LOCUS       NM_023429               1529 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus OCIA domain containing 1 (Ociad1), transcript variant
            1, mRNA.
ACCESSION   NM_023429
VERSION     NM_023429.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1529)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1529)
  AUTHORS   Tscherner,A.K., McClatchie,T., Macaulay,A.D. and Baltz,J.M.
  TITLE     Relationship of quantitative reverse transcription polymerase chain
            reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome
            identifies mouse preimplantation embryo reference genesdagger
  JOURNAL   Biol Reprod 109 (5), 601-617 (2023)
   PUBMED   37669129
REFERENCE   3  (bases 1 to 1529)
  AUTHORS   Li,X., Wang,L., Cykowski,M., He,T., Liu,T., Chakranarayan,J.,
            Rivera,A., Zhao,H., Powell,S., Xia,W. and Wong,S.T.C.
  TITLE     OCIAD1 contributes to neurodegeneration in Alzheimer's disease by
            inducing mitochondria dysfunction, neuronal vulnerability and
            synaptic damages
  JOURNAL   EBioMedicine 51, 102569 (2020)
   PUBMED   31931285
  REMARK    GeneRIF: OCIAD1 contributes to neurodegeneration in Alzheimer's
            disease by inducing mitochondria dysfunction, neuronal
            vulnerability and synaptic damages.
REFERENCE   4  (bases 1 to 1529)
  AUTHORS   Sinha,S., Dwivedi,T.R., Yengkhom,R., Bheemsetty,V.A., Abe,T.,
            Kiyonari,H., VijayRaghavan,K. and Inamdar,M.S.
  TITLE     Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains
            mouse hematopoietic stem cell quiescence
  JOURNAL   Blood 133 (22), 2385-2400 (2019)
   PUBMED   30952670
  REMARK    GeneRIF: Asrij sequesters CSN5 via its conserved OCIA domain,
            thereby preventing p53 degradation.
REFERENCE   5  (bases 1 to 1529)
  AUTHORS   Sinha,A., Khadilkar,R.J., S,V.K., Roychowdhury Sinha,A. and
            Inamdar,M.S.
  TITLE     Conserved regulation of the Jak/STAT pathway by the endosomal
            protein asrij maintains stem cell potency
  JOURNAL   Cell Rep 4 (4), 649-658 (2013)
   PUBMED   23972987
  REMARK    GeneRIF: Asrij regulates mouse embryonic stem cell pluripotency via
            JAK/STAT signaling.
REFERENCE   6  (bases 1 to 1529)
  AUTHORS   Mukhopadhyay,A., Das,D. and Inamdar,M.S.
  TITLE     Embryonic stem cell and tissue-specific expression of a novel
            conserved gene, asrij
  JOURNAL   Dev Dyn 227 (4), 578-586 (2003)
   PUBMED   12889067
  REMARK    GeneRIF: Asrij is expressed predominantly in mouse embryonic blood
            vessels; a splice variant is expressed in the brain, and can serve
            as an early stem cell marker.
REFERENCE   7  (bases 1 to 1529)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1529)
  AUTHORS   Abidari,J.M., Gonzales,E.T., Inoue,K., Lupski,J.R., Karsenty,G. and
            Katsanis,N.
  TITLE     Identification of novel genes expressed during metanephric
            induction through single-cell library screening
  JOURNAL   Kidney Int 57 (6), 2221-2228 (2000)
   PUBMED   10844592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078102.1 and AK077904.1.
            
            On May 7, 2009 this sequence version replaced NM_023429.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077904.1, AK078909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-740               AK078102.1         2-741
            741-1529            AK077904.1         711-1499
FEATURES             Location/Qualifiers
     source          1..1529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 38.44 cM"
     gene            1..1529
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /note="OCIA domain containing 1"
                     /db_xref="GeneID:68095"
                     /db_xref="MGI:MGI:1915345"
     exon            1..183
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            184..246
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..932
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /note="isoform 1 is encoded by transcript variant 1; OCIA
                     domain-containing protein 1; expressed during mesenchymal
                     induction 2; induced during mesenchymal induction 2"
                     /codon_start=1
                     /product="OCIA domain-containing protein 1 isoform 1"
                     /protein_id="NP_075918.1"
                     /db_xref="CCDS:CCDS19339.1"
                     /db_xref="GeneID:68095"
                     /db_xref="MGI:MGI:1915345"
                     /translation="MNGRADFREPNAQVSRPIPDIGGGYIPTEEEWRLFAECHEECFW
                     FRSVPLAATSMLITQGLISKGILSSHPKYGSIPKLLFACIVGYFAGKLSYVKTCQEKF
                     KKLENSPLGEALRSGELRRSSPPGHYTQKPKFDSNVSGQSSFGTSPAADNIEKEALPR
                     YEPIPFSASMNESTPTGITDHIAQGPEPNLEESPKRKGVTYEELRSKNRESYGVTLPH
                     KTDPSVRPMQERVPKKEVKVNKYGDTWDE"
     exon            247..327
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            328..381
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            382..429
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            430..565
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            566..741
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            742..894
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1529
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1373..1378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /note="hexamer: AATAAA"
     polyA_site      1393
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /note="major polyA site"
     regulatory      1510..1515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
                     /note="hexamer: AATACA"
     polyA_site      1521
                     /gene="Ociad1"
                     /gene_synonym="6030432N09Rik; Asrij; B230209J16Rik; Emi2;
                     Imi2; OCIA; TPA018"
ORIGIN      
        1 aagggtactg cttccgggtg tcggcctgct ggcgctcgtg tgtgggtgac atcttggcga
       61 tcgcttggaa gctgccctct ttcccctccc cgcttcccgc gttgtccgct gtgcctgtct
      121 ctggggtcct ctcccggcct ctaccccggg tcctgctccc agcgttgccg cctccatcgt
      181 gaggaactat gaatgggagg gctgattttc gagaaccgaa tgcacaagtg tcaagaccta
      241 ttcccgacat aggaggcggt tatattccga cagaggagga gtggagactc tttgcagagt
      301 gccatgaaga gtgcttctgg ttcagatctg tgccgttggc tgccacaagt atgctgatta
      361 ctcaaggatt aattagtaaa ggaatcctgt caagtcatcc aaaatatggt tcaattccta
      421 aacttctatt cgcttgtatc gtggggtact tcgctggaaa gctttcttac gtgaaaacgt
      481 gccaagagaa gttcaagaag cttgaaaact ccccccttgg agaagcactg cggtcgggag
      541 aattgcggcg ctcttctcca ccagggcact atactcaaaa gcctaaattt gactcaaatg
      601 tgagtggtca gtcctctttc gggacatctc cagcagcaga caacatagaa aaggaggcgc
      661 ttcctcgtta tgagccaatt ccatttagtg cttctatgaa cgagtccact cccactggta
      721 ttactgacca tattgcccaa ggacctgagc ccaaccttga agaaagtccc aaaagaaaag
      781 gtgttacata tgaggaatta aggagtaaga acagagagtc ctatggagta actttacccc
      841 acaagactga cccctcagtc aggcccatgc aggaaagagt gcccaaaaaa gaagtcaaag
      901 taaacaaata tggagatact tgggatgagt gaaagactcc catcattgga cctactgaag
      961 gccttccttc catatccagc ttcatccagg tgtcgtttgt acctacatgc ttggactcag
     1021 cagcagattt cataaataca gttaaaacga aatcctggtt tgtgtaattt aacatacgat
     1081 gctttacaga ctcagatttt atgtttgcta ttgtgtaaat gtaccagcct gggcactgag
     1141 aacggtgggt ttatgccata gttgtgtgca cttggtgaaa ttgttttcag ttacagggag
     1201 agactcatga aactcaactg tgactctcga tcagcccagc ccatgtgacg ataactgata
     1261 gtgcatgttg agggggggag gggggagcaa gcacacgcct agggctcagc ttcgcatcag
     1321 ttattaaaag gcctttctcc agcatttctc gagcatctta atgtttgtga tgaataaaat
     1381 gtaaaaacac ggagcaactg tcattcacat ttttatggct ttgtttgaaa tttgctaatg
     1441 cgttttaatg taaaggtctt atgtaagtgg tattttaagc aaaagaaatt tgtgatgcaa
     1501 atagactcca atacacagta atagctgtc
//
