LOCUS       NM_145226               4718 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus 2'-5' oligoadenylate synthetase 3 (Oas3), mRNA.
ACCESSION   NM_145226
VERSION     NM_145226.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4718)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4718)
  AUTHORS   Xu,Z., Qiao,S., Qian,W., Zhu,Y., Yan,W., Shen,S. and Wang,T.
  TITLE     Card9 protects fungal peritonitis through regulating Malt1-mediated
            activation of autophagy in macrophage
  JOURNAL   Int Immunopharmacol 110, 108941 (2022)
   PUBMED   35850054
REFERENCE   3  (bases 1 to 4718)
  AUTHORS   Kristiansen,H., Gad,H.H., Eskildsen-Larsen,S., Despres,P. and
            Hartmann,R.
  TITLE     The oligoadenylate synthetase family: an ancient protein family
            with multiple antiviral activities
  JOURNAL   J Interferon Cytokine Res 31 (1), 41-47 (2011)
   PUBMED   21142819
  REMARK    Review article
REFERENCE   4  (bases 1 to 4718)
  AUTHORS   Mashimo,T., Glaser,P., Lucas,M., Simon-Chazottes,D., Ceccaldi,P.E.,
            Montagutelli,X., Despres,P. and Guenet,J.L.
  TITLE     Structural and functional genomics and evolutionary relationships
            in the cluster of genes encoding murine 2',5'-oligoadenylate
            synthetases
  JOURNAL   Genomics 82 (5), 537-552 (2003)
   PUBMED   14559211
REFERENCE   5  (bases 1 to 4718)
  AUTHORS   Kakuta,S., Shibata,S. and Iwakura,Y.
  TITLE     Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene
            family
  JOURNAL   J Interferon Cytokine Res 22 (9), 981-993 (2002)
   PUBMED   12396720
REFERENCE   6  (bases 1 to 4718)
  AUTHORS   Perelygin,A.A., Scherbik,S.V., Zhulin,I.B., Stockman,B.M., Li,Y.
            and Brinton,M.A.
  TITLE     Positional cloning of the murine flavivirus resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9322-9327 (2002)
   PUBMED   12080145
REFERENCE   7  (bases 1 to 4718)
  AUTHORS   Eskildsen,S., Hartmann,R., Kjeldgaard,N.O. and Justesen,J.
  TITLE     Gene structure of the murine 2'-5'-oligoadenylate synthetase family
  JOURNAL   Cell Mol Life Sci 59 (7), 1212-1222 (2002)
   PUBMED   12222967
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115937.14.
            
            On Nov 17, 2006 this sequence version replaced NM_145226.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB067534.1, AF453830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC115937.14        140813-141021       c
            210-492             AC115937.14        137229-137511       c
            493-668             AC115937.14        136243-136418       c
            669-904             AC115937.14        134373-134608       c
            905-1058            AC115937.14        133213-133366       c
            1059-1565           AC115937.14        132403-132909       c
            1566-1845           AC115937.14        129360-129639       c
            1846-2021           AC115937.14        127606-127781       c
            2022-2272           AC115937.14        124943-125193       c
            2273-2417           AC115937.14        124487-124631       c
            2418-2591           AC115937.14        123283-123456       c
            2592-2877           AC115937.14        122075-122360       c
            2878-3053           AC115937.14        120267-120442       c
            3054-3292           AC115937.14        119389-119627       c
            3293-3440           AC115937.14        117918-118065       c
            3441-4718           AC115937.14        116460-117737       c
FEATURES             Location/Qualifiers
     source          1..4718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.64 cM"
     gene            1..4718
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /note="2'-5' oligoadenylate synthetase 3"
                     /db_xref="GeneID:246727"
                     /db_xref="MGI:MGI:2180850"
     exon            1..209
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..3452
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /EC_number="2.7.7.84"
                     /note="2-5A synthase 3; (2-5')oligo(A) synthase 3;
                     2',5'-oligoadenylate synthetase-like 10"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase 3"
                     /protein_id="NP_660261.1"
                     /db_xref="CCDS:CCDS39242.1"
                     /db_xref="GeneID:246727"
                     /db_xref="MGI:MGI:2180850"
                     /translation="MDLFHTPAGALDKLVAHNLHPAPEFTAAVRGALGSLNITLQQHR
                     ARGSQRPRVIRIAKGGAYARGTALRGGTDVELVIFLDCFQSFGDQKTCHSETLGAMRM
                     LLESWGGHPGPGLTFEFSQSKASRILQFRLASADGEHWIDVSLVPAFDVLGQPRSGVK
                     PTPNVYSSLLSSHCQAGEYSACFTEPRKNFVNTRPAKLKNLILLVKHWYHQVQTRAVR
                     ATLPPSYALELLTIFAWEQGCGKDSFSLAQGLRTVLALIQHSKYLCIFWTENYGFEDP
                     AVGEFLRRQLKRPRPVILDPADPTWDVGNGTAWRWDVLAQEAESSFSQQCFKQASGVL
                     VQPWEGPGLPRAGILDLGHPIYQGPNQALEDNKGHLAVQSKERSQKPSNSAPGFPEAA
                     TKIPAMPNPSANKTRKIRKKAAHPKTVQEAALDSISSHVRITQSTASSHMPPDRSSIS
                     TAGSRMSPDLSQIPSKDLDCFIQDHLRPSPQFQQQVKQAIDAILCCLREKSVYKVLRV
                     SKGGSFGRGTDLRGSCDVELVIFYKTLGDFKGQKPHQAEILRDMQAQLRHWCQNPVPG
                     LSLQFIEQKPNALQLQLASTDLSNRVDLSVLPAFDAVGPLKSGTKPQPQVYSSLLSSG
                     CQAGEHAACFAELRRNFINTCPPKLKSLMLLVKHWYRQVVTRYKGGEAAGDAPPPAYA
                     LELLTIFAWEQGCGEQKFSLAEGLRTILRLIQQHQSLCIYWTVNYSVQDPAIRAHLLC
                     QLRKARPLVLDPADPTWNVGQGDWKLLAQEAAALGSQVCLQSGDGTLVPPWDVTPALL
                     HQTLAEDLDKFISEFLQPNRHFLTQVKRAVDTICSFLKENCFRNSTIKVLKVVKGGSS
                     AKGTALQGRSDADLVVFLSCFRQFSEQGSHRAEIISEIQAHLEACQQMHSFDVKFEVS
                     KRKNPRVLSFTLTSQTLLDQSVDFDVLPAFDALGQLRSGSRPDPRVYTDLIHSCSNAG
                     EFSTCFTELQRDFITSRPTKLKSLIRLVKYWYQQCNKTIKGKGSLPPQHGLELLTVYA
                     WEQGGQNPQFNMAEGFRTVLELIVQYRQLCVYWTINYSAEDKTIGDFLKMQLRKPRPV
                     ILDPADPTGNLGHNARWDLLAKEATVYASALCCVDRDGNPIKPWPVKAAV"
     exon            210..492
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            493..668
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            669..904
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1058
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1565
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1845
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2021
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2272
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2417
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2591
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2877
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..3053
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3292
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3440
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..4718
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4698..4703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /note="hexamer: AATAAA"
     polyA_site      4718
                     /gene="Oas3"
                     /gene_synonym="Oasl10"
                     /note="major polyA site"
ORIGIN      
        1 agagaaacga aactctactg agagtaccgg tcaacatgga cctgttccac acgccagccg
       61 gagctctgga taagctggtg gcccacaacc tgcacccagc ccctgagttc acagcagccg
      121 tacggggtgc tctggggtcg ctaaacatca ccctacagca gcacagagcc cgagggtcac
      181 agagaccaag agtgataagg attgccaagg gaggagccta tgcccggggc acagctctca
      241 gaggtggcac cgatgtcgaa ctcgtcatct tcctcgactg cttccagagc tttggtgacc
      301 agaagacctg tcactcagag accctgggtg ccatgcgaat gttgctggag tcctgggggg
      361 gccaccccgg gcctggcctg acttttgagt tttctcagtc aaaggcgtcc aggatcttac
      421 agtttcgtct ggcatcggca gacggagaac actggataga tgttagcctg gtgcctgcct
      481 ttgatgtcct aggacagccc cgctctggag tcaagccgac acccaacgtg tactcctccc
      541 tccttagcag ccactgccag gccggggagt actcagcctg cttcactgag ccccgaaaga
      601 actttgtgaa cactcgccca gccaagctta agaacttaat cctgctggtc aaacactggt
      661 accaccaggt gcagacacgg gccgtgaggg ccacactgcc ccccagctac gccctagagc
      721 tgcttaccat ctttgcctgg gagcagggct gtgggaagga cagcttcagc ctggcccaag
      781 ggctccggac cgtcctggcc ttgatccaac acagcaagta cctctgcatt ttctggacgg
      841 aaaactatgg cttcgaggac cctgcagttg gagagttctt gcgaaggcag cttaagagac
      901 ccaggcccgt gatcctggat ccagctgatc caacgtggga cgtgggcaac gggacagcct
      961 ggcgctggga tgtgctggcc caggaggctg agtccagctt tagccagcag tgcttcaagc
     1021 aggcctcagg agtccttgtg cagccttggg aggggccggg cctgccacgg gctgggatct
     1081 tggatttggg ccacccaatc tatcaagggc ctaaccaggc ccttgaagac aacaaaggcc
     1141 accttgctgt tcagtcaaag gaaaggagcc aaaaaccttc caattcagct ccaggatttc
     1201 cagaagcagc caccaagatc cctgctatgc ccaacccaag tgccaataaa acccgcaaga
     1261 tccgcaagaa agcagctcac ccaaagactg tccaggaagc agcattggat agtatctcaa
     1321 gtcatgttcg gatcacccag agcacagcat cctcacacat gcctcctgac cgctctagca
     1381 tctccaccgc tgggtcacgg atgagcccag atctgtcaca gatccccagc aaggatctag
     1441 actgcttcat ccaggaccac cttaggccga gtccccagtt ccagcagcag gtgaagcagg
     1501 ccatcgacgc catcttgtgc tgcctccggg agaagagtgt atacaaagtc ttgagggtca
     1561 gcaagggcgg ctctttcggc cgtggcacag acctcagggg cagctgcgat gtggaacttg
     1621 tcatctttta taaaaccctc ggggacttca agggccagaa gcctcaccag gcagagatcc
     1681 tgcgtgacat gcaggcccag ctacgacact ggtgtcagaa ccccgtgcct ggactgagcc
     1741 tccagtttat tgaacagaag cccaacgctc tgcaactcca gctggcgtcc accgacctca
     1801 gcaaccgggt ggacctcagt gtgctgcctg cttttgatgc tgtggggccg ctgaagtccg
     1861 gcaccaaacc tcagccccag gtgtactcct cgctcctcag cagcggctgc caggctgggg
     1921 agcacgcagc ctgcttcgca gagcttcgaa ggaacttcat aaacacttgc cctcccaaac
     1981 ttaagagcct gatgctactg gtcaaacact ggtaccgcca ggttgtcact cgatataaag
     2041 gaggagaggc ggcaggtgat gctccgcccc cagcctacgc cctggagctc ctgaccatct
     2101 ttgcctggga acaaggctgt ggagagcaaa agttcagcct ggctgaaggc ctgcggacca
     2161 tcctgaggct gatccaacag caccagtcgc tttgtatcta ctggacggtc aactacagtg
     2221 tgcaggaccc ggccatcaga gcacatcttc tctgccagct tcggaaagcc aggcctctag
     2281 tcctggaccc tgcagatccc acctggaacg tgggccaggg cgactggaag ctattagctc
     2341 aggaggcagc tgcccttggg tcacaagtct gccttcagag tggggatggg actctggtgc
     2401 caccctggga tgtgacgcca gccctccttc accagaccct agctgaggac ctggacaaat
     2461 tcatcagtga attcctccag cccaaccgcc acttcctgac tcaagtgaag agagccgtgg
     2521 acaccatatg ttccttcctg aaagaaaact gcttccggaa ctctaccatc aaggtgctca
     2581 aggtggtcaa gggtgggtct tctgccaaag gcacggctct acaaggacgc tcagatgccg
     2641 acctggtggt gtttctcagc tgcttccgcc agttctctga gcaaggcagc catcgggcag
     2701 agatcatctc ggagatccag gctcatctgg aggcgtgtca gcagatgcac agcttcgatg
     2761 tcaagtttga ggtctccaag aggaagaacc cccgagtgct cagcttcacg ctgacatccc
     2821 agacgctgct ggaccaaagc gtggactttg acgtcctgcc agcctttgat gctctcggcc
     2881 agctgaggtc cggctctcgg cctgatcccc gggtctacac agacctcatc cacagctgca
     2941 gtaatgcagg agagttctct acctgcttca cagagctgca gagggacttc attacctccc
     3001 gtcccaccaa actcaagagc ctgatccggc tggtgaaata ctggtaccaa cagtgtaaca
     3061 agaccatcaa ggggaagggt tccttgcctc cccagcacgg gctggagctc ctaactgtgt
     3121 acgcctggga gcaaggtggc cagaatcccc agttcaacat ggcggagggc ttccgcactg
     3181 ttctggagct gattgtccag taccggcagc tctgcgtcta ttggaccatc aactacagcg
     3241 cagaagacaa gaccatcggt gacttcctga agatgcagct tcggaagccc aggcctgtca
     3301 tcctggaccc agctgacccg acaggcaacc tgggccacaa cgctcgctgg gatctgcttg
     3361 ccaaggaggc taccgtgtac gcatctgccc tgtgctgcgt ggacagggat ggcaatccca
     3421 tcaagccatg gccggtaaag gccgctgtgt gaagtctaga gagatcagtg gtcaccattg
     3481 atagaaagtg acaccagccc tcagcaagtg atactcagag tatctgagtg tgtgtgtgtg
     3541 tgtgttgtat ttatctgtat gtgtgtattt gtggtatgtc tgtgtgccta tatgagggtg
     3601 tgtctatgtg cgtgtctgtg tatctgtggg tatctatatg tgtctgtata tatgtatgtg
     3661 tgtgtgtgtg tgtgtgtgta ttcatgtatg tgtgtctgtt tgtgtatagt gtgtctatag
     3721 gtgactctgt gtgtctgtgt atctgtgagt atctatatgt gtctgtctgt atgtaaatgt
     3781 gtgtatgtat gtgtgttcat atgtctgtgt gtgtgtctat atctgtgtat ctttgggtat
     3841 ctatatgtgt ctatctatat gtaaatgtat gtatgtactt atgttcatgt gtatctgtgt
     3901 gaatgtctgt gtgtttatgt gtagtgtatc tgtaagtgta tctgtatgtc tatagatgta
     3961 ttatgtcttt gtgtgtcgac atgtctgtgt gtatgtatgt ttgtatgtgt atgttatata
     4021 tgtatatatg catgtatgtg cttcctcaca ccatctccct tctgcccacc tgcccaccca
     4081 tagccctccc tttcttccca ctgtttaccc acctggtggg gcttcattga cctcaaccat
     4141 gatcatcccg gtgtccctga ctcccacact agacacccta ggaaccagac atctctagat
     4201 cttctagtct gctgttcatc taccatgggc tctgccccaa cttccacagc cccacccagg
     4261 agtgcctcag ccctgccaag aagccatact cctccctggc atctctctgc cccttgagcc
     4321 tgtgtatatc cctctgccta cagagaccca ccagctgagg tccaactatg ttcctgtact
     4381 ggctggtttt gtgtgtcaac ttgacatagg ctggagttat cagagaaagg agcttcagtt
     4441 ggggaaatgc ctccatgaga tccagctgtg gggcattttc tcagttggtg atcaaagagg
     4501 agggcccatt gtgggtggtg ccatccctgg gctggtagtc ttgagttcta taagagatca
     4561 agctgagcaa gccaggggaa gcaagccaat aagaaacatc cctccatggc ctctgcatca
     4621 gctcctgctt cctgacctgt ttgagttcca gttctgactt cctttagtga tgaacagcaa
     4681 tgtggaagtg taagctgaat aaaccctttc ctccccaa
//
