LOCUS       NM_001410130            1283 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus 8-oxoguanine DNA-glycosylase 1 (Ogg1), transcript
            variant 3, mRNA.
ACCESSION   NM_001410130
VERSION     NM_001410130.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1283)
  AUTHORS   Ma,Y., Guo,J., Rao,H., Xin,J., Song,X., Liu,R., Shao,S., Hou,J.,
            Kong,L., Hu,Z., He,L., Pan,F. and Guo,Z.
  TITLE     The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway increases
            extracellular vesicle release and promotes tumour metastasis during
            oxidative stress
  JOURNAL   J Extracell Vesicles 13 (9), e12505 (2024)
   PUBMED   39235072
  REMARK    GeneRIF: The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway
            increases extracellular vesicle release and promotes tumour
            metastasis during oxidative stress.
REFERENCE   2  (bases 1 to 1283)
  AUTHORS   Wu,W., Jia,H., Chen,S., Ma,X., Zhou,S., Qiu,L., Wu,X., Li,P.,
            Chu,H. and Zhang,G.
  TITLE     Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2
            macrophage polarization and activating PINK1-mediated mitophagy
  JOURNAL   Mol Med 30 (1), 72 (2024)
   PUBMED   38822247
  REMARK    GeneRIF: Inhibition of OGG1 ameliorates pulmonary fibrosis via
            preventing M2 macrophage polarization and activating PINK1-mediated
            mitophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1283)
  AUTHORS   Sharma,P., Wong,C.P., Ho,E. and Sampath,H.
  TITLE     Catalytic activity of OGG1 is impaired by Zinc deficiency
  JOURNAL   DNA Repair (Amst) 134, 103628 (2024)
   PUBMED   38228016
  REMARK    GeneRIF: Catalytic activity of OGG1 is impaired by Zinc deficiency.
REFERENCE   4  (bases 1 to 1283)
  AUTHORS   Song,C., Xu,Z., Liang,Q., Mu,Y., Liu,M., Wu,Z., Li,X., Li,J.,
            Chen,H., Wang,Y., Gao,S., Li,A., Yao,W. and Liu,G.
  TITLE     OGG1 promoted lung fibrosis by activating fibroblasts via
            interacting with Snail1
  JOURNAL   Int Immunopharmacol 126, 111148 (2024)
   PUBMED   37977070
  REMARK    GeneRIF: OGG1 promoted lung fibrosis by activating fibroblasts via
            interacting with Snail1.
REFERENCE   5  (bases 1 to 1283)
  AUTHORS   Xue,Y., Li,C., Deng,S., Chen,X., Han,J., Zheng,X., Tian,M., Hao,W.,
            Pan,L., Boldogh,I., Ba,X. and Wang,R.
  TITLE     8-Oxoguanine DNA glycosylase 1 selectively modulates ROS-responsive
            NF-kappaB targets through recruitment of MSK1 and phosphorylation
            of RelA/p65 at Ser276
  JOURNAL   J Biol Chem 299 (11), 105308 (2023)
   PUBMED   37778730
  REMARK    GeneRIF: 8-Oxoguanine DNA glycosylase 1 selectively modulates
            ROS-responsive NF-kappaB targets through recruitment of MSK1 and
            phosphorylation of RelA/p65 at Ser276.
REFERENCE   6  (bases 1 to 1283)
  AUTHORS   Rosenquist,T.A., Zharkov,D.O. and Grollman,A.P.
  TITLE     Cloning and characterization of a mammalian 8-oxoguanine DNA
            glycosylase
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7429-7434 (1997)
   PUBMED   9207108
REFERENCE   7  (bases 1 to 1283)
  AUTHORS   Lu,R., Nash,H.M. and Verdine,G.L.
  TITLE     A mammalian DNA repair enzyme that excises oxidatively damaged
            guanines maps to a locus frequently lost in lung cancer
  JOURNAL   Curr Biol 7 (6), 397-407 (1997)
   PUBMED   9197244
REFERENCE   8  (bases 1 to 1283)
  AUTHORS   Aburatani,H., Hippo,Y., Ishida,T., Takashima,R., Matsuba,C.,
            Kodama,T., Takao,M., Yasui,A., Yamamoto,K. and Asano,M.
  TITLE     Cloning and characterization of mammalian 8-hydroxyguanine-specific
            DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM
            homologue
  JOURNAL   Cancer Res 57 (11), 2151-2156 (1997)
   PUBMED   9187114
REFERENCE   9  (bases 1 to 1283)
  AUTHORS   Takeda,T., Hosokawa,M. and Higuchi,K.
  TITLE     Senescence-accelerated mouse (SAM): a novel murine model of
            senescence
  JOURNAL   Exp Gerontol 32 (1-2), 105-109 (1997)
   PUBMED   9088907
  REMARK    Review article
REFERENCE   10 (bases 1 to 1283)
  AUTHORS   Takeda,T., Hosokawa,M., Takeshita,S., Irino,M., Higuchi,K.,
            Matsushita,T., Tomita,Y., Yasuhira,K., Hamamoto,H., Shimizu,K.,
            Ishii,M. and Yamamuro,T.
  TITLE     A new murine model of accelerated senescence
  JOURNAL   Mech Ageing Dev 17 (2), 183-194 (1981)
   PUBMED   7311623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155287.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.89612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC155287.6         160073-160437
            366-480             AC155287.6         161440-161554
            481-553             AC155287.6         162411-162483
            554-735             AC155287.6         164846-165027
            736-886             AC155287.6         166417-166567
            887-936             AC155287.6         166706-166755
            937-1283            AC155287.6         166917-167263
FEATURES             Location/Qualifiers
     source          1..1283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.75 cM"
     gene            1..1283
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /note="8-oxoguanine DNA-glycosylase 1"
                     /db_xref="GeneID:18294"
                     /db_xref="MGI:MGI:1097693"
     exon            1..365
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1026
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /EC_number="4.2.99.18"
                     /note="isoform 3 is encoded by transcript variant 3;
                     N-glycosylase/DNA lyase"
                     /codon_start=1
                     /product="N-glycosylase/DNA lyase isoform 3"
                     /protein_id="NP_001397059.1"
                     /db_xref="GeneID:18294"
                     /db_xref="MGI:MGI:1097693"
                     /translation="MLFRSWLPSSMRHRTLSSSPALWASIPCPRSELRLDLVLASGQS
                     FRWKEQSPAHWSGVLADQVWTLTQTEDQLYCTVYRGDDSQAFGPRLIQLDDVTYHGFP
                     NLHALAGPEAETHLRKLGLGYRARYVRASAKAILEEQGGPAWLQQLRVAPYEEAHKAL
                     CTLPGVGAKVADCICLMALDKPQAVPVDVHVWQIAHRDYGWHPKTSQAKGPSPLANKE
                     LGNFFRNLWGPYAGWAQAVLFSADLRQPSLSREPPAKRKKGSKRPEG"
     exon            366..480
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     exon            481..553
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     exon            554..735
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     exon            736..886
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     exon            887..936
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1283
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1261..1266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /note="hexamer: AATAGA"
     polyA_site      1283
                     /gene="Ogg1"
                     /gene_synonym="Mmh"
                     /note="major polyA site"
ORIGIN      
        1 agagcggagt ggggcgttta ggggtttggt ggtgtgcgag aggctttcct acgaggagag
       61 ggaaattcat tcaacaggga ctcaaattaa aattacaccg gacccataag ctaggaccca
      121 cggtgctaca ctcccggtgt gtgtggtcac ttgtgtgcga ggctttagga cttgggaaag
      181 tcgagttctg attggacagt gccgtaatgg gctggggctg ctagccgaat gttattccgt
      241 tcctggctgc ctagcagcat gagacatcgc accctaagct ccagcccggc cctctgggcc
      301 tctatcccgt gtccacgctc tgagctgcgt ctggacttgg ttttagcttc tggacagtcc
      361 ttccggtgga aggagcagag ccctgctcac tggagtggcg tgctggcaga tcaagtatgg
      421 acactgactc agacggagga ccagctctat tgcactgtgt accgaggaga cgacagccag
      481 gcctttggac ctcgactcat tcagcttgat gatgtcactt atcatggctt cccaaacctc
      541 catgccctgg ctggtccaga agcagagact cacctgagga agttgggcct ggggtaccgt
      601 gcccgctatg tacgtgccag tgccaaagcc atcctcgaag agcaaggtgg gccagcttgg
      661 ctgcagcagc ttcgagtggc cccttatgaa gaggcccaca aggccctctg caccctgccc
      721 ggggtgggcg ccaaggtggc tgactgcatc tgcttaatgg cccttgacaa accccaggct
      781 gtgcccgtgg atgtccatgt atggcagatt gcccatcgtg actacggctg gcatcctaag
      841 acatcccagg ctaagggccc gagccctttg gccaacaaag aactgggaaa ctttttccgg
      901 aatctgtggg gaccttatgc tggctgggcc caagcagtgc tgttcagtgc tgaccttcgc
      961 caaccaagcc tgtctcggga gccaccagca aagcgcaaaa agggatctaa gaggccagag
     1021 ggctaggtag ggctcagggg caaaaggtct tttttccttt gttctccatt tctttccctt
     1081 gtctctcccc cccccccaac ccccgacccc taagtctcaa gtcagaaaga cttaacactc
     1141 ccacctcaga ggccagaacc ccaaatcaaa gtcagttttt acaataggga aaaaggaagc
     1201 tatttgagca aacggaactg tcttgtttta tcttcccttt attacaagaa ggaacaataa
     1261 aatagaaaca tttgtatgga aaa
//
