LOCUS       NM_001357635            2077 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus olfactomedin 2 (Olfm2), transcript variant 1, mRNA.
ACCESSION   NM_001357635 XM_006510293
VERSION     NM_001357635.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2077)
  AUTHORS   Boudkkazi,S., Schwenk,J., Nakaya,N., Brechet,A., Kollewe,A.,
            Harada,H., Bildl,W., Kulik,A., Dong,L., Sultana,A., Zolles,G.,
            Schulte,U., Tomarev,S. and Fakler,B.
  TITLE     A Noelin-organized extracellular network of proteins required for
            constitutive and context-dependent anchoring of AMPA-receptors
  JOURNAL   Neuron 111 (16), 2544-2556 (2023)
   PUBMED   37591201
REFERENCE   2  (bases 1 to 2077)
  AUTHORS   Gonzalez-Garcia,I., Freire-Agulleiro,O., Nakaya,N., Ortega,F.J.,
            Garrido-Gil,P., Linares-Pose,L., Ferno,J., Labandeira-Garcia,J.L.,
            Dieguez,C., Sultana,A., Tomarev,S.I., Fernandez-Real,J.M. and
            Lopez,M.
  TITLE     Olfactomedin 2 deficiency protects against diet-induced obesity
  JOURNAL   Metabolism 129, 155122 (2022)
   PUBMED   35026233
REFERENCE   3  (bases 1 to 2077)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2077)
  AUTHORS   Shi,N., Li,C.X., Cui,X.B., Tomarev,S.I. and Chen,S.Y.
  TITLE     Olfactomedin 2 Regulates Smooth Muscle Phenotypic Modulation and
            Vascular Remodeling Through Mediating Runt-Related Transcription
            Factor 2 Binding to Serum Response Factor
  JOURNAL   Arterioscler Thromb Vasc Biol 37 (3), 446-454 (2017)
   PUBMED   28062493
REFERENCE   5  (bases 1 to 2077)
  AUTHORS   Sultana,A., Nakaya,N., Dong,L., Abu-Asab,M., Qian,H. and
            Tomarev,S.I.
  TITLE     Deletion of olfactomedin 2 induces changes in the AMPA receptor
            complex and impairs visual, olfactory, and motor functions in mice
  JOURNAL   Exp Neurol 261, 802-811 (2014)
   PUBMED   25218043
  REMARK    GeneRIF: These results suggest that heterodimers of Olfm1 and Olfm2
            interact with AMPAR more efficiently than Olfm2 homodimers and that
            Olfm2 plays a role in the organization of the AMPA receptor
            complexes.
REFERENCE   6  (bases 1 to 2077)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   7  (bases 1 to 2077)
  AUTHORS   Sultana,A., Nakaya,N., Senatorov,V.V. and Tomarev,S.I.
  TITLE     Olfactomedin 2: expression in the eye and interaction with other
            olfactomedin domain-containing proteins
  JOURNAL   Invest Ophthalmol Vis Sci 52 (5), 2584-2592 (2011)
   PUBMED   21228389
  REMARK    GeneRIF: Highly conserved OLFM2 protein may play an important role
            in the course of retinal and eye development.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166365.4 and AC164565.1.
            
            On Nov 4, 2017 this sequence version replaced XM_006510293.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.28449.1,
                                           SRR7652917.1148226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               AC166365.4         54953-55310         c
            359-508             AC164565.1         21636-21785
            509-655             AC164565.1         24586-24732
            656-875             AC164565.1         25005-25224
            876-982             AC164565.1         25553-25659
            983-2077            AC164565.1         28575-29669
FEATURES             Location/Qualifiers
     source          1..2077
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.6 cM"
     gene            1..2077
                     /gene="Olfm2"
                     /gene_synonym="A030009A06Rik"
                     /note="olfactomedin 2"
                     /db_xref="GeneID:244723"
                     /db_xref="MGI:MGI:3045350"
     exon            1..358
                     /gene="Olfm2"
                     /gene_synonym="A030009A06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1660
                     /gene="Olfm2"
                     /gene_synonym="A030009A06Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     noelin-2"
                     /codon_start=1
                     /product="noelin-2 isoform 1"
                     /protein_id="NP_001344564.1"
                     /db_xref="CCDS:CCDS90507.1"
                     /db_xref="GeneID:244723"
                     /db_xref="MGI:MGI:3045350"
                     /translation="MSVPLLKIGAVLSTMAMVTNWMSQTLPSLVGLNSTVSRAGSSEK
                     ITLFQSPEEGWQLYTSAQAPDGKCVCTAVIPAQSTCARDGRSRELRQLMEKVQNVSQS
                     MEVLELRTFRDLQYVRSMETLMRSLDARLRAADGSVSAKSFQELKDRMTELLPLSSVL
                     EQYKADTRTIVRLREEVRNLSGNLAAIQEEMGAYGYEDLQQRVMALEARLHACAQKLG
                     CGKLTGVSNPITIRAMGSRFGSWMTDTMAPSADSRVWYMDGYYKGRRVLEFRTLGDFI
                     KGQNFIQHLLPQPWAGTGHVVYNGSLFYNKYQSNVVVKYHFRSRSVLVQRSLPGAGYN
                     NTFPYSWGGFSDMDFMVDESGLWAVYTTNQNAGNIVVSRLDPHTLEVVRSWDTGYPKR
                     SAGEAFMICGVLYVTNSHLAGAKVYFAYFTNTSSYEYTDVPFHNQYSHISMLDYNPRE
                     RALYTWNNGHQVLYNVTLFHVISTAGDP"
     exon            359..508
                     /gene="Olfm2"
                     /gene_synonym="A030009A06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            509..655
                     /gene="Olfm2"
                     /gene_synonym="A030009A06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            656..875
                     /gene="Olfm2"
                     /gene_synonym="A030009A06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            876..982
                     /gene="Olfm2"
                     /gene_synonym="A030009A06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            983..2077
                     /gene="Olfm2"
                     /gene_synonym="A030009A06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2052..2057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Olfm2"
                     /gene_synonym="A030009A06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2071
                     /gene="Olfm2"
                     /gene_synonym="A030009A06Rik"
                     /note="major polyA site"
ORIGIN      
        1 ataaagctga gcccgcgagg cgcgcggagc cgcagccgag cgcgtcccca gtgtcacccc
       61 atcccaccgg ccaccgcccc cttggacctg gtcatctcgc catcgggatc ccccacccct
      121 ccaccccact ggggtgggta agcgacagct tgagtgccga gcaaaaggga ctgaacacct
      181 gcttttttgg ggtggtggcg cggggcatga ggcgaggggc gcgatgtcgg tgccgctgct
      241 caagatcggg gcggtgctga gcaccatggc catggtcact aactggatgt cgcagacgct
      301 gccctcgctc gtgggactca acagcaccgt gtcccgtgcg ggctcttcgg agaaaatcac
      361 tctcttccag agcccggagg agggctggca gctttatacg tcagcccagg cacctgatgg
      421 caagtgcgtc tgcacagccg tgatccctgc gcagagcacc tgtgcccgag acggtcggag
      481 cagagagctt cggcaactca tggagaaggt ccagaatgtg tcccagtcca tggaggtcct
      541 tgagctaagg acattccggg atctccagta tgttcgcagc atggagaccc tcatgcggag
      601 cctggatgca aggctcaggg cagccgatgg gtcagtctca gccaaaagct ttcaggaact
      661 gaaggacagg atgacagagc tgctgcccct gagttcagtg ctggagcagt acaaagcaga
      721 cacacgaacc attgtgcgcc tgcgggagga ggtgaggaac ctctctggca acctggctgc
      781 catccaagag gaaatgggtg cctacgggta cgaggacttg caacagcgcg tgatggccct
      841 ggaagcccga ctccatgcct gcgcgcagaa gctgggctgc gggaagctga caggcgtcag
      901 taaccctatt accatccggg ccatggggtc ccgcttcggt tcctggatga ctgacacaat
      961 ggcccccagt gcagacagca gggtctggta catggatggt tattacaaag gccgccgagt
     1021 gctggagttc cgtactctgg gagacttcat caaaggccag aacttcatcc agcacctgct
     1081 gccacagcca tgggcaggta cgggccatgt ggtatacaat ggctctctct tctacaataa
     1141 gtaccagagc aatgtggtgg tcaagtacca cttccggtcc cgctcggtgc tggtgcagag
     1201 gagcctcccg ggggctggtt acaataacac cttcccctat tcctggggcg gcttctcgga
     1261 catggacttc atggtagacg agagtgggct gtgggctgtg tataccacca accagaatgc
     1321 gggcaacatc gtagtcagtc ggctggaccc tcacaccctg gaggtcgtga gatcctggga
     1381 caccgggtac cctaagcgca gcgccggcga ggccttcatg atctgcggtg tcctctatgt
     1441 gaccaactct cacctggccg gagccaaggt ctactttgcg tacttcacca acacgtccag
     1501 ctatgagtac acggatgtgc ccttccacaa ccagtattcg cacatctcga tgctggatta
     1561 caaccccagg gagcgggccc tgtatacctg gaacaacggg caccaggtgc tgtacaacgt
     1621 caccctgttc cacgtcatca gcactgccgg ggacccctag gtgcccctgc aagggctttg
     1681 gggagccttc ccacatcgcc tgtgaccccc accccagcct tctcttggtc atgcccttgc
     1741 cttcctagat tccgtctccc cacttcccca gcccagcttt ctgttctcag tatctctacc
     1801 catgcatttc ccccatttta ttgatctctg cttttgatac tccacttctg agtctttctg
     1861 cctttttatg gatgcttctc ttccttattg atcgaacctc tcttctcctc tccctccatc
     1921 tactctccct cctcttcctt tcccactttc ccacattcct tacccctcac tcccacccta
     1981 tccctggatc tgagtgcatg gattttgttt tttaaattta ttatttacat gttttctttc
     2041 cgggttgcca gaataaaccg gacctttgac atttggt
//
