LOCUS       NM_172143               2816 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus orofacial cleft 1 candidate 1 (Ofcc1), mRNA.
ACCESSION   NM_172143 XM_001471988 XM_001473617
VERSION     NM_172143.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2816)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2816)
  AUTHORS   Ohnishi,T., Yamada,K., Watanabe,A., Ohba,H., Sakaguchi,T.,
            Honma,Y., Iwayama,Y., Toyota,T., Maekawa,M., Watanabe,K.,
            Detera-Wadleigh,S.D., Wakana,S. and Yoshikawa,T.
  TITLE     Ablation of Mrds1/Ofcc1 induces hyper-gamma-glutamyl
            transpeptidasemia without abnormal head development and
            schizophrenia-relevant behaviors in mice
  JOURNAL   PLoS One 6 (12), e29499 (2011)
   PUBMED   22242126
  REMARK    GeneRIF: Disruption of the Mrds1/Ofcc1 gene elicits asymptomatic
            hyper-gamma-glutamyl-transpeptidasemia in mice.
REFERENCE   3  (bases 1 to 2816)
  AUTHORS   Mertes,F., Martinez-Morales,J.R., Nolden,T., Sporle,R.,
            Wittbrodt,J., Lehrach,H. and Himmelbauer,H.
  TITLE     Cloning of mouse ojoplano, a reticular cytoplasmic protein
            expressed during embryonic development
  JOURNAL   Gene Expr Patterns 9 (8), 562-567 (2009)
   PUBMED   19766735
  REMARK    GeneRIF: Opo shows homology to human transcripts linked to a
            hereditary craniofacial malformation, orofacial cleft 1 (OFC1). The
            expression of mouse Opo in neural crest derivatives and skull
            elements further supports this link.
REFERENCE   4  (bases 1 to 2816)
  AUTHORS   Watanabe,A., Toyota,T., Owada,Y., Hayashi,T., Iwayama,Y.,
            Matsumata,M., Ishitsuka,Y., Nakaya,A., Maekawa,M., Ohnishi,T.,
            Arai,R., Sakurai,K., Yamada,K., Kondo,H., Hashimoto,K., Osumi,N.
            and Yoshikawa,T.
  TITLE     Fabp7 maps to a quantitative trait locus for a schizophrenia
            endophenotype
  JOURNAL   PLoS Biol 5 (11), e297 (2007)
   PUBMED   18001149
REFERENCE   5  (bases 1 to 2816)
  AUTHORS   Davies,S.J., Wise,C., Venkatesh,B., Mirza,G., Jefferson,A.,
            Volpi,E.V. and Ragoussis,J.
  TITLE     Mapping of three translocation breakpoints associated with
            orofacial clefting within 6p24 and identification of new
            transcripts within the region
  JOURNAL   Cytogenet Genome Res 105 (1), 47-53 (2004)
   PUBMED   15218257
REFERENCE   6  (bases 1 to 2816)
  AUTHORS   Danesch,U., Hoeck,W. and Ringold,G.M.
  TITLE     Cloning and transcriptional regulation of a novel
            adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein
            (C/EBP) and C/EBP-like proteins interact with sequences required
            for differentiation-dependent expression
  JOURNAL   J Biol Chem 267 (10), 7185-7193 (1992)
   PUBMED   1339452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EU683438.1.
            
            On or before Aug 30, 2009 this sequence version replaced
            XM_001473617.1, XM_001471988.1, NM_172143.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU683438.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2816
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 19.45 cM"
     gene            1..2816
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /note="orofacial cleft 1 candidate 1"
                     /db_xref="GeneID:218165"
                     /db_xref="MGI:MGI:2658851"
     exon            1..40
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2809
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /note="ojoplano; orofacial clefting chromosomal breakpoint
                     region candidate 1 protein homolog"
                     /codon_start=1
                     /product="orofacial cleft 1 candidate gene 1 protein
                     homolog"
                     /protein_id="NP_742155.2"
                     /db_xref="CCDS:CCDS49241.1"
                     /db_xref="GeneID:218165"
                     /db_xref="MGI:MGI:2658851"
                     /translation="MDKEKFQQKAVKQTKQKKSTSAEFLMVKEYTDATEGAGNPGFNM
                     SSPELPAHQTPQEKVVRHDMLDHTLATHQQKSRLPASAGPKGNEYSRNYFDPLTEEEI
                     NSRQCRMEVSRQDGRSKVETLDQESPRRSTESLDTCKEDEEDAPGYTEDSERQAQRGA
                     VLLAGSSSGQDLEFERKGLSQNIPMSCLKKEKAFKKAPSQLCTADGNPYTKASDKGQR
                     SFPEVTKESGRTEGTCWKGEQPQLPSLQIQIRCIRGLKDKAPQGSYLLRVSLLSQLGS
                     CASQECQAEQLKTRTCPVLHGGNFYDVGLYFHESVSVVLPQRKAVKPGLSFLFELFLL
                     HGTYAYNDLIMGWAVFPVCDNNFHIVEGKFKCPLLRGPYDQKLDSFRKIENLICQDLD
                     QWLCNLYFKVIKTPLHLDDQKSPESRRQLSPERPVCLMVEAENTEFDLDNTAGPSKKE
                     PPGNVHAVMGGAIHSSQGNISNKTDSCPRGCDLCLFKEARDLQAMGNSLAAQSVKERS
                     TVWRPEDPEDYPGDVSYLEELEKYQFSVCCPSGVDGCGSGRLSKHLHFTLMALFSELE
                     LAQWQSQSFWYILLMMASLWFVRLYLHYLGQWLFLWVLSTPVTKFQFHSYTVELCYLT
                     SSLHVGEELAVIVLGPLALNTITFPLLLIRWGCQLLFSSCPDALSKLIITMGLWTVLD
                     PLAVFLVDAFLGRLAHNGETPIADAAKLYWMFLRTKQPAILGALITVVVYTLLFVISS
                     LILYLYCLRLYNDSWVLDAFQRIHSEEGKFFIPHDLEISNQELSHIVKRSEQWRGIHG
                     ERRKVAVHDYICKSHDTESKVSSCDPHHQDESFESAVGPRRVTSHISVHTVYPNGFQE
                     LYRHFLRLPDGAIIEVFGDISALRFVPSEVITAIEEHIREMDTVQREIFASYQEKEVS
                     EHKRRSLTRVEK"
     exon            41..107
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            108..284
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            285..371
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            372..538
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            539..615
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            616..736
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            737..967
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1231
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1430
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1513
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1638
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1857
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2110
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2274
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2434
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2641
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2781
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2816
                     /gene="Ofcc1"
                     /gene_synonym="opo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtatcgccag ggacagagag cagacaacat ggataaagag aagtttcagc agaaggctgt
       61 gaagcaaact aagcagaaga aatccacgtc ggctgaattt ctgatggtta aagaatacac
      121 ggacgctacc gaaggtgccg ggaatccagg ttttaacatg agcagcccag aactcccagc
      181 acatcagact ccacaagaga aagttgtgag acatgacatg ctggatcaca cccttgcaac
      241 tcatcaacaa aaatccaggc tgccagcttc agcgggaccc aaaggaaatg aatacagcag
      301 aaattacttt gacccactga cggaggagga aataaactca aggcagtgcc ggatggaggt
      361 cagcagacag gatggaaggt caaaggtgga gacactggat caggaatcac ccagacgttc
      421 cactgagagc ctggatacct gcaaagagga tgaggaagat gctcctgggt acactgagga
      481 ctctgagagg caagctcaga gaggcgctgt tctgcttgca ggttcttcat caggacagga
      541 tttggaattt gaaagaaaag gactcagcca gaacattccc atgtcatgtt taaagaaaga
      601 aaaagcattc aagaaagctc cgagtcagct gtgcactgca gacgggaatc cttacacaaa
      661 ggctagtgac aaggggcaac gctcatttcc agaagtgact aaagaatctg gaaggacaga
      721 aggaacttgc tggaagggtg agcagcctca gttgcctagt ctacaaatac agatcagatg
      781 tattaggggc ctcaaggaca aggctcccca aggctcctac ctcctccgag tgtctctgct
      841 cagtcagctg gggagctgtg cctcacagga gtgtcaagct gagcagctga agacaaggac
      901 gtgcccagtt cttcatggtg gcaactttta tgatgtgggg ctctatttcc atgaaagcgt
      961 ttctgtggta cttcctcaaa ggaaagccgt gaagcctggc ttgtctttct tgtttgaact
     1021 cttccttctc catggaacat atgcttacaa tgacctgatt atgggctggg cagtctttcc
     1081 tgtatgtgac aacaacttcc atatagtaga gggaaaattc aagtgtcccc ttctccgagg
     1141 accttatgac caaaaactgg acagcttcag aaaaatagaa aatttgattt gccaagactt
     1201 ggaccagtgg ctgtgcaatc tatattttaa ggtaattaaa actcctttgc atttggatga
     1261 tcaaaaaagc cctgagagcc gcaggcagct ttctccagaa cgtccagtgt gcttaatggt
     1321 ggaagcagag aacacggaat tcgatttgga taatacagcc ggtccttcaa agaaagaacc
     1381 gccaggaaat gttcatgctg taatgggcgg tgcgatccac tcttctcaag ggaatatttc
     1441 taataaaact gactcctgcc ctaggggttg tgatctgtgc ctcttcaaag aagcccgtga
     1501 cttgcaagct atggggaata gtttggctgc tcaatctgtg aaggaaagat ctactgtgtg
     1561 gagacctgaa gatcctgaag actatccggg ggatgtgtct tacctagagg aactggagaa
     1621 atatcagttt tccgtttgct gcccttcagg tgtagatggc tgtggatctg gaaggttgtc
     1681 caagcacctc cacttcacat tgatggcctt attttcagaa cttgaattag ctcaatggca
     1741 aagtcagagc ttctggtaca tccttctgat gatggcatct ctctggttcg tgaggctcta
     1801 cctgcattac ctgggccagt ggcttttcct ctgggtcctc tccactccag ttacaaaatt
     1861 ccagtttcac tcctacactg ttgagctctg ctacctgact tcttcacttc atgtcggaga
     1921 agagctggct gtgattgtat tggggccctt agctctaaac acaatcacgt tccccttgct
     1981 tctgatcaga tggggctgtc agctactgtt ttcctcctgc ccagatgcct tgtcaaagct
     2041 aatcatcacg atgggactat ggacagttct agacccattg gcggtgtttc tagtggatgc
     2101 tttcctgggg cgacttgcac ataatgggga gacacctatt gcagatgcag ctaaactcta
     2161 ctggatgttc ctgagaacca agcaaccagc catcctcggt gctctgatca cagtggtagt
     2221 ttacactctg ctgtttgtca tctcctcctt gattttgtac ttgtattgcc tcaggttgta
     2281 caatgactct tgggtattag atgcatttca gagaatccac agtgaagaag gcaagttctt
     2341 cataccacat gatttggaaa tttccaatca ggagctgagt cacatcgtga aaagatctga
     2401 gcagtggaga gggatccatg gtgagagaag gaaggtggca gtgcacgatt acatctgcaa
     2461 aagccatgac accgagtcca aggtctccag ctgtgacccc caccatcagg atgaaagttt
     2521 tgagtctgca gttggtccaa gaagggttac ttcccacata tcagtacata ctgtttatcc
     2581 caatgggttt caagagttgt atcgccattt tctcaggctc ccggatggcg ccatcattga
     2641 ggtgtttggt gacatcagtg ccttgagatt tgtccccagt gaagtgatca ccgctattga
     2701 ggaacacata agagaaatgg acactgtgca gagagaaatc tttgcttctt accaagagaa
     2761 agaagtctct gagcataaaa ggagatcatt aacccgagtg gaaaaatgag cataat
//
