LOCUS       NM_001359945            2201 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus 2'-5' oligoadenylate synthetase-like 1 (Oasl1),
            transcript variant 1, mRNA.
ACCESSION   NM_001359945 XM_006530294
VERSION     NM_001359945.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2201)
  AUTHORS   Imai,T., Lin,J., Kaya,G.G., Ju,E., Kondylis,V., Kelepouras,K.,
            Liccardi,G., Kim,C. and Pasparakis,M.
  TITLE     The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death
            and inflammation
  JOURNAL   Immunity 57 (7), 1497-1513 (2024)
   PUBMED   38744293
REFERENCE   2  (bases 1 to 2201)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2201)
  AUTHORS   Zhao,W., Yang,H., Liu,L., Qu,X., Ding,J., Yu,H., Xu,B., Zhao,S.,
            Xi,G., Xing,L. and Chai,J.
  TITLE     OASL knockdown inhibits the progression of stomach adenocarcinoma
            by regulating the mTORC1 signaling pathway
  JOURNAL   FASEB J 37 (3), e22824 (2023)
   PUBMED   36809539
  REMARK    GeneRIF: OASL knockdown inhibits the progression of stomach
            adenocarcinoma by regulating the mTORC1 signaling pathway.
REFERENCE   4  (bases 1 to 2201)
  AUTHORS   Lee,S.A., Chang,L.C., Jung,W., Bowman,J.W., Kim,D., Chen,W.,
            Foo,S.S., Choi,Y.J., Choi,U.Y., Bowling,A., Yoo,J.S. and Jung,J.U.
  TITLE     OASL phase condensation induces amyloid-like fibrillation of RIPK3
            to promote virus-induced necroptosis
  JOURNAL   Nat Cell Biol 25 (1), 92-107 (2023)
   PUBMED   36604592
REFERENCE   5  (bases 1 to 2201)
  AUTHORS   Kim,T.K., Jeon,S., Park,S., Sonn,S.K., Seo,S., Suh,J., Jin,J.,
            Kweon,H.Y., Kim,S., Moon,S.H., Kweon,O., Koo,B.H., Kim,N.,
            Lee,H.O., Kim,Y.M., Kim,Y.J., Park,S.H. and Oh,G.T.
  TITLE     2'-5' oligoadenylate synthetase-like 1 (OASL1) protects against
            atherosclerosis by maintaining endothelial nitric oxide synthase
            mRNA stability
  JOURNAL   Nat Commun 13 (1), 6647 (2022)
   PUBMED   36333342
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2201)
  AUTHORS   Eskildsen,S., Justesen,J., Schierup,M.H. and Hartmann,R.
  TITLE     Characterization of the 2'-5'-oligoadenylate synthetase
            ubiquitin-like family
  JOURNAL   Nucleic Acids Res 31 (12), 3166-3173 (2003)
   PUBMED   12799444
REFERENCE   7  (bases 1 to 2201)
  AUTHORS   Kakuta,S., Shibata,S. and Iwakura,Y.
  TITLE     Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene
            family
  JOURNAL   J Interferon Cytokine Res 22 (9), 981-993 (2002)
   PUBMED   12396720
REFERENCE   8  (bases 1 to 2201)
  AUTHORS   Smith,J.B., Nguyen,T.T., Hughes,H.J., Herschman,H.R., Widney,D.P.,
            Bui,K.C. and Rovai,L.E.
  TITLE     Glucocorticoid-attenuated response genes induced in the lung during
            endotoxemia
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 283 (3), L636-L647 (2002)
   PUBMED   12169584
REFERENCE   9  (bases 1 to 2201)
  AUTHORS   Perelygin,A.A., Scherbik,S.V., Zhulin,I.B., Stockman,B.M., Li,Y.
            and Brinton,M.A.
  TITLE     Positional cloning of the murine flavivirus resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9322-9327 (2002)
   PUBMED   12080145
REFERENCE   10 (bases 1 to 2201)
  AUTHORS   Eskildsen,S., Hartmann,R., Kjeldgaard,N.O. and Justesen,J.
  TITLE     Gene structure of the murine 2'-5'-oligoadenylate synthetase family
  JOURNAL   Cell Mol Life Sci 59 (7), 1212-1222 (2002)
   PUBMED   12222967
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117799.9 and AK150863.1.
            
            On Jan 20, 2018 this sequence version replaced XM_006530294.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150863.1, AK089111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC117799.9         52986-53009
            25-1697             AK150863.1         2-1674
            1698-1698           AC117799.9         67154-67154
            1699-2201           AK150863.1         1675-2177
FEATURES             Location/Qualifiers
     source          1..2201
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     gene            1..2201
                     /gene="Oasl1"
                     /gene_synonym="7530414C13Rik; oasl9"
                     /note="2'-5' oligoadenylate synthetase-like 1"
                     /db_xref="GeneID:231655"
                     /db_xref="MGI:MGI:2180849"
     exon            1..370
                     /gene="Oasl1"
                     /gene_synonym="7530414C13Rik; oasl9"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1708
                     /gene="Oasl1"
                     /gene_synonym="7530414C13Rik; oasl9"
                     /note="isoform a is encoded by transcript variant 1;
                     2,5-oligoadenylate synthetase-like 9; 2',5'-oligoadenylate
                     synthetase-like 9; 2'-5'-oligoadenylate synthase-like
                     protein 1"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase-like protein 1
                     isoform a"
                     /protein_id="NP_001346874.1"
                     /db_xref="CCDS:CCDS19575.1"
                     /db_xref="GeneID:231655"
                     /db_xref="MGI:MGI:2180849"
                     /translation="MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFL
                     RQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQ
                     AVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRAL
                     GPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVR
                     DKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKH
                     YTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDN
                     RDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLS
                     FQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLD
                     YVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPF
                     VPS"
     exon            371..653
                     /gene="Oasl1"
                     /gene_synonym="7530414C13Rik; oasl9"
                     /inference="alignment:Splign:2.1.0"
     exon            654..817
                     /gene="Oasl1"
                     /gene_synonym="7530414C13Rik; oasl9"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1059
                     /gene="Oasl1"
                     /gene_synonym="7530414C13Rik; oasl9"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1207
                     /gene="Oasl1"
                     /gene_synonym="7530414C13Rik; oasl9"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..2201
                     /gene="Oasl1"
                     /gene_synonym="7530414C13Rik; oasl9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccatgc tcccaagctt ctctcttcac ccccctttcc gccattgggt gccagaggtc
       61 agctggaaag gagccgcctt aaaaaaggag gaggtgagta ccggcagctg gatgggtgct
      121 tggctatata gccctgcgcc tgcctgaggt agctgacggt cagtttgtag ccatggcagt
      181 cgcccaggag ctgtacggct tcccggcctc caagctggac tcctttgtgg ctcagtggct
      241 gcagccaacc agagagtgga aagaagaggt cctggagacc gtgcagacag tggagcagtt
      301 cctgaggcag gagaatttcc gtgaagatcg tggcccggct cgggatgtgc gcgtgctcaa
      361 ggtactcaag gtaggctgct ttgggaatgg caccgtgctc aggagcacta cagacgtgga
      421 gctggtcgtg ttcctgagct gtttccacag cttccaggaa gaagccaagc accatcaggc
      481 tgtcctgaga ctgatacaga aaaggatgta ctactgccag gagctgatgg accttgggct
      541 cagtaacctg agtgtgacta acagagtacc cagtagtctc atcttcacga tccagaccag
      601 ggagacctgg gagaccatca ctgtcaccgt tgtgcccgcc tacagagccc tgggcccttc
      661 ctgtcccagc tccgaggtct acgcaaatct gatcaaggct aatgggtacc caggaaattt
      721 ctctccatcc ttcagcgagc tgcagcgaaa cttcgtgaag catcggccga cgaagctgaa
      781 gagcctcctt cggttggtca aacactggta ccagcagtat gtgagagaca agtgcccccg
      841 ggccaacctg ccccctctct atgccctgga gctgctcact gtctatgcct gggaagcggg
      901 cacccgggag gatgccaact tcaggctgga tgaaggcctc gccacggtga tggagctgct
      961 ccaggatcat gagctcctct gtatctactg gaccaagcac tacacgctgc agcacccggt
     1021 catcgaggcc tgtgtcagga gacagctcag gggacaaagg cctatcatcc tggacccagc
     1081 agaccccacc aacaatgtgg cagaaggcta cagatgggac atagtggctc agcgggccaa
     1141 ccagtgtctg aaacaggact gttgctatga caacagggac agccccgtcc ccagctggag
     1201 ggtgaagaga gcacccgata tccaggtgac cgtgcaggag tgggggcact cggatttaac
     1261 cttctgggtg aacccttatg aacccataaa gaaactgaaa gagaaaatcc aactgagcca
     1321 gggctacttg ggcctgcagc gtctgtcctt tcaggagccc ggcggagaac gtcagctcat
     1381 cagaagccat tgcacgctcg cctactacgg aatcttctgc gacacccaca tctgcctgct
     1441 ggacaccatc tcccctgaga tccaggtctt tgtgaaaaac ccggatggca ggagccacgc
     1501 ctatgcgatc cacccgcttg attacgtcct gaacctgaag cagcagatag aagacaggca
     1561 gggccttcga tgccaggagc agcgcctgga gttccagggc cacatcctgg aggactggtt
     1621 tgactttaaa tcctatggca tccaagacag tgtcacagtc atcctgtcca agacgacgga
     1681 gggggcagct ccatttgtgc ccagctagct tcctctgtcg gtggctctgc ctgttttatt
     1741 gtctcatcct agactcagcc tagttgcctc tccttcccgt cctctgcccg gatggtccac
     1801 gtcttcagta ccttgccagc agggagtcag agggggtgtg agaagtcgtg tacagccaga
     1861 cactcttgtg tgacaatgga attctgcagt cccctgggaa gtcatgccag gacctctgcc
     1921 ttcctcgtgg cctcactgtc aagactgtgt cagtgaatag ctggcctcac agactattct
     1981 cacatgttca gagaaagcca aaccatcttc ctaaccaatc acagggaccc tgcttgaggt
     2041 tgtcccacct ccaaattctt cccagtgacc tccatcaggg cggctctgaa gccttcccct
     2101 gtgcccccaa ccacttctgc ctgccttcga ctatccaagg caaggtagga ggggatcaag
     2161 ttcctttcaa atggagaata aaaaagccat tgtttcttcc c
//
