LOCUS       NM_001360536            4098 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus occludin (Ocln), transcript variant 2, mRNA.
ACCESSION   NM_001360536 XM_006517563
VERSION     NM_001360536.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4098)
  AUTHORS   Lin,H.H., Yu,I.S., Cheng,M.S., Chang,T.J., Lin,H.Y., Chang,Y.C.,
            Ko,C.J., Chen,P.H., Lin,S.W., Huang,T.C., Huang,S.Y., Chen,T.Y.,
            Kan,K.W., Huang,H.P. and Lee,M.S.
  TITLE     Spint1 disruption in mouse pancreas leads to glucose intolerance
            and impaired insulin production involving HEPSIN/MAFA
  JOURNAL   Nat Commun 15 (1), 10537 (2024)
   PUBMED   39627229
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4098)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
REFERENCE   3  (bases 1 to 4098)
  AUTHORS   Wang,S., Ma,Y., Li,W., Zhao,Y., Gao,Y. and Wang,S.
  TITLE     LncRNA SNHG5/IGF2BP1/Occludin axis regulates Nd2O3 induced
            blood-testis barrier disruption
  JOURNAL   Environ Pollut 358, 124527 (2024)
   PUBMED   38992831
  REMARK    GeneRIF: LncRNA SNHG5/IGF2BP1/Occludin axis regulates Nd2O3 induced
            blood-testis barrier disruption.
REFERENCE   4  (bases 1 to 4098)
  AUTHORS   Zhu,Y., Huang,Y., Tang,T. and Xie,Y.
  TITLE     HDAC1 and HDAC2 orchestrate Wnt signaling to regulate neural
            progenitor transition during brain development
  JOURNAL   iScience 27 (9), 110600 (2024)
   PUBMED   39224519
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4098)
  AUTHORS   Mak,S. and Hammes,A.
  TITLE     Canonical and Non-Canonical Localization of Tight Junction Proteins
            during Early Murine Cranial Development
  JOURNAL   Int J Mol Sci 25 (3), 1426 (2024)
   PUBMED   38338705
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4098)
  AUTHORS   Furuse,M., Sasaki,H., Fujimoto,K. and Tsukita,S.
  TITLE     A single gene product, claudin-1 or -2, reconstitutes tight
            junction strands and recruits occludin in fibroblasts
  JOURNAL   J Cell Biol 143 (2), 391-401 (1998)
   PUBMED   9786950
REFERENCE   7  (bases 1 to 4098)
  AUTHORS   Morita,K., Itoh,M., Saitou,M., Ando-Akatsuka,Y., Furuse,M.,
            Yoneda,K., Imamura,S., Fujimoto,K. and Tsukita,S.
  TITLE     Subcellular distribution of tight junction-associated proteins
            (occludin, ZO-1, ZO-2) in rodent skin
  JOURNAL   J Invest Dermatol 110 (6), 862-866 (1998)
   PUBMED   9620290
REFERENCE   8  (bases 1 to 4098)
  AUTHORS   Saitou,M., Fujimoto,K., Doi,Y., Itoh,M., Fujimoto,T., Furuse,M.,
            Takano,H., Noda,T. and Tsukita,S.
  TITLE     Occludin-deficient embryonic stem cells can differentiate into
            polarized epithelial cells bearing tight junctions
  JOURNAL   J Cell Biol 141 (2), 397-408 (1998)
   PUBMED   9548718
REFERENCE   9  (bases 1 to 4098)
  AUTHORS   Ohsugi,M., Larue,L., Schwarz,H. and Kemler,R.
  TITLE     Cell-junctional and cytoskeletal organization in mouse blastocysts
            lacking E-cadherin
  JOURNAL   Dev Biol 185 (2), 261-271 (1997)
   PUBMED   9187087
REFERENCE   10 (bases 1 to 4098)
  AUTHORS   Ando-Akatsuka,Y., Saitou,M., Hirase,T., Kishi,M., Sakakibara,A.,
            Itoh,M., Yonemura,S., Furuse,M. and Tsukita,S.
  TITLE     Interspecies diversity of the occludin sequence: cDNA cloning of
            human, mouse, dog, and rat-kangaroo homologues
  JOURNAL   J Cell Biol 133 (1), 43-47 (1996)
   PUBMED   8601611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158536.2.
            
            On Feb 6, 2018 this sequence version replaced XM_006517563.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U49185.1, AK033532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AC158536.2         2896-3050
            156-272             AC158536.2         14430-14546
            273-945             AC158536.2         15681-16353
            946-1107            AC158536.2         20490-20651
            1108-1256           AC158536.2         40439-40587
            1257-1472           AC158536.2         43987-44202
            1473-1644           AC158536.2         49292-49463
            1645-1686           AC158536.2         52637-52678
            1687-4098           AC158536.2         56699-59110
FEATURES             Location/Qualifiers
     source          1..4098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.23 cM"
     gene            1..4098
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /note="occludin"
                     /db_xref="GeneID:18260"
                     /db_xref="MGI:MGI:106183"
     exon            1..155
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /inference="alignment:Splign:2.1.0"
     exon            156..272
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1788
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /EC_number="2.1.1.67"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="occludin isoform 1"
                     /protein_id="NP_001347465.1"
                     /db_xref="CCDS:CCDS26731.1"
                     /db_xref="GeneID:18260"
                     /db_xref="MGI:MGI:106183"
                     /translation="MSVRPFESPPPYRPDEFKPNHYAPSNDMYGGEMHVRPMLSQPAY
                     SFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTGLFGGSL
                     NYPYSGFGYGGGYGGGYGGYGYGYGGYTDPRAAKGFLLAMAAFCFIASLVIFVTSVIR
                     SGMSRTRRYYLIVIIVSAILGIMVFIATIVYIMGVNPTAQASGSMYGSQIYMICNQFY
                     TPGGTGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSN
                     ILWDKEHIYDEQPPNVEEWVKNVSAGTQDMPPPPSDYAERVDSPMAYSSNGKVNGKRS
                     YPESFYKSTPLVPEVAQEIPLTLSVDDFRQPRYSSNGNLETPSKRAPTKGKAGKGKRT
                     DPDHYETDYTTGGESCEELEEDWVREYPPITSDQQRQLYKRNFDAGLQEYKSLQAELD
                     DVNKELSRLDKELDDYREESEEYMAAADEYNRLKQVKGSADYKSKRNYCKQLKSKLSH
                     IKRMVGDYDRRKP"
     exon            273..945
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1107
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1256
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1472
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1644
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1686
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..4098
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2813..2818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /note="hexamer: ATTAAA"
     polyA_site      2836
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /note="major polyA site"
     regulatory      4074..4079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ocln"
                     /gene_synonym="Ocl"
                     /note="hexamer: AATAAA"
     polyA_site      4098
                     /gene="Ocln"
                     /gene_synonym="Ocl"
ORIGIN      
        1 ggagtttcag gtgaatgggt caccgaggga ggaggctggc cacgccacac ctcgtcgcta
       61 gtgcccacct cccggcccct ctttccttag gcgacagcgg tggagttgcg ggagagcggt
      121 ccagcgcacg gagcaaccgg ctaggggctc ggcaggttcg cttatcttgg gagcctggac
      181 attttgctca tcataaagat taggtgacca gtgacatcag ccatgtccgt gaggcctttt
      241 gaaagtccac ctccttacag acctgatgaa ttcaaaccca atcattatgc accaagcaat
      301 gacatgtatg gcggagagat gcatgtccgg ccgatgctct ctcagccagc gtactctttt
      361 tatccggaag atgaaattct tcacttctac aaatggacgt cgcccccagg ggtgatccgg
      421 atcctgtcta tgctcattat tgtgatgtgc atcgccatat ttgcctgtgt ggcttccaca
      481 cttgcttggg acagaggcta tgggacaggg ctctttggag gaagcctaaa ctacccttat
      541 agtggctttg gctacggagg tggctatgga ggcggctatg gaggctatgg ctatggctat
      601 ggcggatata cagacccaag agcagccaaa ggcttcctgt tggccatggc agccttctgc
      661 ttcatcgctt ccttagtaat atttgtgacc agtgttataa gatctggaat gtccaggaca
      721 agaagatatt acttgatcgt gatcatagtc agcgctatcc tgggcatcat ggtgtttatt
      781 gccacgatcg tgtacataat gggagtgaac ccgacggccc aggcttctgg atctatgtac
      841 ggctcacaga tatatatgat ctgcaaccag ttttatactc ctggaggtac tggtctctac
      901 gtggatcaat atttgtatca ctactgtgtg gttgatcccc aggaggctat agccattgtc
      961 ctggggttca tgattatcgt ggcttttgct ttaatcatct tttttgctgt gaaaacccga
     1021 agaaagatgg atcggtatga taagtccaat attttgtggg ataaggaaca catttatgat
     1081 gaacagcccc ccaatgttga agagtgggtt aaaaatgtgt ctgcaggcac acaggacatg
     1141 cctccacccc catctgacta tgcggaaaga gttgacagtc caatggccta ctcctccaat
     1201 ggcaaagtga atggcaagcg atcataccca gagtctttct ataagtcaac acctctggtg
     1261 cctgaagtgg cccaggagat tcctctgacc ttgagtgtgg atgacttcag gcagcctcgg
     1321 tacagcagca atggtaacct agagacacct tctaaaaggg ctcccacgaa ggggaaagca
     1381 ggaaagggca agaggacgga ccctgaccac tatgaaacag actacacgac aggtggggag
     1441 tcctgcgagg agctggagga ggactgggtc agggaatatc cacctatcac ttcagatcaa
     1501 caaagacaac tctacaagag aaattttgat gcaggtctgc aggagtataa gagcttacag
     1561 gcagaactag acgacgtcaa taaagagctc tctcgtctag ataaagagct ggatgactac
     1621 agagaggaga gtgaagagta catggctgct gctgatgaat ataatagact aaagcaagtt
     1681 aagggatctg cagattataa aagtaagagg aattactgca agcagttgaa gagcaaatta
     1741 tcgcacatca agaggatggt gggagattat gacagacgga aaccttagag agatgccagt
     1801 tgcgggagaa gggagaggtg catctgcctg cacgatgtct ctgcaattct ctccagaggc
     1861 aaactgactt tggactctaa tctgggaagt taaaactttg tgatcattac aaagtttccg
     1921 tggctttaat tccatcagtt tcctatctcc agtattgaag cattttataa atggcttttg
     1981 ataattgact gggctgaaca ctccaattaa ggattttaca gtttcaacat tgattcttgt
     2041 attaagaatt aaaatgttgc ttgatatttt aaatgtcaag aaaggtcctg gtgtgagctg
     2101 tgatgtgtgt tgagctttga tgtgaaggtt cacacgccag gcagtgtgtt cctccaggta
     2161 gaccgtctaa tcaatctttg cagcagccct caggtgactg ttatttagaa tcaggttgtt
     2221 tttggttttc cagacagggt ttctctgtgt agccctggct gacctagaac ttacgctgta
     2281 gaccaggctg gccttgaact cacacagctt ctctgagtgc tggttcagga gttaacgtcg
     2341 tggaccggta tcatcacttt tcctgcggtg acttctccaa actgaaactg ctaaggcagt
     2401 tttggctaag tctgttttat gactgcaaat gacagcattc ctgcctttgt atttcagggg
     2461 aaatacgata cattatatcg gccacgttcc ccaccactgt ttttcttata ttgactttta
     2521 acaaatgaat aggattattt ttggctttac attttttcct aacacttaag atcatataaa
     2581 attaacaagt atgtgaaatt taagaattgt aaatatatat ttacgtttga aagatgattt
     2641 taaatccagg gttaaagtgc tttttatctt gtatagttta catgcttttt tttttttttt
     2701 ttgataaccc actagacctt tccattgtat cagagtatcc aattacattt acaattatga
     2761 cttgaattgt atttcacagg aatgctcaag ttttgtacat attttataag gtattaaacc
     2821 tgatgttctc tttctataat gtgctcattt gatgtcatta gtactgttct attcagttgt
     2881 gcaaagctat actaaagttt cagtgtgtga actaccttgg gtgctgtgct agcaggtgat
     2941 tgcccagtcc ttgggcagtg aacaaaactc tgactagaaa tgggataatg ttcatagaac
     3001 agcatgatac ttaaacagtg tctgtaaatc ccaggatgtt ctttataaat taaaattttt
     3061 gttaatagta taaaattagc tgatagtgct tcatagacca cattgacatc cagcccaatt
     3121 tggtctgttt tagctgaaaa tgttttatat acctttcaga catggcagta catattcttg
     3181 tttatacaat ttttgaatta ttttccaatg ataaaaattt aaataatgtt tttgtataat
     3241 actgggtcaa tttttttttc aaattaaaga aaaattttat tttctacatg ctgaacatag
     3301 tacaaaaaag tattttcgtc ccttttggat tgacatcgag taggaaagac tgtttggagc
     3361 tccttaactg gtcattatgt taattaacgt ctccctcttg gaaatcattg ttcttttctg
     3421 ttgttttgtt ttgatttaga cagggtttca ctaggtagct caagatggca gacttcaaat
     3481 ttgcagtcct cctgcctccc actccccggg tggcaggtag attagaggtt ctcctccagg
     3541 cctggctcct ccgtagttta tgaagccaat ttgctagtgt cctcacaaag caggtctgtt
     3601 ctgttagatg aagaaaatga agtggcagga attataaaac tgtgccataa aattagatgt
     3661 tggaagagta aaagaaataa ttcttttcca acgtggtgct accactgcag gcctgaagcc
     3721 agtaccaggg tgtgtccatc ggtctgttca ggcagtttct taatgtaaaa taggggctag
     3781 attaaacctt agaggcgttt tacattctga cctatggttt ttggttttca tacctacgtt
     3841 ctgttagtaa aactattctt tacatgcttt ttttttcaat agttatgtga aaacataacc
     3901 cttcttatga agttccctgc attaaatgat gcgcacgtgt gtgtgttatt gtaagttggt
     3961 aagatcaagg tttccatttt gaaaagctga aaacattaga ataaacatac atgaactaac
     4021 ccctccccca ggaaaggcaa tgatgttttg ttgtgtgtgc tttatatttt tgaaataaag
     4081 tctagtattt acagtaaa
//
