LOCUS       NM_001177661            2297 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus outer dense fiber of sperm tails 2 (Odf2), transcript
            variant 5, mRNA.
ACCESSION   NM_001177661
VERSION     NM_001177661.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2297)
  AUTHORS   Ma,Y., Wu,B., Chen,Y., Ma,S., Wang,L., Han,T., Lin,X., Yang,F.,
            Liu,C., Zhao,J. and Li,W.
  TITLE     CCDC146 is required for sperm flagellum biogenesis and male
            fertility in mice
  JOURNAL   Cell Mol Life Sci 81 (1), 1 (2023)
   PUBMED   38038747
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2297)
  AUTHORS   Xu,X., Jiang,X., Song,K., Zhang,J., Tian,Y., Chen,Y., Weng,J.,
            Liang,Y. and Ma,W.
  TITLE     Stable expression and multi-site location of Odf2 in mouse oocytes,
            sperm and early embryos
  JOURNAL   Ann Anat 250, 152126 (2023)
   PUBMED   37364712
  REMARK    GeneRIF: Stable expression and multi-site location of Odf2 in mouse
            oocytes, sperm and early embryos.
REFERENCE   3  (bases 1 to 2297)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   4  (bases 1 to 2297)
  AUTHORS   Cao,H., Xu,H., Zhou,Y., Xu,W., Lu,Q., Jiang,L., Rong,Y., Zhang,Q.
            and Yu,C.
  TITLE     BBOF1 is required for sperm motility and male fertility by
            stabilizing the flagellar axoneme in mice
  JOURNAL   Cell Mol Life Sci 80 (6), 152 (2023)
   PUBMED   37198331
  REMARK    GeneRIF: BBOF1 is required for sperm motility and male fertility by
            stabilizing the flagellar axoneme in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2297)
  AUTHORS   Lu,Z.L., Shan,X.D., DU,J., Zhu,S.M., Zhuang,J., Liang,X. and
            Zhao,Q.M.
  TITLE     [Impacts of ODF2 gene knockdown on the sperm motility and fertility
            of male mice]
  JOURNAL   Zhonghua Nan Ke Xue 28 (10), 867-872 (2022)
   PUBMED   37838951
  REMARK    GeneRIF: [Impacts of ODF2 gene knockdown on the sperm motility and
            fertility of male mice].
REFERENCE   6  (bases 1 to 2297)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2297)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 2297)
  AUTHORS   Hoyer-Fender,S., Petersen,C., Brohmann,H., Rhee,K. and
            Wolgemuth,D.J.
  TITLE     Mouse Odf2 cDNAs consist of evolutionary conserved as well as
            highly variable sequences and encode outer dense fiber proteins of
            the sperm tail
  JOURNAL   Mol Reprod Dev 51 (2), 167-175 (1998)
   PUBMED   9740324
REFERENCE   9  (bases 1 to 2297)
  AUTHORS   Shao,X., Murthy,S., Demetrick,D.J. and van der Hoorn,F.A.
  TITLE     Human outer dense fiber gene, ODF2, localizes to chromosome 9q34
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 221-223 (1998)
   PUBMED   10072582
REFERENCE   10 (bases 1 to 2297)
  AUTHORS   Nakayama,H., Liu,Y., Stifani,S. and Cross,J.C.
  TITLE     Developmental restriction of Mash-2 expression in trophoblast
            correlates with potential activation of the notch-2 pathway
  JOURNAL   Dev Genet 21 (1), 21-30 (1997)
   PUBMED   9291577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928926.9.
            
            On Jan 4, 2022 this sequence version replaced NM_001177661.1.
            
            Transcript Variant: This variant (5) has multiple differences that
            result in a different splice site and distinct 5' and 3' ends,
            compared to variant 4. The encoded protein (isoform c) has shorter
            and distinct termini when it is compared to isoform e.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.136648.1,
                                           ERR3363660.783529.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AL928926.9         68141-68390
            251-341             AL928926.9         70655-70745
            342-467             AL928926.9         71913-72038
            468-638             AL928926.9         79546-79716
            639-799             AL928926.9         80650-80810
            800-929             AL928926.9         81790-81919
            930-1061            AL928926.9         82445-82576
            1062-1133           AL928926.9         91038-91109
            1134-1205           AL928926.9         92700-92771
            1206-1322           AL928926.9         92863-92979
            1323-1508           AL928926.9         93203-93388
            1509-1618           AL928926.9         93677-93786
            1619-1754           AL928926.9         96079-96214
            1755-1865           AL928926.9         99244-99354
            1866-1970           AL928926.9         99473-99577
            1971-2297           AL928926.9         100682-101008
FEATURES             Location/Qualifiers
     source          1..2297
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 20.79 cM"
     gene            1..2297
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /note="outer dense fiber of sperm tails 2"
                     /db_xref="GeneID:18286"
                     /db_xref="MGI:MGI:1098824"
     exon            1..250
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2192
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /note="isoform e is encoded by transcript variant 5; outer
                     dense fiber protein 2; cenexin; 84 kDa outer dense fiber
                     protein; outer dense fiber of sperm tails protein 2"
                     /codon_start=1
                     /product="outer dense fiber protein 2 isoform e"
                     /protein_id="NP_001171132.1"
                     /db_xref="CCDS:CCDS50554.1"
                     /db_xref="GeneID:18286"
                     /db_xref="MGI:MGI:1098824"
                     /translation="MGELPTGCRKRRRKRGGAAAGAGLHPPRRLHGTTLASDFNDFIR
                     RRFWAQPCRSWFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTKSHKRGMKGDTVNVRRS
                     VRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSG
                     HCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH
                     ENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTI
                     GKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQ
                     GTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGH
                     LQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAI
                     RAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIV
                     LNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKL
                     NQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNK
                     EIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRV
                     RDWQKGSHELARAGARLPR"
     exon            251..341
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            342..467
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            468..638
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            639..799
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            800..929
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1061
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1133
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1205
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1322
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1508
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1618
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1754
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1865
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1970
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2297
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2276..2281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /note="hexamer: AATAAA"
     polyA_site      2297
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /note="major polyA site"
ORIGIN      
        1 gtgtggggcg gggcatctct gtgacgctgg gggctgggcc taaatggcga aacccgagag
       61 gctccggggg gggtttgaac tggccaatgg gcgagctgcc gaccggttgt cggaaaagga
      121 ggcggaagcg gggaggagcc gccgcgggag ccggactgca tccgccgcgg cgtctccatg
      181 gcacgaccct ggcctccgac ttcaacgact tcataaggag acggttctgg gcgcagccgt
      241 gccgctcttg gtttccatcg tgtgggaaga acggagtaac gagtctcaca cagaaaaaag
      301 tcttgagaac accttgtggc gcacccagtg taactgttac gaaatctcat aagcgcggaa
      361 tgaaagggga caccgtgaat gtacggcgga gtgtccgggt gaaaaccaag gtaccttgga
      421 tgccccctgg aaaatcatct gcccggcatg tgggatgcaa gtgggagaat ccacctcatt
      481 gcctggagat cacaccacca tcttcagaaa agctggtctc ggtgatgcga ttaagtgacc
      541 tttctacaga agacgacgat tcaggtcact gtaaaatgaa ccgttacgat aagaagattg
      601 acagtctaat gaacgcggtc ggttgtctca aatctgaggt caagatgcag aaaggtgaac
      661 gccaaatggc caaaaggttc ctggaggaga ggaaggaaga gctggaggag gtggcacacg
      721 agcttgcaga gacggagcat gagaacacgg tgctcagaca caacatcgag cgtatcaagg
      781 aggagaagga cttcaccatg cttcaaaaga aacacctcca gcaggagaag gaatgcctca
      841 tgtccaaact agtggaggct gaaatggatg gagcagctgc tgccaagcag gtcatggcct
      901 tgaaggatac catcgggaag ctgaaaaccg agaaacagat gacttgcacc gacatcaaca
      961 ccttaacaag gcagaaggaa cttctcctgc agaagctgag tacctttgag gagaccaatc
     1021 gcaccctccg agatctgttg agggaacagc actgcaaaga ggattccgag agactaatgg
     1081 agcaacaagg tacattactg aagcgtctgg cagaggcaga ctcagagaaa gcgcgcctgc
     1141 tgttactact gcaagacaag gacaaggagg tggaagaact cctccaggag atacaatgtg
     1201 aaaaggctca agcaaagaca gcgtctgagc tttccaagtc catggagtcc atgcgggggc
     1261 atttgcaggc acagcttcgc tgcaaagagg ctgagaacag tcgcctgtgc atgcagatca
     1321 agaacttaga gcgcagtggg aaccagcata aggcggaagt agaggccatc atggagcagc
     1381 taaaggaact gaagcagaag ggagaccgag acaaagagac cctaaagaag gccatccgag
     1441 cccagaaaga gcgagccgag aagagtgagg agtatgccga gcagctgcat gtgcaactgg
     1501 ccgacaagga cctttatgtt gctgaagctt tatctactct ggagtcttgg aggagccgtt
     1561 acaaccaggt tgtgaaggac aaaggagatc ttgagttgga gattatcgtc ctaaatgacc
     1621 gggtgacaga tcttgtaaac caacaacaaa gcttggagga gaagatgcgg gaagaccggg
     1681 acagcttggt agagaggctg caccggcaga cggctgagta ctctgcattc aagctagaga
     1741 acgagaggct caaggctagc tttgccccta tggaggacaa gctcaaccag gctcacttgg
     1801 aggttcagca gctgaaggcg tcagtgaaga actacgaggg gatgatagac aactacaaga
     1861 gccaggtgat gaaaacaaga ttggaggctg atgaagtggc tgcacagcta gagcgctgcg
     1921 acaaagagaa caagatgctt aaagacgaga tgaacaaaga gatcgaggcg gcccgtcggc
     1981 agttccagtc acagctggct gacctacaac agctgcctga catcctcaag atcacggagg
     2041 ccaagctggc tgagtgccaa gaccagctgc agggctacga gaggaagaac atcgacctca
     2101 cagccatcat ttcagacctg cgcagccggg taagggactg gcagaaggga tcccacgaac
     2161 tggcccgagc aggggcccgc ttaccgagat gagctgcacg ccccccaagg gaggaccact
     2221 tcctttttct tggctgccga tttctgaaag gagtgagcta tcatcagtgc tgtgaaataa
     2281 aagtctggtg tgccaaa
//
