LOCUS       NM_026047               3456 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus ORC ubiquitin ligase 1 (Obi1), mRNA.
ACCESSION   NM_026047
VERSION     NM_026047.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3456)
  AUTHORS   Du,H., Chen,C., Wang,Y., Yang,Y., Che,Z., Liu,X., Meng,S., Guo,C.,
            Xu,M., Fang,H., Wang,F., Lin,C. and Luo,Z.
  TITLE     RNF219 interacts with CCR4-NOT in regulating stem cell
            differentiation
  JOURNAL   J Mol Cell Biol 12 (11), 894-905 (2020)
   PUBMED   33104214
  REMARK    GeneRIF: RNF219 interacts with CCR4-NOT in regulating stem cell
            differentiation.
REFERENCE   2  (bases 1 to 3456)
  AUTHORS   Hwang,J.S., Kim,E., Hur,J., Yoon,T.J. and Seo,H.G.
  TITLE     Ring finger protein 219 regulates inflammatory responses by
            stabilizing sirtuin 1
  JOURNAL   Br J Pharmacol 177 (20), 4601-4614 (2020)
   PUBMED   32220064
  REMARK    GeneRIF: Ring finger protein 219 regulates inflammatory responses
            by stabilizing sirtuin 1.
REFERENCE   3  (bases 1 to 3456)
  AUTHORS   Zheng,S., Damoiseaux,R., Chen,L. and Black,D.L.
  TITLE     A broadly applicable high-throughput screening strategy identifies
            new regulators of Dlg4 (Psd-95) alternative splicing
  JOURNAL   Genome Res 23 (6), 998-1007 (2013)
   PUBMED   23636947
REFERENCE   4  (bases 1 to 3456)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   5  (bases 1 to 3456)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   6  (bases 1 to 3456)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 3456)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3456)
  AUTHORS   Peterson,K.A., King,B.L., Hagge-Greenberg,A., Roix,J.J., Bult,C.J.
            and O'Brien,T.P.
  TITLE     Functional and comparative genomic analysis of the piebald deletion
            region of mouse chromosome 14
  JOURNAL   Genomics 80 (2), 172-184 (2002)
   PUBMED   12160731
REFERENCE   9  (bases 1 to 3456)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI986775.1, CN697474.1 and AC121997.3.
            
            On Feb 24, 2006 this sequence version replaced NM_026047.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.45542.1,
                                           SRR1660817.102856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-572               BI986775.1         1-572
            573-1113            CN697474.1         98-638
            1114-3456           AC121997.3         83382-85724         c
FEATURES             Location/Qualifiers
     source          1..3456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 54.24 cM"
     gene            1..3456
                     /gene="Obi1"
                     /gene_synonym="2610206B13Rik; 2810449K13Rik; Obl1; Rnf219"
                     /note="ORC ubiquitin ligase 1"
                     /db_xref="GeneID:72486"
                     /db_xref="MGI:MGI:1919736"
     exon            1..126
                     /gene="Obi1"
                     /gene_synonym="2610206B13Rik; 2810449K13Rik; Obl1; Rnf219"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2223
                     /gene="Obi1"
                     /gene_synonym="2610206B13Rik; 2810449K13Rik; Obl1; Rnf219"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 219"
                     /codon_start=1
                     /product="ORC ubiquitin ligase 1"
                     /protein_id="NP_080323.3"
                     /db_xref="CCDS:CCDS27320.1"
                     /db_xref="GeneID:72486"
                     /db_xref="MGI:MGI:1919736"
                     /translation="MAQTVQNVTLSLTLPITCHICLGKVRQPVVCTNNHVFCSICIDL
                     WLKNNSQCPACRVPITPENPCKEIIGGTSESEPMLSHTVRKHLRKTRLELLHREYEDE
                     IDCLQKEVEELKSKNLSLESQIKTILDPLALMQGSQNEDKHPLADNPSKMDPDSVVEW
                     KKKLRTANEIYEKVKDDVDKLKEANKKLKLENGGLLRENLRLKAEVDNRSPQKFGRFT
                     VAALQSKVEQYERETNRLKKALERSDKYIEELESQVAHLKHSEEAKEDVDALCQRAPS
                     ADSKGPNGSDELGPPKNQSDSARKQAGSASASHLASPSSSRLADSGSVRQESTSRTEP
                     NCPQNKDRYPKPTEPRLGARETPMDTYLEREWGSKPSDCAPYKEDELYGIPASCTPLS
                     LSCLQLNTPENRENPVIKAGSSKKHANHLRKLVFDDFCDSPNACNNNSSEDDRRENEK
                     KSDCFASSKTGFWDCCSTSYAQSLEFDGSEGNAIANSVGEIPSKLSEKSGSCLSKRLS
                     CIRSLEMNRTRTSSEASMDAAYLDKISELDSMMSESDNSKSPCNNGFKSVEVEGPSKS
                     PQGREFLEEPDKLQEGSKLNLSKPALTADGLESGGEWKPSSFFLLSPADHEMSEDFSL
                     HSTSHSGTSEVKPPNCLFQTEFSQGALLSSSQGLFEDQRFGSSLFKMSSEMQSLHSPL
                     QSPWSAAFVPEKRSKNGNQSTKRKIQSSLANASPSKATKS"
     exon            127..262
                     /gene="Obi1"
                     /gene_synonym="2610206B13Rik; 2810449K13Rik; Obl1; Rnf219"
                     /inference="alignment:Splign:2.1.0"
     exon            263..354
                     /gene="Obi1"
                     /gene_synonym="2610206B13Rik; 2810449K13Rik; Obl1; Rnf219"
                     /inference="alignment:Splign:2.1.0"
     exon            355..603
                     /gene="Obi1"
                     /gene_synonym="2610206B13Rik; 2810449K13Rik; Obl1; Rnf219"
                     /inference="alignment:Splign:2.1.0"
     exon            604..692
                     /gene="Obi1"
                     /gene_synonym="2610206B13Rik; 2810449K13Rik; Obl1; Rnf219"
                     /inference="alignment:Splign:2.1.0"
     exon            693..3456
                     /gene="Obi1"
                     /gene_synonym="2610206B13Rik; 2810449K13Rik; Obl1; Rnf219"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3432..3437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Obi1"
                     /gene_synonym="2610206B13Rik; 2810449K13Rik; Obl1; Rnf219"
                     /note="hexamer: AATAAA"
     polyA_site      3454
                     /gene="Obi1"
                     /gene_synonym="2610206B13Rik; 2810449K13Rik; Obl1; Rnf219"
                     /note="major polyA site"
ORIGIN      
        1 gcgaggagct gctgtcggcg ggacttccgt gttggcggga ttctgaacgc tgccatggct
       61 cagaccgtgc agaacgttac attgtccctc actctgccca tcacgtgcca catttgcttg
      121 gggaaggtac gtcagcctgt cgtatgcacc aacaaccatg tgttttgttc catttgcatc
      181 gacttgtggt tgaagaataa tagccagtgt ccagcctgca gagtcccgat cactcctgaa
      241 aacccttgca aagagattat tggaggaacg agtgagagtg agcccatgct gagccatacg
      301 gtcaggaagc acctgcggaa aaccagactg gagctactgc acagagagta tgaggatgaa
      361 atagattgct tgcagaaaga ggtagaagaa cttaaaagta aaaatctcag cttggagtca
      421 cagatcaaga ccattctgga tcctttagcg ttgatgcagg gcagtcaaaa tgaagacaaa
      481 catccactgg ccgataatcc aagtaaaatg gacccagact cagtagtaga gtggaagaaa
      541 aagctgagaa cagctaatga aatatatgaa aaagtaaaag atgatgtgga taagttaaaa
      601 gaggcaaata aaaaattgaa gttggaaaac ggtggcctgc tgagggagaa tttacggctg
      661 aaggctgaag ttgacaacag atctcctcaa aagtttggaa ggtttacagt tgctgctctt
      721 cagtccaaag tagaacagta tgaacgtgaa accaatcgcc tcaagaaagc tctagaacga
      781 agtgataaat atatagagga actagagtct caagtagcac acctgaaaca ctcagaggag
      841 gccaaggaag acgtggatgc tctgtgccag agggcaccct ctgcagatag caaggggccc
      901 aacggcagcg atgagcttgg accaccaaag aatcagagtg acagtgccag aaagcaggct
      961 ggctcggcca gtgcttctca cctggcctca ccttctagca gcagactagc tgactccggt
     1021 tctgtcagac aggagagcac cagcaggact gaaccaaact gtccccaaaa caaagacaga
     1081 taccccaagc ccacagaacc tcggctgggt gcaagagaga ctccgatgga cacttacttg
     1141 gaaagagagt ggggcagcaa gccaagcgac tgtgcacctt acaaagagga tgagctttat
     1201 ggtatcccag cttcctgcac tcccttgtca cttagctgcc ttcagctgaa cactccagaa
     1261 aacagagaga accctgtgat caaagcaggg agctccaaaa agcatgcaaa ccatctcaga
     1321 aaactggtct ttgatgattt ctgtgattct ccaaatgcct gtaataacaa ttcttcagag
     1381 gatgatagaa gggaaaatga aaagaaatca gactgctttg cttcctcaaa gacaggattt
     1441 tgggattgtt gctccacaag ctatgcccag agcttggagt ttgacggttc agagggaaac
     1501 gcaatagcaa actctgttgg ggagatacct tcaaaattga gtgagaagtc aggatcgtgc
     1561 ttgtccaaga gactcagctg tatccgctcc ctcgaaatga atcgaacaag aacatccagt
     1621 gaggcgtcca tggatgctgc ttatctcgac aaaatctctg agctggactc catgatgtca
     1681 gagtctgaca acagcaagag cccttgtaat aacggtttta aatcggtgga ggtggagggg
     1741 ccctcaaagt cacctcaagg cagggagttt ctcgaggaac ctgacaagtt acaagaagga
     1801 agtaaactga acctttccaa acctgctctc acagctgacg ggttagagag tgggggggag
     1861 tggaaaccca gctctttctt tctcctttct ccagctgacc acgagatgag tgaagatttt
     1921 tctctccact ccacttctca ttcaggaact agtgaggtca aacctccaaa ctgtttgttt
     1981 cagacagagt tttcccaggg tgctctgtta agcagttccc agggattatt tgaggatcag
     2041 aggtttggat cgtccttatt taagatgtcc tcagagatgc agagccttca cagccctctt
     2101 cagtctccgt ggtctgctgc ctttgtgcct gaaaagagga gtaagaatgg gaaccagtca
     2161 accaagagaa agatacagag cagccttgcc aacgccagcc cgtccaaagc caccaaaagc
     2221 tgactcacca ggggatagcc ttgcaagggg tgggggtgtt ttcaatgtta ctgtagtcac
     2281 ttcatgaagg ttctatacaa tcctgaactg ataatcttca gtcaagtgtc aactcagaat
     2341 ggtgggtcac ctatctccag ggtactgcat cttgaagaaa ctggtctgtc tctctcgttt
     2401 ggtcatcttt ttaaccagag agcttagaga gatgatcgga tttgtctctg tgttgtttgt
     2461 tctctttgta aggaatgttg tgtgtatctg gattggctcc atattgttct ctcagatctg
     2521 gcttgttagg tatggtggcc tgttaaggct caactgcctt cagaacctgt gtttcttaga
     2581 acatttaatt ttgtctgttc tgttctttaa agcttttcct agaatggaaa tgtgtattcc
     2641 tcattttatt tgtgtttaat gctggcctaa ctattaccaa ggccatgctg gagaaatggc
     2701 actccgatct tagaggattc actgacgttt tcttaggttt tatatagatg tttacaattt
     2761 gttatattgt attctgtcca ttttgtgtgc ctgtgcgtgt gtgtgtttgt gtgtgtgtgt
     2821 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgaacta gtatgaaaga
     2881 gcacattgtt tgtatgaaaa gactttcaag tcatttatat ttgcatattt ttgaacatgt
     2941 gtatgggtgt aaagttagaa tcattatgtg ttggaaggca ggcacatcag ctgggtttgg
     3001 aggaacttaa acatcctagc tccccccccc ccaaatgtgt aggtagacag gccatctgtg
     3061 tcgcagggag cctttttgtg tagtgaagtt cttgtttgca tgttactctc tctgtggcaa
     3121 ccgtaagcat gggagccttt tcgcttgctc cattctccaa ccagagggaa aaaccctctt
     3181 actggctggt gaatgtctta ttatgtagaa cattttttta aaatgagaag taacaggtgt
     3241 gaatggggca atgtgagcgc gaagcacaac tgttagtgta ggatttaaaa gtacgttatt
     3301 ctaaacatgt tcggtatgcc aacataggct ataaaaatgt ctgtatgcta ataacttgct
     3361 tatctaatgt gcgctgaaca ttttacatgt attgttttac cttgacactg catgcttttt
     3421 tatgtgaatt aaataaagga tgtcatatac actaca
//
