LOCUS       NM_001409629            2783 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus ornithine decarboxylase, structural 1 (Odc1),
            transcript variant 6, mRNA.
ACCESSION   NM_001409629
VERSION     NM_001409629.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2783)
  AUTHORS   Imada,S., Khawaled,S., Shin,H., Meckelmann,S.W., Whittaker,C.A.,
            Correa,R.O., Alquati,C., Lu,Y., Tie,G., Pradhan,D.,
            Calibasi-Kocal,G., Nascentes Melo,L.M., Allies,G., Rosler,J.,
            Wittenhofer,P., Krystkiewicz,J., Schmitz,O.J., Roper,J.,
            Vinolo,M.A.R., Ricciardiello,L., Lien,E.C., Vander Heiden,M.G.,
            Shivdasani,R.A., Cheng,C.W., Tasdogan,A. and Yilmaz,O.H.
  TITLE     Short-term post-fast refeeding enhances intestinal stemness via
            polyamines
  JOURNAL   Nature 633 (8031), 895-904 (2024)
   PUBMED   39169180
REFERENCE   2  (bases 1 to 2783)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2783)
  AUTHORS   Bhalla,M. and Lee,C.J.
  TITLE     Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid
            pathology and switches astrocytes from a reactive to active state
  JOURNAL   Mol Brain 17 (1), 3 (2024)
   PUBMED   38216963
  REMARK    GeneRIF: Long-term inhibition of ODC1 in APP/PS1 mice rescues
            amyloid pathology and switches astrocytes from a reactive to active
            state.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2783)
  AUTHORS   Elmarsafawi,A.G., Hesterberg,R.S., Fernandez,M.R., Yang,C.,
            Darville,L.N., Liu,M., Koomen,J.M., Phanstiel,O. 4th, Atkins,R.,
            Mullinax,J.E., Pilon-Thomas,S.A., Locke,F.L., Epling-Burnette,P.K.
            and Cleveland,J.L.
  TITLE     Modulating the polyamine/hypusine axis controls generation of CD8+
            tissue-resident memory T cells
  JOURNAL   JCI Insight 8 (18), e169308 (2023)
   PUBMED   37581943
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2783)
  AUTHORS   Peng,V., Cao,S., Trsan,T., Bando,J.K., Avila-Pacheco,J.,
            Cleveland,J.L., Clish,C., Xavier,R.J. and Colonna,M.
  TITLE     Ornithine decarboxylase supports ILC3 responses in infectious and
            autoimmune colitis through positive regulation of IL-22
            transcription
  JOURNAL   Proc Natl Acad Sci U S A 119 (45), e2214900119 (2022)
   PUBMED   36279426
REFERENCE   6  (bases 1 to 2783)
  AUTHORS   Tsirka,S. and Coffino,P.
  TITLE     Dominant negative mutants of ornithine decarboxylase
  JOURNAL   J Biol Chem 267 (32), 23057-23062 (1992)
   PUBMED   1429654
REFERENCE   7  (bases 1 to 2783)
  AUTHORS   Dietrich,W., Katz,H., Lincoln,S.E., Shin,H.S., Friedman,J.,
            Dracopoli,N.C. and Lander,E.S.
  TITLE     A genetic map of the mouse suitable for typing intraspecific
            crosses
  JOURNAL   Genetics 131 (2), 423-447 (1992)
   PUBMED   1353738
REFERENCE   8  (bases 1 to 2783)
  AUTHORS   Johannes,G. and Berger,F.G.
  TITLE     Alterations in mRNA translation as a mechanism for the modification
            of enzyme synthesis during evolution. The ornithine decarboxylase
            model
  JOURNAL   J Biol Chem 267 (14), 10108-10115 (1992)
   PUBMED   1374399
REFERENCE   9  (bases 1 to 2783)
  AUTHORS   Suorsa,A., Hietala,O. and Pajunen,A.
  TITLE     Developmental expression of ornithine and S-adenosylmethionine
            decarboxylases in mouse brain
  JOURNAL   Biochem Biophys Res Commun 184 (2), 1114-1118 (1992)
   PUBMED   1374235
REFERENCE   10 (bases 1 to 2783)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163651.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3224511.1,
                                           SRR13422601.1621299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-532               AC163651.2         111174-111705
            533-630             AC163651.2         113365-113462
            631-748             AC163651.2         113552-113669
            749-922             AC163651.2         113902-114075
            923-1095            AC163651.2         114219-114391
            1096-1230           AC163651.2         114578-114712
            1231-1312           AC163651.2         114814-114895
            1313-1396           AC163651.2         115056-115139
            1397-1559           AC163651.2         115693-115855
            1560-1672           AC163651.2         115937-116049
            1673-1887           AC163651.2         116132-116346
            1888-2783           AC163651.2         116876-117771
FEATURES             Location/Qualifiers
     source          1..2783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.11 cM"
     gene            1..2783
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /note="ornithine decarboxylase, structural 1"
                     /db_xref="GeneID:18263"
                     /db_xref="MGI:MGI:97402"
     exon            1..532
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            533..630
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            631..748
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /inference="alignment:Splign:2.1.0"
     CDS             647..2032
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /EC_number="4.1.1.17"
                     /note="isoform 1 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="ornithine decarboxylase isoform 1"
                     /protein_id="NP_001396558.1"
                     /db_xref="GeneID:18263"
                     /db_xref="MGI:MGI:97402"
                     /translation="MSSFTKDEFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVAD
                     LGDILKKHLRWLKALPRVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLG
                     VPAERVIYANPCKQVSQIKYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDS
                     KAVCRLSVKFGATLKTSRLLLERAKELNIDVIGVSFHVGSGCTDPETFVQAVSDARCV
                     FDMATEVGFSMHLLDIGGGFPGSEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPG
                     RYYVASAFTLAVNIIAKKTVWKEQPGSDDEDESNEQTFMYYVNDGVYGSFNCILYDHA
                     HVKALLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCNLPEMHVGDWMLFENMGAYTVA
                     AASTFNGFQRPNIYYVMSRPMWQLMKQIQSHGFPPEVEEQDDGTLPMSCAQESGMDRH
                     PAACASARINV"
     exon            749..922
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1095
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1230
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1312
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1396
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1559
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1672
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1887
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2783
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2764..2769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /note="hexamer: AATAAA"
     polyA_site      2783
                     /gene="Odc1"
                     /gene_synonym="ODC"
                     /note="major polyA site"
ORIGIN      
        1 gagctggtgc gtctccatga cgacgtgctc ggcgtataag tagcggcgcg tcgcaccgtc
       61 gggctttgtc agtccctgca gccgccaccg ccggccgccc tcagccagca gctcggcgcc
      121 acctccggtc ggcgtctgcg gcgggctcga cgaggcggct gacggggcgg cggcggcggg
      181 cggacggacg gacggacggg cgctcctcgg ggtttggcgg cggcgcctcc atgggtcagg
      241 ccagccgggc caccgtgctg tgaggtgagc gggacgcggg agggatgtgc ggccacgtgt
      301 cgcgaggccc ggactgcggc cgccggcagg ggacacgtgg cccgggaccg gtgaccttgc
      361 gagccgccgc cctgaaggca gctgctcctg gacctcggct gcaagccctc ggatcccccc
      421 atgggagccc tcttcgcgtc agccggactc agcgctccac ttgcccgggt gatgatggag
      481 ggcaagcccg cggcaggtgc aggggagcgc ggccgcgagc agcggtcctg catgtttcca
      541 ccactccaag aaggcagcat tcagagttct tggctaagtc gaccttgtga ggagctggtg
      601 ataatttgat tccatctcca ggttccctgt aagcacatcg agaaccatga gcagctttac
      661 taaggacgag tttgactgcc acatccttga tgaaggcttt actgctaagg acattctgga
      721 ccaaaaaatc aatgaagtct cttcctctga cgataaggat gcgttctatg ttgcggacct
      781 cggagacatt ctaaagaagc atctgaggtg gctaaaagct cttccccgcg tcactccctt
      841 ttacgcagtc aagtgtaacg atagcagagc catagtgagc accctagctg ccattgggac
      901 aggatttgac tgtgcaagca agactgaaat acagttggtg caggggcttg gggtgcctgc
      961 agagagggtt atctatgcaa atccttgtaa acaagtctct caaatcaagt atgctgccag
     1021 taacggagtc cagatgatga cttttgacag tgaaattgaa ttgatgaaag tcgccagagc
     1081 acatccaaag gcaaagttgg ttctacggat tgccactgat gattccaaag ctgtctgtcg
     1141 cctcagtgtt aagtttggtg ccacactcaa aaccagcagg cttctcttgg aacgggcaaa
     1201 agagctaaat attgacgtca ttggtgtgag cttccatgtg ggcagtggat gtactgatcc
     1261 tgagaccttc gttcaggcag tgtcggatgc ccgctgtgtg tttgacatgg caacagaagt
     1321 tggtttcagc atgcatctgc ttgatattgg tggtggcttt cctggatctg aagatacaaa
     1381 gcttaaattt gaagagatca ccagtgtaat caacccagct ctggacaagt acttcccatc
     1441 agactctgga gtgagaatca tagctgagcc aggcagatac tatgtcgcat cagctttcac
     1501 gcttgcagtc aacatcattg ccaaaaaaac cgtgtggaag gagcagcccg gctctgacga
     1561 tgaagatgag tcaaatgaac aaaccttcat gtattatgtg aatgatggag tatatggatc
     1621 atttaactgc attctttatg atcatgccca tgtgaaggcc ctgctgcaga agagacccaa
     1681 gccagacgag aagtattact catccagcat ctggggacca acatgtgatg gccttgatcg
     1741 gatcgtggag cgctgtaacc tgcctgaaat gcatgtgggt gattggatgc tgtttgagaa
     1801 catgggtgca tacactgttg ctgctgcttc tactttcaat gggttccaga ggccaaacat
     1861 ctactatgta atgtcacggc caatgtggca actcatgaag cagatccaga gccatggctt
     1921 cccgccggag gtggaggagc aggatgatgg cacgctgccc atgtcttgtg cccaggagag
     1981 cgggatggac cgtcaccctg cagcctgtgc ttctgctagg atcaatgtgt agatgccatt
     2041 cttgtagctc ttgcctgcaa gtttagcttg tgttaaggca tttgggggga ccatttaact
     2101 tactgctagt ttgggatgtc tttgtgagag tagggttggc accaatgcag tatggaaggc
     2161 taggagatgg ggggtcacac ttactgtgtt cctatggaaa ctttgaatat ttgtattaca
     2221 tggattttta ttcacttttc agacatgata ctaacgtgtg cccctcagct gctgagcaag
     2281 cgtttgtagc ttgtacattg gcagaatggg ccagaagctt atgttgtgac ccattgtgaa
     2341 aataaagtat cttgaaataa ctgggcatca gggaatgttt gcaagtatcc ttaaagaagg
     2401 caccaacatc tgcacaggct gctgtgtcat ggagagaccc actgcctgtg gatctgaagg
     2461 ttgggctagc cccgcatagc acagaggaga ggtggatggc acaaggctgt gccctctctg
     2521 tacagcatca gtctgcttag cccatcccaa gtgtgcagtt ggctgagaac tttgttgccc
     2581 agagtctgtt ggtgaggaat gtcacctgcc tagtgaccgg ttggcatggc cacttcctag
     2641 ggaggtcatc tgaagtcctt gcctgcagaa accctgactg ttccctcaac ccttgactcc
     2701 caattgcatc accacctagt aacagttggg agtatcatac aacatcggca gtcaacttcc
     2761 tgtaataaat tcaacaacag caa
//
