LOCUS       NM_008753               1092 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ornithine decarboxylase antizyme 1 (Oaz1), transcript
            variant 1, mRNA.
ACCESSION   NM_008753
VERSION     NM_008753.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1092)
  AUTHORS   Cheng,Y.W., Chang,C.C., Chang,T.S., Li,H.H., Hung,H.C., Liu,G.Y.
            and Lin,C.L.
  TITLE     Abeta stimulates microglial activation through antizyme-dependent
            downregulation of ornithine decarboxylase
  JOURNAL   J Cell Physiol 234 (6), 9733-9745 (2019)
   PUBMED   30417362
  REMARK    GeneRIF: Amyloid beta may contribute to M1-like activation by
            disrupting the balance between ODC and AZ in microglia.
REFERENCE   2  (bases 1 to 1092)
  AUTHORS   Ray,R.M., Bavaria,M. and Johnson,L.R.
  TITLE     Interaction of polyamines and mTOR signaling in the synthesis of
            antizyme (AZ)
  JOURNAL   Cell Signal 27 (9), 1850-1859 (2015)
   PUBMED   26093026
  REMARK    GeneRIF: Interaction of polyamines and mTOR signaling in the
            synthesis of antizyme (AZ).
REFERENCE   3  (bases 1 to 1092)
  AUTHORS   Franzoni,E., Booker,S.A., Parthasarathy,S., Rehfeld,F., Grosser,S.,
            Srivatsa,S., Fuchs,H.R., Tarabykin,V., Vida,I. and Wulczyn,F.G.
  TITLE     miR-128 regulates neuronal migration, outgrowth and intrinsic
            excitability via the intellectual disability gene Phf6
  JOURNAL   Elife 4, e04263 (2015)
   PUBMED   25556700
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1092)
  AUTHORS   Gandre,S., Bercovich,Z. and Kahana,C.
  TITLE     Mitochondrial localization of antizyme is determined by
            context-dependent alternative utilization of two AUG initiation
            codons
  JOURNAL   Mitochondrion 2 (4), 245-256 (2003)
   PUBMED   16120325
REFERENCE   5  (bases 1 to 1092)
  AUTHORS   Ivanov,I.P., Gesteland,R.F. and Atkins,J.F.
  TITLE     Antizyme expression: a subversion of triplet decoding, which is
            remarkably conserved by evolution, is a sensor for an
            autoregulatory circuit
  JOURNAL   Nucleic Acids Res 28 (17), 3185-3196 (2000)
   PUBMED   10954585
  REMARK    Review article
REFERENCE   6  (bases 1 to 1092)
  AUTHORS   Nilsson,J., Grahn,B. and Heby,O.
  TITLE     Antizyme inhibitor is rapidly induced in growth-stimulated mouse
            fibroblasts and releases ornithine decarboxylase from antizyme
            suppression
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 699-704 (2000)
   PUBMED   10698696
REFERENCE   7  (bases 1 to 1092)
  AUTHORS   Ivanov,I.P., Gesteland,R.F. and Atkins,J.F.
  TITLE     A second mammalian antizyme: conservation of programmed ribosomal
            frameshifting
  JOURNAL   Genomics 52 (2), 119-129 (1998)
   PUBMED   9782076
REFERENCE   8  (bases 1 to 1092)
  AUTHORS   Nilsson,J., Koskiniemi,S., Persson,K., Grahn,B. and Holm,I.
  TITLE     Polyamines regulate both transcription and translation of the gene
            encoding ornithine decarboxylase antizyme in mouse
  JOURNAL   Eur J Biochem 250 (2), 223-231 (1997)
   PUBMED   9428668
REFERENCE   9  (bases 1 to 1092)
  AUTHORS   Kankare,K., Uusi-Oukari,M. and Janne,O.A.
  TITLE     Structure, organization and expression of the mouse ornithine
            decarboxylase antizyme gene
  JOURNAL   Biochem J 324 (Pt 3) (Pt 3), 807-813 (1997)
   PUBMED   9210404
REFERENCE   10 (bases 1 to 1092)
  AUTHORS   Matsufuji,S., Matsufuji,T., Miyazaki,Y., Murakami,Y., Atkins,J.F.,
            Gesteland,R.F. and Hayashi,S.
  TITLE     Autoregulatory frameshifting in decoding mammalian ornithine
            decarboxylase antizyme
  JOURNAL   Cell 80 (1), 51-60 (1995)
   PUBMED   7813017
  REMARK    GeneRIF: antizyme expression requires programmed, ribosomal
            frameshifting
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY112600.1, AK146571.1 and
            AI838943.1.
            
            On Apr 21, 2006 this sequence version replaced NM_008753.3.
            
            Summary: The protein encoded by this gene belongs to the ornithine
            decarboxylase antizyme family, which plays a role in cell growth
            and proliferation by regulating intracellular polyamine levels.
            Expression of antizymes requires +1 ribosomal frameshifting, which
            is enhanced by high levels of polyamines. Antizymes in turn bind to
            and inhibit ornithine decarboxylase (ODC), the key enzyme in
            polyamine biosynthesis; thus, completing the auto-regulatory
            circuit. This gene encodes antizyme 1, the first member of the
            antizyme family, that has broad tissue distribution, and negatively
            regulates intracellular polyamine levels by binding to and
            targeting ODC for degradation, as well as inhibiting polyamine
            uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and
            studies in rat suggest that alternative use of the two translation
            initiation sites results in N-terminally distinct protein isoforms
            with different subcellular localization. Alternatively spliced
            transcript variants have also been noted for this gene. [provided
            by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146571.1, BC024902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ribosomal slippage                 :: PMID: 9210404
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               BY112600.1         3-328
            327-700             AK146571.1         298-671
            701-1092            AI838943.1         1-392               c
FEATURES             Location/Qualifiers
     source          1..1092
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1092
                     /gene="Oaz1"
                     /gene_synonym="Antizyme; AZ-1; AZ1; Oaz; ODC-Az"
                     /note="ornithine decarboxylase antizyme 1"
                     /db_xref="GeneID:18245"
                     /db_xref="MGI:MGI:109433"
     exon            1..250
                     /gene="Oaz1"
                     /gene_synonym="Antizyme; AZ-1; AZ1; Oaz; ODC-Az"
                     /inference="alignment:Splign:2.1.0"
     CDS             join(105..308,310..789)
                     /gene="Oaz1"
                     /gene_synonym="Antizyme; AZ-1; AZ1; Oaz; ODC-Az"
                     /ribosomal_slippage
                     /note="protein translation is dependent on +1
                     polyamine-induced ribosomal frameshift; isoform 1 is
                     encoded by transcript variant 1; antizyme 1"
                     /codon_start=1
                     /product="ornithine decarboxylase antizyme 1 isoform 1"
                     /protein_id="NP_032779.2"
                     /db_xref="CCDS:CCDS56736.1"
                     /db_xref="GeneID:18245"
                     /db_xref="MGI:MGI:109433"
                     /translation="MVKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGG
                     CSSESSRVALNCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLN
                     VTEEPTSNDKTRVLSIQSTLTEAKQVTWRAVWSGGGLYIELPAGPLPEGSKDSFAALL
                     EFAEEQLQADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTL
                     EREDPGEED"
     exon            251..396
                     /gene="Oaz1"
                     /gene_synonym="Antizyme; AZ-1; AZ1; Oaz; ODC-Az"
                     /inference="alignment:Splign:2.1.0"
     regulatory      315..367
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Oaz1"
                     /gene_synonym="Antizyme; AZ-1; AZ1; Oaz; ODC-Az"
                     /note="recoding_pseudoknot"
                     /function="stimulates +1 ribosomal frameshifting"
     exon            397..569
                     /gene="Oaz1"
                     /gene_synonym="Antizyme; AZ-1; AZ1; Oaz; ODC-Az"
                     /inference="alignment:Splign:2.1.0"
     exon            570..655
                     /gene="Oaz1"
                     /gene_synonym="Antizyme; AZ-1; AZ1; Oaz; ODC-Az"
                     /inference="alignment:Splign:2.1.0"
     exon            656..1075
                     /gene="Oaz1"
                     /gene_synonym="Antizyme; AZ-1; AZ1; Oaz; ODC-Az"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1052..1057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oaz1"
                     /gene_synonym="Antizyme; AZ-1; AZ1; Oaz; ODC-Az"
                     /note="hexamer: AATAAA"
     polyA_site      1070
                     /gene="Oaz1"
                     /gene_synonym="Antizyme; AZ-1; AZ1; Oaz; ODC-Az"
                     /note="major polyA site"
ORIGIN      
        1 aaaagtgggc gtcggcgccg gcgccatttt gcgaacggcg agcagcggcg gcggcgcggg
       61 aagtgcagcg gaggtttttg ctggtttcgg accccagcgg ccggatggtg aaatcctccc
      121 tgcagcggat cctcaacagc cactgcttcg ccagagagaa ggaaggggac aaacgcagcg
      181 ccacgcttca cgccagccgc accatgccgc ttcttagtca gcacagccgc ggcggctgca
      241 gcagcgagag ttctagggtt gcccttaatt gctgtagtaa cctgggtccg gggcctcggt
      301 ggtgctcctg atgtccctca cccacccctg aagatcccag gtgggcgagg gaacagtcag
      361 cgggatcaca gtctttcagc tagcatcctg tactccgacg agcggctgaa tgtgacagag
      421 gagccgacgt ctaacgacaa gaccagggtc ctgagcatcc agtccacgct cacggaggcc
      481 aagcaggtca cctggagggc ggtgtggagt ggtggtggcc tctacatcga gctcccagct
      541 ggacctctgc ctgagggcag taaggacagt tttgcagctc tcctagagtt cgcagaggag
      601 caactccagg ctgaccacgt tttcatctgc ttccccaaga accgtgagga cagagccgcc
      661 ctactccgaa ccttcagctt tcttggcttt gagattgtga gacccgggca tccccttgtc
      721 cccaagagac ccgacgcttg cttcatggtc tacactctgg agagagagga cccgggtgag
      781 gaggactagg tgccagccct gcccagtgtc cctgtgccct ctcctgggtt agtccacatg
      841 tcgtgattgt gcagaataaa cgctcactcc attagcgggg tgcttcttcg agctgaatgc
      901 tgtgtttgtc acactcaagt gttggcttta attctaaata aaggtttcta ttttactttt
      961 ttattgctgt ttaagatggt caggtgacct atgctatagc agtctccttt gaagtctgga
     1021 aaaatagtgt cacctcccct ggctcaaatc caataaagtg atctcgttca ttggcaaaaa
     1081 aaaaaaaaaa aa
//
