LOCUS       NM_008754                757 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus odorant binding protein IA (Obp1a), mRNA.
ACCESSION   NM_008754
VERSION     NM_008754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 757)
  AUTHORS   DeVoss,J.J., LeClair,N.P., Hou,Y., Grewal,N.K., Johannes,K.P.,
            Lu,W., Yang,T., Meagher,C., Fong,L., Strauss,E.C. and Anderson,M.S.
  TITLE     An autoimmune response to odorant binding protein 1a is associated
            with dry eye in the Aire-deficient mouse
  JOURNAL   J Immunol 184 (8), 4236-4246 (2010)
   PUBMED   20237294
  REMARK    GeneRIF: A novel lacrimal gland autoantigen OBP1a is expressed in
            the thymus in an Aire-dependent fashion, suggesting that defective
            thymic expression of OBP1a may play a role in the spontaneous
            dacryoadenitis that develops in the Aire-deficient mouse model.
REFERENCE   2  (bases 1 to 757)
  AUTHORS   Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
            Frierson,H.F. Jr. and Laurie,G.W.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
   PUBMED   15851553
REFERENCE   3  (bases 1 to 757)
  AUTHORS   Thavathiru,E., Jana,N.R. and De,P.K.
  TITLE     Abundant secretory lipocalins displaying male and
            lactation-specific expression in adult hamster submandibular gland.
            cDNA cloning and sex hormone-regulated repression
  JOURNAL   Eur J Biochem 266 (2), 467-476 (1999)
   PUBMED   10561587
REFERENCE   4  (bases 1 to 757)
  AUTHORS   Pes,D., Mameli,M., Andreini,I., Krieger,J., Weber,M., Breer,H. and
            Pelosi,P.
  TITLE     Cloning and expression of odorant-binding proteins Ia and Ib from
            mouse nasal tissue
  JOURNAL   Gene 212 (1), 49-55 (1998)
   PUBMED   9661663
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK017455.1.
            
            On Apr 6, 2007 this sequence version replaced NM_008754.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017455.1, CK616557.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164141
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-757               AK017455.1         2-758
FEATURES             Location/Qualifiers
     source          1..757
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.33 cM"
     gene            1..757
                     /gene="Obp1a"
                     /gene_synonym="OBP-1a; OBP5"
                     /note="odorant binding protein IA"
                     /db_xref="GeneID:18249"
                     /db_xref="MGI:MGI:1277949"
     exon            1..103
                     /gene="Obp1a"
                     /gene_synonym="OBP-1a; OBP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..544
                     /gene="Obp1a"
                     /gene_synonym="OBP-1a; OBP5"
                     /note="odorant-binding protein Ia; odorant binding protein
                     5; odorant-binding protein 1a"
                     /codon_start=1
                     /product="odorant-binding protein 1a precursor"
                     /protein_id="NP_032780.2"
                     /db_xref="CCDS:CCDS30251.1"
                     /db_xref="GeneID:18249"
                     /db_xref="MGI:MGI:1277949"
                     /translation="MAKFLLLALTFGLAHAAMEGPWKTVAIAADRVDKIERGGELRIY
                     CRSLTCEKECKEMKVTFYVNENGQCSLTTITGYLQEDGKTYKTQFQGNNRYKLVDESP
                     ENLTFYSENVDRADRKTKLLFILGHGPLTSEQKEKFAELAEEKGIPAGNIREVLITDY
                     CPE"
     exon            104..243
                     /gene="Obp1a"
                     /gene_synonym="OBP-1a; OBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            244..317
                     /gene="Obp1a"
                     /gene_synonym="OBP-1a; OBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            318..428
                     /gene="Obp1a"
                     /gene_synonym="OBP-1a; OBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            429..527
                     /gene="Obp1a"
                     /gene_synonym="OBP-1a; OBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            528..557
                     /gene="Obp1a"
                     /gene_synonym="OBP-1a; OBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            558..757
                     /gene="Obp1a"
                     /gene_synonym="OBP-1a; OBP5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      757
                     /gene="Obp1a"
                     /gene_synonym="OBP-1a; OBP5"
                     /note="putative"
ORIGIN      
        1 acaactactt atctgctttg agcttctgta gaaaagaaag tcttgtacca tcatggcaaa
       61 atttctgctg cttgctttga catttggact ggcacatgct gcgatggaag gaccatggaa
      121 aactgttgct attgctgctg atagagtaga caagatagag agaggtggag aactgagaat
      181 ctattgtcgt agccttacct gtgaaaagga atgcaaggaa atgaaagtca cattttatgt
      241 caatgaaaat ggacagtgct cattgaccac aatcactggg tatttgcaag aagatggcaa
      301 gacctacaaa actcagtttc aagggaataa tcgttataaa cttgtggatg agtcacctga
      361 gaacttaaca ttttatagtg agaacgtgga cagagctgac cggaaaacaa aattgctatt
      421 tattcttggc catggccctt taacttctga acaaaaggaa aaatttgctg aacttgctga
      481 agaaaaggga attccagctg gaaacatcag agaagtcctg attacagatt actgtcctga
      541 atgaagtact tctgcatatt taaaaacagg atcagaatta tggatcatgt ggtcttgacc
      601 ttgaaatcaa tatcatctat aattaacttg ttctttcaaa acaactttcc ctcccttgtg
      661 aagtcagggt attacatacc aaaatctaaa catgcctttc cttccccttc tcatgatctt
      721 ccttttttga atgacttaat aaagtgattt aagaagc
//
