LOCUS       NM_027128               2024 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus odontogenic, ameloblast asssociated (Odam), mRNA.
ACCESSION   NM_027128 XM_132137
VERSION     NM_027128.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2024)
  AUTHORS   Cai,H., Zhang,B., Ahrenfeldt,J., Joseph,J.V., Riedel,M., Gao,Z.,
            Thomsen,S.K., Christensen,D.S., Bak,R.O., Hager,H., Vendelbo,M.H.,
            Gao,X., Birkbak,N. and Thomsen,M.K.
  TITLE     CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as
            a metastatic driver by Odam/Cabs1 gene cluster expression
  JOURNAL   Nat Commun 15 (1), 2088 (2024)
   PUBMED   38453924
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2024)
  AUTHORS   Lee,H.K., Willi,M., Liu,C. and Hennighausen,L.
  TITLE     Cell-specific and shared regulatory elements control a multigene
            locus active in mammary and salivary glands
  JOURNAL   Nat Commun 14 (1), 4992 (2023)
   PUBMED   37591874
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2024)
  AUTHORS   Song,D., Yang,S., Tan,T., Wang,R., Ma,Z., Wang,Y. and Wang,L.
  TITLE     ODAM promotes junctional epithelium-related gene expression via
            activation of WNT1 signaling pathway in an ameloblast-like cell
            line ALC
  JOURNAL   J Periodontal Res 56 (3), 482-491 (2021)
   PUBMED   33452817
  REMARK    GeneRIF: ODAM promotes junctional epithelium-related gene
            expression via activation of WNT1 signaling pathway in an
            ameloblast-like cell line ALC.
REFERENCE   4  (bases 1 to 2024)
  AUTHORS   Fouillen,A., Dos Santos Neves,J., Mary,C., Castonguay,J.D.,
            Moffatt,P., Baron,C. and Nanci,A.
  TITLE     Interactions of AMTN, ODAM and SCPPPQ1 proteins of a specialized
            basal lamina that attaches epithelial cells to tooth mineral
  JOURNAL   Sci Rep 7, 46683 (2017)
   PUBMED   28436474
  REMARK    GeneRIF: Data suggest that amelotin (AMTN), odontogenic
            ameloblast-associated protein (ODAM) and secretory calcium-binding
            phosphoprotein proline-glutamine rich 1 (SCPPPQ1) participate in
            structuring an extracellular matrix with the distinctive capacity
            of attaching epithelial cells to mineralized surfaces.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2024)
  AUTHORS   Lee,H.K., Ji,S., Park,S.J., Choung,H.W., Choi,Y., Lee,H.J.,
            Park,S.Y. and Park,J.C.
  TITLE     Odontogenic Ameloblast-associated Protein (ODAM) Mediates
            Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho
            Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling
  JOURNAL   J Biol Chem 290 (23), 14740-14753 (2015)
   PUBMED   25911094
REFERENCE   6  (bases 1 to 2024)
  AUTHORS   Lee,H.K., Lee,D.S., Ryoo,H.M., Park,J.T., Park,S.J., Bae,H.S.,
            Cho,M.I. and Park,J.C.
  TITLE     The odontogenic ameloblast-associated protein (ODAM) cooperates
            with RUNX2 and modulates enamel mineralization via regulation of
            MMP-20
  JOURNAL   J Cell Biochem 111 (3), 755-767 (2010)
   PUBMED   20665536
  REMARK    GeneRIF: Runx2 regulates the expression of ODAM and nuclear ODAM
            serves an important regulatory function in the mineralization of
            enamel through the regulation of MMP-20 apart from a different,
            currently unidentified, function of extracellular ODAM.
REFERENCE   7  (bases 1 to 2024)
  AUTHORS   Moffatt,P., Smith,C.E., St-Arnaud,R. and Nanci,A.
  TITLE     Characterization of Apin, a secreted protein highly expressed in
            tooth-associated epithelia
  JOURNAL   J Cell Biochem 103 (3), 941-956 (2008)
   PUBMED   17647262
  REMARK    GeneRIF: The protein sequences deduced from the cloned cDNA for
            rat, mouse, pig, and human were aligned together with those
            obtained from four other mammal genomes. Apin is highly conserved
            in mammals.
REFERENCE   8  (bases 1 to 2024)
  AUTHORS   Moffatt,P., Smith,C.E., Sooknanan,R., St-Arnaud,R. and Nanci,A.
  TITLE     Identification of secreted and membrane proteins in the rat incisor
            enamel organ using a signal-trap screening approach
  JOURNAL   Eur J Oral Sci 114 Suppl 1, 139-46 (2006)
   PUBMED   16674676
REFERENCE   9  (bases 1 to 2024)
  AUTHORS   Khoo,J.P., Nicoli,T., Alp,N.J., Fullerton,J., Flint,J. and
            Channon,K.M.
  TITLE     Congenic mapping and genotyping of the
            tetrahydrobiopterin-deficient hph-1 mouse
  JOURNAL   Mol Genet Metab 82 (3), 251-254 (2004)
   PUBMED   15234340
REFERENCE   10 (bases 1 to 2024)
  AUTHORS   Rijnkels,M., Elnitski,L., Miller,W. and Rosen,J.M.
  TITLE     Multispecies comparative analysis of a mammalian-specific genomic
            domain encoding secretory proteins
  JOURNAL   Genomics 82 (4), 417-432 (2003)
   PUBMED   13679022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022298.31.
            
            On Jan 31, 2019 this sequence version replaced NM_027128.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC022298.31        39276-39312
            38-103              AC022298.31        39963-40028
            104-145             AC022298.31        40120-40161
            146-193             AC022298.31        40822-40869
            194-424             AC022298.31        41586-41816
            425-469             AC022298.31        42206-42250
            470-571             AC022298.31        43632-43733
            572-619             AC022298.31        44353-44400
            620-691             AC022298.31        45618-45689
            692-844             AC022298.31        46582-46734
            845-903             AC022298.31        46949-47007
            904-2024            AC022298.31        47955-49075
FEATURES             Location/Qualifiers
     source          1..2024
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..2024
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /note="odontogenic, ameloblast asssociated"
                     /db_xref="GeneID:69592"
                     /db_xref="MGI:MGI:1916842"
     exon            1..37
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            38..103
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..874
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /note="odontogenic ameloblast-associated protein"
                     /codon_start=1
                     /product="odontogenic ameloblast-associated protein
                     precursor"
                     /protein_id="NP_081404.2"
                     /db_xref="CCDS:CCDS19394.2"
                     /db_xref="GeneID:69592"
                     /db_xref="MGI:MGI:1916842"
                     /translation="MKIIILLGLIGASSSAPLISQRLLSASNSHELLLNLNNGQLLPL
                     QFQGAFNSWIPPFPGFLQQQQAQVSGRPQFTLSTLESFAGLFPNQIPLSRQVGLAQGG
                     QAGQPDLSQQQTPPQTQQSASPMSYVVPVKVPQDQTQMFQYYPVYMLLPWEQPQTVTS
                     SPQHTGQQLFEEQIPFYNQFGFAPPQAEPGVPGGQQHLAFDSFVGTAPETPGMPVEGS
                     LLYPQKEPISFKHDNAGVFMPTTSPKPSTDNFFTSGIDPTIAPEQKVKTDSLREP"
     exon            104..145
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            146..193
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            194..424
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            425..469
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            470..571
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            572..619
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            620..691
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            692..844
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            845..903
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            904..2024
                     /gene="Odam"
                     /gene_synonym="2310011G06Rik; APIN"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaagaaa ggggcacaga tcttgcaaag aagtaaggta taccatctga aaatgaaaat
       61 tataattctt cttggactca taggagcctc atcatcagcc ccgcttatct cgcagcgtct
      121 attgtctgct agcaacagtc atgagctact cctgaatctt aataatggtc aacttttgcc
      181 actgcagttc cagggtgcct tcaactcctg gattcctccc ttccctgggt ttctgcagca
      241 gcagcaggct caggtctcag gacgcccaca gtttactctc tcaacactag agagctttgc
      301 tggactattc ccaaatcaga tacctttatc aagacaggtt ggacttgccc aaggaggcca
      361 ggctggccag ccagacctct ctcagcagca gacaccacct cagacccagc agagtgctag
      421 ccctatgtcc tatgtggtac ctgtcaaagt acctcaagat caaacacaga tgtttcagta
      481 ctatccagtt tacatgcttc tgccctggga gcagcctcag accgtcacat cctcaccaca
      541 gcacacaggg cagcagctat ttgaggaaca gatacctttc tataatcaat ttggattcgc
      601 accaccacaa gcagaacctg gggtaccagg agggcagcag cacttagctt ttgacagctt
      661 tgtaggcaca gctccagaaa ctcctggaat gccagtagaa ggaagcctgc tttatccaca
      721 aaaagaacca atcagcttta agcatgataa tgcaggagtt ttcatgccta caacttcacc
      781 aaagcccagc accgacaatt ttttcacttc tgggatagat ccaactattg ctccagaaca
      841 gaaggtcaag actgatagtc taagagaacc ataagagatt acttaaatca cttggaagtt
      901 ttgggagatg tgatggtacc ttggctgtct tttaaagatg attttctact tacatgctaa
      961 tagaaatttg tttaatgatg taaagcctct gtttgtctaa taattataaa gggtcttcac
     1021 tgatctcatt tctttactta taaaagatac tattcatgtc acaaaaaata atgtatcatg
     1081 gaataagttc tatctttata atgctatctt ttttcccaaa tattctagga ttatataacc
     1141 tggaaaatgg caagcactag aaataaagca catttaacca aaaagctaca ccttcttaaa
     1201 acattgcata atatagtgaa acttgattgc aatgataatc ttccaaacat tcatgtgaca
     1261 cccaagtgca ctcatgtgtg cgcgcacaca cacaataaag cttatgataa cagattaatt
     1321 tgataactgt gttaataaag aatgcctcta aacttatgtc attcaagaga ataaatatgt
     1381 actaattaat agatttgtga tgagtgcact gattggtgtt gacattaaac tatgtgtcta
     1441 tttttctcat gtcaatatct gattattttt cccatgaaca aggttcattc tttcagcttg
     1501 tttgtgactc attctccatg aatatcaaat ttgtttttgt tttgctctgt tttgcctttt
     1561 tttaaggcag gatctcatac tatagccttg actatccttg aactacttag taggtaggcc
     1621 aggctggcct ggtattcata gaaatctacc agttcctgac tctgaatgtg cttaaactgt
     1681 ataccaccac acctggtcct ccaaaatggt tttgaaacag atattgactg tgtgtgccct
     1741 tagtacacca caactacata gaaagatggg tgctgaattc aaatggacaa aaggaagatg
     1801 cgtgtttgtt tagggtgaca gtgacctaca gaaactggga cagattttgc agacataggt
     1861 tttggatttc atctctcttt ggtttgaata ttcaaggtgt cacttaaaca ttagtttctc
     1921 ttctcagttg taaataggag agagtgagac atgaatctca gaatttctga aagcccttct
     1981 ttaaaaaaaa aaaaaacaac acagaagtac acaagactta cttt
//
