LOCUS       NM_001403113            6046 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus obscurin-like 1 (Obsl1), transcript variant 3, mRNA.
ACCESSION   NM_001403113 XM_006496583
VERSION     NM_001403113.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6046)
  AUTHORS   Blondelle,J., Marrocco,V., Clark,M., Desmond,P., Myers,S.,
            Nguyen,J., Wright,M., Bremner,S., Pierantozzi,E., Ward,S.,
            Esteve,E., Sorrentino,V., Ghassemian,M. and Lange,S.
  TITLE     Murine obscurin and Obsl1 have functionally redundant roles in
            sarcolemmal integrity, sarcoplasmic reticulum organization, and
            muscle metabolism
  JOURNAL   Commun Biol 2, 178 (2019)
   PUBMED   31098411
  REMARK    GeneRIF: Skeletal muscle-specific Obsl1 knockouts show a benign
            phenotype similar to obscurin knockouts. Only deletion of both
            proteins and removal of their functional redundancy revealed their
            roles for sarcolemmal stability and sarcoplasmic reticulum
            organization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6046)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6046)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115011.27 and AEKQ02010695.1.
            
            On Mar 28, 2022 this sequence version replaced XM_006496583.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.544.1, SRR10223969.481.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1240              AC115011.27        77878-79117
            1241-1510           AC115011.27        80364-80633
            1511-1762           AC115011.27        80712-80963
            1763-2065           AC115011.27        81115-81417
            2066-2362           AC115011.27        82075-82371
            2363-2635           AC115011.27        84156-84428
            2636-2908           AC115011.27        85983-86255
            2909-3181           AC115011.27        87050-87322
            3182-3454           AC115011.27        90273-90545
            3455-3730           AC115011.27        91185-91460
            3731-4018           AC115011.27        91537-91824
            4019-4294           AC115011.27        91988-92263
            4295-4564           AC115011.27        92873-93142
            4565-4837           AC115011.27        93262-93534
            4838-5104           AC115011.27        94581-94847
            5105-5217           AC115011.27        95629-95741
            5218-5374           AC115011.27        96268-96424
            5375-5536           AC115011.27        96540-96701
            5537-5641           AC115011.27        97003-97107
            5642-5694           AC115011.27        97421-97473
            5695-5895           AEKQ02010695.1     7254-7454
            5896-5911           AC115011.27        97675-97690
            5912-6046           AC115011.27        98371-98505
FEATURES             Location/Qualifiers
     source          1..6046
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 39.15 cM"
     gene            1..6046
                     /gene="Obsl1"
                     /note="obscurin-like 1"
                     /db_xref="GeneID:98733"
                     /db_xref="MGI:MGI:2138628"
     exon            1..1240
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..5919
                     /gene="Obsl1"
                     /EC_number="2.7.11.18"
                     /note="isoform 3 is encoded by transcript variant 3;
                     obscurin-like protein 1"
                     /codon_start=1
                     /product="obscurin-like protein 1 isoform 3"
                     /protein_id="NP_001390042.1"
                     /db_xref="GeneID:98733"
                     /db_xref="MGI:MGI:2138628"
                     /translation="MKAGSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPTVV
                     WEKGGQQLVASERLSFPEDGAEHGLLLSGALPTDAGVYVCRARNAAGEAYAAAAVTVL
                     EPPAPEPEPESSECPLPTPGTGEGAPKFLTGPQSQWVLRGEEVVLTCQVGGLPEPKLY
                     WEKDGMALDEVWDSSHFKLEPGRGASDEGASLTLRILAARLPDSGVYVCHARNAHGHA
                     QAGALLQVHQPRESPPQDPDENPKPVLEPLKGAPKTFWVNEGKHAKFRCYVMGKPEPE
                     IEWHLEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL
                     HVKEPRLRFTRPLQDVEGREHGIVVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEG
                     AVRRLVIHKLKADDDGVYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLV
                     ETQEAGVQGCWSRDGEDLPDTCQSSCGHMHALVLPGVTREDAGEITFSLGNSRTTTLL
                     RVKCVKHSPPGPPVMVEMFKGQKNKVLLTWKPPEPPPETSFIYRLERQEVGSDDWIQC
                     FSIEKAGAVEVPGDCVPTEGDYHFRICTVSEHGRSPHVVFNGSAHLVPTARLVSGLED
                     VQVYDGEDAVFSLDLSAIIQGSWFLNGEQLQSNEPEGQVEPGALRYRIEQKGLQHRLI
                     LQAVKHRDSGALVGFSCPGVQDSAALTIQESSVHILSPQDKVSLTFTTSERVVLTCEL
                     SRVDFPATWYKDGQKVEESESLIVKTEGRKHRLILPEAQVRDSGEFECRTEGVSAFFG
                     VTVQDPPVHIVNPQEHVFVHAITSECVRLTCEVDREDTTVHWYKDGQEVEESDIIVLE
                     NKGPHHRLVLPAARPSDGGEFQCVAGDERAYFTVTITDVFSWIVYPSSEVHVAAVRLE
                     RVVLTCELCRPWAEVRWTKDGEEVVESPALLLEKEDTIRRLVLPSVQLEDSGEYLCEI
                     HDESASFTITVTEPPVRIIYPQDEVTLHAVSLECVVLTCELSREDAPVRWYKDGLEVE
                     ESEALVLQSDGPRRRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARS
                     LDLQFGAPGHVELRCEVAPAGSQVRWYKDGLEVEVSDALQLGAEGPARTLTLPHAQPE
                     DAGEYVCETRDEAVTFNVSLAELPVQFLAPEAAPNPLCVVPGEPVVLSCELSRASAQV
                     FWSHNGSPVQQGEGLELRAEGPRRILCIQAADLAHTGVYTCQSGASPGAPSLSFNVQV
                     AEPPVRVVAPEAAQTSVRSTPGGDLELVVHLSRPGTPVRWYKDGERLASQGRVQLEQA
                     GARQVLRVRGARRGDAGEYLCDAPQDSRIFIVSVEELPPVKLVSELTPLTVHEGDDAT
                     FQCEVSPPDAEVTWLRNGAVITAGPQLEMVQNGSSRTLIIRGCQLKDAGTVTARAGAA
                     DTSARLHVRETELLFLRRLQDVRAEEGQDVHLEVETGRVGAAGTVRWIRGGEPLPLDS
                     RLTTAQDGHVHRLSIHGVLLTDQGTYGCESRHDRTLARLSVRPRQLRELRPLEDVTVH
                     EGGSATFQLELSQEGVTGEWAQGGVRLHPGPKCHIQSEGRTHRLVLSGLGLADSGCVS
                     FTADTLRCAARLTVREVPVTIVQGPQDLEVTEGDTATFECELSQTLADVIWEKDGQAL
                     SLSPRLRLQALGTRRLLLLRRCCSSDAGTYSCVVGTARSEPARLTVREREVSVLRELR
                     SVSAREGDGATFECTVSETEITGRWELGGRALRPGGRVRIRQEGKKHILVLSELRTED
                     TGEVCFQAGPAQSLARLEVEALPLQMCRRPPREKTVLVNRRAVLEVTVSRPGGHVCWM
                     REGVELCPGNKYEMRRHGTTHSLVIHDVRPEDQGTYSCQAGQDSADTQLLVDGD"
     exon            1241..1510
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1762
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..2065
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2362
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2635
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2908
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3181
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3454
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3730
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3731..4018
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            4019..4294
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            4295..4564
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            4565..4837
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            4838..5104
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5105..5217
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5218..5374
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5375..5536
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5537..5641
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5642..5911
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5912..6046
                     /gene="Obsl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6021..6026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Obsl1"
                     /note="hexamer: AATAAA"
     polyA_site      6046
                     /gene="Obsl1"
                     /note="major polyA site"
ORIGIN      
        1 agtctaggct gtagggcccc tcgctgagca ggcaaacagg aaggacagcc ccctgagctc
       61 tgggctcccg gcccgggaat tgccgcgtag cagggctgcg gccagggtcc agggtaaaga
      121 ggcgagcggt cacaggagtc ccaccggtcc cggcgcccgc tccgccacgc cctggtctcg
      181 gctcccggcc ttcccgcgcg cccaggcgag ccatctgcag cggccgcaat gaaggccgga
      241 tcaggggatc aggggagccc cccgtgtttc ctacgcttcc cgcggcccgt gcgggtggta
      301 agtggagcgg aggccgagct caaatgcgtg gtcctgggag agccgccgcc cactgtcgtg
      361 tgggagaaag gcgggcagca gctggtggcc tccgagcgcc taagctttcc ggaggacggc
      421 gccgagcacg gcctgctgct gagcggcgcg ctgcccaccg acgccggggt ctacgtgtgc
      481 cgcgcccgca acgcggccgg agaggcctac gcggcggccg ccgtcaccgt gctggaaccc
      541 ccggcccccg agccggagcc cgagtcctcc gagtgtccgc tgccaacacc gggcaccggg
      601 gagggcgccc cgaagttcct gacggggccc cagtcccagt gggtgctgcg aggggaggag
      661 gtggtgctga cgtgccaggt gggaggcctt ccggagccca agctgtactg ggagaaggat
      721 gggatggcct tggacgaagt atgggacagc agccacttca agctggagcc cggccgcggc
      781 gcgagtgacg agggcgcgag cctgacgttg cgcatcctgg cggcacggct gcccgattcc
      841 ggggtgtacg tgtgtcacgc ccgcaacgcg cacggccacg cgcaggcggg cgcgctgctc
      901 caggtgcacc agccccgcga gagcccgccc caggatcccg atgagaaccc caaacccgtg
      961 ttggagccgc tcaaaggcgc gcccaagacc ttctgggtga acgagggcaa gcacgccaaa
     1021 ttccgctgct acgtgatggg caaacctgag cccgagatcg aatggcactt ggagggccgc
     1081 cctctgctcc ccgatcgccg ccgcctcatg taccgcgacc gcgacggcgg ctttgtactt
     1141 aaggtgctct actgccaggc caaggaccgt gggctctacg tgtgcgcggc gcgcaactcg
     1201 gcgggccaga ccctaagcgc ggtccagctg cacgtgaaag aaccccgcct acggttcacc
     1261 cggcccctgc aggatgtgga gggtcgggaa cacgggattg tggtgctgga gtgtaaagta
     1321 cctaactctc gaattcccac cgcctggttc cgggaggacc aacggctgtt accctgccgc
     1381 aagtacgagc agatcgagga gggcgctgtg agacgcctcg tcatccacaa gctgaaggcc
     1441 gatgatgatg gcgtctatct gtgcgagatg cggggccgag tgcgcactgt ggccaatgtg
     1501 acggtcaaag gacccatcct gaagcgttta ccccggaagc ttgacgtcct ggaaggagag
     1561 aacgcagtac tgctggtgga gactcaagaa gctggggtgc aggggtgctg gagccgtgat
     1621 ggggaggacc tgccagacac ctgccagagc agttgtggtc atatgcatgc cctggtcctt
     1681 ccaggggtga cccgagaaga tgctggagag atcaccttca gcctgggcaa ctcccgtacc
     1741 accaccctgc tcagagtcaa atgtgtcaag cacagtcctc ccgggccccc cgtaatggtt
     1801 gagatgttca aaggccaaaa gaacaaggtt ctgctgacct ggaagccccc agagccacct
     1861 ccagagacct ccttcatcta ccgcctagag cggcaggaag tggggtctga cgattggatc
     1921 cagtgcttca gcattgagaa ggcgggagcc gtagaggtgc ccggggactg tgtacccacc
     1981 gagggtgact atcacttccg catctgcaca gtcagtgaac atggccgcag tccccatgtc
     2041 gtgttcaacg gttctgctca ccttgtgccc acagctcgcc tggtgtcagg cctggaagac
     2101 gtgcaggtat atgatgggga agatgccgtc ttctcccttg atctgtccgc catcatccag
     2161 ggctcttggt tccttaatgg agagcagctc cagagtaatg agccagaggg ccaggtggag
     2221 cctggagccc tgcggtaccg catagagcag aagggcctcc agcacaggct catcctgcaa
     2281 gctgtcaagc accgggacag tggggccctg gttggcttca gctgccctgg tgtgcaagac
     2341 tctgctgccc tcactatcca agaaagctca gtgcacatcc tgagtcccca ggacaaggtg
     2401 tcactgacct tcacgacctc tgaacgggta gtgctgacct gtgagctctc aagggtggat
     2461 tttcctgcaa cctggtacaa ggatgggcag aaggtggagg agagcgagtc gctcatagtg
     2521 aagacagagg gccgcaaaca ccgactgatc ctgcctgagg ctcaagtccg agacagcggt
     2581 gaatttgagt gcagaacgga aggggtctcg gccttctttg gagtcactgt tcaagatccc
     2641 ccagtgcaca tcgtgaaccc ccaagagcat gtgtttgtcc atgccatcac ctccgagtgt
     2701 gtcaggctga cctgtgaggt agaccgagag gacacaactg tacactggta caaggatggg
     2761 caggaggtgg aggagagtga catcatcgta ttagaaaata aagggcccca tcaccgcctg
     2821 gtgctacctg cagcccggcc ctccgacggg ggcgagttcc agtgtgtcgc aggagatgaa
     2881 cgtgcctact tcacagttac catcacagat gtcttctcgt ggatcgtcta ccccagtagc
     2941 gaagtgcatg tggcagccgt acgcctagag cgtgtggtgc tgacctgtga gctgtgccga
     3001 ccctgggctg aggtgcgctg gaccaaagat ggggaggagg tagtggagag cccagcactg
     3061 ctcctggaga aggaagacac catccgccgc ctggtgctgc cctctgtcca gcttgaggat
     3121 tctggcgagt acctgtgtga aatccatgat gagtcggctt ccttcaccat caccgtcaca
     3181 gagccccctg tgcggatcat atacccccag gacgaggtga ccttacacgc cgtgagtttg
     3241 gaatgtgtgg tgctcacctg tgagctgtct agagaggatg ctcctgtacg ctggtacaag
     3301 gatgggttag aggtggagga gagtgaagcc ctggtgctcc agagcgatgg gcctcgtcgc
     3361 cgtctggtgt tgcctgctgc ccagccagag gacgggggcg agtttgtgtg tgatgctggg
     3421 gatgattcag ccttcttcac tgtcactgtc acagctccac cagaaaggat tgtgcaccca
     3481 gcggcccgat ccctggattt gcagtttggg gctccaggac acgtggagct acgctgcgaa
     3541 gtggccccgg ctgggtctca ggtgcgctgg tacaaggatg gcctagaggt agaggtgtca
     3601 gatgcgctgc agctgggtgc tgaggggcct gcccgcactc tcaccctgcc ccacgcccag
     3661 cctgaggatg ccggggagta tgtatgtgag acccgagatg aggctgtcac cttcaacgtc
     3721 agcctggctg agcttccggt gcagtttctg gctccagagg cagccccaaa tccgctctgc
     3781 gtggttcctg gggagcccgt ggtgctgagc tgtgagctgt cccgagcaag cgcacaagtg
     3841 ttctggagcc acaatgggag cccggtgcag cagggtgaag gactagagct gcgagctgag
     3901 ggtcctcgca gaatcctctg catccaggca gcagacctcg ctcacacagg tgtctacact
     3961 tgccaatctg gggcatcccc aggggcccca agcctcagct tcaatgtcca ggtggctgag
     4021 cccccagtgc gggtagtggc ccccgaggca gcccagacga gtgttcgaag caccccaggt
     4081 ggggacctag agctggtggt gcacctctcc aggccaggga cccctgtgcg ctggtacaag
     4141 gacggggagc gcctggcaag ccaggggcgg gtacagctgg aacaagccgg ggcgaggcag
     4201 gtgctgcggg tgcggggggc acggagaggg gatgctgggg aatacctgtg cgacgcaccc
     4261 caggacagtc gcatcttcat cgtcagtgtg gaagagctcc cgccagtgaa gctggtctct
     4321 gaactgacgc ctctgacagt ccatgagggg gacgatgcca cattccagtg tgaggtttca
     4381 ccaccagatg ccgaagtcac ctggctacgc aacggagcgg ttatcactgc agggccacag
     4441 ttggaaatgg tccagaatgg ttcaagccgc accttgatca tccgaggctg ccaactcaaa
     4501 gacgcaggga ccgtgaccgc gcgagccgga gctgctgaca caagtgccag gctccacgtt
     4561 cgagagacag agctgctgtt cttgcggcgg ctgcaggatg tgcgggccga ggaaggccag
     4621 gatgtgcacc ttgaggtaga gacaggccga gttggtgcag ctggaactgt tcgctggata
     4681 cgaggtgggg aacctcttcc cctggactct cgcctgacca cggctcagga tggccatgtc
     4741 caccgcctct ctatccatgg cgttctactt accgaccagg gcacctacgg ctgtgagagc
     4801 cgccacgatc gcaccctggc caggctcagt gtgaggcctc ggcagctgag ggaacttcgg
     4861 cctctggagg atgtgaccgt ccatgagggg ggcagtgcca ccttccagct ggagctgtcc
     4921 caggagggtg tgaccggaga gtgggcccag ggtggagtcc ggctgcaccc agggcccaag
     4981 tgccacattc aatcagaagg ccgcactcac cgcttggtgc taagcggcct gggtctggct
     5041 gactcgggct gtgtctcctt cactgcggac acccttcggt gtgctgctcg gctcacagtg
     5101 agagaggtcc cagtgactat tgtgcagggg ccacaggacc tagaagtgac tgaaggtgac
     5161 acagccacgt tcgagtgcga gctttcccag actttggctg acgtaatatg ggagaaggat
     5221 gggcaggcgc tctctctcag cccacgcctc cggctccagg ctctcggcac gcgccgcctt
     5281 ctgcttctgc ggcgttgctg ctcctcagac gccgggacct acagctgcgt tgtggggaca
     5341 gctcgctccg agcctgcgcg cttgaccgta cgcgaacgag aggtgtctgt actccgtgaa
     5401 ctccggtccg ttagtgcccg cgaaggagac ggcgccacgt ttgagtgcac tgtgtcggag
     5461 accgagatca ccgggcgctg ggagctcgga ggccgcgcgc tgagacccgg aggccgcgtc
     5521 cgcatccgac aggaagggaa gaaacacatt ctggtgctga gcgagctgag aaccgaggac
     5581 accggagaag tctgcttcca ggcgggaccc gcccagtcct tggctcggct ggaggtggag
     5641 gcgttgcctc tccagatgtg ccgccgccca cctcgtgaga agacggttct ggtcaaccgc
     5701 agggcggtgt tggaggtgac tgtgtcccgc cctgggggcc acgtgtgttg gatgcgggag
     5761 ggggtcgaac tctgcccggg aaacaagtat gagatgcgta gacacggcac cacccacagc
     5821 ctagtcatcc atgacgtccg acctgaggac cagggcacct acagctgcca agcaggccag
     5881 gacagtgctg acacacagct gctggtagat ggtgactaga ggactgaaac acaccaagca
     5941 ggtgcccttg gacaatttgg aaggagcgta cccttatgct gggcagggtg gggagggagg
     6001 agccagaggt atcaggtaac aataaagatg ctaatgttca tgccca
//
