LOCUS       NM_001378280             905 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus odorant binding protein 2B (Obp2b), mRNA.
ACCESSION   NM_001378280
VERSION     NM_001378280.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 905)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 905)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 905)
  AUTHORS   Lee,J.T., Huang,Z., Pan,K., Zhang,H.J., Woo,C.W., Xu,A. and
            Wong,C.M.
  TITLE     Adipose-derived lipocalin 14 alleviates hyperglycaemia by
            suppressing both adipocyte glycerol efflux and hepatic
            gluconeogenesis in mice
  JOURNAL   Diabetologia 59 (3), 604-613 (2016)
   PUBMED   26592241
  REMARK    GeneRIF: Reduced LCN14 expression is involved in the pathogenesis
            of obesity-related metabolic dysregulation. LCN14 exerts its
            beneficial effects on glucose homeostasis and insulin sensitivity
            via its actions in both adipocytes and hepatocytes.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX649340.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               BX649340.3         34588-34724
            138-271             BX649340.3         35242-35375
            272-342             BX649340.3         35580-35650
            343-453             BX649340.3         36109-36219
            454-555             BX649340.3         36806-36907
            556-582             BX649340.3         37170-37196
            583-905             BX649340.3         37383-37705
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.91 cM"
     gene            1..905
                     /gene="Obp2b"
                     /gene_synonym="Lcn14"
                     /note="odorant binding protein 2B"
                     /db_xref="GeneID:383678"
                     /db_xref="MGI:MGI:3651927"
     exon            1..137
                     /gene="Obp2b"
                     /gene_synonym="Lcn14"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..581
                     /gene="Obp2b"
                     /gene_synonym="Lcn14"
                     /note="novel lipocalin protein; lipocalin 14"
                     /codon_start=1
                     /product="odorant-binding protein 2a precursor"
                     /protein_id="NP_001365209.1"
                     /db_xref="CCDS:CCDS38080.1"
                     /db_xref="GeneID:383678"
                     /db_xref="MGI:MGI:3651927"
                     /translation="MKSLLLTILLLGLVAVLKAQEAPPDDLEDFSGIWYTQAMVSDRN
                     HTDGKRPMKVFPMTVIALEGGSLEAQLTFWDNGHCHMKKILMHKTDEPHKYTAFKGKK
                     TIYIQETSVKGYYILYCEGQRHGRSHRKGKLIGTNSEKNPEAMEEFKKFAMSKGFREE
                     NIIVPEQLDQCVSGSN"
     exon            138..271
                     /gene="Obp2b"
                     /gene_synonym="Lcn14"
                     /inference="alignment:Splign:2.1.0"
     exon            272..342
                     /gene="Obp2b"
                     /gene_synonym="Lcn14"
                     /inference="alignment:Splign:2.1.0"
     exon            343..453
                     /gene="Obp2b"
                     /gene_synonym="Lcn14"
                     /inference="alignment:Splign:2.1.0"
     exon            454..555
                     /gene="Obp2b"
                     /gene_synonym="Lcn14"
                     /inference="alignment:Splign:2.1.0"
     exon            556..582
                     /gene="Obp2b"
                     /gene_synonym="Lcn14"
                     /inference="alignment:Splign:2.1.0"
     exon            583..905
                     /gene="Obp2b"
                     /gene_synonym="Lcn14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacactctg cccaggtgac ctgccttgtg tgagagccca gtgcctggag atgaagagcc
       61 tgctcctcac catcctgctg ctggggctgg tggctgtcct gaaggctcag gaagccccgc
      121 cagatgacct ggaggatttc tctgggatct ggtacacaca ggccatggtg tctgacagga
      181 atcacacaga tgggaagaga cctatgaaag tgttccctat gaccgtgata gccctggaag
      241 gagggagctt agaggcccag ctaacattct gggacaatgg tcattgtcac atgaaaaaaa
      301 ttttgatgca taaaactgac gagcctcaca agtacactgc cttcaagggc aagaagacca
      361 tctatataca ggagacttct gtaaagggct actacatctt gtattgtgaa ggccagcgcc
      421 atgggaggtc acatcggaag gggaaactca tagggacaaa ctctgagaaa aacccagagg
      481 ccatggaaga attcaagaaa tttgcaatga gcaagggatt cagagaagaa aacatcattg
      541 tacccgagca gctggatcag tgtgtgtctg ggagtaacta gggaacatgc agacacttgc
      601 caggtcacac gtgtaagaaa cagtcactct cctgcctatg gctctccagc aataactgca
      661 caaatgcttg aggatagaag accactggcc agcgcctccc actccgctgt attctcattg
      721 gcacagcagc cagcccatca tggatgcact tgctgatcct gccctaaagc caactcagtt
      781 ctgagacgcc cttggcgctc cctaaccctg gaccattttc ctcaccttca ctgatggact
      841 tccctttgac cttggcttca cctgccccca gccccagcga ctcctaataa agcatttcag
      901 catca
//
