LOCUS       NM_010953               1798 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus otoconin 90 (Oc90), transcript variant 1, mRNA.
ACCESSION   NM_010953 XM_128141
VERSION     NM_010953.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1798)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1798)
  AUTHORS   Szeto,I.Y.Y., Chu,D.K.H., Chen,P., Chu,K.C., Au,T.Y.K.,
            Leung,K.K.H., Huang,Y.H., Wynn,S.L., Mak,A.C.Y., Chan,Y.S.,
            Chan,W.Y., Jauch,R., Fritzsch,B., Sham,M.H., Lovell-Badge,R. and
            Cheah,K.S.E.
  TITLE     SOX9 and SOX10 control fluid homeostasis in the inner ear for
            hearing through independent and cooperative mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 119 (46), e2122121119 (2022)
   PUBMED   36343245
REFERENCE   3  (bases 1 to 1798)
  AUTHORS   Xu,Y., Yang,L., Zhao,X., Zhang,Y., Jones,T.A., Jones,S.M. and
            Lundberg,Y.W.
  TITLE     Functional cooperation between two otoconial proteins Oc90 and Nox3
  JOURNAL   J Vestib Res 31 (6), 441-449 (2021)
   PUBMED   33554930
  REMARK    GeneRIF: Functional cooperation between two otoconial proteins Oc90
            and Nox3.
REFERENCE   4  (bases 1 to 1798)
  AUTHORS   Xu,Y., Zhang,Y. and Lundberg,Y.W.
  TITLE     Spatiotemporal differences in otoconial gene expression
  JOURNAL   Genesis 54 (12), 613-625 (2016)
   PUBMED   27792272
REFERENCE   5  (bases 1 to 1798)
  AUTHORS   Hartman,B.H., Durruthy-Durruthy,R., Laske,R.D., Losorelli,S. and
            Heller,S.
  TITLE     Identification and characterization of mouse otic sensory lineage
            genes
  JOURNAL   Front Cell Neurosci 9, 79 (2015)
   PUBMED   25852475
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1798)
  AUTHORS   Pasqualetti,M., Neun,R., Davenne,M. and Rijli,F.M.
  TITLE     Retinoic acid rescues inner ear defects in Hoxa1 deficient mice
  JOURNAL   Nat Genet 29 (1), 34-39 (2001)
   PUBMED   11528388
REFERENCE   7  (bases 1 to 1798)
  AUTHORS   Wang,Y., Thalmann,I., Thalmann,R. and Ornitz,D.M.
  TITLE     Mapping the mouse otoconin-90 (Oc90) gene to chromosome 15
  JOURNAL   Genomics 58 (2), 214-215 (1999)
   PUBMED   10366455
REFERENCE   8  (bases 1 to 1798)
  AUTHORS   Verpy,E., Leibovici,M. and Petit,C.
  TITLE     Characterization of otoconin-95, the major protein of murine
            otoconia, provides insights into the formation of these inner ear
            biominerals
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 529-534 (1999)
   PUBMED   9892667
REFERENCE   9  (bases 1 to 1798)
  AUTHORS   Wang,Y., Kowalski,P.E., Thalmann,I., Ornitz,D.M., Mager,D.L. and
            Thalmann,R.
  TITLE     Otoconin-90, the mammalian otoconial matrix protein, contains two
            domains of homology to secretory phospholipase A2
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15345-15350 (1998)
   PUBMED   9860971
REFERENCE   10 (bases 1 to 1798)
  AUTHORS   Kowalski,P.E., Freeman,J.D., Nelson,D.T. and Mager,D.L.
  TITLE     Genomic structure and evolution of a novel gene (PLA2L) with
            duplicated phospholipase A2-like domains
  JOURNAL   Genomics 39 (1), 38-46 (1997)
   PUBMED   9027484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091276.7.
            
            On Aug 26, 2022 this sequence version replaced NM_010953.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012981.1, AF093591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC091276.7         158562-158610       c
            50-142              AC091276.7         155283-155375       c
            143-205             AC091276.7         147826-147888       c
            206-262             AC091276.7         146914-146970       c
            263-437             AC091276.7         143989-144163       c
            438-550             AC091276.7         138675-138787       c
            551-679             AC091276.7         135908-136036       c
            680-718             AC091276.7         135731-135769       c
            719-769             AC091276.7         134419-134469       c
            770-817             AC091276.7         133905-133952       c
            818-871             AC091276.7         130144-130197       c
            872-985             AC091276.7         128848-128961       c
            986-1157            AC091276.7         127827-127998       c
            1158-1264           AC091276.7         125050-125156       c
            1265-1798           AC091276.7         122377-122910       c
FEATURES             Location/Qualifiers
     source          1..1798
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 29.16 cM"
     gene            1..1798
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /note="otoconin 90"
                     /db_xref="GeneID:18256"
                     /db_xref="MGI:MGI:1313269"
     exon            1..49
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            50..142
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1554
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; otoconin-95; phospholipase A2-like like"
                     /codon_start=1
                     /product="otoconin-90 isoform 1 precursor"
                     /protein_id="NP_035083.1"
                     /db_xref="CCDS:CCDS27508.1"
                     /db_xref="GeneID:18256"
                     /db_xref="MGI:MGI:1313269"
                     /translation="MIMLLMVGMLMAPCVGAHALDTPNPQELPPGLSKNINITFFNGV
                     FKNVESVAEIFDCLGSHFTWLQAVFTNFPLLLQFVNSMRCVTGLCPRDFEDYGCACRF
                     EMEGMPVDESDICCFQHRRCYEEAVEMDCLQDPAKLSADVDCTNKQITCESEDPCERL
                     LCTCDKAAVECLAQSGINSSLNFLDASFCLPQTPETTSGKAATLLPRGIPEKPTDTSQ
                     IALSGEVAGEVRADTLTTLSRTKSVQDLQDTQASRTTSSPGSAEIIALAKGTTHSAGI
                     KPLRLGVSSVDNGSQEAAGKACDRLAFVHLGDGDSMTAMLQLGEMLFCLTSHCPEEFE
                     TYGCYCGREGRGEPRDTLDRCCLSHHCCLEQMRQVGCLHGRRSQSSVVCEDHMAKCVG
                     QSLCEKLLCACDQMAAECMASAFFNQSLKSPDGAECQGEPVSCEDGMLQGTLASSVDS
                     SSEENSEEAPPQMERLRRFLEKPPGPLGARPLGGK"
     exon            143..205
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            206..262
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            263..437
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            438..550
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            551..679
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            680..718
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            719..769
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            770..817
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            818..871
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            872..985
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1157
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1264
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1798
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1779..1784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /note="hexamer: AATAAA"
     polyA_site      1798
                     /gene="Oc90"
                     /gene_synonym="oc95; Ocn-95; PLA2L; Pla2ll"
                     /note="major polyA site"
ORIGIN      
        1 aagcaacact ggatcattca acagccttcg agtggagctt cacttcacgg aagctgctct
       61 agcctatgcc tacaccttgt cctctgcact gccacaatga ttatgctgct catggtcggt
      121 atgctgatgg ccccctgtgt tggggcccat gctctggaca caccaaatcc ccaggaattg
      181 cctccaggac tgtcaaaaaa tataaatatc actttcttca atggagtgtt taaaaacgtg
      241 gaaagtgtgg ctgaaatttt tgactgccta ggttcccact tcacctggct gcaggctgtc
      301 ttcaccaact tcccgctgct cctccagttt gtaaacagta tgaggtgtgt aactggcctc
      361 tgcccccggg actttgaaga ctatggttgt gcctgtaggt ttgagatgga agggatgcct
      421 gtggacgagt ctgatatctg ctgcttccag catcgcaggt gctatgagga agctgttgag
      481 atggactgtc tccaagaccc tgccaagctc agtgcagatg tggattgcac caacaaacag
      541 atcacatgtg agtccgagga tccctgtgag cgtctactgt gtacgtgtga caaggctgct
      601 gtggagtgcc tggctcagtc tggcatcaac tcctccctga acttcctgga tgcttccttc
      661 tgcctccctc agactccaga gacaactagt gggaaggctg caacactgtt gcctagaggg
      721 attcctgaaa agcccacaga taccagtcag atagccctgt caggagaagt ggctggtgag
      781 gtgagagcag acacactaac aaccctctcc agaacaaagt ctgttcaaga tcttcaagac
      841 acacaagctt ctaggaccac atcaagtcca ggatctgcag agattattgc cctagccaaa
      901 ggtacaaccc actctgctgg catcaaacca ctgaggttgg gagtctcatc tgttgacaat
      961 ggttcccagg aagcagctgg aaaagcctgt gacagattgg ccttcgtgca tctgggtgat
     1021 ggggacagca tgacggccat gctgcagctt ggagagatgc tcttctgtct aacatcccat
     1081 tgcccagagg aatttgaaac ttacggctgc tactgtggaa gagaaggaag aggagagcca
     1141 agggacaccc tggataggtg ctgtctgtcc catcactgct gtttggagca gatgagacaa
     1201 gtgggctgcc tccatggaag gcgttctcag tcatctgtgg tatgtgaaga ccacatggcc
     1261 aaatgtgtgg ggcagagcct gtgtgagaag ctactatgtg cctgtgacca gatggcagct
     1321 gagtgcatgg cctctgcctt ctttaatcaa agcctcaagt caccagacgg agccgagtgt
     1381 caaggcgagc ctgtgtcctg tgaggatggc atgctccagg gcaccttggc ctcttctgtg
     1441 gactccagtt ctgaggagaa tagtgaggaa gctccaccgc agatggaacg cctaagaaga
     1501 tttctggaaa agcctcctgg tcccttgggg gccagacccc tcggtgggaa ataagatgct
     1561 acgtgctagt agctctaagc tgtctgagcc ctttggccct cagtcccacc cataggagcc
     1621 ttagcagggt ctccaaggga gcagggacag ccaccccttt atccatgagt ctccccttta
     1681 tccacgagcc tcctgaaact tgtcagcaca gatacatgtg tctggagaat aactgcagat
     1741 gacagccctt ttcttcctgt agttcactat ggaagctcaa taaattctct atgccaca
//
