LOCUS       NM_139144               5415 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus O-linked N-acetylglucosamine (GlcNAc) transferase
            (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl
            transferase) (Ogt), transcript variant 1, mRNA.
ACCESSION   NM_139144
VERSION     NM_139144.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5415)
  AUTHORS   Formichetti,S., Sadowska,A., Ascolani,M., Hansen,J., Ganter,K.,
            Lancrin,C., Humphreys,N. and Boulard,M.
  TITLE     Genetic gradual reduction of OGT activity unveils the essential
            role of O-GlcNAc in the mouse embryo
  JOURNAL   PLoS Genet 21 (1), e1011507 (2025)
   PUBMED   39787076
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5415)
  AUTHORS   Authier,F., Ondruskova,N., Ferenbach,A.T., McNeilly,A.D. and van
            Aalten,D.M.F.
  TITLE     Neurodevelopmental defects in a mouse model of O-GlcNAc transferase
            intellectual disability
  JOURNAL   Dis Model Mech 17 (4) (2024)
   PUBMED   38566589
  REMARK    GeneRIF: Neurodevelopmental defects in a mouse model of O-GlcNAc
            transferase intellectual disability.
REFERENCE   3  (bases 1 to 5415)
  AUTHORS   Chen,E., da Cruz,R.S., Nascimento,A., Joshi,M., Pereira,D.G.,
            Dominguez,O., Fernandes,G., Smith,M., Paiva,S.P.C. and de Assis,S.
  TITLE     Paternal DDT exposure induces sex-specific programming of fetal
            growth, placenta development and offspring's health phenotypes in a
            mouse model
  JOURNAL   Sci Rep 14 (1), 7567 (2024)
   PUBMED   38555297
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5415)
  AUTHORS   Narayanan,B., Sinha,P., Henry,R., Reeves,R.A., Paolocci,N.,
            Kohr,M.J. and Zachara,N.E.
  TITLE     Cardioprotective O-GlcNAc signaling is elevated in murine female
            hearts via enhanced O-GlcNAc transferase activity
  JOURNAL   J Biol Chem 299 (12), 105447 (2023)
   PUBMED   37949223
  REMARK    GeneRIF: Cardioprotective O-GlcNAc signaling is elevated in murine
            female hearts via enhanced O-GlcNAc transferase activity.
REFERENCE   5  (bases 1 to 5415)
  AUTHORS   Hayashi,Y., Tando,Y., Ito-Matsuoka,Y., Ikuta,K., Takehara,A.,
            Morino,K., Maegawa,H. and Matsui,Y.
  TITLE     Nutritional and metabolic control of germ cell fate through
            O-GlcNAc regulation
  JOURNAL   EMBO Rep 24 (11), e56845 (2023)
   PUBMED   37842859
REFERENCE   6  (bases 1 to 5415)
  AUTHORS   O'Donnell,N., Zachara,N.E., Hart,G.W. and Marth,J.D.
  TITLE     Ogt-dependent X-chromosome-linked protein glycosylation is a
            requisite modification in somatic cell function and embryo
            viability
  JOURNAL   Mol Cell Biol 24 (4), 1680-1690 (2004)
   PUBMED   14749383
  REMARK    GeneRIF: Ogt mutation results in the loss of O-GlcNAc and causes
            T-cell apoptosis, neuronal tau hyperphosphorylation, and fibroblast
            growth arrest with altered expression of c-Fos, c-Jun, c-Myc, Sp1,
            and p27
REFERENCE   7  (bases 1 to 5415)
  AUTHORS   Hanover,J.A., Yu,S., Lubas,W.B., Shin,S.H., Ragano-Caracciola,M.,
            Kochran,J. and Love,D.C.
  TITLE     Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc
            transferase encoded by a single mammalian gene
  JOURNAL   Arch Biochem Biophys 409 (2), 287-297 (2003)
   PUBMED   12504895
  REMARK    GeneRIF: This transferase mediates a novel hexosamine-dependent
            signal transduction pathway.  It is now sequenced and compared to
            the human and rat ogt locus.
REFERENCE   8  (bases 1 to 5415)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 5415)
  AUTHORS   Shafi,R., Iyer,S.P., Ellies,L.G., O'Donnell,N., Marek,K.W.,
            Chui,D., Hart,G.W. and Marth,J.D.
  TITLE     The O-GlcNAc transferase gene resides on the X chromosome and is
            essential for embryonic stem cell viability and mouse ontogeny
  JOURNAL   Proc Natl Acad Sci U S A 97 (11), 5735-5739 (2000)
   PUBMED   10801981
REFERENCE   10 (bases 1 to 5415)
  AUTHORS   Kreppel,L.K., Blomberg,M.A. and Hart,G.W.
  TITLE     Dynamic glycosylation of nuclear and cytosolic proteins. Cloning
            and characterization of a unique O-GlcNAc transferase with multiple
            tetratricopeptide repeats
  JOURNAL   J Biol Chem 272 (14), 9308-9315 (1997)
   PUBMED   9083067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY196484.1, CF166269.1, BC057319.1 and AK045910.1.
            
            On Mar 14, 2014 this sequence version replaced NM_139144.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057319.1, AF363030.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY196484.1         2-24
            24-77               CF166269.1         1-54
            78-3735             BC057319.1         1-3658
            3736-5339           AK045910.1         1486-3089
            5340-5415           BC057319.1         5262-5337
FEATURES             Location/Qualifiers
     source          1..5415
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 44.45 cM"
     gene            1..5415
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /note="O-linked N-acetylglucosamine (GlcNAc) transferase
                     (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl
                     transferase)"
                     /db_xref="GeneID:108155"
                     /db_xref="MGI:MGI:1339639"
     exon            1..272
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            273..453
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            454..697
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            698..766
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            767..883
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            884..963
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1159
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1300
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1401
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1555
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1657
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1837
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1996
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2086
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2212
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2383
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2500
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2671
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2824
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..3077
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3201
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..5397
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5373..5378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /note="hexamer: AATAAA"
     polyA_site      5397
                     /gene="Ogt"
                     /gene_synonym="1110038P24Rik; 4831420N21Rik; Ogtl"
                     /note="major polyA site"
ORIGIN      
        1 agttccggct tgtgttgttt cggtcgagga gccctcgccg ccatttcaag acagtgagag
       61 gtagatgtct accaagagtt cctaagattc gagttcagta ttctgtgccg ccccctgagc
      121 ccttcaaaac actgatacgg ctgctgcctt ttttctgcta cttctagaac cattcttgtc
      181 agtagtggcg gcagtagaag tcaattaccc cttgttctat ctcaagaagc tccagatggc
      241 gtcttccgtg ggcaacgtgg ccgacagtac agaaccaacg aaacgtatgc tttccttcca
      301 agggttagct gagttggcac atcgagaata tcaggcagga gattttgagg cagctgagag
      361 acactgcatg cagctctgga gacaagagcc tgacaatact ggtgttcttt tattactttc
      421 atctatacac ttccagtgtc gaaggctgga cagatctgct cattttagca ccttggcaat
      481 taaacagaat ccccttctag cagaagccta ttcgaatttg ggaaatgtgt acaaggaaag
      541 agggcagttg caggaagcaa tcgagcatta tcgacatgcc ttgcggctga agcctgattt
      601 cattgatggt tatattaacc tggcagcagc cttggtagca gcaggtgaca tggaaggagc
      661 agtacaagcc tatgtctctg ctcttcagta caatcctgat ttgtactgtg ttcgcagtga
      721 cctggggaac ctgctcaaag ccctgggtcg cttggaagaa gccaaggcat gttatttgaa
      781 agcaattgag acgcaaccaa actttgcagt agcctggagt aatctcggct gtgttttcaa
      841 tgcacaaggg gagatttggc tggctattca tcactttgaa aaggctgtca cccttgaccc
      901 aaattttctg gatgcttata tcaatttagg aaatgtcttg aaagaggcac gcatttttga
      961 cagagctgtc gcagcttatc ttcgtgcctt aagtttgagc ccaaatcatg cggtggtgca
     1021 cggcaacctg gcttgtgtgt actacgagca aggcctaata gacctggcca ttgataccta
     1081 caggagagct atcgaactgc aaccccattt ccccgatgct tactgcaacc tagcaaatgc
     1141 tctcaaagag aagggcagtg ttgctgaagc agaagattgt tataacacag ctcttcgtct
     1201 gtgtcctact catgcagact ctttgaataa ccttgccaac atcaaacggg aacagggcaa
     1261 cattgaagag gcagttcgcc tgtatcgcaa agcattagaa gtcttcccag agtttgctgc
     1321 tgcacattcc aatttagcaa gtgtactgca acagcagggc aagctgcagg aagcactgat
     1381 gcactataaa gaagccatac gaattagtcc tacatttgct gatgcttatt ccaatatggg
     1441 aaacactcta aaggagatgc aggatgtgca gggcgctttg cagtgttata ctcgtgccat
     1501 ccagattaat cctgcctttg ctgatgcaca cagcaatctg gcctccattc acaaggattc
     1561 agggaatatc ccagaagcaa tagcttctta ccgcacagct ctgaaactta agcctgactt
     1621 tcctgatgct tattgtaact tggctcattg cctacagatt gtctgtgatt ggacagacta
     1681 tgatgagcgg atgaagaaat tggttagtat tgtagctgag cagctagaga agaatagact
     1741 gccttctgtc catcctcacc atagcatgct gtaccctctt tcccatggct tcaggaaggc
     1801 tattgcagag aggcatggga atctctgctt ggataagatt aatgtccttc ataaaccacc
     1861 atatgaacat ccaaaagact tgaagctcag tgatggccga ttgcgtgtag gctatgtgag
     1921 ttctgacttc gggaatcacc ctacttcaca ccttatgcag tctattccag gcatgcataa
     1981 tcctgataag tttgaggtat tctgctatgc cttgagcccg gatgatggta caaactttcg
     2041 agtgaaggtg atggcggaag ccaatcattt cattgatctt tctcagattc cttgtaatgg
     2101 aaaagcagcc gaccgcatcc accaagatgg aattcacatc cttgtgaata tgaatgggta
     2161 taccaagggt gctcggaatg agctctttgc tcttaggcca gctcctattc aggccatgtg
     2221 gctgggctac cctgggacta gtggtgcact gttcatggat tacatcatca ctgatcagga
     2281 aacttcccca gctgaagttg cagagcagta ttctgagaaa ctggcttata tgccccatac
     2341 tttctttatt ggtgatcatg ctaatatgtt ccctcacctg aagaaaaaag cagtcatcga
     2401 ttttaaatcc aatgggcaca tttatgataa tcggatagtt ctgaatggca tcgatctcaa
     2461 agcatttctc gatagcctac ccgatgtgaa gattgtcaag atgaaatgtc ctgatggagg
     2521 tgacaatcca gacagcagta acacagctct taatatgccc gttattccca tgaatacgat
     2581 tgcagaagca gtaattgaaa tgattaacag agggcagatt cagataacaa ttaacggatt
     2641 cagtattagc aatggactgg cgactacaca gattaataat aaggctgcaa ccggagagga
     2701 agttccccgt accattattg taaccacccg ttcccagtat gggctaccag aagatgccat
     2761 tgtgtactgt aactttaatc agttatataa aattgaccca tctaccctgc agatgtgggc
     2821 aaatattctg aaacgtgtgc ctaacagcgt gctttggctg ttgcgttttc cagcagtagg
     2881 agaacccaat attcaacaat atgcacaaaa tatgggcctt ccccagaacc gtatcatttt
     2941 ctcacctgtg gctcctaaag aggagcatgt caggagaggt cagctggctg atgtctgcct
     3001 ggatactcct ttgtgtaatg gacacaccac agggatggat gttctctggg caggaacacc
     3061 catggtgact atgccaggag agactcttgc ctctcgagtt gcagcttctc agcttacttg
     3121 tctaggatgt ctcgagctca ttgctaaaag cagacaggaa tatgaagaca tagctgtgaa
     3181 actgggaacc gatctagaat acctgaagaa aattcgtggc aaagtctgga aacagagaat
     3241 atctagccct ctgttcaaca ccaaacaata cacaatggaa ttagagcgac tttatctgca
     3301 gatgtgggag cattatgcag ctggcaacaa acctgaccac atgattaagc ctgttgaagt
     3361 caccgagtca gcctgaataa agactgcgca caggagaatt gccctatacc tgagcctcaa
     3421 ccttctgggg gaagggaact agataacatg ctttgtgtgt atctgtgtag ttctgtgttg
     3481 cagacggatg atatataatg ataatagaat agcacattca gacttacttc ctgcatgata
     3541 gggagagaca agaaagaaga aatgctattc cacaaggaat ctcttagagt tttgcagcaa
     3601 acaggtggtg cacaggtctg gaaggtctgg tctcccttgg tcttccatgg gatgcttaat
     3661 gtggagggga gatagagatt aaccagccgt tttgtgatgc cgtggattga tcaagtcttc
     3721 tgatcctttt ttttttcttt atattttggg ttttggagct tttaaaaatg tttgctttca
     3781 ggtattttta ctcatgtgaa gtgatcttga ttcttctgag gttttaaact aaaatgttgc
     3841 ttcctgtttt agtgtctgaa ctctgacagg gtgacaggga ccttgctggt gtagtctttt
     3901 tataggtttt ataaaccaca tgagcctata tcagtcattt tagtgtctga cctaatgctt
     3961 ggcactgtca gtgctttgtt tagatgatga cttaagactt ttcagcctgt tttacacacc
     4021 ccagctcccg ttaaattctc ctgtgactgc taacaaaccc atgtctgctt tcagacatcc
     4081 cagggtgttt ctctcgaaca tgccatctgg tgccaaatga aaattcttag gagtgaatat
     4141 taatcatgaa ggtcacagtt gtggtactgt tattgataat aatatagggt ttttttctgc
     4201 ctaagtttta cctgtttcac cagtgtttca gcccttgact gcccctccta tgctgcttcc
     4261 aaaagtaata gtgtgataag atttttacct tcctttctaa agtttgtttt ttttttaaag
     4321 tgagtcctgt tcttcccatt tctttcagca gaaatgaaat cccaggtaag tatataagta
     4381 ttcaaatgtt tggttagtaa attacagttc tctccagtac cttaaatggt gttcaccgct
     4441 ctgaagaagc atctctatac aggcagttat tttattttta gactgtgtta gaatgtctgg
     4501 acttagcttc aaactctatg gattcggcct tggtagggaa ttgtaccacc acttggtttg
     4561 gactacaaat taaacattgg ccctcgcgga gcttgagttc ttcatggtag aaaacagttg
     4621 catttccgta aagggtggag ggcttgaggc ttaaatatat gagtatgttt atactgctct
     4681 actgcactta gactctccac tcacagataa gtcttgtctg ttagtagtgc tgtagattaa
     4741 gtctttccaa agcacctagg cagtgcacct attctgtagt tgcagctatt gcctgaatgt
     4801 accttagctg acaaattatt gataattaag aacttgaatt tgtgattctt actgctaatt
     4861 aaaacctaag caagaagtct catgtaattc tgatagcaga attgcattgt gtgaactgtg
     4921 taactttagt aatgtaaatc aaggaacatc agttaagaga tttcctaatt tattttttaa
     4981 ctgaataaat atcagttaaa agattgccag catggttaca ggtaaactga ttttcagaat
     5041 tcactgaact actaaatgtg ggattggata atagacttgg agtgccgctg aggctgagat
     5101 ctgtggccat ttacatagca catcattcct cctataggga tgaacttttt ttccgacaca
     5161 aaaagtagcc actgcggtta aagctttgct tattgtaaca ggcttttatt tccaggtaac
     5221 ctatctgtgg aagacctaat tctgaataga gtaatagata ttactggaaa ctgatttgtt
     5281 ttttttttcc tattatactc tgctttattg aaaaagtaaa gcatttaaaa ttgtgctcca
     5341 gaaattcaga tgttgtcttg cgatctttaa acaataaaat ggatgatttc cccttaaaaa
     5401 aaaaaaaaaa aaaaa
//
