LOCUS       NP_001355989             830 aa            linear   ROD 12-JUN-2024
DEFINITION  outer dense fiber protein 2 isoform g [Mus musculus].
ACCESSION   NP_001355989 XP_017171778
VERSION     NP_001355989.1
DBSOURCE    REFSEQ: accession NM_001369060.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 830)
  AUTHORS   Ma,Y., Wu,B., Chen,Y., Ma,S., Wang,L., Han,T., Lin,X., Yang,F.,
            Liu,C., Zhao,J. and Li,W.
  TITLE     CCDC146 is required for sperm flagellum biogenesis and male
            fertility in mice
  JOURNAL   Cell Mol Life Sci 81 (1), 1 (2023)
   PUBMED   38038747
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 830)
  AUTHORS   Xu,X., Jiang,X., Song,K., Zhang,J., Tian,Y., Chen,Y., Weng,J.,
            Liang,Y. and Ma,W.
  TITLE     Stable expression and multi-site location of Odf2 in mouse oocytes,
            sperm and early embryos
  JOURNAL   Ann Anat 250, 152126 (2023)
   PUBMED   37364712
  REMARK    GeneRIF: Stable expression and multi-site location of Odf2 in mouse
            oocytes, sperm and early embryos.
REFERENCE   3  (residues 1 to 830)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   4  (residues 1 to 830)
  AUTHORS   Cao,H., Xu,H., Zhou,Y., Xu,W., Lu,Q., Jiang,L., Rong,Y., Zhang,Q.
            and Yu,C.
  TITLE     BBOF1 is required for sperm motility and male fertility by
            stabilizing the flagellar axoneme in mice
  JOURNAL   Cell Mol Life Sci 80 (6), 152 (2023)
   PUBMED   37198331
  REMARK    GeneRIF: BBOF1 is required for sperm motility and male fertility by
            stabilizing the flagellar axoneme in mice.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 830)
  AUTHORS   Lu,Z.L., Shan,X.D., DU,J., Zhu,S.M., Zhuang,J., Liang,X. and
            Zhao,Q.M.
  TITLE     [Impacts of ODF2 gene knockdown on the sperm motility and fertility
            of male mice]
  JOURNAL   Zhonghua Nan Ke Xue 28 (10), 867-872 (2022)
   PUBMED   37838951
  REMARK    GeneRIF: [Impacts of ODF2 gene knockdown on the sperm motility and
            fertility of male mice].
REFERENCE   6  (residues 1 to 830)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 830)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (residues 1 to 830)
  AUTHORS   Hoyer-Fender,S., Petersen,C., Brohmann,H., Rhee,K. and
            Wolgemuth,D.J.
  TITLE     Mouse Odf2 cDNAs consist of evolutionary conserved as well as
            highly variable sequences and encode outer dense fiber proteins of
            the sperm tail
  JOURNAL   Mol Reprod Dev 51 (2), 167-175 (1998)
   PUBMED   9740324
REFERENCE   9  (residues 1 to 830)
  AUTHORS   Shao,X., Murthy,S., Demetrick,D.J. and van der Hoorn,F.A.
  TITLE     Human outer dense fiber gene, ODF2, localizes to chromosome 9q34
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 221-223 (1998)
   PUBMED   10072582
REFERENCE   10 (residues 1 to 830)
  AUTHORS   Nakayama,H., Liu,Y., Stifani,S. and Cross,J.C.
  TITLE     Developmental restriction of Mash-2 expression in trophoblast
            correlates with potential activation of the notch-2 pathway
  JOURNAL   Dev Genet 21 (1), 21-30 (1997)
   PUBMED   9291577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928926.9.
            
            On Mar 15, 2019 this sequence version replaced XP_017171778.1.
            
            Transcript Variant: This variant (9), encodes the longest isoform
            (g).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..830
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 20.79 cM"
     Protein         1..830
                     /product="outer dense fiber protein 2 isoform g"
                     /note="outer dense fiber protein 2; cenexin; 84 kDa outer
                     dense fiber protein; outer dense fiber of sperm tails
                     protein 2"
                     /calculated_mol_wt=95411
     Site            73
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYX5; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     Site            74
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYX5; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     Site            92
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYX5; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     Site            95
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TSSK4.
                     /evidence=ECO:0000269|PubMed:26961893; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     Site            106
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYX5; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     Site            109
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYX5; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     Site            110
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYX5; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     Site            115
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYX5; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     Region          <119..783
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            129
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYX5; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     Site            139
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYX5; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     Site            231
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q5BJF6; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     Site            261
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYX5; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     Region          537..701
                     /region_name="Interaction with BBOF1.
                     /evidence=ECO:0000269|PubMed:37198331"
                     /note="propagated from UniProtKB/Swiss-Prot (A3KGV1.1)"
     Site            632
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYX5; propagated from
                     UniProtKB/Swiss-Prot (A3KGV1.1)"
     CDS             1..830
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /coded_by="NM_001369060.2:344..2836"
                     /note="isoform g is encoded by transcript variant 9"
                     /db_xref="CCDS:CCDS89461.1"
                     /db_xref="GeneID:18286"
                     /db_xref="MGI:MGI:1098824"
ORIGIN      
        1 msasssggsp rfpscgkngv tsltqkkvlr tpcgapsvtv tkshkrgmkg dtvnvrrsvr
       61 vktkvpwmpp gkssarhvgc kwenpphcle itppsseklv svmrlsdlst edddsghckm
      121 nrydkkidsl mnavgclkse vkmqkgerqm akrfleerke eleevahela etehentvlr
      181 hnierikeek dftmlqkkhl qqekeclmsk lveaemdgaa aakqvmalkd tigklktekq
      241 mtctdintlt rqkelllqkl stfeetnrtl rdllreqhck edserlmeqq gtllkrlaea
      301 dsekarllll lqdkdkevee llqeiqceka qaktaselsk smesmrghlq aqlrckeaen
      361 srlcmqiknl ersgnqhkae veaimeqlke lkqkgdrdke tlkkairaqk eraekseeya
      421 eqlhvqladk dlyvaealst leswrsrynq vvkdkgdlel eiivlndrvt dlvnqqqsle
      481 ekmredrdsl verlhrqtae ysafklener lkasfapmed klnqahlevq qlkasvknye
      541 gmidnyksqv mktrleadev aaqlercdke nkmlkdemnk eieaarrqfq sqladlqqlp
      601 dilkiteakl aecqdqlqgy erknidltai isdlrsrieh qgdklemare khqasqkenk
      661 qlsqkvdele rkleatsaqn veflqviakr eeaihqaqlr leektrecgs larqlesaie
      721 darrqveqtk eqalskeraa qskildletq lsrtktelgq lrrtrddadr ryqsrlqdlk
      781 drleqsestn rsmqnyvqfl kasyanvfgd apytssylts spirsrsppa
//
