LOCUS       NM_138648               3581 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus oxidized low density lipoprotein (lectin-like)
            receptor 1 (Olr1), transcript variant 1, mRNA.
ACCESSION   NM_138648 XM_984831
VERSION     NM_138648.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3581)
  AUTHORS   Qiu,J., Liu,J., Tian,L., Yu,J., Duan,Q., Liu,Y., Zhao,W., Si,H.,
            Lu,X. and Zhang,Q.
  TITLE     Knockdown of LOX-1 ameliorates bone quality and generation of type
            H blood vessels in diabetic mice
  JOURNAL   Arch Biochem Biophys 752, 109870 (2024)
   PUBMED   38141905
  REMARK    GeneRIF: Knockdown of LOX-1 ameliorates bone quality and generation
            of type H blood vessels in diabetic mice.
REFERENCE   2  (bases 1 to 3581)
  AUTHORS   Zeng,J., Xie,C., Huang,Z., Cho,C.H., Chan,H., Li,Q., Ashktorab,H.,
            Smoot,D.T., Wong,S.H., Yu,J., Gong,W., Liang,C., Xu,H., Chen,H.,
            Liu,X., Wu,J.C.Y., Ip,M., Gin,T., Zhang,L., Chan,M.T.V., Hu,W. and
            Wu,W.K.K.
  TITLE     LOX-1 acts as an N6-methyladenosine-regulated receptor for
            Helicobacter pylori by binding to the bacterial catalase
  JOURNAL   Nat Commun 15 (1), 669 (2024)
   PUBMED   38253620
  REMARK    GeneRIF: LOX-1 acts as an N[6]-methyladenosine-regulated receptor
            for Helicobacter pylori by binding to the bacterial catalase.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3581)
  AUTHORS   Song,Z.K., Zhao,L., Liu,D.S., Zhao,L.N., Peng,Q.B., Li,Z.Y.,
            Wu,J.Y., Chen,S.K., Huang,F.Z., Chen,X., Lin,T.X., Guan,L.,
            Meng,W.P., Guo,J.W., Su,Y.N., He,X.X., Liang,S.J., Zhu,P.,
            Zheng,S.Y., Du,S.L. and Liu,X.
  TITLE     Macrophage KLF15 prevents foam cell formation and atherosclerosis
            via transcriptional suppression of OLR-1
  JOURNAL   J Mol Cell Cardiol 186, 57-70 (2024)
   PUBMED   37984156
  REMARK    GeneRIF: Macrophage KLF15 prevents foam cell formation and
            atherosclerosis via transcriptional suppression of OLR-1.
REFERENCE   4  (bases 1 to 3581)
  AUTHORS   Zhang,Q., Du,G., Tong,L., Guo,X. and Wei,Y.
  TITLE     Overexpression of LOX-1 in hepatocytes protects vascular smooth
            muscle cells from phenotype transformation and wire injury induced
            carotid neoatherosclerosis through ALOX15
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (8), 166805 (2023)
   PUBMED   37468019
  REMARK    GeneRIF: Overexpression of LOX-1 in hepatocytes protects vascular
            smooth muscle cells from phenotype transformation and wire injury
            induced carotid neoatherosclerosis through ALOX15.
REFERENCE   5  (bases 1 to 3581)
  AUTHORS   Korkmaz,F.T., Shenoy,A.T., Symer,E.M., Baird,L.A., Odom,C.V.,
            Arafa,E.I., Dimbo,E.L., Na,E., Molina-Arocho,W., Brudner,M.,
            Standiford,T.J., Mehta,J.L., Sawamura,T., Jones,M.R., Mizgerd,J.P.,
            Traber,K.E. and Quinton,L.J.
  TITLE     Lectin-like oxidized low-density lipoprotein receptor 1 attenuates
            pneumonia-induced lung injury
  JOURNAL   JCI Insight 7 (23), e149955 (2022)
   PUBMED   36264633
  REMARK    GeneRIF: Lectin-like oxidized low-density lipoprotein receptor 1
            attenuates pneumonia-induced lung injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3581)
  AUTHORS   Chen,M. and Sawamura,T.
  TITLE     Essential role of cytoplasmic sequences for cell-surface sorting of
            the lectin-like oxidized LDL receptor-1 (LOX-1)
  JOURNAL   J Mol Cell Cardiol 39 (3), 553-561 (2005)
   PUBMED   15935375
  REMARK    GeneRIF: The essential role of cytoplasmic sequences of LOX-1 for
            cell-surface sorting is established.
REFERENCE   7  (bases 1 to 3581)
  AUTHORS   Suga,M., Sawamura,T., Nakatani,T. and Kitamura,S.
  TITLE     Expression of lectin-like oxidized low-density lipoprotein
            receptor-1 in allografted hearts
  JOURNAL   Transplant Proc 36 (8), 2440-2442 (2004)
   PUBMED   15561273
  REMARK    GeneRIF: Alloimmunw responses induce up-regulation of LOX-1 mRNA in
            transplanted hearts.
REFERENCE   8  (bases 1 to 3581)
  AUTHORS   Chen,M., Narumiya,S., Masaki,T. and Sawamura,T.
  TITLE     Conserved C-terminal residues within the lectin-like domain of
            LOX-1 are essential for oxidized low-density-lipoprotein binding
  JOURNAL   Biochem J 355 (Pt 2), 289-296 (2001)
   PUBMED   11284714
REFERENCE   9  (bases 1 to 3581)
  AUTHORS   Shi,X., Niimi,S., Ohtani,T. and Machida,S.
  TITLE     Characterization of residues and sequences of the carbohydrate
            recognition domain required for cell surface localization and
            ligand binding of human lectin-like oxidized LDL receptor
  JOURNAL   J Cell Sci 114 (Pt 7), 1273-1282 (2001)
   PUBMED   11256994
REFERENCE   10 (bases 1 to 3581)
  AUTHORS   Hoshikawa,H., Sawamura,T., Kakutani,M., Aoyama,T., Nakamura,T. and
            Masaki,T.
  TITLE     High affinity binding of oxidized LDL to mouse lectin-like oxidized
            LDL receptor (LOX-1)
  JOURNAL   Biochem Biophys Res Commun 245 (3), 841-846 (1998)
   PUBMED   9588202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160919.1 and BX513847.1.
            
            On Mar 24, 2007 this sequence version replaced NM_138648.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160919.1, AK154687.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-831               AK160919.1         1-831
            832-3563            AK160919.1         833-3564
            3564-3581           BX513847.1         408-425
FEATURES             Location/Qualifiers
     source          1..3581
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.35 cM"
     gene            1..3581
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Scare1; SR-EI"
                     /note="oxidized low density lipoprotein (lectin-like)
                     receptor 1"
                     /db_xref="GeneID:108078"
                     /db_xref="MGI:MGI:1261434"
     exon            1..131
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Scare1; SR-EI"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1150
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Scare1; SR-EI"
                     /note="isoform 1 is encoded by transcript variant 1;
                     oxidized low-density lipoprotein receptor 1; ox-LDL
                     receptor 1; lectin-like oxLDL receptor 1; lectin-like
                     oxidized LDL receptor 1; lectin-type oxidized LDL receptor
                     1; oxidised low density lipoprotein (lectin-like) receptor
                     1"
                     /codon_start=1
                     /product="oxidized low-density lipoprotein receptor 1
                     isoform 1"
                     /protein_id="NP_619589.2"
                     /db_xref="CCDS:CCDS20588.1"
                     /db_xref="GeneID:108078"
                     /db_xref="MGI:MGI:1261434"
                     /translation="MTFDDKMKPANDEPDQKSCGKKPKGLHLLSSPWWFPAAMTLVIL
                     CLVLSVTLIVQWTQLRQVSDLLKQYQANLTQQDRILEGQMLAQQKAENTSQESKKELK
                     GKIDTLTQKLNEKSKEQEELLQKNQNLQEALQRAANSSEESQRELKGKIDTITRKLDE
                     KSKEQEELLQMIQNLQEALQRAANSSEESQRELKGKIDTLTLKLNEKSKEQEELLQKN
                     QNLQEALQRAANFSGPCPQDWLWHKENCYLFHGPFSWEKNRQTCQSLGGQLLQINGAD
                     DLTFILQAISHTTSPFWIGLHRKKPGQPWLWENGTPLNFQFFKTRGVSLQLYSSGNCA
                     YLQDGAVFAENCILIAFSICQKKTNHLQI"
     exon            132..233
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Scare1; SR-EI"
                     /inference="alignment:Splign:2.1.0"
     exon            234..479
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Scare1; SR-EI"
                     /inference="alignment:Splign:2.1.0"
     exon            480..617
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Scare1; SR-EI"
                     /inference="alignment:Splign:2.1.0"
     exon            618..755
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Scare1; SR-EI"
                     /inference="alignment:Splign:2.1.0"
     exon            756..892
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Scare1; SR-EI"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1008
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Scare1; SR-EI"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..3569
                     /gene="Olr1"
                     /gene_synonym="LOX-1; Scare1; SR-EI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagttggc tgaggtcctc gactgtttca gtttttcact cttagcagga atttggagat
       61 gacttttgat gacaagatga agcctgcgaa tgacgagcct gatcagaagt catgtggcaa
      121 gaagcctaaa ggtctgcatt tgctttcttc cccatggtgg ttccctgctg ctatgactct
      181 ggtcatcctc tgcctggtgt tgtcagtgac ccttattgta cagtggacac aattacgcca
      241 ggtatctgac ctcttaaaac aataccaagc gaaccttact cagcaggatc gtatcctgga
      301 agggcagatg ttagcccagc agaaggcaga aaacacttca caggaatcaa agaaggaact
      361 gaaaggaaag atagacaccc tcacccagaa gctgaacgag aaatccaaag agcaggagga
      421 gcttctacag aagaatcaga acctccaaga agccctgcaa agagctgcaa actcttcaga
      481 ggagtcccag agagaactca agggaaagat agacaccatc acccggaagc tggacgagaa
      541 atccaaagag caggaggagc ttctgcagat gattcagaac ctccaagaag ccctgcagag
      601 agctgcaaac tcttcagagg agtcccagag agaactcaag ggaaagatag acaccctcac
      661 cttgaagctg aacgagaaat ccaaagagca ggaggagctt ctacagaaga atcagaacct
      721 ccaagaagcc ctgcaaagag ctgcaaactt ttcaggtcct tgtccacaag actggctctg
      781 gcataaagaa aactgttacc tcttccatgg gccctttagc tgggaaaaaa accggcagac
      841 ctgccaatct ttgggtggcc agttactaca aattaatggt gcagatgatc tgacattcat
      901 cttacaagca atttcccata ccacctcccc gttctggatt ggattgcatc ggaagaagcc
      961 tggccaacca tggctatggg agaatggaac tcctttgaat tttcaattct ttaagaccag
     1021 gggcgtttct ttacagctat attcatcagg caactgtgca taccttcaag acggagctgt
     1081 gttcgctgaa aactgcattc taattgcatt cagcatatgt cagaagaaga caaatcattt
     1141 gcaaatttag tgaatctaaa gattctggag aagaccatga gaagactttt gactgtcgct
     1201 ctgaaattta agctattctt tattacctgc atgtaaagca tgttggcctt gacatctgtc
     1261 agttacctga tagctacagt tcacctcaac aaagacaagg accagaagca aatactggtg
     1321 gatccagatg tttgaaatct ttgtatcaaa acgtgtgagt tcaattgttt atccatatac
     1381 actggccttg cccctccaaa gtctcccaac caacctgcaa tccttcttcc ccttcgtgtt
     1441 ttaaatgatg cttcctgcct gacctggcca tgctttgtac tcagtctcct ctacctcagt
     1501 atgcctcctg ttgccgcatg aaagacagga tgtagaaatc ctcctcaagt gcaggcagag
     1561 ggctcaaagg caaagctcgt ccgagaaata acatgcaaag aaacagaact ggaaaaacta
     1621 cactgcaaac aggaactcat gatctctaaa aagccatggc ttgatcttta tgacaggagt
     1681 ccatctccag actgcacttt tacacacata ttttttattt tccttttatt gtaagtttat
     1741 ggatagtttg cctacttgaa ttctgtgtac cacatgagtg cctggtgcca ctgaagatca
     1801 gaagaggaca tcagattctc tggatctgga attgcagatg gttgtaagct gctatgtaga
     1861 tgtgaagaat tgaattcgtg tcccctggaa gaacagccag tactctttgc catgagctat
     1921 ctctcaagct cctgtgatca attcttgtat cagttatgtc tccatttttg ctctaccaaa
     1981 gaacagtgtt ataactttaa aacagtaagt attttcatta ttctaggggt attatagcag
     2041 atatatagat atagatatag atgatataga tatagatata gatatagata tagatataga
     2101 tatagatata gatatagata tagatataga tatagatata gatatagagt gtgtgtgtgt
     2161 gtgtgtgtgt gtgtgtgtgt gtgtttctat gctagataca tccttgagaa gatgagacag
     2221 ttttgtgtga aatgagtttg taataatcca aatttaaaaa taaattcgat gattacctgt
     2281 agtggtcata ttaccacagc taagatgatg aacatacctg tcacttctgc ccctttccaa
     2341 agcctccccc ctaaaacaaa caccaatctg ctttcagttc gcattttata gagcttatca
     2401 ttttgttttt aagacagaat ctcattatat agttctggct ggcctggaac tcactacaca
     2461 gagcaggctg gcctccacct tctagagctc ctcctgccag actcccaaac cttaagactg
     2521 aaggagtgcc ctgccatgtg tgactcaaac accttaatgt gaatggaata gcataagatg
     2581 tccaggtttt ttcagtccag cttcttccac ttggtacaat ttttaatttt tgtgttcata
     2641 catctccacc acagtgtttg tatcagttca tcattctttt caaatgttga gccttcccct
     2701 gtggatctat agtgtcattt gttatctgtg tatttgttga tgcgatttgg gttgttttta
     2761 tttggggtca cctacaaata aagctgctat ggatgtccat ggacaaggct aatatcttag
     2821 gtaagcacct acgagtaaga tgcttgggtc attcagtgtg ggaatatatg gttggctatt
     2881 ttaaccattc ctgtttgaaa acattaattt ttttattttt gaaatcaatt ttttaaaaaa
     2941 ttagtctatt ttacatctca accccagttt ctcttcctcc tctcctctca accttctccc
     3001 accttctctc cctgacccca tccacccctc ctccctttct ctccagaaga ggggaggcct
     3061 cccatggatg ccaaccagcc tcagcatctc aagttacagt aagaataggt ttgtcttctc
     3121 ttgtgaaaat cttaattttt agatttatct attatatatg cagtactttg cttgcacata
     3181 tgtattggta ccatgtacat gaatggtacc agagaaagtc agaagaggcc attgtatttt
     3241 ctgggactgg aattacagac ggttttgaac aatcctatag actctgggaa ctgaacccag
     3301 gtcctctgga aaggcaagca gtgctcttaa cccctgagcc atttcttctg gccttttagc
     3361 aatttttatt aatatataac tgtgtataat tgcactttta gctcaaagtt cttaagtgtc
     3421 aaatagtctt ggatttattt tcatgttatc actgtctgta caatttctgt gatgaaataa
     3481 ctgagcatat attttgagaa tttggttttc ttaaatttta aatctgaagg atttacatat
     3541 ttgagaataa aaaccagcca gatatgaaaa aaaaaaaaaa a
//
