LOCUS       NM_008760               2597 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus osteoglycin (Ogn), mRNA.
ACCESSION   NM_008760
VERSION     NM_008760.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2597)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2597)
  AUTHORS   Ozekin,Y.H., O'Rourke,R. and Bates,E.A.
  TITLE     Single cell sequencing of the mouse anterior palate reveals
            mesenchymal heterogeneity
  JOURNAL   Dev Dyn 252 (6), 713-727 (2023)
   PUBMED   36734036
REFERENCE   3  (bases 1 to 2597)
  AUTHORS   Boote,C., Ma,Q. and Goh,K.L.
  TITLE     Age-dependent mechanical properties of tail tendons in wild-type
            and mimecan gene-knockout mice - A preliminary study
  JOURNAL   J Mech Behav Biomed Mater 139, 105672 (2023)
   PUBMED   36657194
  REMARK    GeneRIF: Age-dependent mechanical properties of tail tendons in
            wild-type and mimecan gene-knockout mice - A preliminary study.
REFERENCE   4  (bases 1 to 2597)
  AUTHORS   Decourtye,L., McCallum-Loudeac,J.A., Zellhuber-McMillan,S.,
            Young,E., Sircombe,K.J. and Wilson,M.J.
  TITLE     Characterization of a novel Lbx1 mouse loss of function strain
  JOURNAL   Differentiation 123, 30-41 (2022)
   PUBMED   34906895
REFERENCE   5  (bases 1 to 2597)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2597)
  AUTHORS   Tasheva,E.S., Koester,A., Paulsen,A.Q., Garrett,A.S., Boyle,D.L.,
            Davidson,H.J., Song,M., Fox,N. and Conrad,G.W.
  TITLE     Mimecan/osteoglycin-deficient mice have collagen fibril
            abnormalities
  JOURNAL   Mol Vis 8, 407-415 (2002)
   PUBMED   12432342
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2597)
  AUTHORS   Saika,S., Saika,S., Liu,C.Y., Azhar,M., Sanford,L.P.,
            Doetschman,T., Gendron,R.L., Kao,C.W. and Kao,W.W.
  TITLE     TGFbeta2 in corneal morphogenesis during mouse embryonic
            development
  JOURNAL   Dev Biol 240 (2), 419-432 (2001)
   PUBMED   11784073
REFERENCE   8  (bases 1 to 2597)
  AUTHORS   Dunlevy,J.R., Beales,M.P., Berryhill,B.L., Cornuet,P.K. and
            Hassell,J.R.
  TITLE     Expression of the keratan sulfate proteoglycans lumican, keratocan
            and osteoglycin/mimecan during chick corneal development
  JOURNAL   Exp Eye Res 70 (3), 349-362 (2000)
   PUBMED   10712821
REFERENCE   9  (bases 1 to 2597)
  AUTHORS   Ying,S., Shiraishi,A., Kao,C.W., Converse,R.L., Funderburgh,J.L.,
            Swiergiel,J., Roth,M.R., Conrad,G.W. and Kao,W.W.
  TITLE     Characterization and expression of the mouse lumican gene
  JOURNAL   J Biol Chem 272 (48), 30306-30313 (1997)
   PUBMED   9374517
REFERENCE   10 (bases 1 to 2597)
  AUTHORS   Ujita,M., Shinomura,T. and Kimata,K.
  TITLE     Molecular cloning of the mouse osteoglycin-encoding gene
  JOURNAL   Gene 158 (2), 237-240 (1995)
   PUBMED   7607548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB630217.1, AK160760.1, AK163772.1 and BE629408.1.
            
            On Feb 6, 2019 this sequence version replaced NM_008760.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053650.1, AK160760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-538               BB630217.1         6-543
            539-1485            AK160760.1         505-1451
            1486-2596           AK163772.1         1382-2492
            2597-2597           BE629408.1         411-411
FEATURES             Location/Qualifiers
     source          1..2597
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 25.34 cM"
     gene            1..2597
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
                     /note="osteoglycin"
                     /db_xref="GeneID:18295"
                     /db_xref="MGI:MGI:109278"
     exon            1..112
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            113..356
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1079
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
                     /codon_start=1
                     /product="mimecan precursor"
                     /protein_id="NP_032786.1"
                     /db_xref="CCDS:CCDS26505.1"
                     /db_xref="GeneID:18295"
                     /db_xref="MGI:MGI:109278"
                     /translation="METVHSTFLLLLFVPLTQQAPQSQLDSHVNYEYATGNSEETKFS
                     QDYEDKYLDGKSIKEKETMIIPDEKSLQLQKDEVIPSLPTKKENDEMPTCLLCVCLSG
                     SVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADMPNLRRLDFTGNLIEDIED
                     GTFSKLSLLEELTLAENQLLRLPVLPPKLTLLNAKHNKIKSKGIKANTFKKLNKLSFL
                     YLDHNDLESVPPNLPESLRVIHLQFNSISSLTDDTFCKANDTRYIRERIEEIRLEGNP
                     IALGKHPNSFICLKRLPIGSYF"
     exon            357..450
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            451..609
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            610..812
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            813..908
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            909..2597
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2486..2491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
                     /note="hexamer: AATAAA"
     polyA_site      2505
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
     regulatory      2572..2577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
                     /note="hexamer: AATAAA"
     polyA_site      2597
                     /gene="Ogn"
                     /gene_synonym="3110079A16Rik; mimecan; mimican; OG; OIF;
                     SLRR3A"
                     /note="major polyA site"
ORIGIN      
        1 agcagtttga aacaattcca cagctttgct cattcactct ctcacttggg actaatgcac
       61 agggatgaat acctattgag gaaaaccaca aggacttcaa ccagatacta agggaaaaag
      121 agtttcgttc cacagtcatc aggtcagtca ctcctaactt cagtcacctt gtgtctgctg
      181 aaatggagac tgtgcactct acatttctcc tgctactctt cgtgcctctg acacagcaag
      241 caccacagtc gcagctggac tcacatgtta actatgagta tgcaacaggc aattctgaag
      301 aaaccaaatt tagccaggat tatgaagata aatacctgga tgggaaaagt attaaggaaa
      361 aagaaactat gataattcct gatgagaaaa gtcttcagtt acaaaaagat gaagttatac
      421 catcattacc aaccaagaaa gaaaatgatg aaatgcccac atgcctgttg tgtgtctgct
      481 taagtggctc tgtctactgt gaagaagttg acattgatgc tgtaccacca ttgccaaagg
      541 aatcagctta tctttatgca cgattcaaca aaattaaaaa gctgactgcc aaggattttg
      601 cagacatgcc aaacctaaga agacttgatt ttacgggaaa tttgatagaa gacatagaag
      661 atgggacttt ttcaaaactt tctctgttag aagaacttac acttgctgaa aaccaactac
      721 taagacttcc agttcttcct ccaaagctta ctttacttaa tgccaaacac aacaaaatca
      781 agagtaaagg aattaaagca aacacattca aaaaactgaa taaactctct tttctctatt
      841 tggaccataa cgacctggaa tctgtgcctc ctaatttacc agaaagtcta cgtgtaattc
      901 accttcagtt taacagcata tcttcactta cagatgatac attctgcaag gctaatgaca
      961 ctcgttacat tcgggagcga attgaagaga ttcgcctgga gggcaatcca attgctctgg
     1021 gaaagcatcc aaacagtttt atctgcttaa aaagattacc catagggtca tacttctaac
     1081 cccatcagtg cagcttataa cctaaggtac atgtgcctaa tgtctaaagg aacagaaaca
     1141 ttagtttaac attaccgttt tatctcacta tgatggaagt ttatgtttaa acaaagtgtc
     1201 caaaattgtt gtatgtgact acaaaaataa tccagcctga atctcttagt tcaaaacaaa
     1261 atactgtgaa actaaacagc attaagggtc tccttgttgt tataccaaac cactatctaa
     1321 atagcatgct tttacacaga cacttgcttg agatacacca ttcccatgac taatgaagta
     1381 agaaaattcc aagaaacttg caactgtttg tcttttttag catttactgt atctcaaaag
     1441 catttaagac agaggttcca gaacctgtgc aaagccaagt gctcccagtg accttccact
     1501 gactctgatt catcagcatt ctttgtaaag cagaaatgta ctttctgtca aggcagctac
     1561 ttcactgcat ttctcactta gcccaaggaa agggacaaca cacgcaagca aacatttcca
     1621 gagaagggaa aattttactc tttggtacag agccaattta gaaaagttca attttctgct
     1681 ttgtggtcac atggatagcc tttagtcaat tacttaaaaa actttgttaa aaaaaaaaag
     1741 taaaaatcct acccatttct caaaggataa taaggttcct tcaccttaaa gattctcaaa
     1801 tatgaaataa ttgtaaactt tttcacagta taggagttta ttcaaatata ggaaatgaaa
     1861 acaaagtcta caccattgtg ctgtgtgcag cttcacctgt atatgttcac ccaaacaaac
     1921 taaatatgct cattccagcc caagagcacc atttctcaat gaccatggtt tccagataca
     1981 tgtaatagtg aaaacccaat ctcacaatgc agattaaagt tccaaaacta agcttcagag
     2041 gaaggtgcac agaccactca caaatattac tctacatatt acttggagtt gaacataaaa
     2101 tgatcagcgt tttagaaata ttcatctttt atacataaaa gtaccaatat catttctatt
     2161 ataagtttta cattagactc tccatgttct tcccagaata ttcattttaa gtttggtggt
     2221 tttgttccaa cccagattga cccctgtctc ctctgttaag ggtgatgaaa cttttcatta
     2281 aagcatctgt gaactgtaag gccacaacta ttgctctaat aatgtcaact agctcattca
     2341 tttttataag ttaattacag taactttatc ccactgtatt attttgtgtc catgactcat
     2401 tttctctgtg actgaacgct caccaagagc actgaacaca gttctatttt tatgatactt
     2461 aatagcatat ttgagttaaa tatacaataa acattgtgaa atctatccaa gtagaagggt
     2521 tctgtttata tggaaaaaac aagttagtat aatcttgaat aaatcaacag aaataaagcg
     2581 acaagattga gaatgga
//
