LOCUS       NM_145921               1522 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus oleoyl-ACP hydrolase (Olah), mRNA.
ACCESSION   NM_145921
VERSION     NM_145921.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1522)
  AUTHORS   Jia,X., Crawford,J.C., Gebregzabher,D., Monson,E.A.,
            Mettelman,R.C., Wan,Y., Ren,Y., Chou,J., Novak,T., McQuilten,H.A.,
            Clarke,M., Bachem,A., Foo,I.J., Fritzlar,S., Carrera Montoya,J.,
            Trenerry,A.M., Nie,S., Leeming,M.G., Nguyen,T.H.O., Kedzierski,L.,
            Littler,D.R., Kueh,A., Cardamone,T., Wong,C.Y., Hensen,L.,
            Cabug,A., Laguna,J.G., Agrawal,M., Flerlage,T., Boyd,D.F., Van de
            Velde,L.A., Habel,J.R., Loh,L., Koay,H.F., van de Sandt,C.E.,
            Konstantinov,I.E., Berzins,S.P., Flanagan,K.L., Wakim,L.M.,
            Herold,M.J., Green,A.M., Smallwood,H.S., Rossjohn,J.,
            Thwaites,R.S., Chiu,C., Scott,N.E., Mackenzie,J.M., Bedoui,S.,
            Reading,P.C., Londrigan,S.L., Helbig,K.J., Randolph,A.G.,
            Thomas,P.G., Xu,J., Wang,Z., Chua,B.Y. and Kedzierska,K.
  TITLE     High expression of oleoyl-ACP hydrolase underpins life-threatening
            respiratory viral diseases
  JOURNAL   Cell 187 (17), 4586-4604 (2024)
   PUBMED   39137778
REFERENCE   2  (bases 1 to 1522)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1522)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1522)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC025001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025001.1, AK136031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1522
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 1.88 cM"
     gene            1..1522
                     /gene="Olah"
                     /gene_synonym="E230009B14Rik; Thedc1"
                     /note="oleoyl-ACP hydrolase"
                     /db_xref="GeneID:99035"
                     /db_xref="MGI:MGI:2139018"
     exon            1..130
                     /gene="Olah"
                     /gene_synonym="E230009B14Rik; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     exon            131..320
                     /gene="Olah"
                     /gene_synonym="E230009B14Rik; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..1086
                     /gene="Olah"
                     /gene_synonym="E230009B14Rik; Thedc1"
                     /EC_number="3.1.2.14"
                     /note="thioesterase domain containing 1; thioesterase II;
                     thioesterase domain-containing protein 1"
                     /codon_start=1
                     /product="S-acyl fatty acid synthase thioesterase, medium
                     chain"
                     /protein_id="NP_666033.1"
                     /db_xref="CCDS:CCDS15647.1"
                     /db_xref="GeneID:99035"
                     /db_xref="MGI:MGI:2139018"
                     /translation="METAVYAKSTRNEKVLNCLCQKPDALFKLICFPWAGGGSTHFAK
                     WGRKINGLLEVHAVRLAGRETRFEEPFSNDIYQIAEEVVTALLPIIRDKAFAFFGHSF
                     GSYIAFITALHLKEKYKMEPLHIFVSSASAPHSEFRPQVPDINKLSEEQIRDHLLIFG
                     GTPKHLIEDQDFLKQCIPLLKADVDIVKKFIFDKPSKALLSRDITCFIGSEDVVKDIE
                     GWKDITSGKFDVLKLPGDHFYLMEPNNEDFIKNYIVKCLELSSLDYF"
     exon            321..451
                     /gene="Olah"
                     /gene_synonym="E230009B14Rik; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..590
                     /gene="Olah"
                     /gene_synonym="E230009B14Rik; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..690
                     /gene="Olah"
                     /gene_synonym="E230009B14Rik; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..860
                     /gene="Olah"
                     /gene_synonym="E230009B14Rik; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..943
                     /gene="Olah"
                     /gene_synonym="E230009B14Rik; Thedc1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1509
                     /gene="Olah"
                     /gene_synonym="E230009B14Rik; Thedc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctctgga aggagcatcg ctgaaagttg agcctcgctt ctccagaaca ctcctgagat
       61 tcaccatcga gttcgtgaat taaaccttgg tcttagcatg actgccaggg attcagggga
      121 cttctaggtg caggattctg actgacagcc ataatcaacg gattaaaaag aaatctggcc
      181 acttggtgta caaaaggctt attggagatt tttgtgccca gaggggaatt aatttcaaca
      241 cagtcgcaga agatctctga gagcagcaat tcctaatcaa ctcacaggat ggagacagca
      301 gtctatgcta agagtaccag gaatgagaag gttttgaact gtttgtgtca aaagccggat
      361 gcacttttca agctgatctg ctttccctgg gcaggaggcg gctccactca ttttgccaag
      421 tggggccgaa agattaatgg cttattggaa gtgcatgctg taagactggc tgggagagaa
      481 acccgatttg aagaaccttt ctcaaatgac atctaccaga tagctgagga agttgtgact
      541 gccctgttgc ccatcatccg tgacaaagct tttgcatttt ttggccacag tttcggatcc
      601 tacattgctt ttattactgc actgcaccta aaggagaaat ataaaatgga gccgctgcat
      661 atctttgtgt ccagtgcctc tgcccctcac tcagaattcc ggcctcaagt tcctgatatt
      721 aacaaattgt cagaagaaca aataagagat caccttctga tttttggagg cactcccaag
      781 catctcatcg aagaccagga ttttctgaag caatgcattc ctttgctgaa ggcagatgtt
      841 gacattgtga aaaaattcat ctttgacaaa ccctccaaag ctctcctttc tcgggacatc
      901 acgtgcttta ttggatctga agatgtagta aaggatatag aaggctggaa agacataacc
      961 agtgggaagt ttgatgtcct caagctgcca ggtgaccact tttatctgat ggaaccgaac
     1021 aacgaggact ttatcaagaa ctacatagtc aagtgtttgg agctctcctc acttgactac
     1081 ttctagatga gttttctctg gggtttctaa tatgcaaact gatcacaggc tgttcctcca
     1141 agtccagctt ttagttctta gaggtcggaa agatgcatat taatgaattt cttcatggaa
     1201 catttatctc tggggaaagg acacgggctg aagtggagca gcggcattgt tgggcgttga
     1261 cagttgcaga gggaagaggg gtgggttttc tttgggagac tttgccacca ataggttacc
     1321 cagcctccag taaatgacac cacaccgtgt agcacatgca ggcagctcta attggactcc
     1381 gtgggaagct ggggggcggg gatgtctgtc acaggggttg gaaaggccag cgggaagtgg
     1441 gtatgatcaa aatgcacagt ttacacttag gaaaatttca aagaataaat aaaaatattg
     1501 ctaaagaaaa aaaaaaaaaa aa
//
