LOCUS       NM_001419124            2032 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus OMA1 zinc metallopeptidase (Oma1), transcript variant
            12, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001419124
VERSION     NM_001419124.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2032)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2032)
  AUTHORS   Yang,Q., Wang,L., Liang,Y., He,Q., Sun,Q., Luo,J., Cao,H., Fang,Y.,
            Zhou,Y., Yang,J., Wen,P. and Jiang,L.
  TITLE     Loss of UCP2 causes mitochondrial fragmentation by OMA1-dependent
            proteolytic processing of OPA1 in podocytes
  JOURNAL   FASEB J 37 (11), e23265 (2023)
   PUBMED   37874273
  REMARK    GeneRIF: Loss of UCP2 causes mitochondrial fragmentation by
            OMA1-dependent proteolytic processing of OPA1 in podocytes.
REFERENCE   3  (bases 1 to 2032)
  AUTHORS   Miallot,R., Millet,V., Groult,Y., Modelska,A., Crescence,L.,
            Roulland,S., Henri,S., Malissen,B., Brouilly,N., Panicot-Dubois,L.,
            Vincentelli,R., Sulzenbacher,G., Finetti,P., Dutour,A., Blay,J.Y.,
            Bertucci,F., Galland,F. and Naquet,P.
  TITLE     An OMA1 redox site controls mitochondrial homeostasis, sarcoma
            growth, and immunogenicity
  JOURNAL   Life Sci Alliance 6 (6), e202201767 (2023)
   PUBMED   37024121
  REMARK    GeneRIF: An OMA1 redox site controls mitochondrial homeostasis,
            sarcoma growth, and immunogenicity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2032)
  AUTHORS   Ahola,S., Rivera Mejias,P., Hermans,S., Chandragiri,S.,
            Giavalisco,P., Nolte,H. and Langer,T.
  TITLE     OMA1-mediated integrated stress response protects against
            ferroptosis in mitochondrial cardiomyopathy
  JOURNAL   Cell Metab 34 (11), 1875-1891 (2022)
   PUBMED   36113464
  REMARK    GeneRIF: OMA1-mediated integrated stress response protects against
            ferroptosis in mitochondrial cardiomyopathy.
REFERENCE   5  (bases 1 to 2032)
  AUTHORS   Shammas,M.K., Huang,X., Wu,B.P., Fessler,E., Song,I.Y.,
            Randolph,N.P., Li,Y., Bleck,C.K., Springer,D.A., Fratter,C.,
            Barbosa,I.A., Powers,A.F., Quiros,P.M., Lopez-Otin,C., Jae,L.T.,
            Poulton,J. and Narendra,D.P.
  TITLE     OMA1 mediates local and global stress responses against protein
            misfolding in CHCHD10 mitochondrial myopathy
  JOURNAL   J Clin Invest 132 (14) (2022)
   PUBMED   35700042
  REMARK    GeneRIF: OMA1 mediates local and global stress responses against
            protein misfolding in CHCHD10 mitochondrial myopathy.
REFERENCE   6  (bases 1 to 2032)
  AUTHORS   Quiros,P.M., Ramsay,A.J., Sala,D., Fernandez-Vizarra,E.,
            Rodriguez,F., Peinado,J.R., Fernandez-Garcia,M.S., Vega,J.A.,
            Enriquez,J.A., Zorzano,A. and Lopez-Otin,C.
  TITLE     Loss of mitochondrial protease OMA1 alters processing of the GTPase
            OPA1 and causes obesity and defective thermogenesis in mice
  JOURNAL   EMBO J 31 (9), 2117-2133 (2012)
   PUBMED   22433842
  REMARK    GeneRIF: This study shows that OMA1 plays an essential role in the
            proteolytic inactivation of the dynamin-related GTPase OPA1 and
            describes its unexpected role in energy metabolism
REFERENCE   7  (bases 1 to 2032)
  AUTHORS   Ehses,S., Raschke,I., Mancuso,G., Bernacchia,A., Geimer,S.,
            Tondera,D., Martinou,J.C., Westermann,B., Rugarli,E.I. and
            Langer,T.
  TITLE     Regulation of OPA1 processing and mitochondrial fusion by m-AAA
            protease isoenzymes and OMA1
  JOURNAL   J Cell Biol 187 (7), 1023-1036 (2009)
   PUBMED   20038678
  REMARK    GeneRIF: OMA1 regulates OPA1 cleavage in the mitochondrial inner
            membrane.
REFERENCE   8  (bases 1 to 2032)
  AUTHORS   Duvezin-Caubet,S., Koppen,M., Wagener,J., Zick,M., Israel,L.,
            Bernacchia,A., Jagasia,R., Rugarli,E.I., Imhof,A., Neupert,W.,
            Langer,T. and Reichert,A.S.
  TITLE     OPA1 processing reconstituted in yeast depends on the subunit
            composition of the m-AAA protease in mitochondria
  JOURNAL   Mol Biol Cell 18 (9), 3582-3590 (2007)
   PUBMED   17615298
REFERENCE   9  (bases 1 to 2032)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   10 (bases 1 to 2032)
  AUTHORS   Bar,I., Tissir,F., Lambert de Rouvroit,C., De Backer,O. and
            Goffinet,A.M.
  TITLE     The gene encoding disabled-1 (DAB1), the intracellular adaptor of
            the Reelin pathway, reveals unusual complexity in human and mouse
  JOURNAL   J Biol Chem 278 (8), 5802-5812 (2003)
   PUBMED   12446734
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772338.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.2062942.1,
                                           ERR3363658.1424493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AL772338.9         146395-146435
            42-548              AL772338.9         151574-152080
            549-777             AL772338.9         154192-154420
            778-951             AL772338.9         157571-157744
            952-1059            AL772338.9         157845-157952
            1060-1134           AL772338.9         163857-163931
            1135-2032           AL772338.9         186054-186951
FEATURES             Location/Qualifiers
     source          1..2032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 47.6 cM"
     gene            1..2032
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /note="OMA1 zinc metallopeptidase"
                     /db_xref="GeneID:67013"
                     /db_xref="MGI:MGI:1914263"
     exon            1..41
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            42..548
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1293
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /note="isoform h precursor is encoded by transcript
                     variant 12; metalloendopeptidase OMA1, mitochondrial;
                     overlapping with the m-AAA protease 1 homolog; OMA1
                     homolog, zinc metallopeptidase"
                     /codon_start=1
                     /product="metalloendopeptidase OMA1, mitochondrial isoform
                     h precursor"
                     /protein_id="NP_001406053.1"
                     /db_xref="GeneID:67013"
                     /db_xref="MGI:MGI:1914263"
                     /translation="MSLLYGLQSTRINRFLSGVNNLANRRQWTPPASCPLAPKLRAVN
                     AYWGLNTVSHCHSVTLLPRNFLFCRTLNHKKSRCLSSAQSKELGVLTYRCTVRGDSVL
                     RQGARKVAGVPALAASCSPSCPAVIEARSFRTSARVQAAPVPLLLLILKPVQKLLAII
                     VGRGIRKWWQALPPNKKELFKDSVRKNKWRLLLGLSAFGLLFVVFYFTHLEVSPVTGR
                     SKLLLVGKEHFRLLSDLEYEVWMEEFKNDLLPERDPRYLTVKEMVYHLTQCNRDVPGI
                     SETNWVVHVVDSPAVNAFVLPNGQVFIFTGLLNSVTDVHQLSFLLGHEIAHAVLGHAY
                     MFDRPYSRTLEAEADKVGLQLAAKACADVRASSVFWQQMEFSESLHGYPKLPEWLSTH
                     PSHGNRAEYLDRLIPQVS"
     exon            549..777
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..951
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1059
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1134
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..2032
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2013..2018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /note="hexamer: ATTAAA"
     polyA_site      2032
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /note="major polyA site"
ORIGIN      
        1 gttggattcc gctcgggctg tggcttcagt gcgcgctcac gataaccaag caaaagaaag
       61 atgagcctcc tttatggact gcagtctacc aggataaatc ggtttctctc tggagtgaat
      121 aacctggcca acaggagaca gtggaccccc ccagcaagct gtccactggc accaaagctc
      181 cgagcagtaa atgcatactg gggactgaac acagtcagtc attgtcattc agtgacctta
      241 ctgcctagaa actttctttt ctgtaggact ctcaatcaca aaaaatcaag atgcctctca
      301 agtgcccaaa gcaaggaatt gggggtgctt acctacagat gtactgtgcg gggtgattct
      361 gttctaagac aaggagcaag gaaagtggct ggcgttcctg ctctcgcggc ctcctgttct
      421 ccaagctgtc ctgccgtaat agaggcccgg agtttccgta catctgcaag ggttcaggct
      481 gccccagtcc ctctcttgct gctcattctg aagccagtgc aaaagctcct tgctatcatc
      541 gtgggcaggg gcataaggaa atggtggcaa gcacttcccc ctaacaagaa ggagctattt
      601 aaagacagcg tgaggaagaa caagtggcgg ctgcttcttg gtctgagtgc atttggactg
      661 ctctttgtag tgttttattt cactcacctg gaagtgagcc ctgtcaccgg aaggagtaaa
      721 ctactgttag tgggcaaaga acacttccga cttctgtcag acctggaata tgaagtatgg
      781 atggaagaat ttaagaacga tctgctgcct gagagagacc cccgctacct gactgtgaaa
      841 gaaatggttt atcatctgac acagtgcaat cgagacgtcc cggggatctc ggagaccaac
      901 tgggtggttc atgtggttga ctccccagcc gtcaatgcct ttgtgctccc aaatggacaa
      961 gtgtttattt tcaccgggct tctgaatagt gtgacggacg tgcaccagct gtccttcctc
     1021 ctgggccatg agatcgcaca cgcagtcctg gggcacgcct acatgtttga tcgaccatac
     1081 agtagaacat tggaggccga agctgacaaa gttggactac agctggctgc aaaggcatgt
     1141 gccgatgtaa gagctagttc agtgttttgg cagcagatgg agttctcaga gagtcttcat
     1201 ggctatccca agttgccaga gtggctgtcg acacatcctt ctcatgggaa ccgagctgag
     1261 tacttggata gactcatacc acaggtgagc taaccccact aattctgtta cttttttggt
     1321 atagaaaaag tgaatttcag tatgcaatta ttttggttac cataattatc aactattggt
     1381 ttcacagagt tgtattgaaa agggaattcc tatttaccca caagtcctgg ggaataaatt
     1441 gctatgtaca gctgaatttc ctcagtgtaa ggtctactct cgtgtctgac tgagttgtaa
     1501 ttaacttggt aatgtcttaa accttgagaa ggcctggaga cgtggttcag ttgatgaggg
     1561 cttgcctagc atacaggaaa ccctgtattg tacctctagt actttgcaaa gtgggtgtgg
     1621 tgatgcacac ccgtaatacc agtgcttggg aggtggggac aggaaaacca agagttcaag
     1681 gacatcccta gctccacagt gagtttgagg tcatgagacc tcatgagaca tgagaccctg
     1741 tctcaaagca aaaaaataag caaaaaagga aaagaagaca actttgggca ttttttcaat
     1801 atattgatca taatttggtc ttatttgatc ttcccttaac ttttggtttt ggaataaatg
     1861 ggtattaact ctttggtttt ttgtttgttt gtttgtttta gccaaagtca tactacaaag
     1921 tcttggctag cttggaattt acgatgtaga caagcgtggc caagaattca cagagatatt
     1981 tctgcttctg cctttgtctc ccaagttctg ggattaaaaa tgtgctcccc ca
//
