LOCUS       NM_145227               3873 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus 2'-5' oligoadenylate synthetase 2 (Oas2), transcript
            variant 2, mRNA.
ACCESSION   NM_145227
VERSION     NM_145227.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3873)
  AUTHORS   Kwock,J.T., Handfield,C., Suwanpradid,J., Hoang,P., McFadden,M.J.,
            Labagnara,K.F., Floyd,L., Shannon,J., Uppala,R., Sarkar,M.K.,
            Gudjonsson,J.E., Corcoran,D.L., Lazear,H.M., Sempowski,G.,
            Horner,S.M. and MacLeod,A.S.
  TITLE     IL-27 signaling activates skin cells to induce innate antiviral
            proteins and protects against Zika virus infection
  JOURNAL   Sci Adv 6 (14), eaay3245 (2020)
   PUBMED   32270034
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3873)
  AUTHORS   Oakes,S.R., Gallego-Ortega,D., Stanford,P.M., Junankar,S.,
            Au,W.W.Y., Kikhtyak,Z., von Korff,A., Sergio,C.M., Law,A.M.K.,
            Castillo,L.E., Allerdice,S.L., Young,A.I.J., Piggin,C., Whittle,B.,
            Bertram,E., Naylor,M.J., Roden,D.L., Donovan,J., Korennykh,A.,
            Goodnow,C.C., O'Bryan,M.K. and Ormandy,C.J.
  TITLE     A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2
            causes failure of lactation
  JOURNAL   PLoS Genet 13 (11), e1007072 (2017)
   PUBMED   29117179
  REMARK    GeneRIF: A non-synonymous mutation in Oas2 (I405N) in the viral
            sensor Oas2 was found and the mutation caused post-partum failure
            of lactation in healthy mice with otherwise normally developed
            mammary glands, characterized by greatly reduced milk protein
            synthesis coupled with epithelial cell death, inhibition of
            proliferation and a robust interferon response. The mutation
            activates the OAS2 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3873)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3873)
  AUTHORS   Mannion,N.M., Greenwood,S.M., Young,R., Cox,S., Brindle,J.,
            Read,D., Nellaker,C., Vesely,C., Ponting,C.P., McLaughlin,P.J.,
            Jantsch,M.F., Dorin,J., Adams,I.R., Scadden,A.D., Ohman,M.,
            Keegan,L.P. and O'Connell,M.A.
  TITLE     The RNA-editing enzyme ADAR1 controls innate immune responses to
            RNA
  JOURNAL   Cell Rep 9 (4), 1482-1494 (2014)
   PUBMED   25456137
REFERENCE   5  (bases 1 to 3873)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 3873)
  AUTHORS   Mashimo,T., Glaser,P., Lucas,M., Simon-Chazottes,D., Ceccaldi,P.E.,
            Montagutelli,X., Despres,P. and Guenet,J.L.
  TITLE     Structural and functional genomics and evolutionary relationships
            in the cluster of genes encoding murine 2',5'-oligoadenylate
            synthetases
  JOURNAL   Genomics 82 (5), 537-552 (2003)
   PUBMED   14559211
REFERENCE   7  (bases 1 to 3873)
  AUTHORS   Kakuta,S., Shibata,S. and Iwakura,Y.
  TITLE     Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene
            family
  JOURNAL   J Interferon Cytokine Res 22 (9), 981-993 (2002)
   PUBMED   12396720
REFERENCE   8  (bases 1 to 3873)
  AUTHORS   Perelygin,A.A., Scherbik,S.V., Zhulin,I.B., Stockman,B.M., Li,Y.
            and Brinton,M.A.
  TITLE     Positional cloning of the murine flavivirus resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9322-9327 (2002)
   PUBMED   12080145
REFERENCE   9  (bases 1 to 3873)
  AUTHORS   Eskildsen,S., Hartmann,R., Kjeldgaard,N.O. and Justesen,J.
  TITLE     Gene structure of the murine 2'-5'-oligoadenylate synthetase family
  JOURNAL   Cell Mol Life Sci 59 (7), 1212-1222 (2002)
   PUBMED   12222967
REFERENCE   10 (bases 1 to 3873)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU694306.1, AB067535.1 and BC118538.1.
            
            On May 7, 2009 this sequence version replaced NM_145227.2.
            
            Transcript Variant: This variant (2) lacks an alternate coding exon
            in the 3' end compared to variant 1, that causes a frameshift. The
            resulting isoform (2) has a shorter and distinct C-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB067535.1, BC118538.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BU694306.1         1-61
            62-883              AB067535.1         67-888
            884-1750            BC118538.1         824-1690
            1751-2309           BC118538.1         1692-2250
            2310-3783           AB067535.1         2315-3788
            3784-3873           AB067535.1         3790-3879
FEATURES             Location/Qualifiers
     source          1..3873
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.64 cM"
     gene            1..3873
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /note="2'-5' oligoadenylate synthetase 2"
                     /db_xref="GeneID:246728"
                     /db_xref="MGI:MGI:2180852"
     exon            1..390
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..2304
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /EC_number="2.7.7.84"
                     /note="isoform 2 is encoded by transcript variant 2;
                     2,5-oligoadenylate synthetase-like 11; 2-5A synthase 2;
                     (2-5')oligo(A) synthase 2; 2',5'-oligoadenylate
                     synthetase-like 11; 2'-5'-oligoadenylate synthase 2"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase 2 isoform 2"
                     /protein_id="NP_660262.2"
                     /db_xref="CCDS:CCDS19625.2"
                     /db_xref="GeneID:246728"
                     /db_xref="MGI:MGI:2180852"
                     /translation="MGNWLTGNWSSDRSSGYSSGWSPGGSSGVPSGPVHKLEKSIQAN
                     LTPNENCLKQIAVSSVPSQKLEGYIQENLKPNRESLKQIDQAVDAIWDLLRSQIPVKE
                     VAKGGSYGRETALRGCSDGTLVLFMDCFQQFQDQIKYQDAYLDVIELWLKIHEKKSVK
                     HEHALVVQVSVPGQRILLQLLPVFNPLRSNENPSSCVYVDLKKSMDQVRASPGEFSDC
                     FTTLQQRFFKKYPQRLKDLILLVKHWYEQCQEKWKTPPPQPLLYALELLTVYAWEQGC
                     QAEDFDMAQGVRTVLRLIQRPTELCVYWTVNYNFEDETVRNILLHQLRSQRPVILDPT
                     DPTNNVGKDDGFWELLTEEAMAWLYSPSLNTESPAPYWDVLPMPLFVTPSHLLNKFIK
                     DFLQPNKLFLKQIKEAVDIICSFLKNVCFLNSDTKVLKTVKGGSTAKGTALKRGSDAD
                     IVVFLSSLESYDSLKTNRSQFVQEIQKQLEEFVQAQEWEVTFEISKWKAPRVLSFTLK
                     SKTLNESVEFDVLPAYDALGQLRSDFTLRPEAYKDLIELCASQDIKEGEFSICFTELQ
                     RNFIQTRPTKLKSLLRLIKHWYKQYERKMKPKASLPPKYALELLTVYAWEQGSGTDDF
                     DIAEGFRTVLDLVIKYRQLCIFWTVNYNFEEEYMRKFLLTQIQKKRPVILDPADPTGD
                     VGGGDRWCWHLLAEEAKEWLSSPCFQVEQKGLVQPWKVPVMQTPGSCGGQIYPTVGGV
                     TK"
     exon            391..637
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /inference="alignment:Splign:2.1.0"
     exon            638..816
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1055
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1200
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1374
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1657
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1845
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2084
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2238
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..3864
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3844..3849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /note="hexamer: AATAAA"
     polyA_site      3864
                     /gene="Oas2"
                     /gene_synonym="Oasl11"
                     /note="major polyA site"
ORIGIN      
        1 cgggtgcagg gcagaaggcc caggacttga gctacagtgc tctgcctcga caattgacaa
       61 gaccagctag caacgatggg aaactggctg actggaaact ggtcatctga caggtcatct
      121 ggctattcat ctggctggtc acctggtggg tcttcagggg tgccctccgg gccagtgcac
      181 aagttagaaa agtctatcca ggcaaacctc acacccaacg aaaactgtct gaagcagatt
      241 gcggtgtcct cggtgccatc gcagaagcta gaagggtata tccaggaaaa cctcaaacct
      301 aacagagaat ctctgaagca gatagaccag gccgtggatg ccatctggga cctgctgcgc
      361 agtcagatcc ctgtgaagga agtggctaag ggtggctcct atggccggga aacagcccta
      421 agaggctgct ccgatggtac ccttgttctc ttcatggact gcttccaaca gttccaggat
      481 cagataaaat accaagatgc ataccttgac gtcattgaac tgtggctgaa aatccatgag
      541 aagaagtcag taaagcatga acatgccctt gtagtacaag tgtctgtacc agggcagaga
      601 atactcctgc aattacttcc agtcttcaat cctctacgct ccaatgagaa tcccagctcc
      661 tgtgtctatg tggatctcaa aaaatccatg gatcaagtaa gagcctcacc aggggagttc
      721 tcagactgct tcaccacact gcagcagcgg tttttcaaga aatatcccca aagactgaag
      781 gatttgatcc tattggtcaa gcactggtat gaacagtgcc aggagaagtg gaaaacaccc
      841 ccacctcagc cattgctgta cgcactggaa ctgctcactg tgtatgcctg ggaacagggc
      901 tgccaagctg aagacttcga catggcacaa ggcgtcagga ccgtgctgcg acttatccag
      961 cggccgacag agctgtgtgt ctactggaca gtcaattaca actttgagga tgagacagtc
     1021 cggaacatcc ttctgcacca gctcaggtcc caaagaccag tcatcttgga tccaactgac
     1081 ccaaccaata atgtgggcaa agatgatggg ttctgggagc tactgacaga ggaagctatg
     1141 gcctggctgt actctcccag cctgaatact gagtcacctg caccatattg ggatgttctg
     1201 cccatgccac ttttcgtcac tccaagccac ttactgaaca agttcatcaa ggactttctc
     1261 cagcccaaca agctcttcct aaagcagatc aaggaagctg ttgacattat atgttccttc
     1321 cttaaaaatg tctgcttctt gaattctgac accaaagtcc tgaagaccgt caagggagga
     1381 tccactgcca aaggcacagc tctgaagcgg ggatcagatg ctgacattgt tgtgttcctc
     1441 tcctcgctgg agagttacga ctctctaaaa accaaccgct cccagttcgt ccaggagatc
     1501 cagaagcagt tagaagaatt cgtgcaggcg caggagtggg aggtgacgtt tgagatttca
     1561 aaatggaagg ctcccagagt gctgagtttt accttgaaat ccaagactct caatgaaagt
     1621 gtcgagttcg atgtccttcc cgcctatgat gcactaggtc aactgcggtc tgacttcacc
     1681 ctcaggcccg aagcctacaa ggatctcatt gagctgtgtg catcacagga catcaaagaa
     1741 ggagagtttt ctatctgttt tactgagctg cagagaaact tcattcaaac ccggcccacc
     1801 aaactgaaga gtctactccg cctgatcaag cactggtaca aacagtatga aaggaagatg
     1861 aagccaaaag catctttacc cccaaagtac gccctggagc tgctcaccgt gtatgcctgg
     1921 gagcagggca gtggcacaga tgactttgac attgctgaag gcttccggac cgtcctggac
     1981 ctggttataa aataccggca gctctgcatc ttctggacag tcaattacaa ctttgaagag
     2041 gaatacatgc ggaagttcct actgacccag atccagaaaa agaggcctgt aatcctggat
     2101 ccagcagatc ccacaggcga tgtgggagga ggtgaccgct ggtgctggca tcttctagct
     2161 gaagaagcga aggagtggct gtcctcccct tgtttccaag tggagcaaaa aggcctggta
     2221 cagccttgga aagtgccagt aatgcagacc cccggaagct gtggaggtca gatctacccc
     2281 actgtgggtg gagttactaa gtaggagtcc attcagctct ggaagacgct tctggagtga
     2341 tctggcaaag actcagactg tgttagaaaa gggagcctgg ttcagtcctc tctggcaggc
     2401 tcgcacctct attcttcctt cttggaatca agacatggga ttatccttcc tcctccccca
     2461 gggtctcaca gcacaggccc tgctctgtgt gagtgacctc cttcagagac acttgcccca
     2521 tgcagctcga tgggttctgg ttttgtctgt attctgtgca gttattttcc tgcctcctgc
     2581 tctgttagtc tctagtcagc agctccagac tcaccctgtg tcactaaggt taaggccctc
     2641 cctagccctt cagcattgtc aatcccaact agccctcgga gtcttccatt gtgcgtcttt
     2701 gcctgtctct ttccctgtcc ctgtggatac agagatgtac catccatcca gcagctagcc
     2761 aactcccctc cctccacctc tgctgttaaa accctttctc ttggggaaat gtaaacaata
     2821 tctacctctc ttaatgtccc aggacaaact aagctgcatt tctcccttcc ctgagaagcc
     2881 aaagcttccc tgattgagct tagctgctca caggagaggg gttacaggcc tttgaagctg
     2941 ccacactaga agatctgcac ccagctagat gggtgcagat ggcttccctg gggctgcata
     3001 aagagaaccc ctcccctcat ctttcctcct gtatcctcta gcccctctca gagatcctgt
     3061 gcaatcaggg cagaatagca tgcagctggt tgaaaccact tgctaaataa ctcaggtgag
     3121 ggtcccataa ccttcccagc ccacctccct tccaagagtg aagataacag tcaacaagcc
     3181 cagctgtgat gttcattgat aagcaggctc tggtggactc ctaaagatgg tgccagtgtg
     3241 gctcagtgaa tagccctgca taacatttta cacacaccaa atgctggttg atatctcttg
     3301 ctggctgccc agggagcctt caccccaggg ctttaactgc acagagacat gaggtctaag
     3361 cccttcgcat ccccaagtaa ggctgagcct tttttctgcc tgtgcttgct ctgatgcatt
     3421 gaggatcatg cctggccact gtgcaacttt taagcagagc cgtgcaacat cccagggagt
     3481 tgacttctat gtaaacacct tcatccattt ctgatgtatg ctttgaggtg gctcaggctg
     3541 ggctagccca gcccagacag aaatcctagg catgtgatta gaggatcaga acccttctgg
     3601 cccttcttca ggggagagat ggggctgaag gtggggttca aatctcatgc cgagtgatgg
     3661 aacccgacat ccctaggtgc taaggcccca ccaaattctc tggataagga agttccagga
     3721 atctttactg ataaacatcc caatgtatca acaaggtaga ctctgacctc catgggacag
     3781 aagatcctgg gtcagtcccc tccctgggga ctctgcagtt ggctgttcat ttatatgctt
     3841 cataataaat ggtttctttg tgtaaaaaaa aaa
//
