LOCUS       NM_033039                735 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus oncomodulin (Ocm), mRNA.
ACCESSION   NM_033039 XM_001001609
VERSION     NM_033039.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 735)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   2  (bases 1 to 735)
  AUTHORS   Lachgar-Ruiz,M., Ingham,N.J., Martelletti,E., Chen,J., James,E.,
            Panganiban,C., Lewis,M.A. and Steel,K.P.
  TITLE     Two new mouse alleles of Ocm and Slc26a5
  JOURNAL   Hear Res 452, 109109 (2024)
   PUBMED   39241555
REFERENCE   3  (bases 1 to 735)
  AUTHORS   Goodrich,E.J. and Deans,M.R.
  TITLE     Emx2 lineage tracing reveals antecedent patterns of planar polarity
            in the mouse inner ear
  JOURNAL   Development 151 (10) (2024)
   PUBMED   38682291
REFERENCE   4  (bases 1 to 735)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 735)
  AUTHORS   Yang,Y., Murtha,K., Climer,L.K., Ceriani,F., Thompson,P.,
            Hornak,A.J., Marcotti,W. and Simmons,D.D.
  TITLE     Oncomodulin regulates spontaneous calcium signalling and maturation
            of afferent innervation in cochlear outer hair cells
  JOURNAL   J Physiol 601 (19), 4291-4308 (2023)
   PUBMED   37642186
  REMARK    GeneRIF: Oncomodulin regulates spontaneous calcium signalling and
            maturation of afferent innervation in cochlear outer hair cells.
REFERENCE   6  (bases 1 to 735)
  AUTHORS   Hsiao,C.D., Tsai,W.Y. and Tsai,H.J.
  TITLE     Isolation and expression of two zebrafish homologues of parvalbumin
            genes related to chicken CPV3 and mammalian oncomodulin
  JOURNAL   Mech Dev 119 Suppl 1, S161-S166 (2002)
   PUBMED   14516679
REFERENCE   7  (bases 1 to 735)
  AUTHORS   Staubli,F., Klein,A., Rentsch,J.M., Hameister,H. and Berchtold,M.W.
  TITLE     Structure and chromosomal localization of the mouse oncomodulin
            gene
  JOURNAL   Mamm Genome 6 (11), 769-777 (1995)
   PUBMED   8597631
REFERENCE   8  (bases 1 to 735)
  AUTHORS   Ritzler,J.M., Sawhney,R., Geurts van Kessel,A.H., Grzeschik,K.H.,
            Schinzel,A. and Berchtold,M.W.
  TITLE     The genes for the highly homologous Ca(2+)-binding proteins
            oncomodulin and parvalbumin are not linked in the human genome
  JOURNAL   Genomics 12 (3), 567-572 (1992)
   PUBMED   1559707
REFERENCE   9  (bases 1 to 735)
  AUTHORS   Banville,D., Rotaru,M. and Boie,Y.
  TITLE     The intracisternal A particle derived solo LTR promoter of the rat
            oncomodulin gene is not present in the mouse gene
  JOURNAL   Genetica 86 (1-3), 85-97 (1992)
   PUBMED   1468649
REFERENCE   10 (bases 1 to 735)
  AUTHORS   Banville,D. and Boie,Y.
  TITLE     Retroviral long terminal repeat is the promoter of the gene
            encoding the tumor-associated calcium-binding protein oncomodulin
            in the rat
  JOURNAL   J Mol Biol 207 (3), 481-490 (1989)
   PUBMED   2474657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121917.2.
            
            On Nov 16, 2011 this sequence version replaced NM_033039.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EL956645.1, ERR3363658.3031409.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC121917.2         31056-31184
            130-197             AC121917.2         55952-56019
            198-330             AC121917.2         57105-57237
            331-440             AC121917.2         57732-57841
            441-735             AC121917.2         61564-61858
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 82.85 cM"
     gene            1..735
                     /gene="Ocm"
                     /note="oncomodulin"
                     /db_xref="GeneID:18261"
                     /db_xref="MGI:MGI:97401"
     exon            1..129
                     /gene="Ocm"
                     /inference="alignment:Splign:2.1.0"
     exon            130..197
                     /gene="Ocm"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..466
                     /gene="Ocm"
                     /note="OM; parvalbumin beta"
                     /codon_start=1
                     /product="oncomodulin"
                     /protein_id="NP_149028.2"
                     /db_xref="CCDS:CCDS51693.1"
                     /db_xref="GeneID:18261"
                     /db_xref="MGI:MGI:97401"
                     /translation="MSITDILSADDIAAALQECQDPDTFEPQKFFQTSGLSKMSASQL
                     KDIFQFIDNDQSGYLDEDELKYFLQRFQSDARELTESETKSLMDAADNDGDGKIGADE
                     FQEMVHS"
     exon            198..330
                     /gene="Ocm"
                     /inference="alignment:Splign:2.1.0"
     exon            331..440
                     /gene="Ocm"
                     /inference="alignment:Splign:2.1.0"
     exon            441..735
                     /gene="Ocm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      714..719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ocm"
                     /note="hexamer: AATAAA"
     polyA_site      733
                     /gene="Ocm"
                     /note="major polyA site"
ORIGIN      
        1 gcacatctgt tggaatctac ttctacagaa gaccagatga aacaactagc ctagtgggac
       61 cgagcaacta ctagatcctt ggacttccaa ttcacagctg accactgttg gggagttgga
      121 ctacagactg tagaaaatga gcatcacgga cattctgagc gctgatgaca ttgcagcggc
      181 cctgcaggaa tgccaagacc cagacacctt tgaaccacaa aagttcttcc agacatcggg
      241 cctctccaag atgtctgcca gccaattgaa ggatatcttc cagttcatag acaacgacca
      301 gagtggatac ctggatgaag atgagctcaa gtatttccta cagaggttcc agagcgacgc
      361 tagagaactg accgagtcag agaccaagtc cttgatggat gcagcggaca acgatggaga
      421 tgggaagatt ggggctgatg aattccagga aatggtgcat tcttaaagcc caagtcttca
      481 gaagaaagag aggaaggggc attctgccag aaggattcaa aagccctggg actgggatgc
      541 tccccaccct accccgaact aatttaccaa gtccccctga agctcttctg caacgtgctc
      601 cttgcttgag ggaatgcaat ggtttgtggc tcttccttct ttggtggtgg tggataggtc
      661 ctgatgactt ctgtaagccc ccatctggca gacaaggcct ttaaaaatca cccaataaaa
      721 taatttctca tcatt
//
