LOCUS       NP_001344421            1037 aa            linear   ROD 27-APR-2025
DEFINITION  outer dynein arm-docking complex subunit 2 [Mus musculus].
ACCESSION   NP_001344421 XP_006526374
VERSION     NP_001344421.1
DBSOURCE    REFSEQ: accession NM_001357492.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1037)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1037)
  AUTHORS   Liu,S., Zhang,J., Kherraf,Z.E., Sun,S., Zhang,X., Cazin,C.,
            Coutton,C., Zouari,R., Zhao,S., Hu,F., Fourati Ben Mustapha,S.,
            Arnoult,C., Ray,P.F. and Liu,M.
  TITLE     CFAP61 is required for sperm flagellum formation and male fertility
            in human and mouse
  JOURNAL   Development 148 (23) (2021)
   PUBMED   34792097
REFERENCE   3  (residues 1 to 1037)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   4  (residues 1 to 1037)
  AUTHORS   Hjeij,R., Lindstrand,A., Francis,R., Zariwala,M.A., Liu,X., Li,Y.,
            Damerla,R., Dougherty,G.W., Abouhamed,M., Olbrich,H., Loges,N.T.,
            Pennekamp,P., Davis,E.E., Carvalho,C.M., Pehlivan,D., Werner,C.,
            Raidt,J., Kohler,G., Haffner,K., Reyes-Mugica,M., Lupski,J.R.,
            Leigh,M.W., Rosenfeld,M., Morgan,L.C., Knowles,M.R., Lo,C.W.,
            Katsanis,N. and Omran,H.
  TITLE     ARMC4 mutations cause primary ciliary dyskinesia with randomization
            of left/right body asymmetry
  JOURNAL   Am J Hum Genet 93 (2), 357-367 (2013)
   PUBMED   23849778
  REMARK    GeneRIF: ARMC4 mutations cause primary ciliary dyskinesia with
            randomization of left/right body asymmetry.
REFERENCE   5  (residues 1 to 1037)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Armc4 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   6  (residues 1 to 1037)
  AUTHORS   Lonergan,K.M., Chari,R., Deleeuw,R.J., Shadeo,A., Chi,B.,
            Tsao,M.S., Jones,S., Marra,M., Ling,V., Ng,R., Macaulay,C., Lam,S.
            and Lam,W.L.
  TITLE     Identification of novel lung genes in bronchial epithelium by
            serial analysis of gene expression
  JOURNAL   Am J Respir Cell Mol Biol 35 (6), 651-661 (2006)
   PUBMED   16809635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB573298.1, BC158097.1 and BB679543.1.
            
            On Nov 1, 2017 this sequence version replaced XP_006526374.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1037
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.53 cM"
     Protein         1..1037
                     /product="outer dynein arm-docking complex subunit 2"
                     /note="armadillo repeat-containing protein 4; armadillo
                     repeat containing 4"
                     /calculated_mol_wt=115135
     Region          316..353
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RY50.1)"
     Region          376..439
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RY50.1)"
     Region          447..472
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          477..516
                     /region_name="ARM 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RY50.1)"
     Region          482..514
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          518..557
                     /region_name="ARM 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RY50.1)"
     Region          521..557
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          528..570
                     /region_name="ARM 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00259"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RY50.1)"
     Site            545
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q5T2S8; propagated from
                     UniProtKB/Swiss-Prot (B2RY50.1)"
     Region          564..610
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          615..654
                     /region_name="ARM 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RY50.1)"
     Region          620..775
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          620..652
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(643,647,651,684,688,692,726,730)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          656..695
                     /region_name="ARM 5. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RY50.1)"
     Region          658..695
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          700..733
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          739..778
                     /region_name="ARM 6. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RY50.1)"
     Region          742..778
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          821..860
                     /region_name="ARM 7. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RY50.1)"
     Region          823..860
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          847..1025
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          864..903
                     /region_name="ARM 8. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RY50.1)"
     Region          876..901
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(892,896,900,974,978,982,1015,1019,1023)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          905..944
                     /region_name="ARM 9. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RY50.1)"
     Region          908..985
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          919..947
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          946..985
                     /region_name="ARM 10. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RY50.1)"
     Region          991..1024
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     CDS             1..1037
                     /gene="Odad2"
                     /gene_synonym="4930463I21Rik; Armc4; b2b227.1Clo;
                     b2b643Clo"
                     /coded_by="NM_001357492.1:150..3263"
                     /db_xref="CCDS:CCDS37729.1"
                     /db_xref="GeneID:74934"
                     /db_xref="MGI:MGI:1922184"
ORIGIN      
        1 mgvaltrlaq wtaagyetgt leitplnesi lneitkfves fsykypqeak fvfveplewk
       61 tylepsafel gyvvsattae seetgkdgqp llflsvpyik vrsfgqlsql lsiatdsklq
      121 eaqacieanr dpvvkilgpd ynemkedptr ltlldtiikd ketymkrkva illkqldlhl
      181 lnhslkyisl eislnpgtfk kdiellkrfs gkgeqtvles ieytsdyefs ngcrappwrq
      241 iqgeicyvlv kphdmetlcl tcstegvfln ggkteeegei nyerkgeiyk dlvtclkdks
      301 pvfsenmskh eirfteeqqk dnqifekpkt edghssvags ekskiekisf gkspmtkrle
      361 pslnwrvtvd ykdhkssikd sqeekqgkle ksssvsvaps raqshrkgge kveetvsess
      421 seseedeepp dhrqeanadl pseywqiqkl vkylkggnqt atvialcsmr dfnlaqetcq
      481 lairdvggle vlinlldtde vkckigslki lkeishnpqi rrnivdlggl pimvnildsp
      541 hkslkclsae tianvakfkr arravrqhgg itklvalldc gqnsteptqp slyetrdvev
      601 arcgalalws cskshsnkea irkaggipll arllktshen mlipvvgtlq ecaseenyra
      661 aikaeriien lvknlnsene qlqehcamai yqcaedeetr dlvrlhgglk plasllnntd
      721 nkerlaavtg aiwkcsiske nvikfreyka ietlvglltd qpeevlvnvv galgeccqey
      781 enrvlvrkcg giqplvnllv ginqallvnv tkavgacave pesmaiidrl dgvrllwsll
      841 knphpdvkas aawalcpcie nakdagemvr sfvgglelvv nllksdnkev lasvcaaitn
      901 iakdqenlav itdhgvvpll sklantnndk lrrhlaeais rccmwgrnrv afgehkavap
      961 lvrylksndt nvhrataqal yqlsedadnc itmhengavk llldmvgspd qdlqeaaagc
     1021 isnirrlala tekaryn
//
