LOCUS       NM_016967               2462 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus oligodendrocyte transcription factor 2 (Olig2), mRNA.
ACCESSION   NM_016967
VERSION     NM_016967.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2462)
  AUTHORS   Fimiani,C., Pereira,J.A., Gerber,J., Berg,I., DeGeer,J.,
            Bachofner,S., Fischer,J.S., Kauffmann,M. and Suter,U.
  TITLE     The E3 ubiquitin ligase Nedd4 fosters developmental myelination in
            the mouse central and peripheral nervous system
  JOURNAL   Glia 73 (2), 422-444 (2025)
   PUBMED   39511974
REFERENCE   2  (bases 1 to 2462)
  AUTHORS   Harke,J., Lee,J.R., Nguyen,S.C., Arab,A., Rakowiecki,S.M.,
            Hugelier,S., Paliou,C., Rauseo,A., Yunker,R., Xu,K., Yao,Y.,
            Lakadamyali,M., Andrey,G., Epstein,D.J. and Joyce,E.F.
  TITLE     Multiple allelic configurations govern long-range Shh
            enhancer-promoter communication in the embryonic forebrain
  JOURNAL   Mol Cell 84 (24), 4698-4710 (2024)
   PUBMED   39579767
REFERENCE   3  (bases 1 to 2462)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   4  (bases 1 to 2462)
  AUTHORS   Myers,B.L., Brayer,K.J., Paez-Beltran,L.E., Villicana,E.,
            Keith,M.S., Suzuki,H., Newville,J., Anderson,R.H., Lo,Y.,
            Mertz,C.M., Kollipara,R.K., Borromeo,M.D., Lu,Q.R., Bachoo,R.M.,
            Johnson,J.E. and Vue,T.Y.
  TITLE     Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation
            and co-regulate tumor cell types and migration
  JOURNAL   Nat Commun 15 (1), 10363 (2024)
   PUBMED   39609428
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2462)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   6  (bases 1 to 2462)
  AUTHORS   Tekki-Kessaris,N., Woodruff,R., Hall,A.C., Gaffield,W., Kimura,S.,
            Stiles,C.D., Rowitch,D.H. and Richardson,W.D.
  TITLE     Hedgehog-dependent oligodendrocyte lineage specification in the
            telencephalon
  JOURNAL   Development 128 (13), 2545-2554 (2001)
   PUBMED   11493571
REFERENCE   7  (bases 1 to 2462)
  AUTHORS   Nery,S., Wichterle,H. and Fishell,G.
  TITLE     Sonic hedgehog contributes to oligodendrocyte specification in the
            mammalian forebrain
  JOURNAL   Development 128 (4), 527-540 (2001)
   PUBMED   11171336
REFERENCE   8  (bases 1 to 2462)
  AUTHORS   Takebayashi,H., Yoshida,S., Sugimori,M., Kosako,H., Kominami,R.,
            Nakafuku,M. and Nabeshima,Y.
  TITLE     Dynamic expression of basic helix-loop-helix Olig family members:
            implication of Olig2 in neuron and oligodendrocyte differentiation
            and identification of a new member, Olig3
  JOURNAL   Mech Dev 99 (1-2), 143-148 (2000)
   PUBMED   11091082
REFERENCE   9  (bases 1 to 2462)
  AUTHORS   Zhou,Q., Wang,S. and Anderson,D.J.
  TITLE     Identification of a novel family of oligodendrocyte
            lineage-specific basic helix-loop-helix transcription factors
  JOURNAL   Neuron 25 (2), 331-343 (2000)
   PUBMED   10719889
REFERENCE   10 (bases 1 to 2462)
  AUTHORS   Lu,Q.R., Yuk,D., Alberta,J.A., Zhu,Z., Pawlitzky,I., Chan,J.,
            McMahon,A.P., Stiles,C.D. and Rowitch,D.H.
  TITLE     Sonic hedgehog--regulated oligodendrocyte lineage genes encoding
            bHLH proteins in the mammalian central nervous system
  JOURNAL   Neuron 25 (2), 317-329 (2000)
   PUBMED   10719888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051967.1.
            
            On Feb 16, 2005 this sequence version replaced NM_016967.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051967.1, AK080615.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 52.6 cM"
     gene            1..2462
                     /gene="Olig2"
                     /gene_synonym="Bhlhb1; bHLHe19; Olg-2; Oligo2; RK17"
                     /note="oligodendrocyte transcription factor 2"
                     /db_xref="GeneID:50913"
                     /db_xref="MGI:MGI:1355331"
     exon            1..104
                     /gene="Olig2"
                     /gene_synonym="Bhlhb1; bHLHe19; Olg-2; Oligo2; RK17"
                     /inference="alignment:Splign:2.1.0"
     exon            105..2437
                     /gene="Olig2"
                     /gene_synonym="Bhlhb1; bHLHe19; Olg-2; Oligo2; RK17"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1131
                     /gene="Olig2"
                     /gene_synonym="Bhlhb1; bHLHe19; Olg-2; Oligo2; RK17"
                     /codon_start=1
                     /product="oligodendrocyte transcription factor 2"
                     /protein_id="NP_058663.2"
                     /db_xref="CCDS:CCDS28323.1"
                     /db_xref="GeneID:50913"
                     /db_xref="MGI:MGI:1355331"
                     /translation="MDSDASLVSSRPSSPEPDDLFLPARSKGGSSSGFTGGTVSSSTP
                     SDCPPELSSELRGAMGASGAHPGDKLGGGGFKSSSSSTSSSTSSAATSSTKKDKKQMT
                     EPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYIL
                     MLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPTATAHPAAAAHAAHHPAVH
                     HPILPPAAAAAAAAAAAAAVSSASLPGSGLSSVGSIRPPHGLLKSPSAAAAAPLGGGG
                     GGSGGSGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGTLPRLTSDAK"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Olig2"
                     /gene_synonym="Bhlhb1; bHLHe19; Olg-2; Oligo2; RK17"
                     /note="hexamer: AATATA"
     polyA_site      2093
                     /gene="Olig2"
                     /gene_synonym="Bhlhb1; bHLHe19; Olg-2; Oligo2; RK17"
ORIGIN      
        1 ccagcggaac cccgaaaggt gtggatgctt attacagacc gagccaacac cagcgcccag
       61 agccaggttc tcctccgcag cgagcacctc aaatctaatt cacattcgga aggttgaaaa
      121 aagaaggatc attcgagagc ttagatcatc cctggggcca tggactcgga cgccagcctg
      181 gtgtctagtc gcccatcgtc cccagaaccc gatgatcttt ttctgcccgc ccggagcaag
      241 gggggaagca gcagcggctt cacaggaggg actgtgtcct cgtccacgcc gagcgactgc
      301 ccgccagagc tgagctccga gctacgaggg gccatgggcg cgtcaggcgc gcatcccggg
      361 gacaaactgg gcggcggtgg cttcaagtca tcttcctcca gcacctcctc gtccacgtcc
      421 tcggcggcca cgtcttccac caagaaagac aagaagcaga tgactgagcc cgagctgcag
      481 cagctgcgcc tgaagatcaa cagccgcgaa cgcaagcgca tgcacgacct caacatcgcc
      541 atggacggcc tgcgggaggt catgccttac gcgcacgggc cgtcggtgcg caagctctcc
      601 aagatcgcca cgctgctgct ggcgcgaaac tacatcctca tgctcaccaa ctcgctggag
      661 gagatgaagc gactggtgag cgagatctac gggggtcacc acgccggctt ccacccatcg
      721 gcctgtggcg ggctggcaca ctcggcgcct ctacccaccg ccacggcgca ccccgcggcc
      781 gccgcgcacg ccgcgcacca cccggccgtg caccacccca tcctccctcc cgcagccgcc
      841 gccgccgccg cagccgccgc cgccgcagcg gtgtccagcg cctctctacc gggctccggg
      901 ctgtcctcgg tcggatccat ccggcctccg cacggcctgc tcaagtcacc gtcggcagcc
      961 gcagccgccc ctctcggagg cgggggtgga ggcagcggtg gcagcggtgg cttccagcac
     1021 tggggcggca tgccgtgccc ctgcagcatg tgccaggtgc cgccgccgca ccaccacgtg
     1081 tcggctatgg gcgccggcac cttgccgcgc ctcacctccg acgccaagtg agccggccag
     1141 cgggggtgcg tcctggagag ccaagggctg cggagcagcg cggacaggcc agcgctgggg
     1201 ctccggggct ctgttgcaag aaggggagct ggaccacggg ctgggcctag gggattatgg
     1261 ggagtcgaat atatgggaac cgaagcaatg ggagcatttg aagcgatgga gagatgcgtt
     1321 cgttccagaa cctggttgac tctttggctg aacactccaa gggtctggga ggcgccattg
     1381 tacaaaacgg ccacaacgcg cgggtacttt catccctgga acttcctgcc tgcaccccca
     1441 ggaagtctaa aaactaactt tccggtgtac aaagattgac tccctgtctg ggcttagacg
     1501 agacgcagag cactgcactt gacttctttc ccccacttca ggcggggtag gagactccca
     1561 ggaaccgcac tgcagaagcg acctctgggc ctcaccctgc aggttcatcc ctggcccagg
     1621 gccaggcact aagttagtag acgctggcgt gggtatcaga agcacttagg gtcctgtggt
     1681 ctcagaagtg tggccttccc tcctgttgtc tctcctgttg atttgtggtt tcctaacaaa
     1741 tctgtgaatg ttccttttca gagcacagga gcaagcttta cagacgctta aaatagcact
     1801 tgtggaatgg aataatccca aaagtcccga tatggaacgg aatccttttt gggtcttatt
     1861 tttaaataga tctcccccca cacacacgca cacacacact cacgcaacac acattctaag
     1921 cacacatcaa ttggtttctt acccgactgg ggacgctgtt ttttggtacc tgggggcttg
     1981 acaaaagaac aacatcaaaa agttgctgtg aatatagttt gagctttttg ggagggggta
     2041 ttctgttggg tttttaataa tttcttgtgt gtgtaaatat aatatcaacg aaatgcgcga
     2101 tgcgaagctc tttgttcacg tgactccccc ctccgtctaa gcccgctgtt ttctttctgt
     2161 gtcgttgccc tcccacacac acaccttttg ccaccgttaa cacgaggggc aaaccccttc
     2221 atgcgcgctc cctggcgcga cctgcattac aacgtgggct ttactgcgcc tgcctcctaa
     2281 ccttccacct cttccgcgct gcccctgcag agtgtatcta tcacctgttt tatttttgta
     2341 aagaaaaaga agtgctaaat aatatttatt acttgtttgg ttgcataaaa cgaaacaaat
     2401 gatggagtgt tgagatttta aataaaattt aaagcaaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aa
//
