LOCUS       NM_001113214            2306 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus outer dense fiber of sperm tails 2 (Odf2), transcript
            variant 2, mRNA.
ACCESSION   NM_001113214
VERSION     NM_001113214.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Ma,Y., Wu,B., Chen,Y., Ma,S., Wang,L., Han,T., Lin,X., Yang,F.,
            Liu,C., Zhao,J. and Li,W.
  TITLE     CCDC146 is required for sperm flagellum biogenesis and male
            fertility in mice
  JOURNAL   Cell Mol Life Sci 81 (1), 1 (2023)
   PUBMED   38038747
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2306)
  AUTHORS   Xu,X., Jiang,X., Song,K., Zhang,J., Tian,Y., Chen,Y., Weng,J.,
            Liang,Y. and Ma,W.
  TITLE     Stable expression and multi-site location of Odf2 in mouse oocytes,
            sperm and early embryos
  JOURNAL   Ann Anat 250, 152126 (2023)
   PUBMED   37364712
  REMARK    GeneRIF: Stable expression and multi-site location of Odf2 in mouse
            oocytes, sperm and early embryos.
REFERENCE   3  (bases 1 to 2306)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   4  (bases 1 to 2306)
  AUTHORS   Cao,H., Xu,H., Zhou,Y., Xu,W., Lu,Q., Jiang,L., Rong,Y., Zhang,Q.
            and Yu,C.
  TITLE     BBOF1 is required for sperm motility and male fertility by
            stabilizing the flagellar axoneme in mice
  JOURNAL   Cell Mol Life Sci 80 (6), 152 (2023)
   PUBMED   37198331
  REMARK    GeneRIF: BBOF1 is required for sperm motility and male fertility by
            stabilizing the flagellar axoneme in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2306)
  AUTHORS   Lu,Z.L., Shan,X.D., DU,J., Zhu,S.M., Zhuang,J., Liang,X. and
            Zhao,Q.M.
  TITLE     [Impacts of ODF2 gene knockdown on the sperm motility and fertility
            of male mice]
  JOURNAL   Zhonghua Nan Ke Xue 28 (10), 867-872 (2022)
   PUBMED   37838951
  REMARK    GeneRIF: [Impacts of ODF2 gene knockdown on the sperm motility and
            fertility of male mice].
REFERENCE   6  (bases 1 to 2306)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2306)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 2306)
  AUTHORS   Hoyer-Fender,S., Petersen,C., Brohmann,H., Rhee,K. and
            Wolgemuth,D.J.
  TITLE     Mouse Odf2 cDNAs consist of evolutionary conserved as well as
            highly variable sequences and encode outer dense fiber proteins of
            the sperm tail
  JOURNAL   Mol Reprod Dev 51 (2), 167-175 (1998)
   PUBMED   9740324
REFERENCE   9  (bases 1 to 2306)
  AUTHORS   Shao,X., Murthy,S., Demetrick,D.J. and van der Hoorn,F.A.
  TITLE     Human outer dense fiber gene, ODF2, localizes to chromosome 9q34
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 221-223 (1998)
   PUBMED   10072582
REFERENCE   10 (bases 1 to 2306)
  AUTHORS   Nakayama,H., Liu,Y., Stifani,S. and Cross,J.C.
  TITLE     Developmental restriction of Mash-2 expression in trophoblast
            correlates with potential activation of the notch-2 pathway
  JOURNAL   Dev Genet 21 (1), 21-30 (1997)
   PUBMED   9291577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928926.9.
            
            On Jan 4, 2022 this sequence version replaced NM_001113214.1.
            
            Transcript Variant: This variant (2) uses a different splice site
            and contains a different 3' end, compared to variant 4. The
            resulting protein (isoform b) has a shorter and distinct C-terminus
            when it is compared to isoform d. Variants 2 and 7 both encode the
            same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168415.1, SRR7345562.1537709.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AL928926.9         68286-68390
            106-196             AL928926.9         70655-70745
            197-350             AL928926.9         71470-71623
            351-476             AL928926.9         71913-72038
            477-647             AL928926.9         79546-79716
            648-808             AL928926.9         80650-80810
            809-938             AL928926.9         81790-81919
            939-1070            AL928926.9         82445-82576
            1071-1142           AL928926.9         91038-91109
            1143-1214           AL928926.9         92700-92771
            1215-1331           AL928926.9         92863-92979
            1332-1517           AL928926.9         93203-93388
            1518-1627           AL928926.9         93677-93786
            1628-1763           AL928926.9         96079-96214
            1764-1874           AL928926.9         99244-99354
            1875-1979           AL928926.9         99473-99577
            1980-2306           AL928926.9         100682-101008
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 20.79 cM"
     gene            1..2306
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /note="outer dense fiber of sperm tails 2"
                     /db_xref="GeneID:18286"
                     /db_xref="MGI:MGI:1098824"
     exon            1..105
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            106..196
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            197..350
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2201
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /note="isoform b is encoded by transcript variant 2; outer
                     dense fiber protein 2; cenexin; 84 kDa outer dense fiber
                     protein; outer dense fiber of sperm tails protein 2"
                     /codon_start=1
                     /product="outer dense fiber protein 2 isoform b"
                     /protein_id="NP_001106685.1"
                     /db_xref="CCDS:CCDS50557.1"
                     /db_xref="GeneID:18286"
                     /db_xref="MGI:MGI:1098824"
                     /translation="MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSAASSQKSHKRGMK
                     GDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSD
                     LSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEV
                     AHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAK
                     QVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKE
                     DSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELS
                     KSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR
                     DKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDK
                     GDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKA
                     SFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKEN
                     KMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTA
                     IISDLRSRVRDWQKGSHELARAGARLPR"
     exon            351..476
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            477..647
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            648..808
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            809..938
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1070
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1142
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1214
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1331
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1517
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1627
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1763
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1874
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1979
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2306
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2285..2290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /note="hexamer: AATAAA"
     polyA_site      2306
                     /gene="Odf2"
                     /gene_synonym="MMTEST29"
                     /note="major polyA site"
ORIGIN      
        1 gggagccgga ctgcatccgc cgcggcgtct ccatggcacg accctggcct ccgacttcaa
       61 cgacttcata aggagacggt tctgggcgca gccgtgccgc tcttggtttc catcgtgtgg
      121 gaagaacgga gtaacgagtc tcacacagaa aaaagtcttg agaacacctt gtggcgcacc
      181 cagtgtaact gttacgatcc atcttttttg tgttgccctc ccctgcctgc cagaagtgaa
      241 ccatgaagga ccgatcttca actcccccct tacatgttca cgtggatgag aacactcctg
      301 tccacgtcca cataaaaaaa ctcccgaaac cgtcagcagc cagcagccag aaatctcata
      361 agcgcggaat gaaaggggac accgtgaatg tacggcggag tgtccgggtg aaaaccaagg
      421 taccttggat gccccctgga aaatcatctg cccggcatgt gggatgcaag tgggagaatc
      481 cacctcattg cctggagatc acaccaccat cttcagaaaa gctggtctcg gtgatgcgat
      541 taagtgacct ttctacagaa gacgacgatt caggtcactg taaaatgaac cgttacgata
      601 agaagattga cagtctaatg aacgcggtcg gttgtctcaa atctgaggtc aagatgcaga
      661 aaggtgaacg ccaaatggcc aaaaggttcc tggaggagag gaaggaagag ctggaggagg
      721 tggcacacga gcttgcagag acggagcatg agaacacggt gctcagacac aacatcgagc
      781 gtatcaagga ggagaaggac ttcaccatgc ttcaaaagaa acacctccag caggagaagg
      841 aatgcctcat gtccaaacta gtggaggctg aaatggatgg agcagctgct gccaagcagg
      901 tcatggcctt gaaggatacc atcgggaagc tgaaaaccga gaaacagatg acttgcaccg
      961 acatcaacac cttaacaagg cagaaggaac ttctcctgca gaagctgagt acctttgagg
     1021 agaccaatcg caccctccga gatctgttga gggaacagca ctgcaaagag gattccgaga
     1081 gactaatgga gcaacaaggt acattactga agcgtctggc agaggcagac tcagagaaag
     1141 cgcgcctgct gttactactg caagacaagg acaaggaggt ggaagaactc ctccaggaga
     1201 tacaatgtga aaaggctcaa gcaaagacag cgtctgagct ttccaagtcc atggagtcca
     1261 tgcgggggca tttgcaggca cagcttcgct gcaaagaggc tgagaacagt cgcctgtgca
     1321 tgcagatcaa gaacttagag cgcagtggga accagcataa ggcggaagta gaggccatca
     1381 tggagcagct aaaggaactg aagcagaagg gagaccgaga caaagagacc ctaaagaagg
     1441 ccatccgagc ccagaaagag cgagccgaga agagtgagga gtatgccgag cagctgcatg
     1501 tgcaactggc cgacaaggac ctttatgttg ctgaagcttt atctactctg gagtcttgga
     1561 ggagccgtta caaccaggtt gtgaaggaca aaggagatct tgagttggag attatcgtcc
     1621 taaatgaccg ggtgacagat cttgtaaacc aacaacaaag cttggaggag aagatgcggg
     1681 aagaccggga cagcttggta gagaggctgc accggcagac ggctgagtac tctgcattca
     1741 agctagagaa cgagaggctc aaggctagct ttgcccctat ggaggacaag ctcaaccagg
     1801 ctcacttgga ggttcagcag ctgaaggcgt cagtgaagaa ctacgagggg atgatagaca
     1861 actacaagag ccaggtgatg aaaacaagat tggaggctga tgaagtggct gcacagctag
     1921 agcgctgcga caaagagaac aagatgctta aagacgagat gaacaaagag atcgaggcgg
     1981 cccgtcggca gttccagtca cagctggctg acctacaaca gctgcctgac atcctcaaga
     2041 tcacggaggc caagctggct gagtgccaag accagctgca gggctacgag aggaagaaca
     2101 tcgacctcac agccatcatt tcagacctgc gcagccgggt aagggactgg cagaagggat
     2161 cccacgaact ggcccgagca ggggcccgct taccgagatg agctgcacgc cccccaaggg
     2221 aggaccactt cctttttctt ggctgccgat ttctgaaagg agtgagctat catcagtgct
     2281 gtgaaataaa agtctggtgt gccaaa
//
