LOCUS       NM_153558                738 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus odorant binding protein 2A (Obp2a), mRNA.
ACCESSION   NM_153558
VERSION     NM_153558.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 738)
  AUTHORS   Qin,X., Tan,Y., Ren,W., Zhou,W., Niu,R., Liang,L., Li,J., Cao,K.,
            Wei,G., Zhu,X. and Huang,M.
  TITLE     Elevated expression of LCN13 through FXR activation ameliorates
            hepatocellular lipid accumulation and inflammation
  JOURNAL   Int Immunopharmacol 131, 111812 (2024)
   PUBMED   38493698
  REMARK    GeneRIF: Elevated expression of LCN13 through FXR activation
            ameliorates hepatocellular lipid accumulation and inflammation.
REFERENCE   2  (bases 1 to 738)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 738)
  AUTHORS   Buhler,L., Maida,A., Vogl,E.S., Georgiadi,A., Takacs,A., Kluth,O.,
            Schurmann,A., Feuchtinger,A., von Toerne,C., Tsokanos,F.F.,
            Klepac,K., Wolff,G., Sakurai,M., Ekim Ustunel,B., Nawroth,P. and
            Herzig,S.
  TITLE     Lipocalin 13 enhances insulin secretion but is dispensable for
            systemic metabolic control
  JOURNAL   Life Sci Alliance 4 (4), e202000898 (2021)
   PUBMED   33536239
  REMARK    GeneRIF: Lipocalin 13 enhances insulin secretion but is dispensable
            for systemic metabolic control.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 738)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 738)
  AUTHORS   Ekim Ustunel,B., Friedrich,K., Maida,A., Wang,X., Krones-Herzig,A.,
            Seibert,O., Sommerfeld,A., Jones,A., Sijmonsma,T.P., Sticht,C.,
            Gretz,N., Fleming,T., Nawroth,P.P., Stremmel,W., Rose,A.J.,
            Berriel-Diaz,M., Bluher,M. and Herzig,S.
  TITLE     Control of diabetic hyperglycaemia and insulin resistance through
            TSC22D4
  JOURNAL   Nat Commun 7, 13267 (2016)
   PUBMED   27827363
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 738)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   7  (bases 1 to 738)
  AUTHORS   Pehrson,J.R., Changolkar,L.N., Costanzi,C. and Leu,N.A.
  TITLE     Mice without macroH2A histone variants
  JOURNAL   Mol Cell Biol 34 (24), 4523-4533 (2014)
   PUBMED   25312643
REFERENCE   8  (bases 1 to 738)
  AUTHORS   Sheng,L., Cho,K.W., Zhou,Y., Shen,H. and Rui,L.
  TITLE     Lipocalin 13 protein protects against hepatic steatosis by both
            inhibiting lipogenesis and stimulating fatty acid beta-oxidation
  JOURNAL   J Biol Chem 286 (44), 38128-38135 (2011)
   PUBMED   21908604
  REMARK    GeneRIF: LCN13 decreases liver lipid levels by both inhibiting
            hepatic lipogenesis and stimulating beta-oxidation
REFERENCE   9  (bases 1 to 738)
  AUTHORS   Cho,K.W., Zhou,Y., Sheng,L. and Rui,L.
  TITLE     Lipocalin-13 regulates glucose metabolism by both insulin-dependent
            and insulin-independent mechanisms
  JOURNAL   Mol Cell Biol 31 (3), 450-457 (2011)
   PUBMED   21135134
  REMARK    GeneRIF: LCN13 regulates glucose metabolism by both
            insulin-dependent and insulin-independent mechanisms.
REFERENCE   10 (bases 1 to 738)
  AUTHORS   Suzuki,K., Lareyre,J.J., Sanchez,D., Gutierrez,G., Araki,Y.,
            Matusik,R.J. and Orgebin-Crist,M.C.
  TITLE     Molecular evolution of epididymal lipocalin genes localized on
            mouse chromosome 2
  JOURNAL   Gene 339, 49-59 (2004)
   PUBMED   15363845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC027556.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027556.1, AY360148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.8 cM"
     gene            1..738
                     /gene="Obp2a"
                     /gene_synonym="Lcn13"
                     /note="odorant binding protein 2A"
                     /db_xref="GeneID:227627"
                     /db_xref="MGI:MGI:2387617"
     exon            1..104
                     /gene="Obp2a"
                     /gene_synonym="Lcn13"
                     /inference="alignment:Splign:2.1.0"
     exon            105..238
                     /gene="Obp2a"
                     /gene_synonym="Lcn13"
                     /inference="alignment:Splign:2.1.0"
     exon            239..309
                     /gene="Obp2a"
                     /gene_synonym="Lcn13"
                     /inference="alignment:Splign:2.1.0"
     exon            310..423
                     /gene="Obp2a"
                     /gene_synonym="Lcn13"
                     /inference="alignment:Splign:2.1.0"
     exon            424..525
                     /gene="Obp2a"
                     /gene_synonym="Lcn13"
                     /inference="alignment:Splign:2.1.0"
     exon            526..549
                     /gene="Obp2a"
                     /gene_synonym="Lcn13"
                     /inference="alignment:Splign:2.1.0"
     exon            550..713
                     /gene="Obp2a"
                     /gene_synonym="Lcn13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      694..699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Obp2a"
                     /gene_synonym="Lcn13"
                     /note="hexamer: AATAAA"
     polyA_site      713
                     /gene="Obp2a"
                     /gene_synonym="Lcn13"
                     /note="major polyA site"
ORIGIN      
        1 gagcccagtg cctggagatg aagagcctgc tcctcaccat cctgctgctg gggctggtgg
       61 ctgtcctgaa ggctcaggaa gccccgccag atgacctggt ggattactct gggatctggt
      121 acgcaaaggc catggtacac aatggtaccc tacccagtca caagataccc agtatagttt
      181 tccctgtgag aataatagct ctggaagaag gagacttgga gaccacagtt gtattctgga
      241 acaatggtca ttgccgtgag tttaaattcg tgatgaagaa aacagaagag cctggcaaat
      301 acaccgcttt tcataacacg aaggttattc atgtggaaaa gacgtcggtg aatgagcact
      361 acattttcta ctgcgaaggc cggcacaatg ggacgtcgtc attcgggatg ggaaagctca
      421 tggggagaga ctctggtgaa aatccagagg ccatggaaga atttaagaat ttcataaagc
      481 gcatgaatct ccgactggaa aacatgtttg tgccagagat cggagataaa tgtgttgaaa
      541 gtgactaggc agctacccag gtctgcaaca gctgagccag ccttgcttcc aacaccaagc
      601 tgggacatcc cttcaccaca cctctcctgg accaaacttc ccactgcttc accaccacca
      661 cctcagtacc tgctcccctc tcccctgact ccaaataaat ctctttagca gtgaaaaaaa
      721 aaaaaaaaaa aaaaaaaa
//
