LOCUS       NP_001346874             511 aa            linear   ROD 06-NOV-2024
DEFINITION  2'-5'-oligoadenylate synthase-like protein 1 isoform a [Mus
            musculus].
ACCESSION   NP_001346874 XP_006530357
VERSION     NP_001346874.1
DBSOURCE    REFSEQ: accession NM_001359945.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 511)
  AUTHORS   Imai,T., Lin,J., Kaya,G.G., Ju,E., Kondylis,V., Kelepouras,K.,
            Liccardi,G., Kim,C. and Pasparakis,M.
  TITLE     The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death
            and inflammation
  JOURNAL   Immunity 57 (7), 1497-1513 (2024)
   PUBMED   38744293
REFERENCE   2  (residues 1 to 511)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 511)
  AUTHORS   Zhao,W., Yang,H., Liu,L., Qu,X., Ding,J., Yu,H., Xu,B., Zhao,S.,
            Xi,G., Xing,L. and Chai,J.
  TITLE     OASL knockdown inhibits the progression of stomach adenocarcinoma
            by regulating the mTORC1 signaling pathway
  JOURNAL   FASEB J 37 (3), e22824 (2023)
   PUBMED   36809539
  REMARK    GeneRIF: OASL knockdown inhibits the progression of stomach
            adenocarcinoma by regulating the mTORC1 signaling pathway.
REFERENCE   4  (residues 1 to 511)
  AUTHORS   Lee,S.A., Chang,L.C., Jung,W., Bowman,J.W., Kim,D., Chen,W.,
            Foo,S.S., Choi,Y.J., Choi,U.Y., Bowling,A., Yoo,J.S. and Jung,J.U.
  TITLE     OASL phase condensation induces amyloid-like fibrillation of RIPK3
            to promote virus-induced necroptosis
  JOURNAL   Nat Cell Biol 25 (1), 92-107 (2023)
   PUBMED   36604592
REFERENCE   5  (residues 1 to 511)
  AUTHORS   Kim,T.K., Jeon,S., Park,S., Sonn,S.K., Seo,S., Suh,J., Jin,J.,
            Kweon,H.Y., Kim,S., Moon,S.H., Kweon,O., Koo,B.H., Kim,N.,
            Lee,H.O., Kim,Y.M., Kim,Y.J., Park,S.H. and Oh,G.T.
  TITLE     2'-5' oligoadenylate synthetase-like 1 (OASL1) protects against
            atherosclerosis by maintaining endothelial nitric oxide synthase
            mRNA stability
  JOURNAL   Nat Commun 13 (1), 6647 (2022)
   PUBMED   36333342
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 511)
  AUTHORS   Eskildsen,S., Justesen,J., Schierup,M.H. and Hartmann,R.
  TITLE     Characterization of the 2'-5'-oligoadenylate synthetase
            ubiquitin-like family
  JOURNAL   Nucleic Acids Res 31 (12), 3166-3173 (2003)
   PUBMED   12799444
REFERENCE   7  (residues 1 to 511)
  AUTHORS   Kakuta,S., Shibata,S. and Iwakura,Y.
  TITLE     Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene
            family
  JOURNAL   J Interferon Cytokine Res 22 (9), 981-993 (2002)
   PUBMED   12396720
REFERENCE   8  (residues 1 to 511)
  AUTHORS   Smith,J.B., Nguyen,T.T., Hughes,H.J., Herschman,H.R., Widney,D.P.,
            Bui,K.C. and Rovai,L.E.
  TITLE     Glucocorticoid-attenuated response genes induced in the lung during
            endotoxemia
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 283 (3), L636-L647 (2002)
   PUBMED   12169584
REFERENCE   9  (residues 1 to 511)
  AUTHORS   Perelygin,A.A., Scherbik,S.V., Zhulin,I.B., Stockman,B.M., Li,Y.
            and Brinton,M.A.
  TITLE     Positional cloning of the murine flavivirus resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9322-9327 (2002)
   PUBMED   12080145
REFERENCE   10 (residues 1 to 511)
  AUTHORS   Eskildsen,S., Hartmann,R., Kjeldgaard,N.O. and Justesen,J.
  TITLE     Gene structure of the murine 2'-5'-oligoadenylate synthetase family
  JOURNAL   Cell Mol Life Sci 59 (7), 1212-1222 (2002)
   PUBMED   12222967
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117799.9 and AK150863.1.
            
            On Jan 20, 2018 this sequence version replaced XP_006530357.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150863.1, AK089111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     Protein         1..511
                     /product="2'-5'-oligoadenylate synthase-like protein 1
                     isoform a"
                     /note="2,5-oligoadenylate synthetase-like 9;
                     2',5'-oligoadenylate synthetase-like 9;
                     2'-5'-oligoadenylate synthase-like protein 1"
                     /calculated_mol_wt=58958
     Region          29..208
                     /region_name="NT_2-5OAS_ClassI-CCAase"
                     /note="Nucleotidyltransferase (NT) domain of
                     2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I
                     CCA-adding enzyme; cd05400"
                     /db_xref="CDD:143390"
     Site            order(67..69,72,74..76,81,83,133..134,137,152,194,198,201)
                     /site_type="active"
                     /db_xref="CDD:143390"
     Site            order(68..69,81,83,134,194,198,201)
                     /site_type="other"
                     /note="NTP binding site [chemical binding]"
                     /db_xref="CDD:143390"
     Site            order(81,83,152)
                     /site_type="metal-binding"
                     /note="metal binding triad [ion binding]"
                     /db_xref="CDD:143390"
     Region          163..347
                     /region_name="OAS1_C"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; pfam10421"
                     /db_xref="CDD:463087"
     Region          350..423
                     /region_name="Ubl1_OASL"
                     /note="ubiquitin-like (Ubl) domain 1 found in
                     2'-5'-oligoadenylate synthase-like protein (OASL) and
                     similar proteins; cd01811"
                     /db_xref="CDD:340509"
     Region          429..500
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     CDS             1..511
                     /gene="Oasl1"
                     /gene_synonym="7530414C13Rik; oasl9"
                     /coded_by="NM_001359945.1:173..1708"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19575.1"
                     /db_xref="GeneID:231655"
                     /db_xref="MGI:MGI:2180849"
ORIGIN      
        1 mavaqelygf paskldsfva qwlqptrewk eevletvqtv eqflrqenfr edrgpardvr
       61 vlkvlkvgcf gngtvlrstt dvelvvflsc fhsfqeeakh hqavlrliqk rmyycqelmd
      121 lglsnlsvtn rvpsslifti qtretwetit vtvvpayral gpscpssevy anlikangyp
      181 gnfspsfsel qrnfvkhrpt klksllrlvk hwyqqyvrdk cpranlpply alelltvyaw
      241 eagtredanf rldeglatvm ellqdhellc iywtkhytlq hpvieacvrr qlrgqrpiil
      301 dpadptnnva egyrwdivaq ranqclkqdc cydnrdspvp swrvkrapdi qvtvqewghs
      361 dltfwvnpye pikklkekiq lsqgylglqr lsfqepgger qlirshctla yygifcdthi
      421 clldtispei qvfvknpdgr shayaihpld yvlnlkqqie drqglrcqeq rlefqghile
      481 dwfdfksygi qdsvtvilsk ttegaapfvp s
//
