LOCUS       NM_016978               2155 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ornithine aminotransferase (Oat), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_016978
VERSION     NM_016978.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2155)
  AUTHORS   Key,J., Gispert,S., Kandi,A.R., Heinz,D., Hamann,A., Osiewacz,H.D.,
            Meierhofer,D. and Auburger,G.
  TITLE     CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced
            L-arginine Levels, Probably via CLPX-Mediated OAT Activation
  JOURNAL   Biomolecules 14 (2), 241 (2024)
   PUBMED   38397478
  REMARK    GeneRIF: CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show
            Reduced L-arginine Levels, Probably via CLPX-Mediated OAT
            Activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2155)
  AUTHORS   Lee,J.U., Song,K.S., Hong,J., Shin,H., Park,E., Baek,J., Park,S.,
            Baek,A.R., Lee,J., Jang,A.S., Kim,D.J., Chin,S.S., Kim,U.J.,
            Jeong,S.H. and Park,S.W.
  TITLE     Role of lung ornithine aminotransferase in idiopathic pulmonary
            fibrosis: regulation of mitochondrial ROS generation and TGF-beta1
            activity
  JOURNAL   Exp Mol Med 56 (2), 478-490 (2024)
   PUBMED   38413821
  REMARK    GeneRIF: Role of lung ornithine aminotransferase in idiopathic
            pulmonary fibrosis: regulation of mitochondrial ROS generation and
            TGF-beta1 activity.
REFERENCE   3  (bases 1 to 2155)
  AUTHORS   Rong,R., Wei,Y., Li,L., Wang,T., Zhu,H., Xiao,G. and Wang,Y.
  TITLE     Image-based quantification of histological features as a function
            of spatial location using the Tissue Positioning System
  JOURNAL   EBioMedicine 94, 104698 (2023)
   PUBMED   37453365
REFERENCE   4  (bases 1 to 2155)
  AUTHORS   Lee,M.S., Dennis,C., Naqvi,I., Dailey,L., Lorzadeh,A., Ye,G.,
            Zaytouni,T., Adler,A., Hitchcock,D.S., Lin,L., Hoffman,M.T.,
            Bhuiyan,A.M., Barth,J.L., Machacek,M.E., Mino-Kenudson,M.,
            Dougan,S.K., Jadhav,U., Clish,C.B. and Kalaany,N.Y.
  TITLE     Ornithine aminotransferase supports polyamine synthesis in
            pancreatic cancer
  JOURNAL   Nature 616 (7956), 339-347 (2023)
   PUBMED   36991126
  REMARK    GeneRIF: Ornithine aminotransferase supports polyamine synthesis in
            pancreatic cancer.
REFERENCE   5  (bases 1 to 2155)
  AUTHORS   Chen,A., Liao,S., Cheng,M., Ma,K., Wu,L., Lai,Y., Qiu,X., Yang,J.,
            Xu,J., Hao,S., Wang,X., Lu,H., Chen,X., Liu,X., Huang,X., Li,Z.,
            Hong,Y., Jiang,Y., Peng,J., Liu,S., Shen,M., Liu,C., Li,Q.,
            Yuan,Y., Wei,X., Zheng,H., Feng,W., Wang,Z., Liu,Y., Wang,Z.,
            Yang,Y., Xiang,H., Han,L., Qin,B., Guo,P., Lai,G.,
            Munoz-Canoves,P., Maxwell,P.H., Thiery,J.P., Wu,Q.F., Zhao,F.,
            Chen,B., Li,M., Dai,X., Wang,S., Kuang,H., Hui,J., Wang,L.,
            Fei,J.F., Wang,O., Wei,X., Lu,H., Wang,B., Liu,S., Gu,Y., Ni,M.,
            Zhang,W., Mu,F., Yin,Y., Yang,H., Lisby,M., Cornall,R.J.,
            Mulder,J., Uhlen,M., Esteban,M.A., Li,Y., Liu,L., Xu,X. and Wang,J.
  TITLE     Spatiotemporal transcriptomic atlas of mouse organogenesis using
            DNA nanoball-patterned arrays
  JOURNAL   Cell 185 (10), 1777-1792 (2022)
   PUBMED   35512705
REFERENCE   6  (bases 1 to 2155)
  AUTHORS   Giometti,C.S., Taylor,J. and Tollaksen,S.L.
  TITLE     Mouse liver protein database: a catalog of proteins detected by
            two-dimensional gel electrophoresis
  JOURNAL   Electrophoresis 13 (12), 970-991 (1992)
   PUBMED   1286668
REFERENCE   7  (bases 1 to 2155)
  AUTHORS   Ramesh,V., Cheng,S.V., Kozak,C.A., Herron,B.J., Shih,V.E.,
            Taylor,B.A. and Gusella,J.F.
  TITLE     Mapping of ornithine aminotransferase gene sequences to mouse
            chromosomes 7, X, and 3
  JOURNAL   Mamm Genome 3 (1), 17-22 (1992)
   PUBMED   1349842
REFERENCE   8  (bases 1 to 2155)
  AUTHORS   Threadgill,D.S. and Womack,J.E.
  TITLE     Mapping HSA10 homologous loci in cattle
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 123-126 (1991)
   PUBMED   1655359
REFERENCE   9  (bases 1 to 2155)
  AUTHORS   O'Donnell,J.J., Vannas-Sulonen,K., Shows,T.B. and Cox,D.R.
  TITLE     Gyrate atrophy of the choroid and retina: assignment of the
            ornithine aminotransferase structural gene to human chromosome 10
            and mouse chromosome 7
  JOURNAL   Am J Hum Genet 43 (6), 922-928 (1988)
   PUBMED   3195589
REFERENCE   10 (bases 1 to 2155)
  AUTHORS   Giometti,C.S., Tollaksen,S.L., Gemmell,M.A., Burcham,J. and
            Peraino,C.
  TITLE     A heritable variant of mouse liver ornithine aminotransferase (EC
            2.6.1.13) induced by ethylnitrosourea
  JOURNAL   J Biol Chem 263 (30), 15781-15784 (1988)
   PUBMED   3170611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145877.1, AK168851.1 and BY435126.1.
            
            On Mar 23, 2007 this sequence version replaced NM_016978.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145877.1, AK168851.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               AK145877.1         2-378
            378-2151            AK168851.1         327-2100
            2152-2155           BY435126.1         419-422
FEATURES             Location/Qualifiers
     source          1..2155
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 76.3 cM"
     gene            1..2155
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /note="ornithine aminotransferase"
                     /db_xref="GeneID:18242"
                     /db_xref="MGI:MGI:97394"
     exon            1..104
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /inference="alignment:Splign:2.1.0"
     exon            105..339
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1460
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /EC_number="2.6.1.13"
                     /note="ornithine aminotransferase, mitochondrial;
                     ornithine--oxo-acid aminotransferase"
                     /codon_start=1
                     /product="ornithine aminotransferase, mitochondrial
                     precursor"
                     /protein_id="NP_058674.1"
                     /db_xref="CCDS:CCDS21923.1"
                     /db_xref="GeneID:18242"
                     /db_xref="MGI:MGI:97394"
                     /translation="MLSKLASLQTIAALRRGVHTSVASATSVATKKTEQGPPSSEYIF
                     ERESKYGAHNYHPLPVALERGKGIYMWDVEGRQYFDFLSAYGAVSQGHCHPKIIDAMK
                     SQVDKLTLTSRAFYNNVLGEYEEYITKLFNYNKVLPMNTGVEAGETACKLARRWGYTV
                     KGIQKYKAKIVFADGNFWGRTLSAISSSTDPTSYDGFGPFMPGFETIPYNDLPALERA
                     LQDPNVAAFMVEPIQGEAGVIVPDPGYLTGVRELCTRHQVLFIADEIQTGLARTGRWL
                     AVDHENVRPDMVLLGKALSGGLYPVSAVLCDDEIMLTIKPGEHGSTYGGNPLGCRIAI
                     AALEVLEEENLAENADKMGAILRKELMKLPSDVVTSVRGKGLLNAIVIRETKDCDAWK
                     VCLRLRDNGLLAKPTHGDIIRLAPPLVIKEDEIRESVEIINKTILSF"
     exon            340..564
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /inference="alignment:Splign:2.1.0"
     exon            565..660
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /inference="alignment:Splign:2.1.0"
     exon            661..788
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /inference="alignment:Splign:2.1.0"
     exon            789..911
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1040
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1154
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1299
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..2155
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1982..1987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /note="hexamer: AATAAA"
     polyA_site      2011
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /note="major polyA site"
     regulatory      2124..2129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /note="hexamer: AATAAA"
     polyA_site      2152
                     /gene="Oat"
                     /gene_synonym="rhg"
                     /note="major polyA site"
ORIGIN      
        1 gggggcggga cagacacgtc gtcttaaacg acctgacgcg ccgggcagcc acatcgcgct
       61 tcgtggctga agtacagtca gtgtcgctta gcggacgctg tcaggtctgt ctgcactccc
      121 actcctgaag gacccacacg atgctttcta aactagcaag tctgcagacc attgctgctc
      181 tgcgccgagg agtccacacc tcagtcgcct ctgccacgtc tgttgccaca aagaagacag
      241 agcaaggccc accatcctcc gagtacattt ttgaacggga atctaaatat ggtgcacaca
      301 attaccatcc tttgcctgta gccctggaga gaggaaaagg catttatatg tgggatgtgg
      361 aaggcaggca gtacttcgat ttcctgagtg cttatggtgc tgtcagccaa ggacactgcc
      421 acccaaagat catagatgcc atgaagagtc aggtggacaa gctgacatta acatctcggg
      481 ctttctataa caatgtcctt ggtgaatacg aggagtacat caccaagctt ttcaactaca
      541 acaaagttct ccctatgaat acaggagtgg aggctggaga gactgcatgt aagctcgctc
      601 gtcgttgggg ctacaccgtg aaaggcatcc agaaatacaa agcaaagatt gtttttgctg
      661 atgggaactt ttggggtcga acactatctg caatctccag ttccacagat ccgaccagtt
      721 atgatggctt tggacccttc atgccaggct ttgaaaccat cccatataac gatctgcccg
      781 cactggagcg tgctcttcag gatccaaatg ttgctgcctt catggtggag cccatccagg
      841 gtgaagcagg cgttatcgtt ccggatccag gatacctgac aggagttcgg gaactctgca
      901 ccaggcacca ggtcctgttt attgctgatg aaatacagac aggattggcc agaactggta
      961 gatggctggc tgtggatcat gagaatgtca gacctgatat ggttcttctt gggaaggccc
     1021 tttctggcgg tttataccct gtgtctgcag tgctgtgtga cgatgagata atgctgacca
     1081 ttaaaccagg cgagcacggc tccacatacg gcggaaaccc actaggctgc cgaattgcca
     1141 ttgcggctct tgaggtttta gaagaggaga atcttgctga gaatgcagac aagatgggcg
     1201 ctatcctgag gaaggagctc atgaagctgc cctctgacgt tgtgacctca gtgagaggga
     1261 aagggttgct aaatgccatt gtcatcagag aaaccaaaga ctgtgatgct tggaaggtgt
     1321 gcctgcgact tcgagataac gggcttctgg ccaagccaac ccacggtgat atcatcaggc
     1381 ttgcccctcc ccttgtgatc aaggaggatg agatccggga gtccgtggag atcatcaaca
     1441 agactatctt gtccttctga gagtaggaac tctggggagc catcttcaga cagggctctt
     1501 gtgaaactct gcttgcagtg gccagagcct gtctcctgaa aggcatatat ttcagttgat
     1561 gcataataga gtgacaccta ggaacctgca ggtggctgcg tgacagaaaa gtgagagcga
     1621 gaggcgaggc gtctctttgt tgaggtttga ctgtgtggga actttctaag gagaaacgga
     1681 cccatctgcg tacagcctgc agatggaggc ctgcagtcat ttacgtgcgt ctttacagtt
     1741 tccttgctga tgtgaatggt ttgtatttag aagttatttc tgagatacta cagaacagtt
     1801 aaatcattat aatcaatgaa tgttaagttg attgaaggtt aagcatatgt aaaatactag
     1861 tttaaagtaa acttttcatt ggccaacacc agaatgtatt atatagattc tgagaattca
     1921 ttactaaatt acactttgct tgattgcaat ttgtaaaaca tttattttca gtatttcttt
     1981 gaataaagct taatgtttct ttttacgcca acagagtatt ttgtatttcc attttggtaa
     2041 taatcagtgt attatttcat cctgatgact ggcatttcat cacctattga gatcactggg
     2101 tgtgtttcag gccttttatt ctaaataaag ctatgaccag tttctgtctg tacaa
//
