LOCUS       NM_031373               2306 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus opioid growth factor receptor (Ogfr), mRNA.
ACCESSION   NM_031373
VERSION     NM_031373.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2306)
  AUTHORS   Kareem,Z.Y., McLaughlin,P.J. and Kumari,R.
  TITLE     Opioid growth factor receptor: Anatomical distribution and receptor
            colocalization in neurons of the adult mouse brain
  JOURNAL   Neuropeptides 99, 102325 (2023)
   PUBMED   36812665
  REMARK    GeneRIF: Opioid growth factor receptor: Anatomical distribution and
            receptor colocalization in neurons of the adult mouse brain.
REFERENCE   3  (bases 1 to 2306)
  AUTHORS   McLaughlin,P.J., Keiper,C.L., Verderame,M.F. and Zagon,I.S.
  TITLE     Targeted overexpression of OGFr in epithelium of transgenic mice
            suppresses cell proliferation and impairs full-thickness wound
            closure
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 302 (9), R1084-R1090 (2012)
   PUBMED   22338080
  REMARK    GeneRIF: These data demonstrate for the first time that stable
            genetic amplification of OGFr downregulates homeostatic cell
            proliferation, as well as pathophysiological processes with respect
            to wound repair.
REFERENCE   4  (bases 1 to 2306)
  AUTHORS   Challen,G., Gardiner,B., Caruana,G., Kostoulias,X., Martinez,G.,
            Crowe,M., Taylor,D.F., Bertram,J., Little,M. and Grimmond,S.M.
  TITLE     Temporal and spatial transcriptional programs in murine kidney
            development
  JOURNAL   Physiol Genomics 23 (2), 159-171 (2005)
   PUBMED   15998744
REFERENCE   5  (bases 1 to 2306)
  AUTHORS   Zagon,I.S., Verderame,M.F. and McLaughlin,P.J.
  TITLE     The biology of the opioid growth factor receptor (OGFr)
  JOURNAL   Brain Res Brain Res Rev 38 (3), 351-376 (2002)
   PUBMED   11890982
  REMARK    Review article
REFERENCE   6  (bases 1 to 2306)
  AUTHORS   Zagon,I.S., Verderame,M.F., Zimmer,W.E. and McLaughlin,P.J.
  TITLE     Molecular characterization and distribution of the opioid growth
            factor receptor (OGFr) in mouse
  JOURNAL   Brain Res Mol Brain Res 84 (1-2), 106-114 (2000)
   PUBMED   11113537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ144579.1, AF303894.1 and CO040942.1.
            
            On Sep 19, 2009 this sequence version replaced NM_031373.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049965.1, AF303894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                CJ144579.1         1-52
            53-1976             AF303894.1         1-1924
            1977-2306           CO040942.1         1-330               c
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.13 cM"
     gene            1..2306
                     /gene="Ogfr"
                     /gene_synonym="2010013E17Rik"
                     /note="opioid growth factor receptor"
                     /db_xref="GeneID:72075"
                     /db_xref="MGI:MGI:1919325"
     exon            1..215
                     /gene="Ogfr"
                     /gene_synonym="2010013E17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1976
                     /gene="Ogfr"
                     /gene_synonym="2010013E17Rik"
                     /note="zeta-type opioid receptor"
                     /codon_start=1
                     /product="opioid growth factor receptor"
                     /protein_id="NP_113550.3"
                     /db_xref="CCDS:CCDS17179.1"
                     /db_xref="GeneID:72075"
                     /db_xref="MGI:MGI:1919325"
                     /translation="MDDPECDSTWEDESEEDGEDGQADDTTDEDTGDDDGDAEEARPS
                     LFQSRMTRYRNWRAMQDMQRYRHNYPDLTDQDCNGDMCNLSFYKNEICFQPNGFLIED
                     ILQNWKDNYDLLEENHSYIQWLFPLREPGVNWHAKPLTLKEVEAFKSSKEVRERLVRA
                     YELMLGFYGIQLEDRNTGAVCRAQNFQPRFHNLNSHSHNNLRITRILKSLGELGLEHY
                     QAPLVRFFLEETLVQHKLPSVRQSALDYFLFAVRCRHQRRELVHFAWEHFKPRREFVW
                     GPRDKLRRFRPQTISRPLMGLGQADKDEGPGDPSQEAGTQGRTCGSGRDLSGDSGTAE
                     DLSLLSAKPQDVGTLDGDQRHEAKSPSPKESKKRKLEGNRQEQVPGEPDPQGVSEVEK
                     IALNLEGCALSPTSQEPREAEQPCLVARVANEVRKRRKVEEGAEGDGVASNTQVQASA
                     LSPTPSECPESQKDGNGPEDPKSQVGPEDPKSQVGPEDPKSQVGPEDPKSQVGPEDPK
                     GQVEPEDPKGQVGPEDPKGQVGPEDPKGQVGPEDPKSQVGPEDPKSQVEPEDPKSQVE
                     PEDPKSQVEPEDPKSQVGPEDPQSQVGPEQAASKSLGEDPDSDTTGTSMSESEELARI
                     EASVEPPKP"
     exon            216..284
                     /gene="Ogfr"
                     /gene_synonym="2010013E17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            285..363
                     /gene="Ogfr"
                     /gene_synonym="2010013E17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            364..442
                     /gene="Ogfr"
                     /gene_synonym="2010013E17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            443..509
                     /gene="Ogfr"
                     /gene_synonym="2010013E17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            510..658
                     /gene="Ogfr"
                     /gene_synonym="2010013E17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            659..2288
                     /gene="Ogfr"
                     /gene_synonym="2010013E17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2261..2266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ogfr"
                     /gene_synonym="2010013E17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2282
                     /gene="Ogfr"
                     /gene_synonym="2010013E17Rik"
                     /note="major polyA site"
ORIGIN      
        1 tggcgccgcc ccgcccccgc gcttcctcct ctttcacttt cctttccgcg gaaagcgggt
       61 ccagcctgtc gagtatggac gacccggaat gcgattccac ctgggaggac gagagcgagg
      121 aggacggcga ggatggccag gcggatgata cgaccgatga ggacacgggc gacgatgacg
      181 gcgacgcgga ggaggcacgg ccaagcctgt tccagtctag gatgacaagg taccgaaact
      241 ggcgtgctat gcaggacatg caaagatacc ggcacaacta cccggatttg acagatcaag
      301 actgcaacgg agacatgtgc aacctgagct tctacaaaaa tgagatctgc ttccagccaa
      361 atggctttct cattgaggac attcttcaga actggaaaga caactatgac ctcctggaag
      421 agaatcactc ctacatccag tggctgtttc ccctgaggga accaggagtg aactggcatg
      481 ccaagcccct cacactgaag gaggttgagg catttaaaag ctccaaggaa gtcagagagc
      541 gtcttgtccg ggcctatgag ctcatgctgg gcttctatgg gatccaactt gaggaccgga
      601 acacaggcgc cgtatgccgt gcacagaact tccagccacg cttccacaat ctcaacagcc
      661 acagccacaa caatctgcgt attacacgca tcctcaagtc gctgggcgag ctgggcttag
      721 agcactacca ggcaccgctg gtgcgcttct tcctggagga gaccctagta cagcacaaac
      781 tgcccagcgt tcgccagagt gccctggact acttcctgtt tgccgtgcgc tgccggcacc
      841 agcgccggga gctcgtgcac tttgcttggg agcacttcaa gcctcgccga gagtttgtct
      901 gggggccccg tgacaagctg cggaggttca ggccccagac tatatcccgg ccactgatgg
      961 gactagggca ggcagataaa gatgagggcc ccggggaccc ctcccaagag gctggcaccc
     1021 agggtcggac ctgtggatct ggaagggacc tgagtgggga cagtggaaca gctgaggatc
     1081 tctcactgtt gagcgcaaaa ccccaggatg tgggaacctt ggatggggac caaaggcatg
     1141 aggctaagtc cccgagtccc aaagaaagca agaagaggaa gttggagggg aacaggcagg
     1201 agcaggtccc aggggagcca gatcctcagg gtgtctctga ggtagagaaa attgccctca
     1261 accttgaggg gtgtgccctc agccctacca gccaggagcc cagggaggct gaacagccct
     1321 gtcttgtggc tagggtggct aatgaggtaa gaaaacggag gaaggtggag gaaggagctg
     1381 agggtgatgg agtagccagt aacactcaag tgcaggccag tgccctgtct cctacccctt
     1441 cagagtgtcc tgagtcccaa aaggatggga atgggccaga ggaccccaaa agccaggtgg
     1501 ggccagaaga ccccaaaagc caggtggggc cagaggaccc caaaagccag gtggggccag
     1561 aggaccccaa aagccaggtg gggccagagg acccaaaagg ccaggtggag ccagaggacc
     1621 caaaaggcca ggtggggcca gaagacccaa aaggccaggt ggggccagag gacccaaaag
     1681 gccaggtggg gccagaggac cccaaaagcc aggtggggcc agaggacccc aaaagccagg
     1741 tggagccaga ggaccccaaa agccaggtgg agccagagga ccccaaaagc caggtggagc
     1801 cagaggaccc caaaagccag gtggggccag aggaccccca aagccaggtg gggccagagc
     1861 aagctgcctc taagagcctg ggggaggatc ctgactctga cactacagga acctcaatga
     1921 gtgagtcaga ggagttggca aggattgagg cctctgttga acccccaaag ccttagaggt
     1981 acccctcagt cctaattagc ccactgcagg gggtttctgt cccagagctc tgttgttggc
     2041 tcttcttggt gccccacagt gctggcctct ccctagtggt cactgaagtg gccaccagag
     2101 ggactgaggc cctgccctca gggaaggcca aggccttcag aagcctcctt acctcactgt
     2161 gtcctccact gccctctgag ccctgtgttg tgaacagacc ctaagggtct aaggggatgg
     2221 gcctcttttc ttcgtctggt gccaagtgag gccttttctg aataaactct ttaggctttg
     2281 tcttttggaa aaaaaaaaaa aaaaaa
//
