LOCUS       NM_028918               2842 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus outer dynein arm complex subunit 4 (Odad4), transcript
            variant 1, mRNA.
ACCESSION   NM_028918 XM_126529 XM_903052 XM_903053 XM_905314 XM_919279
            XM_919301 XM_987522 XM_987558 XM_987586
VERSION     NM_028918.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2842)
  AUTHORS   Ide,T., Twan,W.K., Lu,H., Ikawa,Y., Lim,L.X., Henninger,N.,
            Nishimura,H., Takaoka,K., Narasimhan,V., Yan,X., Shiratori,H.,
            Roy,S. and Hamada,H.
  TITLE     CFAP53 regulates mammalian cilia-type motility patterns through
            differential localization and recruitment of axonemal dynein
            components
  JOURNAL   PLoS Genet 16 (12), e1009232 (2020)
   PUBMED   33347437
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2842)
  AUTHORS   Wallmeier,J., Shiratori,H., Dougherty,G.W., Edelbusch,C., Hjeij,R.,
            Loges,N.T., Menchen,T., Olbrich,H., Pennekamp,P., Raidt,J.,
            Werner,C., Minegishi,K., Shinohara,K., Asai,Y., Takaoka,K., Lee,C.,
            Griese,M., Memari,Y., Durbin,R., Kolb-Kokocinski,A., Sauer,S.,
            Wallingford,J.B., Hamada,H. and Omran,H.
  TITLE     TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking
            Machinery and Primary Ciliary Dyskinesia with Left-Right Body
            Asymmetry Randomization
  JOURNAL   Am J Hum Genet 99 (2), 460-469 (2016)
   PUBMED   27486780
  REMARK    GeneRIF: report of TTC25 as a new member of the outer dynein arms
            docking machinery in humans and mice
REFERENCE   3  (bases 1 to 2842)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Ttc25 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX842667.2, CA463990.1, AK161541.1 and AK016657.1.
            
            On May 10, 2018 this sequence version replaced NM_028918.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016657.1, SRR5189685.158911.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BX842667.2         47492-47515
            25-507              CA463990.1         28-510
            508-1630            AK161541.1         423-1545
            1631-2161           AK016657.1         1538-2068
            2162-2842           AK161541.1         1992-2672
FEATURES             Location/Qualifiers
     source          1..2842
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.47 cM"
     gene            1..2842
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /note="outer dynein arm complex subunit 4"
                     /db_xref="GeneID:74407"
                     /db_xref="MGI:MGI:1921657"
     exon            1..301
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..2068
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 25; TPR repeat protein
                     25; tetratricopeptide repeat domain 25; outer dynein
                     arm-docking complex subunit 4"
                     /codon_start=1
                     /product="outer dynein arm-docking complex subunit 4
                     isoform 1"
                     /protein_id="NP_083194.2"
                     /db_xref="CCDS:CCDS36331.1"
                     /db_xref="GeneID:74407"
                     /db_xref="MGI:MGI:1921657"
                     /translation="MSDGDILRSTFPSYMAEGERLYLCGEFTKAIQSFTNALHLQSGD
                     KNCLVARSKCYLKMGDLEKSLNDAEASLRNDPTFCKGILQKAETLYTMGDFEFALVFY
                     HRGYKLRPDREFKVGIQKAQEAINNSVGSPSSIKLENKGDLSFLSKQAESKKAQQKHL
                     PIKQLSYSTKHEIKRKGSLKSEKTVRQLLGELYVDKEYLEKLLLDEDLIKGTIKSGLT
                     VEDLIMTGINYLDTRSNFWRQQKPIYARERDRKLMQEKWLRDRKRSPSQTAHYILKSL
                     EDIDMLLTSGSADGSLQKAEKVLKKVLEWNQEEVPNKDELVGNLYSCIGNAQIELGQM
                     VAALQSHRKDLEIAKEHDLPDAKSRALDNIGRVFARVGKFQQAIDTWEEKIPLAKTTL
                     EKTWLFHEIGRCYLELDQAWQAQSYGEKSQQYAEEEGDLEWQLNASVLVAQAQVKLRD
                     FESAVNNFEKALERAKLVHNNEAQQAIISALDDANKGIIEELKKTNYREILREKAERQ
                     DIMSQMDLQGASEKEPLRGREEQERVVKQWERDQESEREATDDEQDRKSSGGLSKKLL
                     GDGHSSNLGIRRESREIYRRLSDYSSHLPSEDGSQKQEKKQAEAAKGEVQKLEKTKEE
                     "
     exon            302..433
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /inference="alignment:Splign:2.1.0"
     exon            434..584
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /inference="alignment:Splign:2.1.0"
     exon            585..646
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /inference="alignment:Splign:2.1.0"
     exon            647..812
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1037
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1245
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1332
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1529
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1630
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1715
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..2842
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2213..2218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /note="hexamer: ATTAAA"
     polyA_site      2239
                     /gene="Odad4"
                     /gene_synonym="4933404O19Rik; Ttc25"
                     /note="major polyA site"
ORIGIN      
        1 acacaggcgc atgagcacgc tgggcgggct cacccggagg cctaacaccg ccaggggagg
       61 ggaggggagg gaccggaagt tagactatct ctctaggttg ctaagagacc gggctgtccc
      121 aaaacaagcc ggcgattctc cagcctcttt tcctttctga atctgcttca gaatttccaa
      181 aagtagggtg accatgtcgg acggtgatat cttaagaagc acttttccct cttacatggc
      241 agagggggag aggctttatc tgtgcgggga gttcactaag gccattcaaa gctttaccaa
      301 cgctcttcac cttcaaagtg gagataagaa ctgcctggtt gcccgctcca aatgctacct
      361 gaagatggga gacttagaga agtccttgaa cgatgctgag gcctcacttc ggaacgaccc
      421 gactttctgc aaggggatct tacagaaggc tgagacactg tacaccatgg gagactttga
      481 gtttgccctg gtgttctatc atcgaggcta caaactgaga cctgatcggg aattcaaagt
      541 aggaattcag aaggcccagg aagccatcaa caactcggtg ggaagtcctt cttcaatcaa
      601 gctggagaac aaaggcgacc tctccttctt aagcaagcaa gctgagagta agaaagccca
      661 acagaagcat ctgcctataa agcaactctc gtacagcacc aagcatgaaa tcaagcggaa
      721 gggctcgctc aagagcgaga agaccgtgcg gcagctgctc ggggagctgt acgtggacaa
      781 ggagtatctg gagaagctcc ttctggatga agatctcatc aaaggcacca tcaagagtgg
      841 cctgaccgtg gaggacctca ttatgactgg catcaactac ctggacaccc gcagcaactt
      901 ctggaggcag cagaagccca tctatgccag ggagcgagac cggaagctga tgcaagagaa
      961 gtggctgagg gaccggaaac gcagcccctc gcagacagcc cactacatcc tcaagagcct
     1021 agaggacatt gacatgttgt tgaccagtgg cagtgctgat gggagcctcc aaaaagctga
     1081 gaaagtcctt aagaaggttc tggaatggaa ccaagaggag gtacccaaca aggacgagct
     1141 ggtcgggaac ttgtacagct gcataggcaa cgcccagatt gagctggggc agatggtggc
     1201 tgccttgcag agccaccgaa aggacctgga gatcgccaag gaacatgacc ttccagatgc
     1261 aaaatcgaga gcccttgaca atattggcag agtttttgcc agagttggga aattccagca
     1321 agccattgac acgtgggagg agaagatccc tctagccaaa accaccctgg agaagacctg
     1381 gctcttccac gagattggcc gctgttactt ggagctggac caggcgtggc aggcccagag
     1441 ttatggggaa aagtctcagc agtacgctga ggaggaaggg gacctcgagt ggcagctgaa
     1501 cgccagtgtc ctggtggcgc aggcccaagt gaagctgaga gacttcgagt cagctgtgaa
     1561 taactttgag aaggccctgg agagagccaa gctggtccac aacaacgagg cgcagcaggc
     1621 catcatcagc gccttggacg atgccaacaa gggcatcatc gaagaactta agaaaacgaa
     1681 ctacagggag atactcaggg aaaaggcaga gagacaggac atcatgtcac agatggattt
     1741 gcagggagca tctgagaagg agccgctgcg agggcgagag gagcaggaga gggtggtgaa
     1801 gcagtgggag agggaccagg aaagtgagag agaagccacg gatgacgagc aagacaggaa
     1861 aagctcggga ggactcagca aaaaactgtt gggagacggt cactcgtcaa acctagggat
     1921 taggagagag tccagagaaa tctacagaag gctctcggac tactccagcc acctaccctc
     1981 agaggacggc agccaaaaac aagagaagaa acaagcagaa gcagccaaag gggaggtcca
     2041 aaagttggag aagacaaaag aggaataatc taaagcccag gctacttaac aacagagaag
     2101 ggatgaagac cgctcagtag gctccgaggt tcaggcggac agtgttccca ggtgttttgg
     2161 agaggaaaca ctgggagact cactcctaca gaccccccgc ccccgtttct ccattaaata
     2221 tgcgccttta acttttatag atcttgagtg acactgtgct gcctcccacc cctcgttctc
     2281 agtagggacc aatggaagag atgagcaggg tgggtggaga agcaggtgag tgtctgagag
     2341 cgcagaaccc tgaaagaaca ggaaaggaaa gccccgagaa ccgttgactc agtttcccca
     2401 ggatgtacaa ggcttgggag tggggtggag atatacagaa accccagctc tgctgacatc
     2461 atccatctta taaagcctgt aggccttcag agtagattgg agtaaaagct gtgtctaccg
     2521 gcagactgtc tgggagaaga gtcccagaat gtgcggcctc ctctgtgcag ccttaagctg
     2581 ccctgggaat attatgttct agaacagcac agaaatccca ctgagaaggc tgtgacttcc
     2641 tagagttagc gaataaacat ctggcctcaa aaggatcagc ctgggctgga gagatggctc
     2701 agtggttaac agcagtcctg agttcaattc ccagcaacca tgtggtggct cacaactgtc
     2761 tgtaatggga tctgatgccc tcttctagtg gatctgaaaa cagcaacagt gttctcatac
     2821 acataaaata aataaataaa tc
//
