LOCUS       NM_019409               2226 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus oligodendrocyte myelin glycoprotein (Omg), mRNA.
ACCESSION   NM_019409
VERSION     NM_019409.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2226)
  AUTHORS   Zhai,J., Kim,H., Han,S.B., Manire,M., Yoo,R., Pang,S., Smith,G.M.
            and Son,Y.J.
  TITLE     Co-targeting myelin inhibitors and CSPGs markedly enhances
            regeneration of GDNF-stimulated, but not conditioning-lesioned,
            sensory axons into the spinal cord
  JOURNAL   Elife 10, e63050 (2021)
   PUBMED   33942723
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2226)
  AUTHORS   Nishino,J., Kim,S., Zhu,Y., Zhu,H. and Morrison,S.J.
  TITLE     A network of heterochronic genes including Imp1 regulates temporal
            changes in stem cell properties
  JOURNAL   Elife 2, e00924 (2013)
   PUBMED   24192035
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2226)
  AUTHORS   Duffy,P., Wang,X., Siegel,C.S., Tu,N., Henkemeyer,M., Cafferty,W.B.
            and Strittmatter,S.M.
  TITLE     Myelin-derived ephrinB3 restricts axonal regeneration and recovery
            after adult CNS injury
  JOURNAL   Proc Natl Acad Sci U S A 109 (13), 5063-5068 (2012)
   PUBMED   22411787
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5905.
            Seigel, Chad S [corrected to Siegel, Chad S]]
REFERENCE   4  (bases 1 to 2226)
  AUTHORS   Dickendesher,T.L., Baldwin,K.T., Mironova,Y.A., Koriyama,Y.,
            Raiker,S.J., Askew,K.L., Wood,A., Geoffroy,C.G., Zheng,B.,
            Liepmann,C.D., Katagiri,Y., Benowitz,L.I., Geller,H.M. and
            Giger,R.J.
  TITLE     NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans
  JOURNAL   Nat Neurosci 15 (5), 703-712 (2012)
   PUBMED   22406547
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2226)
  AUTHORS   Lee,X., Hu,Y., Zhang,Y., Yang,Z., Shao,Z., Qiu,M., Pepinsky,B.,
            Miller,R.H. and Mi,S.
  TITLE     Oligodendrocyte differentiation and myelination defects in OMgp
            null mice
  JOURNAL   Mol Cell Neurosci 46 (4), 752-761 (2011)
   PUBMED   21352918
  REMARK    GeneRIF: study provided in vitro and in vivo evidence that
            endogenous OMgp plays an important role in oligodendrocyte
            differentiation and myelination
REFERENCE   6  (bases 1 to 2226)
  AUTHORS   Kerlero de Rosbo,N., Mendel,I. and Ben-Nun,A.
  TITLE     Chronic relapsing experimental autoimmune encephalomyelitis with a
            delayed onset and an atypical clinical course, induced in PL/J mice
            by myelin oligodendrocyte glycoprotein (MOG)-derived peptide:
            preliminary analysis of MOG T cell epitopes
  JOURNAL   Eur J Immunol 25 (4), 985-993 (1995)
   PUBMED   7737302
REFERENCE   7  (bases 1 to 2226)
  AUTHORS   Daubas,P., Pham-Dinh,D. and Dautigny,A.
  TITLE     Structure and polymorphism of the mouse myelin/oligodendrocyte
            glycoprotein gene
  JOURNAL   Genomics 23 (1), 36-41 (1994)
   PUBMED   7829100
REFERENCE   8  (bases 1 to 2226)
  AUTHORS   Mikol,D.D., Rongnoparut,P., Allwardt,B.A., Marton,L.S. and
            Stefansson,K.
  TITLE     The oligodendrocyte-myelin glycoprotein of mouse: primary structure
            and gene structure
  JOURNAL   Genomics 17 (3), 604-610 (1993)
   PUBMED   8244377
REFERENCE   9  (bases 1 to 2226)
  AUTHORS   Amiguet,P., Gardinier,M.V., Zanetta,J.P. and Matthieu,J.M.
  TITLE     Purification and partial structural and functional characterization
            of mouse myelin/oligodendrocyte glycoprotein
  JOURNAL   J Neurochem 58 (5), 1676-1682 (1992)
   PUBMED   1373175
REFERENCE   10 (bases 1 to 2226)
  AUTHORS   Lebar,R., Lubetzki,C., Vincent,C., Lombrail,P. and Boutry,J.M.
  TITLE     The M2 autoantigen of central nervous system myelin, a glycoprotein
            present in oligodendrocyte membrane
  JOURNAL   Clin Exp Immunol 66 (2), 423-434 (1986)
   PUBMED   2434274
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY721452.1, BC024757.1 and AK039141.1.
            
            On Apr 16, 2009 this sequence version replaced NM_019409.1.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by available transcript
            and conservation data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY721452.1, SRR1660821.167224.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               BY721452.1         1-107
            108-1870            BC024757.1         1-1763
            1871-2226           AK039141.1         1238-1593
FEATURES             Location/Qualifiers
     source          1..2226
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.79 cM"
     gene            1..2226
                     /gene="Omg"
                     /note="oligodendrocyte myelin glycoprotein"
                     /db_xref="GeneID:18377"
                     /db_xref="MGI:MGI:106586"
     exon            1..180
                     /gene="Omg"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1509
                     /gene="Omg"
                     /codon_start=1
                     /product="oligodendrocyte-myelin glycoprotein precursor"
                     /protein_id="NP_062282.2"
                     /db_xref="CCDS:CCDS25120.2"
                     /db_xref="GeneID:18377"
                     /db_xref="MGI:MGI:106586"
                     /translation="MALMEYQILKMSSCLFILLFLTPGILCICPLQCTCTERHRHVDC
                     SGRNLTTLPPGLQENIIHLNLSYNHFTDLHNQLTPYTNLRTLDISNNRLESLPAQLPR
                     SLWNMSAANNNIKLLDKSDTAYQWNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNK
                     LWTVPTNMPSKLHIVDLSNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPEQSFDQLL
                     QLQEITLHNNRWSCDHKQNITYLLKWVMETKAHVIGTPCSKQVSSLKEQSMYPTPPGF
                     TSSLFTMSEMQTVDTINSLSMVTQPKVTKTPKQYRGKETTFGVTLSKDTTFSSTDRAV
                     VAYPEDTPTEMTNSHEAAAATLTIHLQDGMSSNASLTSATKSPPSPVTLSIARGMPNN
                     FSEMPRQSTTLNLRREETTANGNTRPPSAASAWKVNASLLLMLNAVVMLAG"
     exon            181..2226
                     /gene="Omg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1665..1670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Omg"
                     /note="hexamer: ATTAAA"
     polyA_site      1692
                     /gene="Omg"
                     /note="major polyA site"
     regulatory      1850..1855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Omg"
                     /note="hexamer: AATAAA"
     polyA_site      1872
                     /gene="Omg"
                     /note="major polyA site"
ORIGIN      
        1 agtcctccta tgtggtgctg atcaggtggt tgcagagctt cggctcacag caacacaatg
       61 cagctgagct ggcaagcaga gcccacagcc agaaaccctt ccgactccca caacaagacg
      121 acctttaagc tgcaagtttc ccggagaaaa tgagatactg atagtgaaga cgacattatg
      181 gctttgatgg aatatcagat actgaaaatg tcttcctgcc tgttcatcct tctgtttctc
      241 acgcctggca tcttatgcat ttgtcctctc cagtgtacat gcacagagag gcacaggcat
      301 gtggactgtt caggcagaaa cttgactaca ttaccacctg gactgcagga gaacattata
      361 catttaaacc tgtcttataa ccactttact gatctgcata accagttaac cccatatacc
      421 aatctgagaa ccctggatat ttcaaacaac aggcttgaaa gtctgcctgc tcagttacct
      481 cggtctctct ggaacatgtc tgctgctaac aacaatatta aacttcttga caaatctgat
      541 actgcttatc agtggaacct taaatacctg gatgtttcta agaatatgct ggaaaaggtt
      601 gttctcatta aaaataccct aagaagtctc gaggttctta acctcagcag taacaagctt
      661 tggacagttc caaccaacat gccttccaaa ctgcatatcg tggacctgtc taataactca
      721 ctgacacaaa tccttccagg gacattaata aacctgacaa atctcacaca tctttacctg
      781 cacaacaata aattcacatt cattccagaa cagtcttttg accaactttt gcagttgcaa
      841 gagataactc ttcataataa caggtggtca tgtgaccata aacaaaacat tacttactta
      901 ttgaagtggg tgatggaaac gaaagcccat gtgataggga ctccttgttc taagcaagta
      961 tcctctctaa aggaacagag catgtacccc acacctcctg ggtttacctc aagcttattt
     1021 actatgagtg agatgcagac agtggacacc attaactctt tgagtatggt aactcaaccc
     1081 aaagtgacca aaacacccaa acaatatcga ggaaaggaaa ccacatttgg tgtcactcta
     1141 agcaaagata ccacttttag tagcactgat agggctgtgg tggcctaccc agaagacaca
     1201 cccacagaaa tgaccaattc ccatgaagca gcagctgcaa ctctaactat tcacctccag
     1261 gatggaatga gttcaaatgc aagcctcacc agtgcaacaa agtcaccccc aagccccgtg
     1321 accctcagca tagctcgtgg catgccaaat aacttctctg aaatgcctcg acaaagcaca
     1381 accctcaact tacggaggga agaaaccact gcaaatggaa acactcggcc accttctgcg
     1441 gctagtgctt ggaaagtaaa tgcctcgctc cttttaatgc tcaatgctgt ggtcatgctg
     1501 gcaggctgag ggtctgcagt ttctgaaacg aaggagaacc ttcctccatg atgtacagtt
     1561 gggaaaacgt gcccctatct aaccagtgat tcaagctata ttatgtattc aagaaagcca
     1621 gtcttatatt tctgactttg atgtaaatga agtaatttgt cttaattaaa agaagtgcac
     1681 aatgtcttgg tacttgctgc tattttcctg tcttaagtaa aactaatgac tttttttttt
     1741 aatgaaatgt tttcttttta aggcttcaac ttattgcaca aactataaag agcatctaaa
     1801 ctttaatatg tattttatgt atgtttacac tgtcaaatgt ctgggacaaa ataaaaggcc
     1861 tatgctcctg gctgtgtcac gtggtctcta gacattatca cagcttttgc tgtagggaag
     1921 atgaagtctg taaggtgaat gaaacgtgag ccactcaaaa gggttttgcc acttaagtga
     1981 aaccaaggct gtcactgtaa ataaatgctc acaccacatc attgttttac acacaagaca
     2041 gaactacttc caatctaaac aatgtcctgc ttctgaggga ctcttgctag tctgcagatt
     2101 atataatgga caactgctct tcaaaaggct aggaggctct tagcttggca tcttaacagg
     2161 gaaaatttaa ctttgctttg catttaagaa aagtataaaa aacaaaagaa taaaaagttt
     2221 ccattt
//
