LOCUS       NM_029939               2218 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus outer dynein arm docking complex subunit 3 (Odad3),
            transcript variant 2, mRNA.
ACCESSION   NM_029939 XM_134745
VERSION     NM_029939.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2218)
  AUTHORS   Pasquini,M., Chiani,F., Gambadoro,A., Di Pietro,C., Paoletti,R.,
            Orsini,T., Putti,S., Scavizzi,F., La Sala,G. and Ermakova,O.
  TITLE     The Odad3 Gene Is Necessary for Spermatozoa Development and Male
            Fertility in Mice
  JOURNAL   Cells 13 (12), 1053 (2024)
   PUBMED   38920681
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2218)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2218)
  AUTHORS   Chiani,F., Orsini,T., Gambadoro,A., Pasquini,M., Putti,S.,
            Cirilli,M., Ermakova,O. and Tocchini-Valentini,G.P.
  TITLE     Functional loss of Ccdc151 leads to hydrocephalus in a mouse model
            of primary ciliary dyskinesia
  JOURNAL   Dis Model Mech 12 (8) (2019)
   PUBMED   31383820
  REMARK    GeneRIF: Ccdc151 gene deletion in adult animals results in abnormal
            sperm counts and defective sperm motility.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2218)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   5  (bases 1 to 2218)
  AUTHORS   Hjeij,R., Onoufriadis,A., Watson,C.M., Slagle,C.E., Klena,N.T.,
            Dougherty,G.W., Kurkowiak,M., Loges,N.T., Diggle,C.P.,
            Morante,N.F., Gabriel,G.C., Lemke,K.L., Li,Y., Pennekamp,P.,
            Menchen,T., Konert,F., Marthin,J.K., Mans,D.A., Letteboer,S.J.,
            Werner,C., Burgoyne,T., Westermann,C., Rutman,A., Carr,I.M.,
            O'Callaghan,C., Moya,E., Chung,E.M., Sheridan,E., Nielsen,K.G.,
            Roepman,R., Bartscherer,K., Burdine,R.D., Lo,C.W., Omran,H. and
            Mitchison,H.M.
  CONSRTM   UK10K Consortium
  TITLE     CCDC151 mutations cause primary ciliary dyskinesia by disruption of
            the outer dynein arm docking complex formation
  JOURNAL   Am J Hum Genet 95 (3), 257-274 (2014)
   PUBMED   25192045
REFERENCE   6  (bases 1 to 2218)
  AUTHORS   Jerber,J., Baas,D., Soulavie,F., Chhin,B., Cortier,E., Vesque,C.,
            Thomas,J. and Durand,B.
  TITLE     The coiled-coil domain containing protein CCDC151 is required for
            the function of IFT-dependent motile cilia in animals
  JOURNAL   Hum Mol Genet 23 (3), 563-577 (2014)
   PUBMED   24067530
  REMARK    GeneRIF: Ccdc151 expression is strongly induced during in vitro
            differentiation of motile cilia of ependymal cells.
REFERENCE   7  (bases 1 to 2218)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: C330001K17Rik is most abundantly expressed in tissues rich
            in highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031175.1, AC163623.5 and BC057069.1.
            
            On Aug 8, 2009 this sequence version replaced NM_029939.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. This
            results in a shorter isoform (2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031175.1, BC051179.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               AK031175.1         2-300
            300-355             AC163623.5         68422-68477         c
            356-1905            AK031175.1         357-1906
            1906-1906           AC163623.5         56304-56304         c
            1907-2196           AK031175.1         1908-2197
            2197-2218           BC057069.1         2103-2124
FEATURES             Location/Qualifiers
     source          1..2218
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 8.01 cM"
     gene            1..2218
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /note="outer dynein arm docking complex subunit 3"
                     /db_xref="GeneID:77609"
                     /db_xref="MGI:MGI:1924859"
     exon            1..389
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1942
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /note="isoform 2 is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 151; coiled-coil
                     domain containing 151"
                     /codon_start=1
                     /product="outer dynein arm-docking complex subunit 3
                     isoform 2"
                     /protein_id="NP_084215.2"
                     /db_xref="CCDS:CCDS22917.1"
                     /db_xref="GeneID:77609"
                     /db_xref="MGI:MGI:1924859"
                     /translation="MTSPLCWAAATTTVTSPEQAPAPSSKAKGSKVHRSKSMGRAQAW
                     PAHHPKSATSFHAMKSSVHAQVLELQRKIQLLEGDRKAFYESSQWNMKKNQDTINQLQ
                     EETKALHVQLKDLLQGDSKVIQAIIQEWKSEKPFLKNRTCEQALEHLEHQLREKMNQL
                     NALRHQVILRQKRLEDLRLQHSLRQLEMAEVQDSNMEAAKTMRNLENRLEKARMKAEE
                     AEHITNVYLQLKSYLQEESLNLESRLDSMEAEVMNTKHEVQELKVVNQEAINARDIAK
                     NQLQYLEESAIRDRKKREHYITDCKKRAEEKKLQTERMERKTHRDHVLLQSEDTIQDH
                     QRHREEELRQRWSMYQMEVMFGKVKDATGVAESHAVVRRFLAQDETFTQLENLKKDNE
                     LALAKLKEEKQRLQRELENLKYSGDATLVSQRRLHEEMQKTFKKEEQRHNDVHERLEH
                     TSRILQLVKDCLEHLANKLSHVKLDDTVLAGKKLDRDSEDYAYNLLVVVQEKLLKLQD
                     QLESQDVPELLRHIADREFLATLEGKLPLYNTRILLPVASVKDKFFDEEESEDDDRDV
                     VTRAAFKLRSQKLIEARSKKRNRLRRS"
     exon            390..511
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     exon            512..589
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     exon            590..760
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     exon            761..862
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     exon            863..988
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1111
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1264
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1425
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1582
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1738
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1823
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2197
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2177..2182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /note="hexamer: AATAAA"
     polyA_site      2197
                     /gene="Odad3"
                     /gene_synonym="b2b1885Clo; C330001K17Rik; Ccdc151"
                     /note="major polyA site"
ORIGIN      
        1 acttagcaac cgggagatgc taagaggccc gcagccaggc agttagcaga agtgcattcc
       61 cagagcctag ggaaccagcg tttaggatcc tggattatag aggccaactt gtagttattc
      121 tcctacccct tagaggcttc ccgaccttaa cccgatcacc atgacgtccc ccctgtgctg
      181 ggcagccgcg accaccacgg tgactagccc ggagcaagct ccagcgccct cttccaaagc
      241 caaaggcagt aaggttcacc gaagcaagtc tatgggccgg gcacaggcct ggcctgcaca
      301 tcatcccaag tcagcaacct ccttccatgc aatgaagtct tctgtgcacg cacaggtgct
      361 tgagttacaa agaaaaatcc aactgttaga gggtgaccgg aaggcctttt atgagagctc
      421 ccaatggaac atgaagaaga accaagacac catcaaccag cttcaggagg agaccaaggc
      481 tctccacgtg cagctcaaag acctgctgca gggagactcg aaagtgattc aagcaatcat
      541 tcaggaatgg aagtcagaga aaccgttctt gaagaacagg acttgtgagc aggccctgga
      601 gcacctggag caccagttga gggagaagat gaaccagctg aatgccttgc gacaccaggt
      661 aatactgcgg cagaaacggc tggaggacct gaggctgcag cacagcctgc gccagctgga
      721 gatggcagag gtccaagaca gcaacatgga ggctgccaag accatgcgca acctggagaa
      781 tcggctggag aaggcccgga tgaaggcaga ggaggcagag cacatcacta atgtgtacct
      841 gcagctcaag tcttacctcc aggaggagag tctcaacttg gagagccggc tagattccat
      901 ggaggctgag gtgatgaaca ccaaacatga ggttcaagag ctgaaagtag tgaatcaaga
      961 ggctataaat gcccgggaca ttgccaagaa ccagctgcag tatctggagg agtctgcgat
     1021 cagagatcgc aagaagcgcg agcattacat aactgactgc aagaagcggg cagaagagaa
     1081 gaaacttcag acagagcgta tggagcgcaa gacccaccga gaccacgtat tgctgcagtc
     1141 agaagataca atacaggacc accagcgcca cagggaggag gagctgaggc agcgctggag
     1201 catgtaccag atggaagtga tgtttggcaa ggtcaaggat gccactggag tagctgaatc
     1261 gcatgcggta gtgcgcaggt tcctggccca ggatgagacc ttcacacagt tggagaatct
     1321 caagaaggac aatgaactgg cgttggcgaa gttgaaggag gagaagcagc ggctccagag
     1381 ggagctggag aacctcaagt actcggggga tgctacgctg gtgagccagc ggaggctcca
     1441 cgaagagatg caaaagacat tcaagaagga ggagcagcgt cacaatgatg tccacgagag
     1501 actggagcac acctcgcgaa tcctccagtt ggtcaaagat tgcttggagc atttggccaa
     1561 caaactgagt cacgtaaaac tggatgatac ggtattggca ggaaagaagt tagaccggga
     1621 ctcagaggac tacgcttaca atctgctggt agttgtccag gaaaagctgc tgaaactgca
     1681 ggaccaactg gagagccagg acgtgcctga gttgctgcga cacatagcag accgagagtt
     1741 cctggccacg ctagaaggaa agctgcccct atacaacacc cgcatccttc tgcccgtcgc
     1801 cagtgtcaag gacaagttct ttgatgaaga ggagagtgag gatgatgacc gtgatgtggt
     1861 gacccgcgct gccttcaagc tccgttccca gaagttaatc gaagcccgca gcaagaagcg
     1921 caataggttg cgcagatctt agactcgcag tcaagtccta tcggatgcct ccgggactct
     1981 agggagccct ccgaccctct gggtccacct acgggtggtg tgtgtctggg agccccggag
     2041 gctccttcaa gggcttggag gaagctcaag cagggagcac cgcaggccag cagcgcccgg
     2101 aggagagaaa aggccgagcc agaagttccc acagtaaatc tctcgaggcg ggttggtgcc
     2161 cgcctcggaa tcgcgcaata aaggtcactg aacaaccaaa aaaaaaaaaa aaaaaaaa
//
