LOCUS       NM_001419121            1985 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus OMA1 zinc metallopeptidase (Oma1), transcript variant
            9, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001419121 XM_006503300
VERSION     NM_001419121.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1985)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1985)
  AUTHORS   Yang,Q., Wang,L., Liang,Y., He,Q., Sun,Q., Luo,J., Cao,H., Fang,Y.,
            Zhou,Y., Yang,J., Wen,P. and Jiang,L.
  TITLE     Loss of UCP2 causes mitochondrial fragmentation by OMA1-dependent
            proteolytic processing of OPA1 in podocytes
  JOURNAL   FASEB J 37 (11), e23265 (2023)
   PUBMED   37874273
  REMARK    GeneRIF: Loss of UCP2 causes mitochondrial fragmentation by
            OMA1-dependent proteolytic processing of OPA1 in podocytes.
REFERENCE   3  (bases 1 to 1985)
  AUTHORS   Miallot,R., Millet,V., Groult,Y., Modelska,A., Crescence,L.,
            Roulland,S., Henri,S., Malissen,B., Brouilly,N., Panicot-Dubois,L.,
            Vincentelli,R., Sulzenbacher,G., Finetti,P., Dutour,A., Blay,J.Y.,
            Bertucci,F., Galland,F. and Naquet,P.
  TITLE     An OMA1 redox site controls mitochondrial homeostasis, sarcoma
            growth, and immunogenicity
  JOURNAL   Life Sci Alliance 6 (6), e202201767 (2023)
   PUBMED   37024121
  REMARK    GeneRIF: An OMA1 redox site controls mitochondrial homeostasis,
            sarcoma growth, and immunogenicity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1985)
  AUTHORS   Ahola,S., Rivera Mejias,P., Hermans,S., Chandragiri,S.,
            Giavalisco,P., Nolte,H. and Langer,T.
  TITLE     OMA1-mediated integrated stress response protects against
            ferroptosis in mitochondrial cardiomyopathy
  JOURNAL   Cell Metab 34 (11), 1875-1891 (2022)
   PUBMED   36113464
  REMARK    GeneRIF: OMA1-mediated integrated stress response protects against
            ferroptosis in mitochondrial cardiomyopathy.
REFERENCE   5  (bases 1 to 1985)
  AUTHORS   Shammas,M.K., Huang,X., Wu,B.P., Fessler,E., Song,I.Y.,
            Randolph,N.P., Li,Y., Bleck,C.K., Springer,D.A., Fratter,C.,
            Barbosa,I.A., Powers,A.F., Quiros,P.M., Lopez-Otin,C., Jae,L.T.,
            Poulton,J. and Narendra,D.P.
  TITLE     OMA1 mediates local and global stress responses against protein
            misfolding in CHCHD10 mitochondrial myopathy
  JOURNAL   J Clin Invest 132 (14) (2022)
   PUBMED   35700042
  REMARK    GeneRIF: OMA1 mediates local and global stress responses against
            protein misfolding in CHCHD10 mitochondrial myopathy.
REFERENCE   6  (bases 1 to 1985)
  AUTHORS   Quiros,P.M., Ramsay,A.J., Sala,D., Fernandez-Vizarra,E.,
            Rodriguez,F., Peinado,J.R., Fernandez-Garcia,M.S., Vega,J.A.,
            Enriquez,J.A., Zorzano,A. and Lopez-Otin,C.
  TITLE     Loss of mitochondrial protease OMA1 alters processing of the GTPase
            OPA1 and causes obesity and defective thermogenesis in mice
  JOURNAL   EMBO J 31 (9), 2117-2133 (2012)
   PUBMED   22433842
  REMARK    GeneRIF: This study shows that OMA1 plays an essential role in the
            proteolytic inactivation of the dynamin-related GTPase OPA1 and
            describes its unexpected role in energy metabolism
REFERENCE   7  (bases 1 to 1985)
  AUTHORS   Ehses,S., Raschke,I., Mancuso,G., Bernacchia,A., Geimer,S.,
            Tondera,D., Martinou,J.C., Westermann,B., Rugarli,E.I. and
            Langer,T.
  TITLE     Regulation of OPA1 processing and mitochondrial fusion by m-AAA
            protease isoenzymes and OMA1
  JOURNAL   J Cell Biol 187 (7), 1023-1036 (2009)
   PUBMED   20038678
  REMARK    GeneRIF: OMA1 regulates OPA1 cleavage in the mitochondrial inner
            membrane.
REFERENCE   8  (bases 1 to 1985)
  AUTHORS   Duvezin-Caubet,S., Koppen,M., Wagener,J., Zick,M., Israel,L.,
            Bernacchia,A., Jagasia,R., Rugarli,E.I., Imhof,A., Neupert,W.,
            Langer,T. and Reichert,A.S.
  TITLE     OPA1 processing reconstituted in yeast depends on the subunit
            composition of the m-AAA protease in mitochondria
  JOURNAL   Mol Biol Cell 18 (9), 3582-3590 (2007)
   PUBMED   17615298
REFERENCE   9  (bases 1 to 1985)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   10 (bases 1 to 1985)
  AUTHORS   Bar,I., Tissir,F., Lambert de Rouvroit,C., De Backer,O. and
            Goffinet,A.M.
  TITLE     The gene encoding disabled-1 (DAB1), the intracellular adaptor of
            the Reelin pathway, reveals unusual complexity in human and mouse
  JOURNAL   J Biol Chem 278 (8), 5802-5812 (2003)
   PUBMED   12446734
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772338.9.
            
            On Mar 28, 2023 this sequence version replaced XM_006503300.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.2203475.1,
                                           SRR13422603.391436.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AL772338.9         146395-146550
            157-663             AL772338.9         151574-152080
            664-892             AL772338.9         154192-154420
            893-1066            AL772338.9         157571-157744
            1067-1174           AL772338.9         157845-157952
            1175-1303           AL772338.9         161390-161518
            1304-1378           AL772338.9         163857-163931
            1379-1528           AL772338.9         186054-186203
            1529-1985           AL772338.9         198525-198981
FEATURES             Location/Qualifiers
     source          1..1985
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 47.6 cM"
     gene            1..1985
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /note="OMA1 zinc metallopeptidase"
                     /db_xref="GeneID:67013"
                     /db_xref="MGI:MGI:1914263"
     exon            1..156
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            157..663
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1741
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /note="isoform e precursor is encoded by transcript
                     variant 9; metalloendopeptidase OMA1, mitochondrial;
                     overlapping with the m-AAA protease 1 homolog; OMA1
                     homolog, zinc metallopeptidase"
                     /codon_start=1
                     /product="metalloendopeptidase OMA1, mitochondrial isoform
                     e precursor"
                     /protein_id="NP_001406050.1"
                     /db_xref="GeneID:67013"
                     /db_xref="MGI:MGI:1914263"
                     /translation="MSLLYGLQSTRINRFLSGVNNLANRRQWTPPASCPLAPKLRAVN
                     AYWGLNTVSHCHSVTLLPRNFLFCRTLNHKKSRCLSSAQSKELGVLTYRCTVRGDSVL
                     RQGARKVAGVPALAASCSPSCPAVIEARSFRTSARVQAAPVPLLLLILKPVQKLLAII
                     VGRGIRKWWQALPPNKKELFKDSVRKNKWRLLLGLSAFGLLFVVFYFTHLEVSPVTGR
                     SKLLLVGKEHFRLLSDLEYEVWMEEFKNDLLPERDPRYLTVKEMVYHLTQCNRDVPGI
                     SETNWVVHVVDSPAVNAFVLPNGQVFIFTGLLNSVTDVHQLSFLLGHEIAHAVLGHAA
                     EKASLVHLLDFLGMIFLTMIWAICPRDSLAVLGQWIQSKLQEYMFDRPYSRTLEAEAD
                     KVGLQLAAKACADVRASSVFWQQMEFSESLHGYPKLPEWLSTHPSHGNRAEYLDRLIP
                     QALKLREVCNCPPLSGPDPRLLFRLTVKRFLEDSEKEDLNITVKKQKTDALPMQKQEQ
                     IPLTYVLEKRTAG"
     exon            664..892
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1066
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1174
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1303
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1378
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1528
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1985
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1967..1972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /note="hexamer: AATAAA"
     polyA_site      1985
                     /gene="Oma1"
                     /gene_synonym="2010001O09Rik; MPRP-1; ZMPOMA1"
                     /note="major polyA site"
ORIGIN      
        1 gttggattcc gctcgggctg tggcttcagt gcgcgctcac ggtgacggct cggcgttctt
       61 ccagagcggg gcggggaggg cggagagggg agcggggccc gggggattcg gggaccgcgg
      121 tgggcctagg ccgtgccgga cgaggcgaac ggctcgataa ccaagcaaaa gaaagatgag
      181 cctcctttat ggactgcagt ctaccaggat aaatcggttt ctctctggag tgaataacct
      241 ggccaacagg agacagtgga cccccccagc aagctgtcca ctggcaccaa agctccgagc
      301 agtaaatgca tactggggac tgaacacagt cagtcattgt cattcagtga ccttactgcc
      361 tagaaacttt cttttctgta ggactctcaa tcacaaaaaa tcaagatgcc tctcaagtgc
      421 ccaaagcaag gaattggggg tgcttaccta cagatgtact gtgcggggtg attctgttct
      481 aagacaagga gcaaggaaag tggctggcgt tcctgctctc gcggcctcct gttctccaag
      541 ctgtcctgcc gtaatagagg cccggagttt ccgtacatct gcaagggttc aggctgcccc
      601 agtccctctc ttgctgctca ttctgaagcc agtgcaaaag ctccttgcta tcatcgtggg
      661 caggggcata aggaaatggt ggcaagcact tccccctaac aagaaggagc tatttaaaga
      721 cagcgtgagg aagaacaagt ggcggctgct tcttggtctg agtgcatttg gactgctctt
      781 tgtagtgttt tatttcactc acctggaagt gagccctgtc accggaagga gtaaactact
      841 gttagtgggc aaagaacact tccgacttct gtcagacctg gaatatgaag tatggatgga
      901 agaatttaag aacgatctgc tgcctgagag agacccccgc tacctgactg tgaaagaaat
      961 ggtttatcat ctgacacagt gcaatcgaga cgtcccgggg atctcggaga ccaactgggt
     1021 ggttcatgtg gttgactccc cagccgtcaa tgcctttgtg ctcccaaatg gacaagtgtt
     1081 tattttcacc gggcttctga atagtgtgac ggacgtgcac cagctgtcct tcctcctggg
     1141 ccatgagatc gcacacgcag tcctggggca cgccgcagaa aaggctagct tggttcattt
     1201 actggatttc cttggtatga tttttctcac aatgatttgg gccatttgtc cccgagacag
     1261 cttggcagtt ttgggccagt ggatacagtc aaagttgcag gagtacatgt ttgatcgacc
     1321 atacagtaga acattggagg ccgaagctga caaagttgga ctacagctgg ctgcaaaggc
     1381 atgtgccgat gtaagagcta gttcagtgtt ttggcagcag atggagttct cagagagtct
     1441 tcatggctat cccaagttgc cagagtggct gtcgacacat ccttctcatg ggaaccgagc
     1501 tgagtacttg gatagactca taccacaggc tctcaaactc cgggaggtct gcaattgccc
     1561 gccactctct ggcccagacc ctcggctatt gttcaggctt actgtgaagc gttttcttga
     1621 agactcggag aaagaggacc taaacatcac tgtcaaaaag cagaaaacgg atgctctccc
     1681 catgcagaag caggagcaga taccactgac gtatgtccta gagaagagaa ctgcaggctg
     1741 aacggaagtg ggtgaatcgt gggctccatg agcagcacag tggacctttt ccttattacg
     1801 caacttttaa aaatgatgtt ttcaaggaaa aaaaaaaaag aatgttcaaa ggccaagtca
     1861 cttatattat agatattatc tggatttttc taggttttta tctttcatga aatattaatg
     1921 tgtttccacc tattttaaaa tactgccaat gaggaaaaca tcacagaata aattgatatt
     1981 atgca
//
