LOCUS       NM_029021               1956 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus osteoclast stimulatory transmembrane protein
            (Ocstamp), mRNA.
ACCESSION   NM_029021
VERSION     NM_029021.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1956)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1956)
  AUTHORS   Geng,F., Cai,Y.H., Zhao,Y., Wei,Z.Q., Xu,H. and Yang,F.
  TITLE     [The mechanism of OC-STAMP overexpression induced actin
            cytoskeleton remodeling in promoting epithelial-mesenchymal
            transition in the alveolar type epithelial cell]
  JOURNAL   Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 41 (11), 801-807
            (2023)
   PUBMED   38073205
  REMARK    GeneRIF: [The mechanism of OC-STAMP overexpression induced actin
            cytoskeleton remodeling in promoting epithelial-mesenchymal
            transition in the alveolar type epithelial cell].
REFERENCE   3  (bases 1 to 1956)
  AUTHORS   Ishii,T., Ruiz-Torruella,M., Ikeda,A., Shindo,S., Movila,A.,
            Mawardi,H., Albassam,A., Kayal,R.A., Al-Dharrab,A.A., Egashira,K.,
            Wisitrasameewong,W., Yamamoto,K., Mira,A.I., Sueishi,K., Han,X.,
            Taubman,M.A., Miyamoto,T. and Kawai,T.
  TITLE     OC-STAMP promotes osteoclast fusion for pathogenic bone resorption
            in periodontitis via up-regulation of permissive fusogen CD9
  JOURNAL   FASEB J 32 (7), 4016-4030 (2018)
   PUBMED   29533736
  REMARK    GeneRIF: Significantly lower level of bone resorption was found in
            OC-STAMP-KO mice compared to WT mice.  OC-STAMP partners CD9 to
            promote periodontal bone destruction.
REFERENCE   4  (bases 1 to 1956)
  AUTHORS   Yuan,H., He,J., Zhang,G., Zhang,D., Kong,X. and Chen,F.
  TITLE     Osteoclast stimulatory transmembrane protein induces a phenotypic
            switch in macrophage polarization suppressing an M1
            pro-inflammatory state
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 49 (10), 935-944 (2017)
   PUBMED   28981605
  REMARK    GeneRIF: Results indicte that oc-stamp may play an important role
            in macrophage polarization and inhibit the M1 pro-inflammatory
            state.
REFERENCE   5  (bases 1 to 1956)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   6  (bases 1 to 1956)
  AUTHORS   Khan,U.A., Hashimi,S.M., Bakr,M.M., Forwood,M.R. and Morrison,N.A.
  TITLE     Foreign body giant cells and osteoclasts are TRAP positive, have
            podosome-belts and both require OC-STAMP for cell fusion
  JOURNAL   J Cell Biochem 114 (8), 1772-1778 (2013)
   PUBMED   23444125
  REMARK    GeneRIF: OC-STAMP is a regulatory molecule for FBGCs; and that they
            are functionally distinct from OCs, despite similarities in gene
            expression profile, podosome belt formation, and TRAP expression.
REFERENCE   7  (bases 1 to 1956)
  AUTHORS   Miyamoto,H., Katsuyama,E., Miyauchi,Y., Hoshi,H., Miyamoto,K.,
            Sato,Y., Kobayashi,T., Iwasaki,R., Yoshida,S., Mori,T.,
            Kanagawa,H., Fujie,A., Hao,W., Morioka,H., Matsumoto,M., Toyama,Y.
            and Miyamoto,T.
  TITLE     An essential role for STAT6-STAT1 protein signaling in promoting
            macrophage cell-cell fusion
  JOURNAL   J Biol Chem 287 (39), 32479-32484 (2012)
   PUBMED   22865856
REFERENCE   8  (bases 1 to 1956)
  AUTHORS   Miyamoto,H., Suzuki,T., Miyauchi,Y., Iwasaki,R., Kobayashi,T.,
            Sato,Y., Miyamoto,K., Hoshi,H., Hashimoto,K., Yoshida,S., Hao,W.,
            Mori,T., Kanagawa,H., Katsuyama,E., Fujie,A., Morioka,H.,
            Matsumoto,M., Chiba,K., Takeya,M., Toyama,Y. and Miyamoto,T.
  TITLE     Osteoclast stimulatory transmembrane protein and dendritic
            cell-specific transmembrane protein cooperatively modulate
            cell-cell fusion to form osteoclasts and foreign body giant cells
  JOURNAL   J Bone Miner Res 27 (6), 1289-1297 (2012)
   PUBMED   22337159
  REMARK    GeneRIF: Fusogenic mechanisms in macrophage-lineage cells are
            regulated via OC-STAMP and DC-STAMP.
REFERENCE   9  (bases 1 to 1956)
  AUTHORS   Kim,M.H., Park,M., Baek,S.H., Kim,H.J. and Kim,S.H.
  TITLE     Molecules and signaling pathways involved in the expression of
            OC-STAMP during osteoclastogenesis
  JOURNAL   Amino Acids 40 (5), 1447-1459 (2011)
   PUBMED   20882308
  REMARK    GeneRIF: The osteoclast differentiation needs the coordinated
            expression of OC-STAMP with several molecules required for
            transcription, signaling transduction, and cell fusion.
REFERENCE   10 (bases 1 to 1956)
  AUTHORS   Yang,M., Birnbaum,M.J., MacKay,C.A., Mason-Savas,A., Thompson,B.
            and Odgren,P.R.
  TITLE     Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel
            protein induced by RANKL that promotes osteoclast differentiation
  JOURNAL   J Cell Physiol 215 (2), 497-505 (2008)
   PUBMED   18064667
  REMARK    GeneRIF: OC-STAMP is a previously unknown, RANKL-induced, multipass
            transmembrane protein that promotes the formation of multinucleated
            osteoclasts. (Osteoclast stimulatory transmembrane protein)
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK014751.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014751.1, AK042271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.53 cM"
     gene            1..1956
                     /gene="Ocstamp"
                     /gene_synonym="4833422F24Rik; OC-STAMP"
                     /note="osteoclast stimulatory transmembrane protein"
                     /db_xref="GeneID:74614"
                     /db_xref="MGI:MGI:1921864"
     exon            1..107
                     /gene="Ocstamp"
                     /gene_synonym="4833422F24Rik; OC-STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            108..1107
                     /gene="Ocstamp"
                     /gene_synonym="4833422F24Rik; OC-STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1956
                     /gene="Ocstamp"
                     /gene_synonym="4833422F24Rik; OC-STAMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1861..1866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ocstamp"
                     /gene_synonym="4833422F24Rik; OC-STAMP"
                     /note="hexamer: ATTAAA"
     polyA_site      1878
                     /gene="Ocstamp"
                     /gene_synonym="4833422F24Rik; OC-STAMP"
                     /note="major polyA site"
ORIGIN      
        1 gactcccgat ccccacactt cctcttcacc tgctgtgcct ccagaacaca gctttcaaag
       61 actatgagga ccatcagggc agccacggaa cacctctttg gcttggggtg gaagttctgg
      121 cgcttgggga tctgcaaggc agttgttcca ctgcaggctg cctggaaagc cttctcccag
      181 cctgtcccag ccagctgtaa cgaactactg acccagcttc tcctgtgtgt ttccttggcc
      241 agtcttatcg caggcctggc gcatcactgg ctggtctctt tgcagcttta tcctttggga
      301 ccccctgccc tggtgacctc tctctgtggt ctcttcgtct tcctaagcct gggcctggtg
      361 ccccccatcc gctgcctatt tgtgctcagt gtgccaaccc tgggctccaa gcagggccgc
      421 cgcttgctcc tgtcctacag tgcagccaac ctggctgtcg ctgtggtgcc aaacgtctta
      481 ggcaatgtgc gtgcagctgg gcaagtgctg agctgtgtta ctgagggctc tttggagagt
      541 ctgcttaata ccacttacca gctgcgccag gcagccaggg aactgggccc agccagccga
      601 gcaggcagcc gcagcctgac atttgaggtc gagggcaagg gctcagcctt ccgccttcac
      661 atgcacacga tcactcagga gatcctggaa gacttctctg gcctggagtt cctggctcga
      721 gcagcactgg gcactcagcg ggtggtcacc gggttgttcc tgctgggcct cctgggagag
      781 tcggcctggt accttcatcg ctacctcact gacctgcgtt tcgacaatat ctacgcgact
      841 cggcagctgg ttcggcagct ggcccaggct ggtgccacac atctgctgac ctctccgcct
      901 ccgtggctgc tccaaacagc ccagcctaag ttgtcacggg aggagctgct gagctgtctc
      961 ctaaggctgg ggctactggc attgctctta gtagccacag ctgtgacagt ggcctcagac
     1021 tatggggcct tcctcttggc acaagcagct gtagcctggg ctcagaagtt acccactgtc
     1081 ccaatcacac tcacagtcaa atatgacgcc tcatataagg ttctggactt catcctcttc
     1141 gtcctcaacc aacctccggt ggagagcgtg tttgcctcca tgcagcgctc cttccagtgg
     1201 gagctgcgct tcacgcccca cgactgtcat ctaccacagg ctcaaccacc ccgtgtcacc
     1261 gctgctctgg cggcgggcgc cctgcaactg ctggcgggcg ccaccttggt gctacaggcc
     1321 tacgcctggc gcctgcgcca caccatcgca gcctccttct tcccagacca ggaggccagg
     1381 aggcttagcc acttgcaggc ccggctccag aggagacaca accagagtga ccacctgaac
     1441 aaacagcccg gcactatggc cacccgggaa tccaggaagc ctggacaggg aactcggact
     1501 ctggagtcac agggacctca ggcacatgac tcccttgggc ctccatatga cctcgagtag
     1561 gtcgttgcac atctcggagc ttcagtttcc aaatctacat aataattggg cgtggcaaca
     1621 gtgatctgct tttcacgggg aatgtgcgcg aaatcgcagc gagtggaagg tcgggaagac
     1681 gcggctgcgg taactggacg tttgggagga ccagaccgcc cagtcccttt ccgctagaca
     1741 gccctgataa catcctcaat ggagaccctg caagtggatt cacctcggca ctcctccaat
     1801 ttacaagcct ttgagaattc acgttaatct gcaagtttga tcttacaaat gagcatagtc
     1861 attaaataga agagtaaatg gtgttgctct ttcctgctcc tttggggcct ttccatctag
     1921 acttctgacg tttagtgaat aaaaatacaa gatgcc
//
