaata gctttattct ggatctctca taactaaagc
     8161 gaaatccaaa gaccttaaaa agaacaaaaa aggggggaac tgggggtgat gtggaataaa
     8221 gtacaaacca atggcagaaa gtggggtctg gttccagggt tgaaagaaca aaggtgtggt
     8281 cttgtggagg ttgtgttagc tagttgggtg tgtgtgtgtg tgtgatgatt tttcctccat
     8341 gtttgtcaca tcaaagtggt ctttaatgtg ataaagcttt agacgttata ctttgctgct
     8401 ttattttatt tagactttag aatgaaatga tccatttttg tccaccaaat aaaaaaagaa
     8461 agaaagaaaa agaaaaagaa gaccacctct ccccacccct cagctgtatt ttaacgtttc
     8521 tctttcagtt gtgacccaac gagctgttaa tataattaat ttattttaat tagtttttgt
     8581 atgctagcat gtaggattcg ggtaattatt taattttcct tttttagttt gattttactc
     8641 cttgttctta tttatcaaaa tctgtagcag tggtgcatct gagatgcaaa accctggctg
     8701 ctatacagct ctagtgtagc gtgcttcata aagcggtgaa cttctgttac agggaagaaa
     8761 cataggttac aatgaaaacg aaaaacaatc tgggtgtatt tcccgtcttg gattaattta
     8821 taaaatggtt taatggttat taaattattt aatttaagtt cacagcccca cttggtacca
     8881 ggcgaatttc acctcttaat taccggggcc ctcagagcct ttctattgta acttatttat
     8941 ttaacttatt cagcatctgc gacggatgcg ctgtatagtt tgcgtttatt atttaaaaca
     9001 acagagagca ctgcggtttg tttgctgtca gaacaacaga gcagatttgt ggacaagcag
     9061 tgactgatca gcctgaacct gcttcagaac tcaagctgag atccaacgtc atcagcccgg
     9121 attttcgggg cttctataaa ggaaactgga aaaaaaattt aataataaat aaataaataa
     9181 taagaaatcg taaaccaaaa agagagaacc cttatactag ctgcttccaa gaaagaactc
     9241 agtgtgcgta aagtagcaaa acaaaaaagg gaaaaaaaaa aaagcagaaa aaaaaagaaa
     9301 aaaaaaaaga actggaaaaa ctttctattt gtagtgagaa ccaaagaagg ctacctcact
     9361 gactttttcc atttgtaatt ttaatcgtgt tgacgacacc aaagatacca aagattcctt
     9421 tctctgtgcg gtctgcattt cgcttctgct ctattatgat ttgagctctt ctttctgacg
     9481 tatggtatgg acagccacag ctcagactcc cccaaagaaa caacaacgat gtgtgcggac
     9541 gaaggcggct gctaacctgg agagggatat tttctgtgtc tcttgcatct gtctgctgcc
     9601 tcctcccaca tgttcagcac gccagttggg acgctgctgt cactgggatc tttaaagttc
     9661 ccattccaat ttggtagaga acactgcttg gaaatagttt gccatcctag ccccacccca
     9721 ctctgtgtcc tggagctatc acagggaaaa gtgtcccaag ctactgcaac tacaggaata
     9781 agaattgggt aggagagctg gaagggaccc taggacccat acagtcaccc cactggggcc
     9841 caggttggag tagttatctg aatgtaggaa agtagcaatc ctttagcagt gaaaagaagc
     9901 tgtagtttat ggattaatat tttcatcctt ttaagaataa tcttcacact ctgacacccg
     9961 atacataaat tatgtatcca gagctgtgta tgatctttgc ttagtaaggt ggccagcctt
    10021 gacattctag ggcttcttca ggggttctac cctggcaagc atattgactc aaacagtaat
    10081 atgactgtgg aatgcaccca ttacaacatt ttaaataaaa agccttgcca tcggtgggag
    10141 gagaaagccc agtcttgacc tattgagttt aattaccatg gctattctaa agtcaatatt
    10201 tatcaagcca ggatacttga ctctcacttt tggtaggtga ttcctcctgt cagcttttta
    10261 tttttttatt tttttactta acagtcccca tttcattgct aaatcaattc tatttccaag
    10321 agaaatgcaa taagccttat gttgtttgct gctaaagcgt attccttgca aataaaaaat
    10381 atctcaaata tcagatgaat ggatatacca atttaaataa cagtttaagt tacttctttc
    10441 ttttttcccc ttatcaaaac ttcactggtc ttctttaagt tcctttagag tctattaaaa
    10501 tgactaagtc gttattagga tcgctcacca aagtgatgag aatgctagcc agtgaatcct
    10561 tcttagcttt tggtcaagca ggaattagct actcgctgat tccattctct actctacaga
    10621 gctctttact gaatactgca tttttacatt tcacataata gttatcactg agcatttaaa
    10681 aaggctctta gataaaggga agatcaattt acccctctgt cacacaccaa cagagtgtag
    10741 ccggtagagg aatttacaac agacttacag actattcaac atgctccatt ttacctctct
    10801 tttctatcct tcccattaaa aaaaaaaaaa aagacagggt cttatgtgtt ccaaggtagc
    10861 tttaaactca ttgtgtagaa gatggctttg aactcccaat ccttctgcct ctatgtgctt
    10921 agtggtgagc ttacagttat gagccaccat gtccggccag ttatcttctt tctaaagtgt
    10981 gcaagctcca tgccggcata tgcgaaagtt cttttctacc tagatagacc tccctatcaa
    11041 ggccaatctg caaggtcttc tttccaagca gttgatcacc gaattcctat tggcaataaa
    11101 aattcccaga atacctggga gaacataaat tcaccaagca gcagggtaat tccccataag
    11161 caacatcacc ttttctggcc ttcctaccac tgagacccta ggagggagga tctagaaaga
    11221 gcaatggcag cctgaacaca gaaaatatct ccattagcag acccctcttc agcgacaacc
    11281 cccccccccc agcctcatgc ttcacttgca aagtgtgaca ttaccacggg acgagtgcct
    11341 tgcttgaacc aaagcaacga tttagccagt ctggacctct ctgtgctttt cttaattctt
    11401 cctgtgatta cctcagcttc aactgggcct ccaaacagta aattggtagg cttattgtac
    11461 tgtggtgctt tgcaatgcaa ccctgcaaag aacaagattt gtactaatac caaaggttct
    11521 ttctctacgt ctcttccttc tgcctcccca ctgtcccccc ttttctagtc cctcacagtt
    11581 ccaaagcttt aacatgaacc tgggcatgtt ggcaatgcag accgcgcaat tccttaccga
    11641 attttctcag atatacctca tagataatag tgtttagagt aatgttatta tagcgtatgt
    11701 aataaattat tcactgtttc ttttggtaac tgtgatttaa aaaaagaaaa aaggaaaaaa
    11761 aaagctttat acagtttagg ttgtgctttt gtaatagatg aaaatgtgcg cttaaaaaaa
    11821 aaagaaacat acgttctttt tatttttctt ctccccccac cccctttgga ttttatttat
    11881 tctggattgg ggaaagttgc agaatgagcc caaagtttac agtttcatat tttgctgaag
    11941 aaacaatctg tgttcatttg ctctgttgaa aaaaaaaaaa aagaagttat tttctacatg
    12001 tgtgctaatt gttctgtgtt aacggtgtaa tattataatt agcaactgcc aatcagtgct
    12061 ataattttat gcatgaggct aaaaacttag cagtgtgatg cattgtggtc ttaatagcaa
    12121 cattttttca ttttgtacta gatccttccc tttggttcaa cagacattat ttatgcatgg
    12181 gtgcctattg tttgttagca gtcgtgaacc cttgtgtata cattaaactg tgaacatgtg
    12241 cacagttcgg cctcagacag tgataatacc agttttcttg ggaaatgtat taccttggca
    12301 aataccttca catctgttgg gatttcaaca tgagtcagat cgaatcaggt ttgtattatg
    12361 atgagaaaag tcacccaagt tggaattagc ccactagaac cccacaactc tggagcctca
    12421 taacccagat atatcactat agatttttaa tttccactaa agggaatctt agctttatgt
    12481 tcatggtctc agaccttttg ggccatgtat atgatacagc tagttcatct aggcctcact
    12541 tttctgggtt tccccttggg aattagattc tgttgtcagt tcccagtaga catgtacaga
    12601 gcattgacat cagtgaccca tccctgacct atttgtacac tctcccagat aacccctcca
    12661 gttatctgga caaaaagatg tggtcattcc ctaaactttc actcatgtgg tctatcatac
    12721 ttttcttctt tagggtctga aatgactcta gattgatcct tacaaagcta tatctatatt
    12781 ctaaaggggt ttttgggttt gtttgtttgt ttgttttgaa gaccaattca cggaaaccat
    12841 tttgtttgaa ttccccagtc tttgagatct ttatctcaaa aaatattttt cagacccagt
    12901 ggattgaatg aacataatat tataattggg ttctgagatc cgttcttgag tttcatacct
    12961 acttcctata ccagtatgct ccccgtaaaa cccaatcagc taccaggttc tgcagttctg
    13021 agaatggaga tgaggaataa tgatggactc aacagtctgc catgcagaat tctggaactc
    13081 accaacagac agcagagcat cgcacatgtc tgtcagtgag gatgctggag acatcttttc
    13141 attgataacg agaaggaacg gccttataag taggctgcag tgatggcagc tttgtaatgt
    13201 agtccttttt gttttccctt tttattaatc tgccaaagat ggaaatggat ataaaaactt
    13261 taaaatcagc ttttgcaagc cagttttttg attgtaatag tgtttaatct tccggaaagc
    13321 tttacatatt cctctgcaat aagtcaagcc actatttgtt tgcattaagt tctcctctta
    13381 tacttacaag cccgcaaacg gttcctcttg atgaagatat ggtaatacct acaatgttct
    13441 aatgtatttt gggtccaaaa cagacaaaag ggtgtgtgag acaggagcat gcccagcccc
    13501 tttttacaac aagcaagcct gggatctggc tcactagaat ttgccaagaa gacttgtctt
    13561 atgaaattcg aggtatattt tgttatgctg ttttatttcc tttttttttt ttaaagaaaa
    13621 gaaaactgtg gaaagtgata tgttgaatca agtgtaagct gagttttcca gacaactgaa
    13681 gtagcttcat tgtgaatgtt attttgttat taaagggttt ttactcaa
//
