LOCUS       NM_001410131            1390 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus 8-oxoguanine DNA-glycosylase 1 (Ogg1), transcript
            variant 4, mRNA.
ACCESSION   NM_001410131 XM_006505720
VERSION     NM_001410131.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1390)
  AUTHORS   Ma,Y., Guo,J., Rao,H., Xin,J., Song,X., Liu,R., Shao,S., Hou,J.,
            Kong,L., Hu,Z., He,L., Pan,F. and Guo,Z.
  TITLE     The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway increases
            extracellular vesicle release and promotes tumour metastasis during
            oxidative stress
  JOURNAL   J Extracell Vesicles 13 (9), e12505 (2024)
   PUBMED   39235072
  REMARK    GeneRIF: The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway
            increases extracellular vesicle release and promotes tumour
            metastasis during oxidative stress.
REFERENCE   2  (bases 1 to 1390)
  AUTHORS   Wu,W., Jia,H., Chen,S., Ma,X., Zhou,S., Qiu,L., Wu,X., Li,P.,
            Chu,H. and Zhang,G.
  TITLE     Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2
            macrophage polarization and activating PINK1-mediated mitophagy
  JOURNAL   Mol Med 30 (1), 72 (2024)
   PUBMED   38822247
  REMARK    GeneRIF: Inhibition of OGG1 ameliorates pulmonary fibrosis via
            preventing M2 macrophage polarization and activating PINK1-mediated
            mitophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1390)
  AUTHORS   Sharma,P., Wong,C.P., Ho,E. and Sampath,H.
  TITLE     Catalytic activity of OGG1 is impaired by Zinc deficiency
  JOURNAL   DNA Repair (Amst) 134, 103628 (2024)
   PUBMED   38228016
  REMARK    GeneRIF: Catalytic activity of OGG1 is impaired by Zinc deficiency.
REFERENCE   4  (bases 1 to 1390)
  AUTHORS   Song,C., Xu,Z., Liang,Q., Mu,Y., Liu,M., Wu,Z., Li,X., Li,J.,
            Chen,H., Wang,Y., Gao,S., Li,A., Yao,W. and Liu,G.
  TITLE     OGG1 promoted lung fibrosis by activating fibroblasts via
            interacting with Snail1
  JOURNAL   Int Immunopharmacol 126, 111148 (2024)
   PUBMED   37977070
  REMARK    GeneRIF: OGG1 promoted lung fibrosis by activating fibroblasts via
            interacting with Snail1.
REFERENCE   5  (bases 1 to 1390)
  AUTHORS   Xue,Y., Li,C., Deng,S., Chen,X., Han,J., Zheng,X., Tian,M., Hao,W.,
            Pan,L., Boldogh,I., Ba,X. and Wang,R.
  TITLE     8-Oxoguanine DNA glycosylase 1 selectively modulates ROS-responsive
            NF-kappaB targets through recruitment of MSK1 and phosphorylation
            of RelA/p65 at Ser276
  JOURNAL   J Biol Chem 299 (11), 105308 (2023)
   PUBMED   37778730
  REMARK    GeneRIF: 8-Oxoguanine DNA glycosylase 1 selectively modulates
            ROS-responsive NF-kappaB targets through recruitment of MSK1 and
            phosphorylation of RelA/p65 at Ser276.
REFERENCE   6  (bases 1 to 1390)
  AUTHORS   Rosenquist,T.A., Zharkov,D.O. and Grollman,A.P.
  TITLE     Cloning and characterization of a mammalian 8-oxoguanine DNA
            glycosylase
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7429-7434 (1997)
   PUBMED   9207108
REFERENCE   7  (bases 1 to 1390)
  AUTHORS   Lu,R., Nash,H.M. and Verdine,G.L.
  TITLE     A mammalian DNA repair enzyme that excises oxidatively damaged
            guanines maps to a locus frequently lost in lung cancer
  JOURNAL   Curr Biol 7 (6), 397-407 (1997)
   PUBMED   9197244
REFERENCE   8  (bases 1 to 1390)
  AUTHORS   Aburatani,H., Hippo,Y., Ishida,T., Takashima,R., Matsuba,C.,
            Kodama,T., Takao,M., Yasui,A., Yamamoto,K. and Asano,M.
  TITLE     Cloning and characterization of mammalian 8-hydroxyguanine-specific
            DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM
            homologue
  JOURNAL   Cancer Res 57 (11), 2151-2156 (1997)
   PUBMED   9187114
REFERENCE   9  (bases 1 to 1390)
  AUTHORS   Takeda,T., Hosokawa,M. and Higuchi,K.
  TITLE     Senescence-accelerated mouse (SAM): a novel murine model of
            senescence
  JOURNAL   Exp Gerontol 32 (1-2), 105-109 (1997)
   PUBMED   9088907
  REMARK    Review article
REFERENCE   10 (bases 1 to 1390)
  AUTHORS   Takeda,T., Hosokawa,M., Takeshita,S., Irino,M., Higuchi,K.,
            Matsushita,T., Tomita,Y., Yasuhira,K., Hamamoto,H., Shimizu,K.,
            Ishii,M. and Yamamuro,T.
  TITLE     A new murine model of accelerated senescence
  JOURNAL   Mech Ageing Dev 17 (2), 183-194 (1981)
   PUBMED   7311623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155287.6.
            
            On Jul 27, 2022 this sequence version replaced XM_006505720.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2047257.1,
                                           SRR13422603.324268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC155287.6         160073-160437
            366-480             AC155287.6         161440-161554
            481-660             AC155287.6         162304-162483
            661-842             AC155287.6         164846-165027
            843-993             AC155287.6         166417-166567
            994-1043            AC155287.6         166706-166755
            1044-1390           AC155287.6         166917-167263
FEATURES             Location/Qualifiers
     source          1..1390
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.75 cM"
     gene            1..1390
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /note="8-oxoguanine DNA-glycosylase 1"
                     /db_xref="GeneID:18294"
                     /db_xref="MGI:MGI:1097693"
     exon            1..365
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     exon            366..480
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..1133
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /EC_number="4.2.99.18"
                     /note="isoform 4 is encoded by transcript variant 4;
                     N-glycosylase/DNA lyase"
                     /codon_start=1
                     /product="N-glycosylase/DNA lyase isoform 4"
                     /protein_id="NP_001397060.1"
                     /db_xref="GeneID:18294"
                     /db_xref="MGI:MGI:1097693"
                     /translation="MDTDSDGGPALLHCVPRRRQPGVRLLRQDPTECLFSFICSSNNN
                     IARITGMVERLCQAFGPRLIQLDDVTYHGFPNLHALAGPEAETHLRKLGLGYRARYVR
                     ASAKAILEEQGGPAWLQQLRVAPYEEAHKALCTLPGVGAKVADCICLMALDKPQAVPV
                     DVHVWQIAHRDYGWHPKTSQAKGPSPLANKELGNFFRNLWGPYAGWAQAVLFSADLRQ
                     PSLSREPPAKRKKGSKRPEG"
     exon            481..660
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     exon            661..842
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     exon            843..993
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1043
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1390
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1368..1373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /note="hexamer: AATAGA"
     polyA_site      1390
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /note="major polyA site"
ORIGIN      
        1 agagcggagt ggggcgttta ggggtttggt ggtgtgcgag aggctttcct acgaggagag
       61 ggaaattcat tcaacaggga ctcaaattaa aattacaccg gacccataag ctaggaccca
      121 cggtgctaca ctcccggtgt gtgtggtcac ttgtgtgcga ggctttagga cttgggaaag
      181 tcgagttctg attggacagt gccgtaatgg gctggggctg ctagccgaat gttattccgt
      241 tcctggctgc ctagcagcat gagacatcgc accctaagct ccagcccggc cctctgggcc
      301 tctatcccgt gtccacgctc tgagctgcgt ctggacttgg ttttagcttc tggacagtcc
      361 ttccggtgga aggagcagag ccctgctcac tggagtggcg tgctggcaga tcaagtatgg
      421 acactgactc agacggagga ccagctctat tgcactgtgt accgaggaga cgacagccag
      481 gtgtgagact gctgagacaa gaccccactg agtgcctttt ctctttcatc tgttcctcca
      541 acaacaacat tgctcgcatt actggcatgg tggaacggct ctgccaggcc tttggacctc
      601 gactcattca gcttgatgat gtcacttatc atggcttccc aaacctccat gccctggctg
      661 gtccagaagc agagactcac ctgaggaagt tgggcctggg gtaccgtgcc cgctatgtac
      721 gtgccagtgc caaagccatc ctcgaagagc aaggtgggcc agcttggctg cagcagcttc
      781 gagtggcccc ttatgaagag gcccacaagg ccctctgcac cctgcccggg gtgggcgcca
      841 aggtggctga ctgcatctgc ttaatggccc ttgacaaacc ccaggctgtg cccgtggatg
      901 tccatgtatg gcagattgcc catcgtgact acggctggca tcctaagaca tcccaggcta
      961 agggcccgag ccctttggcc aacaaagaac tgggaaactt tttccggaat ctgtggggac
     1021 cttatgctgg ctgggcccaa gcagtgctgt tcagtgctga ccttcgccaa ccaagcctgt
     1081 ctcgggagcc accagcaaag cgcaaaaagg gatctaagag gccagagggc taggtagggc
     1141 tcaggggcaa aaggtctttt ttcctttgtt ctccatttct ttcccttgtc tctccccccc
     1201 ccccaacccc cgacccctaa gtctcaagtc agaaagactt aacactccca cctcagaggc
     1261 cagaacccca aatcaaagtc agtttttaca atagggaaaa aggaagctat ttgagcaaac
     1321 ggaactgtct tgttttatct tccctttatt acaagaagga acaataaaat agaaacattt
     1381 gtatggaaaa
//
