LOCUS       NM_001351947            2768 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus olfactomedin 4 (Olfm4), mRNA.
ACCESSION   NM_001351947 XM_006519174
VERSION     NM_001351947.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2768)
  AUTHORS   Trinh,L.T., Finnel,R.R., Osipovich,A.B., Musselman,J.R.,
            Sampson,L.L., Wright,C.V.E. and Magnuson,M.A.
  TITLE     Positive autoregulation of Sox17 is necessary for gallbladder and
            extrahepatic bile duct formation
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39745200
REFERENCE   2  (bases 1 to 2768)
  AUTHORS   Mulet,I., Grueso-Cortina,C., Cortes-Cano,M., Gerovska,D., Wu,G.,
            Iakab,S.A., Jimenez-Blasco,D., Curtabbi,A., Hernansanz-Agustin,P.,
            Ketchum,H., Manjarres-Raza,I., Wunderlich,F.T., Bolanos,J.P.,
            Dawlaty,M.M., Hopf,C., Enriquez,J.A., Arauzo-Bravo,M.J. and
            Tapia,N.
  TITLE     TET3 regulates terminal cell differentiation at the metabolic level
  JOURNAL   Nat Commun 15 (1), 9749 (2024)
   PUBMED   39557858
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2768)
  AUTHORS   Xing,Z., Li,X., He,J., Chen,Y., Zhu,L., Zhang,X., Huang,Z.,
            Tang,J., Guo,Y. and He,Y.
  TITLE     OLFM4 modulates intestinal inflammation by promoting IL-22+ILC3 in
            the gut
  JOURNAL   Commun Biol 7 (1), 914 (2024)
   PUBMED   39075283
  REMARK    GeneRIF: OLFM4 modulates intestinal inflammation by promoting
            IL-22[+]ILC3 in the gut.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2768)
  AUTHORS   Lv,S., Chen,M., Li,Z., Huang,Z., Wan,S., Kuang,S., Peng,L., Ye,J.,
            Yang,M., Li,J. and He,Y.
  TITLE     Blocking OLFM4/galectin-3 axis in placental polymorphonuclear
            myeloid-derived suppressor cells triggers intestinal inflammation
            in newborns
  JOURNAL   Int Immunopharmacol 133, 112058 (2024)
   PUBMED   38613883
  REMARK    GeneRIF: Blocking OLFM4/galectin-3 axis in placental
            polymorphonuclear myeloid-derived suppressor cells triggers
            intestinal inflammation in newborns.
REFERENCE   5  (bases 1 to 2768)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2768)
  AUTHORS   Park,K.S., Kim,K.K., Piao,Z.H., Kim,M.K., Lee,H.J., Kim,Y.C.,
            Lee,K.S., Lee,J.H. and Kim,K.E.
  TITLE     Olfactomedin 4 suppresses tumor growth and metastasis of mouse
            melanoma cells through downregulation of integrin and MMP genes
  JOURNAL   Mol Cells 34 (6), 555-561 (2012)
   PUBMED   23161172
  REMARK    GeneRIF: OLFM4 may function as a tumor suppressor and an
            anti-metastatic gene during tumor progression
REFERENCE   7  (bases 1 to 2768)
  AUTHORS   Liu,W., Yan,M., Liu,Y., McLeish,K.R., Coleman,W.G. Jr. and
            Rodgers,G.P.
  TITLE     Olfactomedin 4 inhibits cathepsin C-mediated protease activities,
            thereby modulating neutrophil killing of Staphylococcus aureus and
            Escherichia coli in mice
  JOURNAL   J Immunol 189 (5), 2460-2467 (2012)
   PUBMED   22844115
REFERENCE   8  (bases 1 to 2768)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 2768)
  AUTHORS   Liu,W., Yan,M., Liu,Y., Wang,R., Li,C., Deng,C., Singh,A.,
            Coleman,W.G. Jr. and Rodgers,G.P.
  TITLE     Olfactomedin 4 down-regulates innate immunity against Helicobacter
            pylori infection
  JOURNAL   Proc Natl Acad Sci U S A 107 (24), 11056-11061 (2010)
   PUBMED   20534456
  REMARK    GeneRIF: OLFM4 exerts considerable influence on the host defense
            against H. pylori infection acting through NOD1 and NOD2 mediated
            NF-kappaB activation and subsequent cytokines and chemokines
            production, which in turn inhibit host immune response.
REFERENCE   10 (bases 1 to 2768)
  AUTHORS   Rosenbauer,F., Wagner,K., Zhang,P., Knobeloch,K.P., Iwama,A. and
            Tenen,D.G.
  TITLE     pDP4, a novel glycoprotein secreted by mature granulocytes, is
            regulated by transcription factor PU.1
  JOURNAL   Blood 103 (11), 4294-4301 (2004)
   PUBMED   14962908
  REMARK    GeneRIF: a novel PU.1-regulated extracellular glycoprotein of the
            olfactomedin-like family has a possible role in neutrophilic
            trafficking.(pdp4)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133536.1 and BQ179233.1.
            
            On Jun 2, 2017 this sequence version replaced XM_006519174.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133536.1, BC141127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2471              AK133536.1         3-2473
            2472-2768           BQ179233.1         25-321              c
FEATURES             Location/Qualifiers
     source          1..2768
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 42.78 cM"
     gene            1..2768
                     /gene="Olfm4"
                     /gene_synonym="GC1; Gm296; Gm913; GW112; OlfD; pPD4"
                     /note="olfactomedin 4"
                     /db_xref="GeneID:380924"
                     /db_xref="MGI:MGI:2685142"
     exon            1..203
                     /gene="Olfm4"
                     /gene_synonym="GC1; Gm296; Gm913; GW112; OlfD; pPD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1541
                     /gene="Olfm4"
                     /gene_synonym="GC1; Gm296; Gm913; GW112; OlfD; pPD4"
                     /note="OLM4; PU.1 difference product 4"
                     /codon_start=1
                     /product="olfactomedin-4 precursor"
                     /protein_id="NP_001338876.1"
                     /db_xref="CCDS:CCDS36989.2"
                     /db_xref="GeneID:380924"
                     /db_xref="MGI:MGI:2685142"
                     /translation="MSYSLLFLLALQFCLGSASRTTLTSAHSRELTTPPTSPQATAAW
                     LPPGGTSWAEGGTVSQPLSNFTGSVDSHGTCQCSVSLPDTAFPADRVERLEYTAHILS
                     QKFEREFSKVKEYVQLISVYEKRLLNLTVRVEVMEKDSISYTELDFELIKLEVKEMQK
                     LVLQLKKNFVGSTHIIDMLEVEIRNMTLLVEKLESLDQNNVLSIRRQILALKTKLKEC
                     EASKSDLVPATPPPPAPGSCSHGGVVNISAPSVIQLNWLGFSYKYGAWGRDYSPQHPE
                     RTLYWVAPLNTDARALEYYRLYDSLDNLLIYSHFRDYRIRYGQGGGTVAFNNNLYVNW
                     YNGGNIAKINLTTNVVDVNRPLPLAAYNNRFSYANVNWQDIDLAVDEQALWAIYATEA
                     STGNIVISKLNDTTLEVISTWVTKQYKPSVSNAFMVCGVLYATRTLNTKTEEIFYYYD
                     TNTEREGNLGITMRKMQERIQSINYHPFDQKLYVYNDGYLLNYDLVFLQTPRQPV"
     exon            204..356
                     /gene="Olfm4"
                     /gene_synonym="GC1; Gm296; Gm913; GW112; OlfD; pPD4"
                     /inference="alignment:Splign:2.1.0"
     exon            357..569
                     /gene="Olfm4"
                     /gene_synonym="GC1; Gm296; Gm913; GW112; OlfD; pPD4"
                     /inference="alignment:Splign:2.1.0"
     exon            570..729
                     /gene="Olfm4"
                     /gene_synonym="GC1; Gm296; Gm913; GW112; OlfD; pPD4"
                     /inference="alignment:Splign:2.1.0"
     exon            730..2752
                     /gene="Olfm4"
                     /gene_synonym="GC1; Gm296; Gm913; GW112; OlfD; pPD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2449..2454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Olfm4"
                     /gene_synonym="GC1; Gm296; Gm913; GW112; OlfD; pPD4"
                     /note="hexamer: AATAAA"
     polyA_site      2473
                     /gene="Olfm4"
                     /gene_synonym="GC1; Gm296; Gm913; GW112; OlfD; pPD4"
                     /note="major polyA site"
     regulatory      2735..2740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Olfm4"
                     /gene_synonym="GC1; Gm296; Gm913; GW112; OlfD; pPD4"
                     /note="hexamer: ACTAAA"
     polyA_site      2752
                     /gene="Olfm4"
                     /gene_synonym="GC1; Gm296; Gm913; GW112; OlfD; pPD4"
ORIGIN      
        1 agcatcttaa cttagaaggc acgatgagtt acagccttct ctttctcctg gcccttcagt
       61 tctgccttgg ctctgcctcc cggacaactc tgacctctgc acattcccgg gaattgacca
      121 cacctccaac atcaccccag gctacagctg cctggttgcc tccgggaggc acttcttggg
      181 cagaaggtgg gactgtgtct cagccacttt ccaatttcac tgggtctgtg gacagccatg
      241 ggacctgcca gtgttctgtt tccctgccgg ataccgcctt tcccgctgac agagtggagc
      301 gcttagagta cacagctcac atcctttctc agaaattcga gagagagttt tctaaggtga
      361 aggagtatgt ccagctaata agtgtgtatg agaagaggct cctgaacctg acggtccgag
      421 tagaggtcat ggagaaggac agcatctctt acacagaact ggactttgag ttgatcaagc
      481 tggaagtgaa ggagatgcaa aaactggtct tacagctgaa gaagaatttt gttggaagta
      541 cacatattat tgacatgctc gaagtggaga taaggaatat gaccctcttg gtagagaagc
      601 tggagtctct agaccaaaac aatgtcctta gcattcgccg ccagatcttg gctctgaaga
      661 ccaagctgaa agaatgtgag gcctccaaaa gtgaccttgt gcctgccaca ccccctcctc
      721 ctgctcctgg aagctgtagt catggtggcg tggtgaacat cagcgctcct tctgtgattc
      781 agctcaactg gctggggttt agttataaat atggtgcctg gggccgagat tactctcctc
      841 agcatccaga gagaaccctg tactgggtgg cacctttgaa tacagatgca agggctctag
      901 agtattacag actttacgac tcattggaca atttgttaat ctattcccac ttccgagact
      961 atcggattcg ctatggccaa ggaggtggta cagtagcatt caacaacaac ctgtatgtga
     1021 attggtacaa tggggggaac attgccaaaa ttaatctaac taccaatgta gttgatgtga
     1081 atcggcccct ccctctggct gcctacaata atcgcttctc atatgctaat gtgaattggc
     1141 aagacattga ccttgctgtg gatgagcaag cactgtgggc aatttatgca actgaggcca
     1201 gcactggtaa catagtgatt agtaaactca atgacaccac tcttgaggtg ataagcactt
     1261 gggttaccaa gcagtacaag ccatctgttt cgaatgcctt catggtatgt ggagttcttt
     1321 atgctactcg cactttgaac accaaaacag aagagatctt ttactattat gacacaaaca
     1381 cagagaggga aggcaaccta ggcatcacaa tgagaaagat gcaggaaaga attcagagca
     1441 tcaattacca tccctttgac caaaaacttt atgtctataa tgatggttat cttctgaact
     1501 atgatcttgt cttcttacag acgcccaggc aacctgtcta agtgttaggg tgaaggagga
     1561 atgaaatgtt tgatggcaat tttcttctct acatatttag acagcttcag ggaagtctag
     1621 gagtgtgttt ctttagtcat gatgttagta gagatagttt tatcacaata gagacctagg
     1681 ctatttgtct cagtttgatt tctcttggga attatcatcc tctttggata gatttaacaa
     1741 atgaaataag gtctttgcaa gtaaagttct cagcggctag gggtgctatg agcctaataa
     1801 agtttctagt gaggtaaagt ctagaagata aagaacttaa ggggtactta gtatgaattc
     1861 tgggaattct ttctcttaga aaatttgcat ggtgacccac cacatagaac cattgagttg
     1921 tgcatgacag aaaggacgct ggggcttaat taggtagatc aacatcagga ggtggacatg
     1981 agagcaaata tttagctttg ttttcctcct ggctcctgaa acctgtgtat agcagatagg
     2041 taaatttggc atcttaaatg atatctctca gacattttga gttttctgca gaatggacct
     2101 actttatgtt aagttgcaca gtgcaaatat gtcctggaag ggttttcaga tgatatactt
     2161 gggttttctt ttctctcatt cttcacctac acaattcagt agaccccttt acctcataat
     2221 tcaggtccca gggcaaccat aagattagaa acagacttaa caaccagtca catttcttta
     2281 ctgcttatgt gtttttctta gacattaact agtttttttt tttatgggtc agatataaaa
     2341 tcaatgaact ttctcttgta ttttcctgca attttggttt atgtaattac aagactgtaa
     2401 aaaaatacca gttgttagtg atgttgctgg ttgcatttct agctatataa taaagatcgt
     2461 gaaataaatt gtaccagttg tttcatatag tttctctctt taatcctgga atttgcaaga
     2521 aagtgaaaat tttttatatg taaaacttta tatataaaaa taatgtagga aatcaccttg
     2581 tagtatcagc ttaatcaggg caccgcttga gagcatgcta ggtgcagatc ctctggtggc
     2641 tttgaatggc tctatcacat ggtcttggtt attttccatt gatgttcaaa tcctaatctt
     2701 taaattctgt ctttctattt tttaaaaata aactactaaa gagtgaactg aaaaaaaaaa
     2761 aaaaaaaa
//
