LOCUS       NM_010952               1861 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ornithine decarboxylase antizyme 2 (Oaz2), transcript
            variant 1, mRNA.
ACCESSION   NM_010952
VERSION     NM_010952.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1861)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1861)
  AUTHORS   Ramos-Molina,B., Lambertos,A., Lopez-Contreras,A.J., Kasprzak,J.M.,
            Czerwoniec,A., Bujnicki,J.M., Cremades,A. and Penafiel,R.
  TITLE     Structural and degradative aspects of ornithine decarboxylase
            antizyme inhibitor 2
  JOURNAL   FEBS Open Bio 4, 510-521 (2014)
   PUBMED   24967154
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1861)
  AUTHORS   Murakami,Y., Suzuki,J., Samejima,K. and Oka,T.
  TITLE     Developmental alterations in expression and subcellular
            localization of antizyme and antizyme inhibitor and their
            functional importance in the murine mammary gland
  JOURNAL   Amino Acids 38 (2), 591-601 (2010)
   PUBMED   19997757
  REMARK    GeneRIF: The level of AZ2 mRNA decreased during mammary gland
            development.
REFERENCE   4  (bases 1 to 1861)
  AUTHORS   Murai,N., Shimizu,A., Murakami,Y. and Matsufuji,S.
  TITLE     Subcellular localization and phosphorylation of antizyme 2
  JOURNAL   J Cell Biochem 108 (4), 1012-1021 (2009)
   PUBMED   19725046
REFERENCE   5  (bases 1 to 1861)
  AUTHORS   Lopez-Contreras,A.J., Sanchez-Laorden,B.L., Ramos-Molina,B., de la
            Morena,M.E., Cremades,A. and Penafiel,R.
  TITLE     Subcellular localization of antizyme inhibitor 2 in mammalian
            cells: Influence of intrinsic sequences and interaction with
            antizymes
  JOURNAL   J Cell Biochem 107 (4), 732-740 (2009)
   PUBMED   19449338
REFERENCE   6  (bases 1 to 1861)
  AUTHORS   Ivanov,I.P., Gesteland,R.F. and Atkins,J.F.
  TITLE     Antizyme expression: a subversion of triplet decoding, which is
            remarkably conserved by evolution, is a sensor for an
            autoregulatory circuit
  JOURNAL   Nucleic Acids Res 28 (17), 3185-3196 (2000)
   PUBMED   10954585
  REMARK    Review article
REFERENCE   7  (bases 1 to 1861)
  AUTHORS   Wakana,S., Sugaya,E., Naramoto,F., Yokote,N., Maruyama,C., Jin,W.,
            Ohguchi,H., Tsuda,T., Sugaya,A. and Kajiwara,K.
  TITLE     Gene mapping of SEZ group genes and determination of
            pentylenetetrazol susceptible quantitative trait loci in the mouse
            chromosome
  JOURNAL   Brain Res 857 (1-2), 286-290 (2000)
   PUBMED   10700579
REFERENCE   8  (bases 1 to 1861)
  AUTHORS   Ivanov,I.P., Gesteland,R.F. and Atkins,J.F.
  TITLE     A second mammalian antizyme: conservation of programmed ribosomal
            frameshifting
  JOURNAL   Genomics 52 (2), 119-129 (1998)
   PUBMED   9782076
  REMARK    GeneRIF: The protein product is generated using polyamine-regulated
            programmed ribosomal frameshifting.
REFERENCE   9  (bases 1 to 1861)
  AUTHORS   Nilsson,J., Koskiniemi,S., Persson,K., Grahn,B. and Holm,I.
  TITLE     Polyamines regulate both transcription and translation of the gene
            encoding ornithine decarboxylase antizyme in mouse
  JOURNAL   Eur J Biochem 250 (2), 223-231 (1997)
   PUBMED   9428668
REFERENCE   10 (bases 1 to 1861)
  AUTHORS   Kajiwara,K., Nagawawa,H., Shimizu-Nishikawa,S., Ookuri,T.,
            Kimura,M. and Sugaya,E.
  TITLE     Molecular characterization of seizure-related genes isolated by
            differential screening
  JOURNAL   Biochem Biophys Res Commun 219 (3), 795-799 (1996)
   PUBMED   8645260
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK169243.1 and BC083114.1.
            
            On Nov 30, 2007 this sequence version replaced NM_010952.2.
            
            Summary: The protein encoded by this gene belongs to the ornithine
            decarboxylase antizyme family, which plays a role in cell growth
            and proliferation by regulating intracellular polyamine levels.
            Expression of antizymes requires +1 ribosomal frameshifting, which
            is enhanced by high levels of polyamines. Antizymes in turn bind to
            and inhibit ornithine decarboxylase (ODC), the key enzyme in
            polyamine biosynthesis; thus, completing the auto-regulatory
            circuit. This gene encodes antizyme 2, the second member of the
            antizyme family. Like antizyme 1, antizyme 2 has broad tissue
            distribution, inhibits ODC activity and polyamine uptake, and
            stimulates ODC degradation in vivo; however, it fails to promote
            ODC degradation in vitro. Antizyme 2 is expressed at lower levels
            than antizyme 1, but is evolutionary more conserved, suggesting it
            likely has an important biological role. Studies also show
            different subcellular localization of antizymes 1 and 2, indicating
            specific function for each antizyme in discrete compartments of the
            cell. Alternatively spliced transcript variants have been found for
            this gene. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169243.1, BC110690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ribosomal slippage     :: PMID: 9782076
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1843              AK169243.1         1-1843
            1844-1861           BC083114.1         1802-1819
FEATURES             Location/Qualifiers
     source          1..1861
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.45 cM"
     gene            1..1861
                     /gene="Oaz2"
                     /gene_synonym="AZ-2; AZ2; Oaz2-ps; Sez15"
                     /note="ornithine decarboxylase antizyme 2"
                     /db_xref="GeneID:18247"
                     /db_xref="MGI:MGI:109492"
     exon            1..218
                     /gene="Oaz2"
                     /gene_synonym="AZ-2; AZ2; Oaz2-ps; Sez15"
                     /inference="alignment:Splign:2.1.0"
     CDS             join(199..294,296..769)
                     /gene="Oaz2"
                     /gene_synonym="AZ-2; AZ2; Oaz2-ps; Sez15"
                     /ribosomal_slippage
                     /note="protein translation is dependent on
                     polyamine-induced +1 ribosomal frameshift; isoform 1 is
                     encoded by transcript variant 1; ODC-Az 2; seizure-related
                     protein 15; antizyme 2"
                     /codon_start=1
                     /product="ornithine decarboxylase antizyme 2 isoform 1"
                     /protein_id="NP_035082.1"
                     /db_xref="CCDS:CCDS57683.1"
                     /db_xref="GeneID:18247"
                     /db_xref="MGI:MGI:109492"
                     /translation="MINTQDSSILPLSKCPQLQCCRHIVPGPLWCSDAPHPLSKIPGG
                     RGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSL
                     FVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEI
                     VRPGHPCVPSRPDVMFMVYPLDQNLSDED"
     exon            219..376
                     /gene="Oaz2"
                     /gene_synonym="AZ-2; AZ2; Oaz2-ps; Sez15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      301..350
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Oaz2"
                     /gene_synonym="AZ-2; AZ2; Oaz2-ps; Sez15"
                     /note="recoding_pseudoknot"
                     /function="stimulates +1 ribosomal frameshifting"
     exon            377..552
                     /gene="Oaz2"
                     /gene_synonym="AZ-2; AZ2; Oaz2-ps; Sez15"
                     /inference="alignment:Splign:2.1.0"
     exon            553..638
                     /gene="Oaz2"
                     /gene_synonym="AZ-2; AZ2; Oaz2-ps; Sez15"
                     /inference="alignment:Splign:2.1.0"
     exon            639..1844
                     /gene="Oaz2"
                     /gene_synonym="AZ-2; AZ2; Oaz2-ps; Sez15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1823..1828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oaz2"
                     /gene_synonym="AZ-2; AZ2; Oaz2-ps; Sez15"
                     /note="hexamer: AATAAA"
     polyA_site      1841
                     /gene="Oaz2"
                     /gene_synonym="AZ-2; AZ2; Oaz2-ps; Sez15"
                     /note="major polyA site"
ORIGIN      
        1 ggcggttgcg cggcggcggc cggggagggt cagttggagg caggcgctcg ctgaggcaag
       61 aggagggcac tcggcccgcg gcctgacagg gacttagccc acagagaccg gcccgcgcgc
      121 gcgaccccac acccacccac tcgtccacct acccactccc cgcgccgcct cctcccaccc
      181 tgagcagagc caccgaggat gataaacacc caggacagta gtattttgcc gttgagtaag
      241 tgtccccagc tccagtgctg caggcacatt gttccagggc ctctgtggtg ctcctgatgc
      301 ccctcaccca ctgtcgaaga tccccggtgg gcgagggggc ggcagggatc cttctctctc
      361 agctctaata tataaggacg agaagctcac tgtaacccag gacctccctg tgaacgatgg
      421 aaaacctcac atcgtccact tccagtatga ggtcaccgag gtgaaggtct cttcctggga
      481 tgcagtcctg tccagccaga gcctgtttgt agaaatccca gatggattat tagctgatgg
      541 gagcaaagaa ggattattag cactgctaga gtttgctgag gagaagatga aagtgaacta
      601 cgtcttcatc tgcttcagga agggccggga agacagagct ccactcctga agacgttcag
      661 cttcttgggc tttgagattg tgcgtccagg tcatccctgt gtcccctctc ggccagatgt
      721 gatgtttatg gtttaccccc tggaccagaa cttgtctgat gaggactaat ggtcacagag
      781 gatgctttgc ctaagagcca cagtggggga agaggggaag ttaggcagcc ttgggacaga
      841 ggagagggtc tctggctgtc tagggaagga cattgagggg ctcaggttga gggttgccca
      901 ttgtgttctc ggagttgact cgttgaaatt gttttccata aagaacagta taagcatatt
      961 attcacatgt aatcaccaat agtaaatgaa gatgtttatg aactggcatt agaagctttt
     1021 taaactgcgc tgtgatgtgc tccatctacc ctaggggagg acattgcctg caggggcggg
     1081 actgccgggc ccaggacagg cctggagggc tggtgggcag gactgtcagg ctcaggtctc
     1141 cttggagttg ggctttcttc ttttggtttt gaagacttag gtattttctt tctttgcttc
     1201 ttgtcatcta ggggctcctg agtataggct ttagctcctg ggcagtgtcc ttgggttgtc
     1261 ttcaacactc caccttgagc ttctggcatt ttgtgtctgg cctggtgtaa gcaggtctga
     1321 ccttgctttc tttacagctt agtgttattc tggcatttgg ttaagctggc ttaatctgtt
     1381 taatgttacc agtgcatttt aaataggggc attgaaactc actcccccac accagggctt
     1441 tttggggggt gcctgggcct taagaaacta gccaaactac atctcaagtt accaccagag
     1501 ctcttgcctc tgtggcctag gccccaggat ctctttcctt gcaagagcag agaggaagaa
     1561 taccaaactc agggcctggg gtttgtgggg gagcctgttc ttagcgcctg gatgcctctg
     1621 gctggccaag cacagtactg cctgcctcct taacaggttc agaacagtgc ctgcgctgca
     1681 gagctgagag gtagggctgg actgcagaaa tggcctgcct tttactgctt tcaccaaaca
     1741 gcttgttcta aagagaaaag ggagagagat ctacattggg tgtgggggtg tcagggagac
     1801 aagtgtgttg tgttactgtg tcaataaact gatttaaagt tgtgaaaaaa aaaaaaaaaa
     1861 a
//
