LOCUS       NP_032783                248 aa            linear   ROD 27-APR-2025
DEFINITION  outer dense fiber protein 1 [Mus musculus].
ACCESSION   NP_032783
VERSION     NP_032783.2
DBSOURCE    REFSEQ: accession NM_008757.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 248)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 248)
  AUTHORS   He,X., Mu,W., Wang,Z., Xu,K., Yin,Y., Lu,G., Chan,W.Y., Liu,H.,
            Lv,Y. and Liu,S.
  TITLE     Deficiency of the Tmem232 Gene Causes Male Infertility with
            Morphological Abnormalities of the Sperm Flagellum in Mice
  JOURNAL   Cells 12 (12), 1614 (2023)
   PUBMED   37371084
  REMARK    GeneRIF: Deficiency of the Tmem232 Gene Causes Male Infertility
            with Morphological Abnormalities of the Sperm Flagellum in Mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 248)
  AUTHORS   Uchida,A., Imaimatsu,K., Suzuki,H., Han,X., Ushioda,H., Uemura,M.,
            Imura-Kishi,K., Hiramatsu,R., Takase,H.M., Hirate,Y., Ogura,A.,
            Kanai-Azuma,M., Kudo,A. and Kanai,Y.
  TITLE     SOX17-positive rete testis epithelium is required for Sertoli valve
            formation and normal spermiogenesis in the male mouse
  JOURNAL   Nat Commun 13 (1), 7860 (2022)
   PUBMED   36543770
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 248)
  AUTHORS   Hoyer-Fender,S.
  TITLE     Development of the Connecting Piece in ODF1-Deficient Mouse
            Spermatids
  JOURNAL   Int J Mol Sci 23 (18), 10280 (2022)
   PUBMED   36142191
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 248)
  AUTHORS   Tapia Contreras,C. and Hoyer-Fender,S.
  TITLE     The WD40-protein CFAP52/WDR16 is a centrosome/basal body protein
            and localizes to the manchette and the flagellum in male germ cells
  JOURNAL   Sci Rep 10 (1), 14240 (2020)
   PUBMED   32859975
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 248)
  AUTHORS   Bhullar,B., Zhang,Y., Junco,A., Oko,R. and van der Hoorn,F.A.
  TITLE     Association of kinesin light chain with outer dense fibers in a
            microtubule-independent fashion
  JOURNAL   J Biol Chem 278 (18), 16159-16168 (2003)
   PUBMED   12594206
  REMARK    GeneRIF: Association of kinesin light chain with outer dense fibers
            in a microtubule-independent fashion.
REFERENCE   7  (residues 1 to 248)
  AUTHORS   Nakamura,Y., Tanaka,H., Koga,M., Miyagawa,Y., Iguchi,N., Egydio de
            Carvalho,C., Yomogida,K., Nozaki,M., Nojima,H., Matsumiya,K.,
            Okuyama,A. and Nishimune,Y.
  TITLE     Molecular cloning and characterization of oppo 1: a haploid germ
            cell-specific complementary DNA encoding sperm tail protein
  JOURNAL   Biol Reprod 67 (1), 1-7 (2002)
   PUBMED   12079992
REFERENCE   8  (residues 1 to 248)
  AUTHORS   Deng,W. and Lin,H.
  TITLE     miwi, a murine homolog of piwi, encodes a cytoplasmic protein
            essential for spermatogenesis
  JOURNAL   Dev Cell 2 (6), 819-830 (2002)
   PUBMED   12062093
REFERENCE   9  (residues 1 to 248)
  AUTHORS   Matsui,M., Ichihara,H., Kobayashi,S., Tanaka,H., Tsuchida,J.,
            Nozaki,M., Yoshimura,Y., Nojima,H., Rochelle,J.M., Nishimune,Y.,
            Taketo,M.M. and Seldin,M.F.
  TITLE     Mapping of six germ-cell-specific genes to mouse chromosomes
  JOURNAL   Mamm Genome 8 (11), 873-874 (1997)
   PUBMED   9337410
REFERENCE   10 (residues 1 to 248)
  AUTHORS   Hoyer-Fender,S., Burfeind,P. and Hameister,H.
  TITLE     Sequence of mouse Odf1 cDNA and its chromosomal localization:
            extension of the linkage group between human chromosome 8 and mouse
            chromosome 15
  JOURNAL   Cytogenet Cell Genet 70 (3-4), 200-204 (1995)
   PUBMED   7789171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC145758.1, CJ042343.1 and BX632868.1.
            
            On Oct 17, 2007 this sequence version replaced NP_032783.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU791469.1, X79446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..248
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 15.14 cM"
     Protein         1..248
                     /product="outer dense fiber protein 1"
                     /calculated_mol_wt=27491
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21769; propagated from
                     UniProtKB/Swiss-Prot (Q61999.1)"
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21769; propagated from
                     UniProtKB/Swiss-Prot (Q61999.1)"
     Region          34..78
                     /region_name="2 X 5 AA repeats of [RC]-C-L-C-D"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61999.1)"
     Site            64
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21769; propagated from
                     UniProtKB/Swiss-Prot (Q61999.1)"
     Site            87
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21769; propagated from
                     UniProtKB/Swiss-Prot (Q61999.1)"
     Region          102..188
                     /region_name="ACD_HspB10"
                     /note="Alpha crystallin domain (ACD) found in mammalian
                     small heat shock protein (sHsp) HspB10, also known as
                     sperm outer dense fiber protein (ODFP), and similar
                     proteins. sHsps are molecular chaperones that suppress
                     protein aggregation and protect against cell...; cd06482"
                     /db_xref="CDD:107237"
     Site            order(102..106,114,116,118..119,159,180..181)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:107237"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21769; propagated from
                     UniProtKB/Swiss-Prot (Q61999.1)"
     Site            109
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21769; propagated from
                     UniProtKB/Swiss-Prot (Q61999.1)"
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21769; propagated from
                     UniProtKB/Swiss-Prot (Q61999.1)"
     Site            153
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21769; propagated from
                     UniProtKB/Swiss-Prot (Q61999.1)"
     Site            175
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21769; propagated from
                     UniProtKB/Swiss-Prot (Q61999.1)"
     Site            180
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21769; propagated from
                     UniProtKB/Swiss-Prot (Q61999.1)"
     CDS             1..248
                     /gene="Odf1"
                     /coded_by="NM_008757.3:228..974"
                     /db_xref="CCDS:CCDS49596.1"
                     /db_xref="GeneID:18285"
                     /db_xref="MGI:MGI:97424"
ORIGIN      
        1 maalscllds vrrdikkvdr elrqlrcide issrclcdly mhpycccdlh pypyclcysk
       61 rsrscglcdl yypcclcdyk lyclrpslrs lerlrrttnr ilassccssn ilgsvnvcgf
      121 epdqvkvrvk dgkvcvsaer enrydclgsk kysymnicke fslppcvdek dvtysyglgs
      181 cvkiespcyp ctspcnpcnp cspcspcapc gpcgpcgpcg pcgpcgpcdp cnpcypcgsr
      241 fscrkmil
//
