LOCUS       NM_177429               4453 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus OFD1, centriole and centriolar satellite protein
            (Ofd1), mRNA.
ACCESSION   NM_177429
VERSION     NM_177429.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4453)
  AUTHORS   Okuhara S, Birjandi AA, Adel Al-Lami H, Sagai T, Amano T, Shiroishi
            T, Xavier GM, Liu KJ, Cobourne MT and Iseki S.
  TITLE     Temporospatial sonic hedgehog signalling is essential for neural
            crest-dependent patterning of the intrinsic tongue musculature
  JOURNAL   Development 146 (21) (2019)
   PUBMED   31719045
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4453)
  AUTHORS   Wang C, Li J, Takemaru KI, Jiang X, Xu G and Wang B.
  TITLE     Centrosomal protein Dzip1l binds Cby, promotes ciliary bud
            formation, and acts redundantly with Bromi to regulate ciliogenesis
            in the mouse
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29487109
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4453)
  AUTHORS   Struchtrup A, Wiegering A, Stork B, Ruther U and Gerhardt C.
  TITLE     The ciliary protein RPGRIP1L governs autophagy independently of its
            proteasome-regulating function at the ciliary base in mouse
            embryonic fibroblasts
  JOURNAL   Autophagy 14 (4), 567-583 (2018)
   PUBMED   29372668
REFERENCE   4  (bases 1 to 4453)
  AUTHORS   Iaconis D, Monti M, Renda M, van Koppen A, Tammaro R, Chiaravalli
            M, Cozzolino F, Pignata P, Crina C, Pucci P, Boletta A, Belcastro
            V, Giles RH, Surace EM, Gallo S, Pende M and Franco B.
  TITLE     The centrosomal OFD1 protein interacts with the translation
            machinery and regulates the synthesis of specific targets
  JOURNAL   Sci Rep 7 (1), 1224 (2017)
   PUBMED   28450740
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4453)
  AUTHORS   Rasouly HM, Kumar S, Chan S, Pisarek-Horowitz A, Sharma R, Xi QJ,
            Nishizaki Y, Higashi Y, Salant DJ, Maas RL and Lu W.
  TITLE     Loss of Zeb2 in mesenchyme-derived nephrons causes primary
            glomerulocystic disease
  JOURNAL   Kidney Int 90 (6), 1262-1273 (2016)
   PUBMED   27591083
REFERENCE   6  (bases 1 to 4453)
  AUTHORS   Romio L, Fry AM, Winyard PJ, Malcolm S, Woolf AS and Feather SA.
  TITLE     OFD1 is a centrosomal/basal body protein expressed during
            mesenchymal-epithelial transition in human nephrogenesis
  JOURNAL   J Am Soc Nephrol 15 (10), 2556-2568 (2004)
   PUBMED   15466260
REFERENCE   7  (bases 1 to 4453)
  AUTHORS   Ferrante MI, Barra A, Truong JP, Banfi S, Disteche CM and Franco B.
  TITLE     Characterization of the OFD1/Ofd1 genes on the human and mouse sex
            chromosomes and exclusion of Ofd1 for the Xpl mouse mutant
  JOURNAL   Genomics 81 (6), 560-569 (2003)
   PUBMED   12782125
  REMARK    GeneRIF: the mouse Ofd1 gene is subject to X-inactivation, in
            contrast to the human gene; a role for Ofd1 in the pathogenesis of
            the spontaneous mouse mutant Xpl was excluded; evolutionarily
            conserved domains in the protein were identified.
REFERENCE   8  (bases 1 to 4453)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4453)
  AUTHORS   Ferrante MI, Giorgio G, Feather SA, Bulfone A, Wright V, Ghiani M,
            Selicorni A, Gammaro L, Scolari F, Woolf AS, Sylvie O, Bernard L,
            Malcolm S, Winter R, Ballabio A and Franco B.
  TITLE     Identification of the gene for oral-facial-digital type I syndrome
  JOURNAL   Am J Hum Genet 68 (3), 569-576 (2001)
   PUBMED   11179005
REFERENCE   10 (bases 1 to 4453)
  AUTHORS   de Conciliis L, Marchitiello A, Wapenaar MC, Borsani G, Giglio S,
            Mariani M, Consalez GG, Zuffardi O, Franco B, Ballabio A and Banfi
            S.
  TITLE     Characterization of Cxorf5 (71-7A), a novel human cDNA mapping to
            Xp22 and encoding a protein containing coiled-coil alpha-helical
            domains
  JOURNAL   Genomics 51 (2), 243-250 (1998)
   PUBMED   9722947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB652746.1, AJ438159.1 and AK141310.1.
            
            [WARNING] On Jul 24, 2023 this sequence was replaced by
            NM_177429.4.
            
            On Mar 17, 2009 this sequence version replaced NM_177429.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ438159.1, BC119070.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               BB652746.1         2-150
            150-3550            AJ438159.1         1-3401
            3551-4453           AK141310.1         1068-1970
FEATURES             Location/Qualifiers
     source          1..4453
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 77.28 cM"
     gene            1..4453
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /note="OFD1, centriole and centriolar satellite protein"
                     /db_xref="GeneID:237222"
                     /db_xref="MGI:MGI:1350328"
     exon            1..425
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             411..3470
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /note="oral-facial-digital syndrome 1 protein homolog;
                     oral-facial-digital syndrome 1 gene homolog"
                     /codon_start=1
                     /product="centriole and centriolar satellite protein OFD1"
                     /protein_id="NP_803178.2"
                     /db_xref="CCDS:CCDS53248.1"
                     /db_xref="GeneID:237222"
                     /db_xref="MGI:MGI:1350328"
                     /translation="MRMAQSNMPHKSDVLSQDELRKKLYQTFKDRGVLDTLQTQLRNQ
                     LIHELMHPVLSGEVKPPSISVEGSALLIGASNSLVADHLQRCGYEYSLSVFFPESGLA
                     KEKIFTMQDLLQLIRINPSSSLYKSLISGFDKENKKGFLMSFLKELAEYYQAKESCDA
                     ETQTSTTFPSQVSLAEKFQLIDAQFADGFPHRSKLESLETKLNEYKKEVQHQLQVEMC
                     HKLKYFREAEITKVKMEERRKYEKELAEFQNEFERTCQAKNEALISQEKNSLERIKKH
                     REMESKEIYAQRQLLLNDIALLRGREAELKERIETFELTQKLQEEKIKSEAEALERRE
                     QNLKNIEDTYDQKLKTELLKYQLELKDDYITRTNKLLEEERKNKEKTIHLQEELTVIN
                     SKKEELSKSVKHMKEVELELESVKAQFLAISKQNHLLNEKVREMSDYSQLKEEKVELQ
                     AQNKLLKLQLEETRNENLRLLDRITQPPPELVIFQKELQKTEKAMELEHKDFETHRQA
                     LEKQLQSEIENSAQLRTQIAEYDASVKRLTVQVAELKSQLKQTQIALENEVYRNPKHS
                     LIHSLSGLLLSGKMAPHSEDKSGDFLNVPLEQNKVIAGAVMSRVPPYVNTATEASSPE
                     SDFEFIASSTKAKVRELEQEAERLEKAFRTYYQRATQNPSTSPQPAKSPPSVNSVAAL
                     RSIASSSMDRPVSAEDRVVSEQPLGDMLKEEMSDMSKAFMGSVVSRPRRTSSSTRLSS
                     TPHPKSRRSLDNEMYLEGLGRLHMTSSSPLLDRVSASPAASPSPCPERTAQASPVPSR
                     HSFSGLPEQNACLYQRQTETQDKSELSNVDKQSLKDEKFEPPFRWNKTEQFEAEGLHP
                     AGDMPGIDFAVATQSSRLISYDYPSAVQSQTGEQDEQELWELHMKERRQREEQRHNER
                     QEALERERRELGKLEQERRMIEESLKMEMEEELEKSVQDQKDKSAHCENTLEKYMKII
                     QQRQEESNADKSSKKSGKECSLVDMMMPSDKDESSPGFSHEEPDDMW"
     exon            426..524
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            525..725
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..794
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            795..825
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..933
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1070
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1244
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1351
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1471
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1545
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1637
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1827
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1958
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2070
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2682
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2839
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2937
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3051
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3206
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3359
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3427
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..4453
                     /gene="Ofd1"
                     /gene_synonym="Cxorf5; DXGgc7e; ORF2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagagcgcgc aggcgtcacg gagggccaaa gcctgggcgg ttaggctgag ccggccgagc
       61 gggccgagcg gccggagcgg gcggagcagg cggcgggcgg cgggcagtgt agggatgagc
      121 tacggagcag ggaaaactgc cgactgagcg gccgcttcgg ggccctcgct tgtcgtttcc
      181 gtctttattc cgtccagagt ccctcctggc tcgcggaccc gcccaccctt cccataccgt
      241 gggaggaagc gcggctgctt gacgagttag gggctgaatg tttagctctc ttgctcccct
      301 aggtccccag agacaagctg gattccgagg tcaagggctc cctctcctcc tgcgccccgg
      361 cccgggccga ggagtccgac cgtggagggg cgagctcggg aggaaagcag atgaggatgg
      421 ctcagtccaa catgccccac aagtctgatg tgttgagtca agatgaactg cgcaaaaagc
      481 tataccagac gtttaaggat cggggtgtac tggacacact tcagacccaa ctccgaaacc
      541 agctaattca tgaattgatg catcctgtat tgagtggaga agtgaagccg ccatccattt
      601 cagtggaagg gagtgccctc ctaatagggg cttctaactc gctggtggca gaccacttac
      661 aaagatgtgg ctatgaatat tcactctctg ttttctttcc agaaagtggt ttggcaaaag
      721 aaaagatatt tactatgcag gatctactac aactcattcg gattaacccc tcatccagtc
      781 tctataaatc attgatttca ggatttgata aagaaaataa aaaaggtttt cttatgagtt
      841 tcttaaagga gttggcagaa tattatcaag ctaaagagag ctgtgatgcg gaaactcaga
      901 caagcaccac atttcccagc caagtgtccc tagccgagaa gtttcagctt attgacgctc
      961 aatttgcaga tggttttcct caccgttcca agctagaatc tttagagaca aagttaaacg
     1021 agtataagaa agaagtacaa caccagcttc aggtagaaat gtgtcataag ctgaagtatt
     1081 ttagagaagc tgaaataaca aaagttaaga tggaagagag aagaaagtat gaaaaggaat
     1141 tggctgagtt ccagaatgaa tttgaaagaa cttgtcaagc aaaaaatgaa gccctcattt
     1201 ctcaggagaa gaattctctg gaaagaatta aaaaacaccg agagatggaa tcaaaagaaa
     1261 tttatgctca aagacagctt ctactaaatg atatagcttt gcttagaggt agagaagcag
     1321 agctgaagga gcgaatcgaa acttttgaat tgacccagaa gctccaagaa gaaaaaatta
     1381 aaagtgaggc tgaggcactt gagagacggg aacagaatct gaagaatatt gaagacacct
     1441 atgatcagaa actcaaaact gaactgctaa agtaccaact ggagctaaag gatgactaca
     1501 tcactaggac aaataaactc ctggaagagg aaaggaagaa taaagaaaaa actattcatt
     1561 tgcaagagga gctcacagtt attaattcaa aaaaggaaga actcagtaaa tctgttaagc
     1621 atatgaaaga agttgagctg gaactggagt ctgtgaaagc tcagttttta gcaatatcaa
     1681 aacaaaacca cttgctgaat gaaaaggtga gagagatgag tgattactca caactgaaag
     1741 aagagaaagt ggagcttcag gcacaaaata aactacttaa actgcaactg gaagagacta
     1801 ggaatgaaaa cttacgactc ctagaccgca taactcagcc acctcctgag cttgtgattt
     1861 ttcagaagga attacagaaa acagaaaagg ctatggaact ggagcacaag gactttgaaa
     1921 ctcataggca ggctcttgag aaacagctgc agagtgaaat tgaaaattct gcacagctaa
     1981 ggacccagat agcagaatat gatgcttctg tcaaaaggtt aactgttcag gtggctgagt
     2041 taaagtcaca actaaaacaa actcagatag ccctagagaa tgaagtgtac cgaaatccaa
     2101 aacactctct gattcattcc ctgagtggcc tcctattgag cggcaagatg gcaccccaca
     2161 gtgaagataa aagtggggat ttcttgaatg taccccttga acagaacaag gttatagcag
     2221 gtgcagttat gtcaagggtc ccaccttatg taaatacagc aacagaagct agttccccag
     2281 agtctgactt tgagtttata gccagtagta ctaaagccaa agtaagagag ctagagcaag
     2341 aggctgaacg cttggaaaag gcattcagaa cttactatca aagagctact cagaatcctt
     2401 ctacgagccc tcagccggca aagagtcctc catctgtaaa ctcggtggca gctctcagaa
     2461 gcatagcttc cagttccatg gacagacctg tttctgcaga ggacagagtt gtctcggaac
     2521 agcctcttgg ggacatgctg aaggaagaaa tgagtgatat gtccaaagca ttcatgggca
     2581 gtgtggtttc acggccacgc aggacctctt cctccacacg cctctcctct acaccccatc
     2641 caaaatcgag aagaagtctt gataatgaaa tgtatctgga aggtctcggg agattacaca
     2701 tgacttcctc cagccctctt cttgacagag tttctgcatc acctgctgct tcccctagtc
     2761 cttgtcctga gagaacagcc caggcgtcac ctgttccatc taggcacagc ttctctggtc
     2821 ttccagagca aaatgcctgt ttatatcaga gacaaactga aacgcaagat aaaagtgagc
     2881 tttcaaatgt ggacaagcaa tctttgaaag atgagaaatt tgaaccacct ttcagatgga
     2941 acaagacaga acagtttgaa gcagaaggac tccaccctgc tggtgacatg cctggaatag
     3001 attttgctgt ggctactcag tcttcaagac tcatttcata cgactaccca agtgctgttc
     3061 agagccaaac tggagaacaa gacgaacagg agctatggga gcttcacatg aaagaacgca
     3121 ggcagagaga agaacaaagg cataatgaac ggcaagaagc tttagagagg gaaagaagag
     3181 agctgggaaa actagagcag gagcggagga tgattgaaga gtcactgaag atggagatgg
     3241 aagaagaatt agaaaagagt gttcaagacc agaaagacaa atcagctcat tgtgaaaata
     3301 ctttagaaaa atacatgaaa attatccagc agagacagga agaatcaaat gcagataaga
     3361 gctccaaaaa atcgggcaaa gaatgctcac tagtggacat gatgatgcct agtgacaagg
     3421 atgaaagttc tccaggattt tctcatgaag aaccagatga catgtggtaa taacattagc
     3481 tgtctagttt ctcacaagaa gtcacgtaat atgtgttctt gtttttctgg aattaaagtt
     3541 gtcaaaaaaa ctttgtgtat ttttttaaca ttgttttaat tttataccat aatgtctgag
     3601 acaacagtaa cagagtcagc tgaacccttc ccccctcccc ttttattttt ggagacaaga
     3661 tctctgtgaa gccctggctg gccttgaagt cacagattcg cctgcctctg cctccctttg
     3721 aaggcatgca ccaccacact tggcccatgt agtcctctag ccatggcatg tattcattgt
     3781 tttaaaatga cattcctctc tctggctttg tcttaagtta catctatttg aaaacttatc
     3841 ttgtcacctt ccaggcttgc atttgctaag tttaagctgt gtgcctcctg ctccacactt
     3901 gggctataat gtgtaaaaca ggaagccatc ctcccagcac agttttgtcc ctggacatga
     3961 acacaaatct tttcattgta atgtctataa ataatatttt gcatctggtg tggttaaact
     4021 tgtaggttct ccagtattca tatgtttgaa ccctagtgtg atggtattag ctggtgggcc
     4081 tctggggcgt gatgccatga aagcagaccc tcctacatag aatgaatgag agcgcagtca
     4141 tccctttcag aagtaccaag aacttgacac tgtacaaacc aaggcctgac ccttaccagg
     4201 cactgaactt gccagcactt tgttactgag attctcagtc tccagaactg taaaaatgaa
     4261 acaaaaactc caaagttcta ttctttactc cctaccttgt ctaagattat ttttgtagca
     4321 ggagtaagcc agcatcttta ctgtagaatc ctttaatctt atttataatg gataatgggt
     4381 gaacttgttg atttttaaat atttaggtta ctaaatattt taaatatttt aaaatataat
     4441 aaaaaggtaa ctt
//
