LOCUS       NM_011854               3136 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 2'-5' oligoadenylate synthetase-like 2 (Oasl2),
            transcript variant 1, mRNA.
ACCESSION   NM_011854
VERSION     NM_011854.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3136)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3136)
  AUTHORS   Hoffmann,S., Schmitteckert,S., Raedecke,K., Rheinert,D.,
            Diebold,S., Roeth,R., Weiss,B., Granzow,M., Niesler,B.,
            Griesbeck,A., Eckstein,V., Zimmermann,W.H., Just,S. and
            Rappold,G.A.
  TITLE     Network-driven discovery yields new insight into Shox2-dependent
            cardiac rhythm control
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (4-5), 194702 (2021)
   PUBMED   33706013
REFERENCE   3  (bases 1 to 3136)
  AUTHORS   Bankers,L., Miller,C., Liu,G., Thongkittidilok,C., Morrison,J. and
            Poeschla,E.M.
  TITLE     Development of IFN-Stimulated Gene Expression from Embryogenesis
            through Adulthood, with and without Constitutive MDA5 Pathway
            Activation
  JOURNAL   J Immunol 204 (10), 2791-2807 (2020)
   PUBMED   32277054
REFERENCE   4  (bases 1 to 3136)
  AUTHORS   Kwock,J.T., Handfield,C., Suwanpradid,J., Hoang,P., McFadden,M.J.,
            Labagnara,K.F., Floyd,L., Shannon,J., Uppala,R., Sarkar,M.K.,
            Gudjonsson,J.E., Corcoran,D.L., Lazear,H.M., Sempowski,G.,
            Horner,S.M. and MacLeod,A.S.
  TITLE     IL-27 signaling activates skin cells to induce innate antiviral
            proteins and protects against Zika virus infection
  JOURNAL   Sci Adv 6 (14), eaay3245 (2020)
   PUBMED   32270034
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3136)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3136)
  AUTHORS   Kristiansen,H., Gad,H.H., Eskildsen-Larsen,S., Despres,P. and
            Hartmann,R.
  TITLE     The oligoadenylate synthetase family: an ancient protein family
            with multiple antiviral activities
  JOURNAL   J Interferon Cytokine Res 31 (1), 41-47 (2011)
   PUBMED   21142819
  REMARK    Review article
REFERENCE   7  (bases 1 to 3136)
  AUTHORS   Eskildsen,S., Justesen,J., Schierup,M.H. and Hartmann,R.
  TITLE     Characterization of the 2'-5'-oligoadenylate synthetase
            ubiquitin-like family
  JOURNAL   Nucleic Acids Res 31 (12), 3166-3173 (2003)
   PUBMED   12799444
REFERENCE   8  (bases 1 to 3136)
  AUTHORS   Kakuta,S., Shibata,S. and Iwakura,Y.
  TITLE     Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene
            family
  JOURNAL   J Interferon Cytokine Res 22 (9), 981-993 (2002)
   PUBMED   12396720
REFERENCE   9  (bases 1 to 3136)
  AUTHORS   Kumar,S., Mitnik,C., Valente,G. and Floyd-Smith,G.
  TITLE     Expansion and molecular evolution of the interferon-induced 2'-5'
            oligoadenylate synthetase gene family
  JOURNAL   Mol Biol Evol 17 (5), 738-750 (2000)
   PUBMED   10779534
REFERENCE   10 (bases 1 to 3136)
  AUTHORS   Tiefenthaler,M., Marksteiner,R., Neyer,S., Koch,F., Hofer,S.,
            Schuler,G., Nussenzweig,M., Schneider,R. and Heufler,C.
  TITLE     M1204, a novel 2',5' oligoadenylate synthetase with a
            ubiquitin-like extension, is induced during maturation of murine
            dendritic cells
  JOURNAL   J Immunol 163 (2), 760-765 (1999)
   PUBMED   10395668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116500.13, AK010034.1 and BY426738.1.
            
            On Mar 24, 2007 this sequence version replaced NM_011854.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034361.1, AK010034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-659               AC116500.13        102005-102663
            660-3115            AK010034.1         2-2457
            3116-3136           BY426738.1         342-362
FEATURES             Location/Qualifiers
     source          1..3136
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     gene            1..3136
                     /gene="Oasl2"
                     /gene_synonym="M1204; Mmu-OASL; Oasl"
                     /note="2'-5' oligoadenylate synthetase-like 2"
                     /db_xref="GeneID:23962"
                     /db_xref="MGI:MGI:1344390"
     exon            1..929
                     /gene="Oasl2"
                     /gene_synonym="M1204; Mmu-OASL; Oasl"
                     /inference="alignment:Splign:2.1.0"
     CDS             732..2258
                     /gene="Oasl2"
                     /gene_synonym="M1204; Mmu-OASL; Oasl"
                     /EC_number="2.7.7.84"
                     /note="isoform 1 is encoded by transcript variant 1; 54
                     kDa 2'-5'-oligoadenylate synthetase-like protein 2; 54 kDa
                     2'-5'-oligoadenylate synthase-like protein 2; p54 OASL"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase-like protein 2
                     isoform 1"
                     /protein_id="NP_035984.2"
                     /db_xref="CCDS:CCDS39226.1"
                     /db_xref="GeneID:23962"
                     /db_xref="MGI:MGI:1344390"
                     /translation="MDPFPDLYATPGDSLDHFLEHSLQPQRDWKEEGQDAWERIERFF
                     REQCFRDELLLDQEVRVIKVVKGGSSGKGTTLNHRSDQDMILFLSCFSSFEEQARNRE
                     VVISFIKKRLIHCSRSLAYNIIVLTHREGKRAPRSLTLKVQSRKTDDIIWMDILPAYD
                     ALGPISRDSKPAPAIYETLIRSKGYPGDFSPSFTELQRHFVKTRPVKLKNLLRLVKFW
                     YLQCLRRKYGRGAVLPSKYALELLTIYAWEMGTESSDSFNLDEGFVAVMELLVNYRDI
                     CIYWTKYYNFQNEVVRNFLKKQLKGDRPIILDPADPTNNLGRRKGWEQVAAEAAFCLL
                     QVCCTTVGPSERWNVQRARDVQVRVKQTGTVDWTLWTNPYSPIRKMKAEIRREKNFGG
                     ELRISFQEPGGERQLLSSRKTLADYGIFSKVNIQVLETFPPEILVFVKYPGGQSKPFT
                     IDPDDTILDLKEKIEDAGGPCAEDQVLLLDDEELEDDESLKELEIKDCDTIILIRVID
                     "
     exon            930..1218
                     /gene="Oasl2"
                     /gene_synonym="M1204; Mmu-OASL; Oasl"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1394
                     /gene="Oasl2"
                     /gene_synonym="M1204; Mmu-OASL; Oasl"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1639
                     /gene="Oasl2"
                     /gene_synonym="M1204; Mmu-OASL; Oasl"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1781
                     /gene="Oasl2"
                     /gene_synonym="M1204; Mmu-OASL; Oasl"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..3136
                     /gene="Oasl2"
                     /gene_synonym="M1204; Mmu-OASL; Oasl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3100..3105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oasl2"
                     /gene_synonym="M1204; Mmu-OASL; Oasl"
                     /note="hexamer: AATAAA"
     polyA_site      3118
                     /gene="Oasl2"
                     /gene_synonym="M1204; Mmu-OASL; Oasl"
                     /note="major polyA site"
ORIGIN      
        1 cactcactga agataactag acagaaaaca tcgtgagact acctcacgct gtccattgac
       61 caggagcaat cctttgtgcc tcacatcttt gggactgcgg taggcatcag agaaatgtca
      121 cctcgatggg ccctgcagct ggagagtctg accctggata tggccttcag ctaagacacc
      181 tgcacagatg atgagcagcc tcggggagac tagctgaggt cggtagttag gaatgtggag
      241 tgtggatgtt gtgaccctca gcataagcag gaataaccta gcctaaccct atcgctcgag
      301 acgccactag taacggagac actatgcgtg attaagaatg aaataaatgc atttgccact
      361 gccagatcac caggcagatg agattatgtg gccaaatcgc tgccactgaa actgctgaat
      421 cttactctgt tgtggtaaac aacatcctgt gctcacaaca gagccggtgg ggagactgca
      481 tccttaactc ctgttccctt ctgccttgaa gaaggtaaac tggatctccc tgcagtttca
      541 ctttcaattc ttgtcaaagc ttggtttctg tttccagttt ctccaaggag ggaggggcag
      601 agcgcttttc ttctttccat gcaactctcc atcccattgt ctcctccaga gaacgctgca
      661 ggaagcttct cccatcagag ctgagcagaa gctcagagga tttatctaga ggacaggctg
      721 gcccagctga aatggacccg ttccccgacc tgtatgcgac ccctggggac agtctagacc
      781 acttcctgga acacagcctt cagccccaga gggactggaa agaggaaggg caggatgcct
      841 gggagagaat cgagaggttc tttcgggaac agtgcttccg tgatgagctg ctcctggacc
      901 aagaagtcag ggtgattaag gtggtgaagg gaggctcctc gggaaagggg acaacgctga
      961 accacagatc tgaccaagac atgattctgt tcttaagctg cttttccagt ttcgaagagc
     1021 aggcgagaaa ccgggaggtc gtcatcagct tcattaagaa gaggctgatt cattgtagca
     1081 gaagcctggc ctacaacatc attgtcctta cccacagaga gggcaaaagg gcccctcgct
     1141 ccctcaccct aaaggttcag tcccggaaga ctgatgacat tatttggatg gatatcctcc
     1201 cagcttacga tgctttggga cctatttcca gagactcaaa accagcaccg gcaatctacg
     1261 agactctgat aagaagtaag ggctaccctg gtgacttctc accaagcttc acagagttac
     1321 agagacattt tgtgaaaact cgcccagtta aactgaagaa cctcctccgg ttggtgaagt
     1381 tctggtacct gcagtgcctg agacgtaaat atggaagagg tgcagtgttg ccctcaaaat
     1441 atgctctgga gctgctgacc atctacgcct gggagatggg tacagagagc agtgatagct
     1501 tcaatctgga tgaagggttc gtagccgtga tggagctcct cgtaaactac cgcgacatct
     1561 gcatctactg gaccaagtac tacaatttcc aaaacgaggt cgtcaggaac tttctgaaga
     1621 aacagctgaa gggagaccgg cccatcatcc tagacccagc tgaccccacc aacaacctgg
     1681 gaagaagaaa gggatgggaa caggtggctg cagaagctgc tttctgcctg ctgcaggtct
     1741 gttgcacgac tgtaggcccc agcgagcgct ggaatgtaca gcgagcgagg gatgttcagg
     1801 tgagagtgaa acaaacggga acagtggatt ggacactctg gacaaacccc tacagcccca
     1861 tcagaaagat gaaggcagag atcaggaggg aaaagaactt tggaggggaa ctgcgcatct
     1921 ccttccagga gcccggaggg gagagacagc tgctcagcag caggaagacc ctagcagatt
     1981 atgggatatt ctctaaggtg aacattcaag tgctggagac ctttcctcct gagatcctgg
     2041 tctttgtgaa gtatcctggt ggccagagca agcctttcac catcgaccct gatgatacca
     2101 tcttagatct gaaagagaag atagaagatg ctggaggccc ttgtgcggag gatcaggtac
     2161 tactgttgga tgatgaggag ttggaagatg atgagagcct taaagagctt gagatcaaag
     2221 actgcgacac catcatactc attagggtaa tcgactagtc tggctgcttg agtccgtgcc
     2281 tagagtctta cgcctcccta cctcatccct agactctgat gggttctttc tatagcttaa
     2341 atatcaacat tcccttctct tgcttaaaac cctctcctat agccgggcag tggtggtgca
     2401 tgcctttatc tcagcactta gagaatttct gagttcaagg ccagcctggt ctatagagtg
     2461 agttacagaa cagccagagc tatacggaga aaccctgtct cagataaaca aacaaacaaa
     2521 caaacaaacc ctctcctgtg ttttccaata atacagaatg aagttcaagt ttcttttcct
     2581 aacagtcaat taagctgaac cctgcttagt ccccgacccc caactctaaa cactcaactc
     2641 atactgaatg cagagtgaca ccttgagtca cactgagagc tgagtcacac ctgtgtctct
     2701 tttcctcaaa catcctttcc ctcagcctct gttttcatca ttctgtgagt caccgaatct
     2761 caaagagcag accccagact gtcagattcc ccacctctcc agaaacctct tagaatggaa
     2821 aactaaccca agccagacat ttcaccgaga ctcagcggtc ctggacttaa caagcctttc
     2881 acatcattct gcatgctcct gtttgaaaac aactactatc tggcccatgc agcaggccaa
     2941 atcatcttgt gttcccgccc tctcccttca tccatgttag actcccgtgg acgtaaatct
     3001 atctcccttg tctaatcaga ctcgattgtt tttaatgatt taggccttgt gctctagaat
     3061 ggtaccaatc cagtatcaat gtatgacaag tgcttgttaa ataaagaagc gaaccagaga
     3121 atggctttgg atcctc
//
