LOCUS       NM_010959               2716 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus oncoprotein induced transcript 3 (Oit3), mRNA.
ACCESSION   NM_010959
VERSION     NM_010959.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2716)
  AUTHORS   Wu,J.X., He,K.Y., Zhang,Z.Z., Qu,Y.L., Su,X.B., Shi,Y., Wang,N.,
            Wang,L. and Han,Z.G.
  TITLE     LZP is required for hepatic triacylglycerol transportation through
            maintaining apolipoprotein B stability
  JOURNAL   PLoS Genet 17 (2), e1009357 (2021)
   PUBMED   33591966
  REMARK    GeneRIF: LZP is required for hepatic triacylglycerol transportation
            through maintaining apolipoprotein B stability.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2716)
  AUTHORS   Yan,B., Zhang,Z.Z., Huang,L.Y., Shen,H.L. and Han,Z.G.
  TITLE     OIT3 deficiency impairs uric acid reabsorption in renal tubule
  JOURNAL   FEBS Lett 586 (6), 760-765 (2012)
   PUBMED   22306318
  REMARK    GeneRIF: Data suggest that OIT3 could maintain urate homeostasis by
            regulating the excretion and reabsorption of uric acid in renal
            tubule via cooperating with THP.
REFERENCE   3  (bases 1 to 2716)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 2716)
  AUTHORS   Shen,H.L., Xu,Z.G., Huang,L.Y., Liu,D., Lin,D.H., Cao,J.B.,
            Zhang,X., Wang,Z.Q., Wang,W.H., Yang,P.Y. and Han,Z.G.
  TITLE     Liver-specific ZP domain-containing protein (LZP) as a new partner
            of Tamm-Horsfall protein harbors on renal tubules
  JOURNAL   Mol Cell Biochem 321 (1-2), 73-83 (2009)
   PUBMED   18830570
  REMARK    GeneRIF: The finding that LZP might act as a new partner of THP
            would provide novel insights into renal functions related to THP
            and LZP, such as the urothelial permeability barrier and the host
            defense against the adhesion of pathogens.
REFERENCE   5  (bases 1 to 2716)
  AUTHORS   Xu,Z.G., Du,J.J., Cui,S.J., Wang,Z.Q., Huo,K.K., Li,Y.Y. and
            Han,Z.G.
  TITLE     Identification of LZP gene from Mus musculus and Rattus norvegicus
            coding for a novel liver-specific ZP domain-containing secretory
            protein
  JOURNAL   DNA Seq 15 (2), 81-87 (2004)
   PUBMED   15346761
  REMARK    GeneRIF: mouse LZP localizes mostly on nuclear envelope, and at the
            same time, it can be secreted into blood in a truncated form.
REFERENCE   6  (bases 1 to 2716)
  AUTHORS   Fu,X. and Kamps,M.P.
  TITLE     E2a-Pbx1 induces aberrant expression of tissue-specific and
            developmentally regulated genes when expressed in NIH 3T3
            fibroblasts
  JOURNAL   Mol Cell Biol 17 (3), 1503-1512 (1997)
   PUBMED   9032278
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK040570.1.
            
            On Apr 6, 2007 this sequence version replaced NM_010959.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040570.1, AY180915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2716              AK040570.1         2-2717
FEATURES             Location/Qualifiers
     source          1..2716
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.54 cM"
     gene            1..2716
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /note="oncoprotein induced transcript 3"
                     /db_xref="GeneID:18302"
                     /db_xref="MGI:MGI:1201782"
     exon            1..157
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1737
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /note="oncoprotein-induced transcript 3 protein;
                     liver-specific zona pellucida domain-containing protein"
                     /codon_start=1
                     /product="oncoprotein-induced transcript 3 protein
                     precursor"
                     /protein_id="NP_035089.1"
                     /db_xref="CCDS:CCDS23865.1"
                     /db_xref="GeneID:18302"
                     /db_xref="MGI:MGI:1201782"
                     /translation="MPLSLLLTCLSTTVTLVSPAVLDPCSAYISLNEPWRNTDHQFDE
                     SQNQPLCDNHMNGEWYRFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEEDGIVQR
                     QACASFKGNCCLWNATVEVKACPRGYYVYRLARPSVCFHVYCGHFYDICDEDCHGNCL
                     DTTECACSPGTSLGPDGQTCFDENECEHNNGGCSEICVNLKNSHRCACGVGRVLRSDG
                     KTCEDIEGCHNNNGGCSHSCLGSEEGYQCECPRGLVLSEDNHTCQVPVLCKSSAIEVS
                     VPRELVGGLELFLTNTSCRGVSNGTHVNIVFSLKTCGTVVDVVNDKIVASNIVTGLPK
                     ETPGSSGDIIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNAPLEIRSRNHGIFPFTLE
                     IFKDHEFEEPYRETLPTLKLRDSLYFGIEPLVHVNGLESLVESCFATPTAKMDEILKY
                     YLIQDGCVSDDSVKQYSSRDHLAKHFQAPVFKFVGKDHKEVFLHCRVLVCGVLDERSR
                     CAQGCHRRVRREVGEDEDSAGLQSQTLTGGPIAIDWED"
     exon            158..532
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            533..640
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            641..763
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            764..886
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1047
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1463
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1563
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..2716
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2215..2220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /note="hexamer: AATAAT"
     polyA_site      2238
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /note="major polyA site"
     regulatory      2506..2511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /note="hexamer: AATAAA"
     polyA_site      2527
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
     regulatory      2685..2690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
                     /note="hexamer: AATAAA"
     polyA_site      2705
                     /gene="Oit3"
                     /gene_synonym="EF-9; LZP"
ORIGIN      
        1 cagagggata ttctccccta agtgcttgag agaacaacgg agaactgttg ttacaccggg
       61 aatcttctat ccactcctgg cagctggatc agaacgatgc ctctgtccct gctgctcacc
      121 tgcctctcca ccacagtcac cttggtgtca cctgcggtcc tagatccttg ttccgcttac
      181 atcagtctga acgagccctg gaggaacact gaccaccagt tcgacgagtc ccagaatcaa
      241 cctctttgcg acaaccatat gaacggggag tggtatcgct tcacggggat ggcaggagat
      301 gccatgccta ccttctgcat accggaaaat cactgtggga cccatgctcc tgtctggctc
      361 aatggcagcc accccctaga agaggatggc attgtgcaac gccaggcctg tgccagcttc
      421 aaaggaaact gctgtctgtg gaacgccacg gtggaagtca aggcctgccc cagaggctac
      481 tacgtgtatc ggctggccag acccagcgtc tgcttccatg tctactgtgg ccatttctat
      541 gacatctgtg atgaggattg tcacggcaac tgcctggata ccaccgagtg tgcatgctct
      601 ccaggaacct cgctgggccc agatgggcag acttgctttg acgaaaatga atgtgagcac
      661 aacaacggtg gctgcagcga gatctgcgtg aacctcaaaa actcacaccg ctgcgcatgc
      721 ggggttggcc gcgtgctcag gagcgacggg aagacttgcg aagacatcga aggttgtcac
      781 aacaacaatg gtggctgcag ccattcctgc cttgggtctg aggagggcta tcagtgtgaa
      841 tgtccccggg gcttggtgct gtctgaagat aatcacactt gccaagtccc cgtgttgtgc
      901 aagtccagcg ccattgaagt gagtgtcccc cgggagctgg ttggaggcct ggagctcttc
      961 ctgaccaaca cctcctgccg aggagtgtcc aatggcaccc acgtcaacat cgtcttctca
     1021 ctcaagacct gcggcaccgt ggttgacgtg gtgaatgaca aaatcgtggc cagcaacatc
     1081 gtgacgggcc tgcccaagga gacccctggg agcagtgggg acatcatcat tcggaccagc
     1141 aaactgttga tccccgtgac ctgcgagttc ccacgactgt acaccatctc ggaaggatac
     1201 gtgcccaacc tgcgcaatgc cccattggaa atcaggagcc gaaaccacgg catctttccc
     1261 ttcacactgg agattttcaa ggaccacgaa ttcgaggaac cgtaccggga gactctgccc
     1321 acactcaagc ttcgcgactc actctacttt ggcatagagc ccctggtgca tgtgaacggc
     1381 ctggagagcc tggtagagag ctgctttgcc acgcccactg caaagatgga tgaaatcctc
     1441 aagtactacc tgatccagga cggctgtgtt tccgatgact cagtaaagca gtactcatcc
     1501 agggaccacc tagcaaagca cttccaagcc cccgtcttca agtttgtggg caaagaccac
     1561 aaggaggtat ttttacactg ccgcgtcctt gtatgtgggg tgctggatga gcgttcccgc
     1621 tgtgcccaag ggtgccaccg aagagtacgt cgtgaggtgg gtgaggacga ggactctgct
     1681 gggctgcaga gccagacact gacaggtggc cccatcgcca tcgactggga ggactagttc
     1741 ctgcttcttc acttccagcc gtcctcccct ctagaacgac ttcctgtgtc ctcagagaca
     1801 tcagagaacc tcctaagaca gctggcttct ttaaatcatg tactgtgagt ttagacaacc
     1861 ccaccccatg aaaggactgg ctggctggtt ttgtccctga gttcgtccaa atcacggcac
     1921 tgctggcccg tgtgcctagg tgggcctcag cttctggact caaagatttg tgtttttcct
     1981 cagggaagga cacctccctc attctccctg ttcctttctt acaacgaaat acctcgtttg
     2041 tggtgtaact gggccactaa tataaggagc tgggaatgtc attccaagtc aaaaccctaa
     2101 aataatgaat gactaagagc ataactcatg atctcctaga tacctaataa ttgtgaccta
     2161 aaatctcaac cccagtatag agtatttaaa ggggatttga aagtctatca ataaaataat
     2221 gtgtaacagg aaacacaata ggttgaacgt cacatagtac tttttagtgt tttcatattg
     2281 cctggatgaa atgttttcac ctaaaaataa ttcataaggt gcttaagggc actggctgct
     2341 cttgtggagg acccgggttc aattcacggc accccgttgt ggtggctcac aactgtctgt
     2401 aactctgtcc agggatccaa tggccacttc tgaactcccc aggcacggga catgcatatg
     2461 ctacataaac acacatgcag gcaaaccact catacatcta agtaaaataa attaattttt
     2521 caaactatca gaatgcacat aagtaattca atggctatac tataagcaaa actaaatttt
     2581 ggctccatat acccagaata tcagtattct gtgccctggg ttagataaga caataggaaa
     2641 aggtatatat acaattatgt catactctta ctttgtaggt gctcaataaa ttttattgaa
     2701 ataaatacca taaact
//
