LOCUS       NM_177767               5329 bp    mRNA    linear   ROD 04-FEB-2024
DEFINITION  Mus musculus 2-oxoglutarate and iron-dependent oxygenase domain
            containing 1 (Ogfod1), transcript variant 1, mRNA.
ACCESSION   NM_177767
VERSION     NM_177767.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5329)
  AUTHORS   Rodriguez,R., Harris,M., Murphy,E. and Kennedy,L.M.
  TITLE     OGFOD1 modulates the transcriptional and proteomic landscapes to
            alter isoproterenol-induced hypertrophy susceptibility
  JOURNAL   J Mol Cell Cardiol 179, 42-46 (2023)
   PUBMED   37084634
  REMARK    GeneRIF: OGFOD1 modulates the transcriptional and proteomic
            landscapes to alter isoproterenol-induced hypertrophy
            susceptibility.
REFERENCE   2  (bases 1 to 5329)
  AUTHORS   Harris,M., Sun,J., Keeran,K., Aponte,A., Singh,K., Springer,D.,
            Gucek,M., Pirooznia,M., Cockman,M.E., Murphy,E. and Kennedy,L.M.
  TITLE     Ogfod1 deletion increases cardiac beta-alanine levels and protects
            mice against ischaemia- reperfusion injury
  JOURNAL   Cardiovasc Res 118 (13), 2847-2858 (2022)
   PUBMED   34668514
  REMARK    GeneRIF: Ogfod1 deletion increases cardiac beta-alanine levels and
            protects mice against ischaemia- reperfusion injury.
REFERENCE   3  (bases 1 to 5329)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5329)
  AUTHORS   Singleton,R.S., Liu-Yi,P., Formenti,F., Ge,W., Sekirnik,R.,
            Fischer,R., Adam,J., Pollard,P.J., Wolf,A., Thalhammer,A.,
            Loenarz,C., Flashman,E., Yamamoto,A., Coleman,M.L., Kessler,B.M.,
            Wappner,P., Schofield,C.J., Ratcliffe,P.J. and Cockman,M.E.
  TITLE     OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in
            translation control and stress granule formation
  JOURNAL   Proc Natl Acad Sci U S A 111 (11), 4031-4036 (2014)
   PUBMED   24550447
REFERENCE   5  (bases 1 to 5329)
  AUTHORS   Kim,S., Zhang,S., Choi,K.H., Reister,R., Do,C., Baykiz,A.F. and
            Gershenfeld,H.K.
  TITLE     An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger
            41, is a candidate gene for anxiety-like behavior and
            beta-carboline-induced seizures
  JOURNAL   Biol Psychiatry 65 (5), 425-431 (2009)
   PUBMED   18986647
REFERENCE   6  (bases 1 to 5329)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029629.1, EL608450.1, AC138118.4 and BQ033095.1.
            
            [WARNING] On Mar 11, 2024 this sequence was replaced by
            NM_177767.5.
            
            On May 22, 2007 this sequence version replaced NM_177767.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156765.1, AK166343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               AK029629.1         2-558
            558-1303            AK029629.1         560-1305
            1304-1675           EL608450.1         65-436              c
            1676-2057           AK029629.1         1678-2059
            2058-4807           AC138118.4         10301-13050         c
            4808-5329           BQ033095.1         1-522               c
FEATURES             Location/Qualifiers
     source          1..5329
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.08 cM"
     gene            1..5329
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /note="2-oxoglutarate and iron-dependent oxygenase domain
                     containing 1"
                     /db_xref="GeneID:270086"
                     /db_xref="MGI:MGI:2442978"
     exon            1..245
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1729
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /EC_number="1.14.11.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     2-oxoglutarate and iron-dependent oxygenase
                     domain-containing protein 1; prolyl 3-hydroxylase OGFOD1;
                     uS12 prolyl 3-hydroxylase"
                     /codon_start=1
                     /product="prolyl 3-hydroxylase OGFOD1 isoform 1"
                     /protein_id="NP_808435.3"
                     /db_xref="CCDS:CCDS22535.2"
                     /db_xref="GeneID:270086"
                     /db_xref="MGI:MGI:2442978"
                     /translation="MNGKRPADPGPARPMKKGKKQVSAEFSDAVTEEILRKQVAEAWS
                     CRTPFSHEAIALDMDPFLHCVIPNFIQSQDFLEGLHKELLSLDFHEKYNDLYKFQQSD
                     DLKNRKEPHISALRKLMFEDFRAWLSKVSGIDLEPTIDMSCAKYEFTDALLCHDDELE
                     GRRIAFILYLVPSWDRDLGGTLDLYDTDEHLQPKQIVKSLIPSWNKLVFFEVSPVSFH
                     QVSEVLSEETSRLSISGWFYGPSLTRPPTYFEPPIPRNPHIPQDHEILYEWINPAYLE
                     MDYQMQIQEEFEERSEILLKEFLKPEKFAEVCEALEKGDVEWKSHGPPNKRFYEKAEE
                     NNLPDVLKECMGLFRSEALFLLLSNLTGLKLHFLAPSEDDETEEKGEGETASAAAGTE
                     EGTSRRPSGPENNQVAAGSHSQENGEQADPEAQEEEAKKESSVPMCQGELRRWKTGHY
                     TLVHDNTKTEFALDLFLYCGCEGWEPEYGGFTSYIAKGEDEELLIVNPENNSLALVYR
                     DRETLRFVKHINHRSLEQSKAFPSRSGFWDFAFIYYE"
     exon            246..391
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
     exon            392..438
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
     exon            439..539
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
     exon            540..656
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
     exon            657..748
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
     exon            749..877
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
     exon            878..991
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1071
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1385
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1508
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1567
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..5311
                     /gene="Ogfod1"
                     /gene_synonym="4930415J21Rik; mKIAA1612"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaataagga aagagggttt tcgggaactg tagtttctgg agggaagtag cgtcctgact
       61 tccttggcgt gggtctgtgc accgtgagaa gatgaacggg aagcggccgg cggatcctgg
      121 cccagcgcgg ccaatgaaga agggaaagaa gcaggtatcg gcagagtttt cggacgctgt
      181 cactgaagaa atcctgagga agcaggtggc tgaggcctgg agctgccgga caccgttcag
      241 ccatgaagct attgccttgg acatggatcc tttccttcac tgtgtgatcc caaacttcat
      301 ccaaagccaa gacttcttgg aaggacttca caaagagctt ttgagcctgg acttccatga
      361 aaagtacaat gatttatata agttccaaca gtctgatgat ttgaagaacc gaaaagagcc
      421 ccatatctca gctttaagga aacttatgtt tgaagatttt cgggcctggc tttctaaggt
      481 ttccggcatt gacctagaac caaccattga catgtcgtgt gcgaaatacg agttcactga
      541 tgctctgctc tgccatgatg atgaactgga ggggcgccgg atcgctttca ttctgtacct
      601 ggttccttct tgggacaggg acttgggggg caccctggac ctttatgaca ctgatgaaca
      661 cttgcagcca aagcagattg tcaagtctct tatcccttcc tggaacaaac tggttttctt
      721 tgaagtgtct ccagtatcct ttcaccaggt gtctgaagtc ctgtctgaag aaacatcacg
      781 tttgtctata agtggctggt tttatggtcc ttcattaacc aggcctccta cctactttga
      841 gcccccaatc cctcgaaacc ctcacatccc acaagatcat gaaattttat atgagtggat
      901 caaccctgct tacctggaaa tggattatca aatgcaaatt caagaagaat ttgaagaaag
      961 gtctgaaatt ctcctgaagg agtttcttaa gcctgagaaa tttgcagagg tctgtgaagc
     1021 cttggagaaa ggagatgtgg aatggaaaag ccatggtccc ccaaacaaaa ggttttatga
     1081 gaaagcagaa gaaaataacc tccctgacgt gctgaaggaa tgcatgggcc tgttccgctc
     1141 tgaggcgctc ttcctgctgc tctccaacct cactggcctg aagcttcact tcttggcccc
     1201 ttcagaagat gatgagactg aggagaaagg agagggggag acagccagtg ctgctgctgg
     1261 cactgaagaa gggactagcc gacgcccctc ggggccagag aataatcagg tggccgctgg
     1321 cagtcacagt caagagaacg gtgaacaggc agacccagaa gcacaggaag aggaagcaaa
     1381 gaaagaatcg agcgttccca tgtgccaggg ggagctgagg cgttggaaga ctggccatta
     1441 cacattagtc cacgacaaca ccaagactga atttgccctg gacctgtttc tgtactgtgg
     1501 ctgtgaaggc tgggagcccg aatatggcgg ctttacctcc tacattgcta aaggtgaaga
     1561 tgaagagctg ctcatagtga atccagaaaa caactctttg gcgttggtct acagagacag
     1621 agaaacgctg aggtttgtga aacacatcaa ccaccgcagc ctagagcaga gcaaagcctt
     1681 cccaagcaga agcggcttct gggacttcgc attcatctac tatgagtaac aagatggggc
     1741 agagccagct agcattcact ccaccagtgc caggaacatg gggtcttcgt ggagtgaggg
     1801 agagtggggc atgctgggta acagcgtcct ccgagcaggc tgtccttgca ggctgtgtgg
     1861 gtgcacacct gtgatgccag cctcgggagg cagagaaagg ggaccttcag ttcccaaggt
     1921 cagtgtggct tacacggtga gaccctgtcc ccaagcaaaa caactcttgg tcatcctttc
     1981 agaaaattca tctagacctc atgctagagc tatgtactcg tccctgggtt gcagaaaaaa
     2041 atgttttccc ccattgcaat tctcttcgtt ctgtagtaac tgccttggcg actttctaac
     2101 tttggtgatt ttttttttaa tttatggtgt atatacaaaa tttagcaggg tcactttttt
     2161 ttggcttaga gtttggtttg gtttggtttg gtttcttttg acagggttgt actatgtagc
     2221 ccaggctagc tctgaagtac tgattctgcc acctcaacct cctaagtgct ggaattgcag
     2281 gcatgagcca ctgcaccagt tcctgcatgt gcagtccgtg gaattgagca tactgaagtg
     2341 ctccaaagca cccgtcactg ccatctggaa aacacccaga cctcatagga agtggaaatg
     2401 gttttctgtc ttcccatagg ggagtgctac tgcccttctt tgatgactgt tcgcctcatg
     2461 agtgaatcgt gcagtgggtc tcgcttcctg attggcttgt ttcacttagc acagcgtcct
     2521 caaggcctat cagtgttttt cttcttcact cctaagtagt tgtagaaact tgctgagccc
     2581 gagagctgtg acacacggtg ctcccactgt gggctgagct ccaccctgac tctgaggata
     2641 gggtaccctc ggggaggtag tgttgctctt ttggaagagg tctgcctgaa acctaacata
     2701 gctccaggaa ttccatagct gcttactgcc ctatgtattt cctctcgtct actgccttcc
     2761 agacctggca tcgtggcttc tctgagtcta gcctcccagt gactatgcgt tcctaaatgc
     2821 tggaaggccg ggtgtggaac ttgctgcctt tcccttcctt ttgaaagacc cccgtgctaa
     2881 aaggcagtgt caggaggaga agttcaggag gagaagccct ccttttgtct ctggtctttc
     2941 ccctgaactg ctccatgggg ctgtggcaca gctcttccca ttgtgggggt gtgcatgatg
     3001 gctgagagat gtcctcacac caccccacac cacatctatt tgctgctttc ttggttcctg
     3061 actatccttg caggtttcag tgtggacttt acttatcggt aggaaaaacg ctggaccttt
     3121 aagtatctta ttcacacttc tctgacgtcc taaaagtcca tccaaatgca ttctgtcttt
     3181 tacattggct ttcaatttgt tttgtttacc cagtcagtaa aacacacttt aacattcata
     3241 tcctagtaga tacttacaag ttttatatgt tttggtatta atcataaaac aaagtaattt
     3301 ttaaataatg acatgagaat atccagacct aaactgaggg gacatacttt aatcccagct
     3361 tttggaaggt agaggcaaga ggattaagag ttcaagacta tcctcagcca cacagcgagt
     3421 ttaaggccag cctgggcagc agtacacctt gcctcaaaaa caaagatgga gccaggagtg
     3481 ggaagcacgc atctttattc tagcactcag gaggcagagg caggcagatg tgtgaattca
     3541 aggccagcct ggtctacaaa gagagtttca ggacagtcag agctatatag tgaaaccctg
     3601 attcaaaaat taaaaacaaa agactctcca gacctagttt gagagttgtc ttcccacgcc
     3661 aggcagtgac caatgacagg ctgttgccca cgcatactgt tgtagactcc accgcacttt
     3721 aatccagagt agtgctcaag ttggactacg catactttgt tgctaacggt tacttttgaa
     3781 gcttgccttt tctgaactgc tgcagactaa aggcaggccc actcccccac ccatcccacc
     3841 ctcactcccc accccccatt gaagtgcctg agtgggaaga actctgaagg gtccctctgt
     3901 ctttgcagag cctcctggtc tgcaagaaca atagaaccta caggttgcct ttctgctcta
     3961 gtgagcagct gcgtttttca gttgccatgt gccgcattgt tgatgtatgg gtgagacaga
     4021 tggtgtatga cagtgagccc gtacgtctac agtggagctg aaagatgcct gaattccaaa
     4081 tcactcaaag tcaccgagag gctagggaga acaggcagct gtgcacacaa ctgtcactca
     4141 caggccacca ccttatgtgt tcactcacat gacctgctca gagtgtgtgc tgttaaagcg
     4201 ctaactccca tgtgcagaca acacaggtgg aaagcagtga gaatgaagac aatcaataag
     4261 tgtatgggcc tgtgtgtgtg tgtgtgtgtg ttagtattaa cagaaaattc agaaaggtta
     4321 aaaatgaaaa taactcaaaa tatttttgta cagctataca atataaagtt ataagtcaaa
     4381 gtttaaaata aagttctatt gcataagcta aggctattga agatggagta tttttaacgt
     4441 gtcgtccatg ttggaaggca gaaaagcttc cacttagtct gtccaagaat actgtcacgt
     4501 ttgcacaagt gatcttgcct cagtttgcaa ttgcttcatt cttgatcctg attgcttgct
     4561 gctttgggca tggggcaaga gagtcaaatg tgggctctca atacctcttg ttggtaaaag
     4621 ctatgctgct ttctgtgtga ccaatggcat gtctctctta ataatgagcc tctaattctt
     4681 tcttgttttc ttattgattg gtgttttcga gaagggtcta tgtataccct agctctctaa
     4741 ttgctaagat tctagagtac cacggtgtcc agctgtgaac ttccagttct cataactcct
     4801 tttcctaaag gtgatattcc ctccaaagat aacaatacat aaacaatgca tgttcattgt
     4861 tgggaattta aaagtgtgga aaaacacata ggtcagctga aaccccttgc caccaccctt
     4921 tgacaactgt gtgctgccgt aagcgtgtca gcatggccac cctgccctgt attaggaagc
     4981 atggctcctc tctgccctct cttccctctc tcctgttggg taaatacaag gttgtaaggc
     5041 actttgtcag gctgggctca gagggagcca ctaaggccgc cgctgcagac aagaatgaaa
     5101 acagttttca gtggctcctt aagaataaaa aggagcagcc agagatgcgt ttggagatct
     5161 gtattccagc taatgctacc ccaactgata gactgccttt agatttgttt tcccttaata
     5221 taaatgttta cacatacatt tgagtgataa aaaaaaatgg atgtctgtat tttttgtttt
     5281 ccccacaaaa taaaagtgtt tgtgcatttc taaaaaaaaa aaaaaaaaa
//
