LOCUS       NM_001081130            3723 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus oxoglutarate dehydrogenase-like (Ogdhl), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001081130 XM_006518951 XM_138959
VERSION     NM_001081130.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3723)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3723)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   3  (bases 1 to 3723)
  AUTHORS   Yousefi,K., Irion,C.I., Takeuchi,L.M., Ding,W., Lambert,G.,
            Eisenberg,T., Sukkar,S., Granzier,H.L., Methawasin,M., Lee,D.I.,
            Hahn,V.S., Kass,D.A., Hatzistergos,K.E., Hare,J.M., Webster,K.A.
            and Shehadeh,L.A.
  TITLE     Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through
            a Mitochondrial Pathway
  JOURNAL   J Am Coll Cardiol 73 (21), 2705-2718 (2019)
   PUBMED   31146816
  REMARK    GeneRIF: Col4a3(-/-) mice present a model of heart failure with
            preserved ejection fraction secondary to chronic kidney disease
            wherein OPN and OGDHL are intermediates.
REFERENCE   4  (bases 1 to 3723)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   5  (bases 1 to 3723)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (bases 1 to 3723)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167565.1 and BC157970.1.
            
            On or before Dec 6, 2017 this sequence version replaced
            XM_006518951.2, NM_001081130.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.49474.1,
                                           SRR7345562.5124712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC167565.1         52918-53015
            99-143              AC167565.1         54778-54822
            144-3384            BC157970.1         1-3241
            3385-3723           AC167565.1         78712-79050
FEATURES             Location/Qualifiers
     source          1..3723
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.4 cM"
     gene            1..3723
                     /gene="Ogdhl"
                     /note="oxoglutarate dehydrogenase-like"
                     /db_xref="GeneID:239017"
                     /db_xref="MGI:MGI:3616088"
     exon            1..98
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            99..167
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            168..372
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..3201
                     /gene="Ogdhl"
                     /EC_number="1.2.4.-"
                     /codon_start=1
                     /product="2-oxoglutarate dehydrogenase-like,
                     mitochondrial"
                     /protein_id="NP_001074599.2"
                     /db_xref="CCDS:CCDS36866.2"
                     /db_xref="GeneID:239017"
                     /db_xref="MGI:MGI:3616088"
                     /translation="MSQLRLLPFRLGPRATKLLATRAIPVFSGCRRSSGPPTTIPRSR
                     SGVSSSYVEEMYFAWLENPQSVHKSWDSFFQRASKEASVGPAQPQLPAVLQESRTSVS
                     SCTKTSKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLA
                     FYDLQEADLDKEFRLPTTTFIGGPENTLSLREIIRRLESTYCQHIGLEFMFINDVEQC
                     QWIRQKFETPGVMQFSVEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPA
                     LKTIIDKSSEMGIENVILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDV
                     KYHLGMYHERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQGRKVMS
                     ILVHGDAAFAGQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTD
                     VARVVNAPIFHVNADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMF
                     TQPLMYKQIHKQVPVLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKIL
                     HIKHWLDSPWPGFFNVDGEPKSMTCPTTGIPEEMLTHIGSVASSVPLEDFKIHTGLSR
                     ILRGRADMTKKRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEV
                     DRRTCVPMNHLWPDQAPYTVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNT
                     AQCIIDQFISTGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPV
                     FTEDFEVSQLYDCNWIVVNCSTPASYFHVLRRQILLPFRKPLIVFTPKSLLRHPDAKS
                     SFDQMVSGTSFQRLIPEDGPAAHSPEQVQRLIFCTGKVYYDLVKERSSQGLEQQVAIT
                     RLEQISPFPFDLIMREAEKYSGAELVWCQEEHKNMGYYDYISPRFMTLLGHSRPIWYV
                     GRDPAAAPATGNKNAHLVSLRRFLDTAFNLKAFEGKTF"
     exon            373..543
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            544..646
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            647..762
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            763..917
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1064
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1155
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1335
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1464
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1644
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1797
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1900
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2029
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2180
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2308
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2487
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2559
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2685
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2758
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2922
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3077
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3723
                     /gene="Ogdhl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3701..3706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ogdhl"
                     /note="hexamer: AATAAA"
     polyA_site      3721
                     /gene="Ogdhl"
                     /note="major polyA site"
ORIGIN      
        1 gacctaggta attgatacag cgcgctgctc gtgaccctcc gctcagtccc cggaccttca
       61 gccccccgga ccgcgtggcc cggaacctcg gccagccgac ttgccacagg tcacctcagg
      121 aaatcaccat tccttggctg aggaactcac ctgccccttc agctcaagat gagccagctg
      181 aggctgctgc cattccggct ggggccacgg gccaccaagc tcctggccac acgggctatc
      241 ccggtgttca gtgggtgcag gaggtcttct ggaccaccaa cgaccatccc gaggagcaga
      301 agcggagtca gctccagtta tgtggaagag atgtactttg cctggttgga aaacccacag
      361 agcgttcaca agtcctggga cagctttttt cagagagcaa gtaaggaggc ctctgtgggt
      421 cctgctcagc cgcagctccc agctgttctc caagaaagca ggacatcagt gtcaagctgc
      481 accaagacca gcaagctggt ggaagaccac ttggcagtcc agtccctgat ccgggcctac
      541 cagatccgag gccaccatgt ggcccagctg gaccccctgg gcatcctgga tgcagaccta
      601 gattcctttg tgccctctga cttgatcaca accattgata aattggcctt ctatgacctg
      661 caggaggctg atctggataa ggagttccgg ctgcccacca cgactttcat cgggggccca
      721 gagaacacac tctctcttcg agagatcata cgtcgcttgg agagcaccta ctgccagcat
      781 attggcctgg agttcatgtt tattaatgac gtggaacagt gccagtggat cagacagaaa
      841 tttgaaactc ctggcgtgat gcagttttcc gtcgaggaga agaggaccct gctggctaga
      901 ctggtgcgct ccatgaggtt tgaagacttc ctggccagga agtggtcttc ggagaagcgg
      961 tttggcctgg aaggctgcga ggtcatgatt cctgctctca agaccattat cgacaagtct
     1021 agtgagatgg ggattgagaa cgtcatcctg gggatgccac acaggggcag gctgaatgtg
     1081 ctggctaacg tgatccgcaa ggacctggaa cagatcttct gtcagtttga tcccaagctg
     1141 gaagcagcag atgagggctc tggtgatgtc aaataccatc tgggcatgta ccacgagagg
     1201 atcaaccgtg tcaccaacag gaacatcaca ttgtcactgg tagccaaccc ttcccatcta
     1261 gaagctgtgg accccgtggt acagggcaag acgaaggcag agcagttcta ccgtggggat
     1321 gcccagggta ggaaggtcat gtctatcctg gtccatgggg atgccgcctt cgctggccag
     1381 ggggtcgtct atgagacctt ccatctcagt gacctgcctt cttataccac caatggcaca
     1441 gtgcacgttg tggtcaacaa ccagatcggc ttcaccacag atccccgaat ggctcgctcc
     1501 tccccttacc ccactgatgt ggcgcgggtg gtcaatgcac ccatcttcca tgtgaacgca
     1561 gacgacccag aggctgtgat ctatgtgtgc agtgtggcag ctgagtggag gaacaccttc
     1621 aacaaagatg ttgttgtaga cctggtctgt taccgccggc gtggtcacaa tgagatggac
     1681 gagcccatgt tcacgcagcc actcatgtac aagcagatcc acaagcaggt acccgtgctg
     1741 aagaagtatg cagacaagct catcgccgag ggcaccgtca ctctgcagga gtttgaggag
     1801 gaaattgcca aatatgaccg tatctgtgag gaggcctacg gcaggtccaa ggataagaag
     1861 atcctgcata taaagcactg gctggactcc ccctggcctg gcttcttcaa tgtggatggg
     1921 gagcccaaga gcatgacatg ccctacgaca ggcatccctg aggagatgct gacccacatt
     1981 ggcagtgtgg ccagctctgt gcccctggag gactttaaga tccacacagg cctctctcgc
     2041 atcctgcgtg gccgtgcaga catgacaaag aagcgcacag tggactgggc cctggcagag
     2101 tacatggcct ttggttcatt gctgaaggag ggcatccacg tgcgactcag cggccaggat
     2161 gtggagaggg gcacattcag ccaccggcac catgttcttc atgaccagga agttgaccgg
     2221 aggacgtgtg tcccgatgaa tcatctgtgg cctgaccagg ccccgtacac tgtgtgcaat
     2281 agctccctct cagagtatgg agttctaggc tttgagctgg gctatgccat ggccagcccc
     2341 aacgccctgg tcctctggga agctcagttt ggtgatttcc acaacacagc ccagtgtatc
     2401 atcgaccagt tcatcagcac tggccaggcc aagtgggtgc ggcacaatgg catcgtgctt
     2461 ctgctgcccc acggcatgga gggcatgggt ccagagcact cctcagcaag gccagagagg
     2521 ttcctgcaga tgagcaatga cgactcggat gcctacccag tgttcactga ggactttgag
     2581 gtgagccagc tctacgactg caactggatt gtggtgaact gctccacccc agccagctac
     2641 ttccacgtgc tgcgccgaca gatcctgctg cccttccgca agcctctcat tgtcttcaca
     2701 cccaagtctc tgctgaggca ccctgatgcc aagtccagct ttgaccagat ggtgtccgga
     2761 actagcttcc agcggctgat tccggaagac ggccccgcag cacattctcc tgagcaggtc
     2821 cagcggctca tcttctgcac gggaaaggtg tactatgacc tggtaaagga acgcagcagc
     2881 cagggcctgg agcaacaagt ggccatcaca cgcctggagc agatctctcc gtttcctttc
     2941 gacctgatca tgcgggaggc agagaagtac tcgggagctg agctggtgtg gtgtcaggag
     3001 gaacataaga acatgggcta ttacgactac atcagtccac gcttcatgac tctcctcggc
     3061 cactcccggc ccatatggta tgtcggccgg gacccagcag ccgcaccagc cactgggaat
     3121 aagaacgctc acttggtgtc actgaggagg tttctggata ctgccttcaa tctgaaggcc
     3181 ttcgagggca agacatttta gagtgatctt ctgaaggagg ttatatctgg aaactctggg
     3241 ccccagatga accacatcca tgtagcaatt tggaccaaag agtagcgctg ctggctttgg
     3301 tctgttattt caggattaat tggtcaggat caaggattag ctttcctcag atagagggga
     3361 catcgatgtg gtgtcttgcc agccctgcta acctttctgg attttttttt tttttttttt
     3421 tttttttttt tttttttggt gtggtgatgg tttctttagc tttactagtc atgtctctag
     3481 acagccactg gagccgtata gggttgtgcc catcctggca gacttagttg ccgatcacct
     3541 tgttgtagcc atttcgtctg tagattcaga gatgctctct gttgtgctct tggaagtaga
     3601 gagtccagca ataagagcag gtaaagctca gccacaccag gagatgcagt gagatgcagc
     3661 acacgtgtgc gaacctaagc aggagaccaa agcgcagagg aataaagaca tgcctgagaa
     3721 agc
//
