LOCUS       NM_145228               1708 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus 2'-5' oligoadenylate synthetase 1H (Oas1h), transcript
            variant 1, mRNA.
ACCESSION   NM_145228
VERSION     NM_145228.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1708)
  AUTHORS   Pham,A.H., Emori,C., Ishikawa-Yamauchi,Y., Tokuhiro,K.,
            Kamoshita,M., Fujihara,Y. and Ikawa,M.
  TITLE     Thirteen Ovary-Enriched Genes Are Individually Not Essential for
            Female Fertility in Mice
  JOURNAL   Cells 13 (10), 802 (2024)
   PUBMED   38786026
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1708)
  AUTHORS   Kristiansen,H., Gad,H.H., Eskildsen-Larsen,S., Despres,P. and
            Hartmann,R.
  TITLE     The oligoadenylate synthetase family: an ancient protein family
            with multiple antiviral activities
  JOURNAL   J Interferon Cytokine Res 31 (1), 41-47 (2011)
   PUBMED   21142819
  REMARK    Review article
REFERENCE   3  (bases 1 to 1708)
  AUTHORS   Joshi,S., Davies,H., Sims,L.P., Levy,S.E. and Dean,J.
  TITLE     Ovarian gene expression in the absence of FIGLA, an oocyte-specific
            transcription factor
  JOURNAL   BMC Dev Biol 7, 67 (2007)
   PUBMED   17567914
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1708)
  AUTHORS   Mashimo,T., Glaser,P., Lucas,M., Simon-Chazottes,D., Ceccaldi,P.E.,
            Montagutelli,X., Despres,P. and Guenet,J.L.
  TITLE     Structural and functional genomics and evolutionary relationships
            in the cluster of genes encoding murine 2',5'-oligoadenylate
            synthetases
  JOURNAL   Genomics 82 (5), 537-552 (2003)
   PUBMED   14559211
REFERENCE   5  (bases 1 to 1708)
  AUTHORS   Kakuta,S., Shibata,S. and Iwakura,Y.
  TITLE     Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene
            family
  JOURNAL   J Interferon Cytokine Res 22 (9), 981-993 (2002)
   PUBMED   12396720
REFERENCE   6  (bases 1 to 1708)
  AUTHORS   Perelygin,A.A., Scherbik,S.V., Zhulin,I.B., Stockman,B.M., Li,Y.
            and Brinton,M.A.
  TITLE     Positional cloning of the murine flavivirus resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9322-9327 (2002)
   PUBMED   12080145
REFERENCE   7  (bases 1 to 1708)
  AUTHORS   Eskildsen,S., Hartmann,R., Kjeldgaard,N.O. and Justesen,J.
  TITLE     Gene structure of the murine 2'-5'-oligoadenylate synthetase family
  JOURNAL   Cell Mol Life Sci 59 (7), 1212-1222 (2002)
   PUBMED   12222967
REFERENCE   8  (bases 1 to 1708)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB067530.1 and CF174513.1.
            
            On May 7, 2009 this sequence version replaced NM_145228.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB067530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1150              AB067530.1         1-1150
            1151-1171           CF174513.1         474-494
            1172-1708           AB067530.1         1174-1710
FEATURES             Location/Qualifiers
     source          1..1708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.64 cM"
     gene            1..1708
                     /gene="Oas1h"
                     /note="2'-5' oligoadenylate synthetase 1H"
                     /db_xref="GeneID:246729"
                     /db_xref="MGI:MGI:2180853"
     exon            1..236
                     /gene="Oas1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1142
                     /gene="Oas1h"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="2'-5' oligoadenylate synthetase 1H isoform 1"
                     /protein_id="NP_660263.1"
                     /db_xref="CCDS:CCDS19629.1"
                     /db_xref="GeneID:246729"
                     /db_xref="MGI:MGI:2180853"
                     /translation="MAKNLSSTRIALCSTPAWRLDKFIEGHLLGDITFLTELRTDVNS
                     ISAFLKERCFQGAAHPMRVSRVVMGGSYNRYTVLKGRSEVDLLVFFNNLTCFDDQFKL
                     QKEVIEEIQKHLCQFQQEKRLREKFKVQSSDQPNFRSVSFKLSYPKFQQEVEFHMQTA
                     YDALYEVRRKENHNCEIYNKVYARLIRECTMLGKEGEFNICFMELQQDFLWKRPCELK
                     NLICLVKHWYQLCKEKLREPLPPQYALELLTVYAWEHELPDKHETQTARGFRTVLELI
                     TKYLCLRIYWTLYYDVLHEQVNAYLYSQVKRVSPLILDPADPTWNVAGLNLQGWCILA
                     EEAKAWLDYPCFKNRDGSRVSSWDVPPDKKGFVFL"
     exon            237..525
                     /gene="Oas1h"
                     /inference="alignment:Splign:2.1.0"
     exon            526..722
                     /gene="Oas1h"
                     /inference="alignment:Splign:2.1.0"
     exon            723..958
                     /gene="Oas1h"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1112
                     /gene="Oas1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1702
                     /gene="Oas1h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1615..1620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oas1h"
                     /note="hexamer: AATAAA"
     polyA_site      1638
                     /gene="Oas1h"
                     /note="major polyA site"
ORIGIN      
        1 ggctgcagtc agcaaacatt cctgccctca ggatggcgaa aaaccttagc agcactcgga
       61 ttgctctctg cagcactccg gcttggaggt tggataagtt catagagggt cacctccttg
      121 gtgacatcac cttccttact gagctcagaa cagacgtgaa ctccataagt gctttcctga
      181 aggagagatg cttccaaggt gccgcccacc ctatgagggt ctccagggtt gtgatgggtg
      241 gttcctacaa tcgatacact gtgctcaagg gcaggtcaga ggtcgaccta ttggtattct
      301 ttaataatct cacctgcttt gacgatcagt tcaagctaca gaaagaggtc attgaggaaa
      361 ttcagaaaca cctgtgccag ttccagcaag aaaaacgact gagagagaag tttaaggtcc
      421 agagctcaga ccagcccaac tttaggtccg tgagcttcaa actgagctac cccaagtttc
      481 agcaggaggt ggaatttcat atgcagacag cctatgatgc cctgtatgaa gtgagaagaa
      541 aagagaatca taactgtgaa atctacaaca aagtatacgc ccgactcatc cgtgagtgca
      601 ccatgctggg caaggagggc gagttcaaca tctgcttcat ggagcttcag caagactttc
      661 tgtggaaacg tccatgcgag ctgaagaacc tcatttgtct ggtcaagcac tggtatcaac
      721 tgtgtaagga gaagctgagg gagccgctgc ctccacagta cgccctggag ctgctcactg
      781 tctatgcctg ggaacatgag cttccagaca aacatgaaac acagacagct cggggtttcc
      841 ggaccgtctt agaactgatc actaagtacc tatgtcttcg aatctactgg acattgtatt
      901 atgacgttct acatgaacag gtcaatgcct acctgtactc acaggtcaaa agagtcagtc
      961 ctctgatctt ggacccagca gacccaacat ggaacgtggc tggtttaaac ttacagggct
     1021 ggtgcatact ggcagaagag gcaaaagcct ggctggatta cccatgcttt aagaacaggg
     1081 atggttcccg agtgagctcc tgggatgtgc cgccagacaa aaaaggattt gtcttcctgt
     1141 gagcacccaa gcatctgcca aggagactcc agagtcaggg tcatgtgctc ctctgctgta
     1201 agactttgac ctagagagga ccggatggtg ctcatggagc cagcgagggg tatccaacct
     1261 gtgatcagac tccaggcttc tgatccctgc ctgcccgccc atggacagcc ttcctcacag
     1321 cctgcttcat ctgcctaagc ctctaacagt gttttctggg agtcaggctg tgatggacag
     1381 agatttgact tccatctgtc cacctgttgg gaggttctgt ccaatagtgg ctgatcatca
     1441 tcaacaaacc acagcaagcc atgagatggg tgtgtactct gagggatcca tcctcatctc
     1501 acatagaaac tcttccacag ctgcacatgt cccggagcca tgggaatctg tctagtgatc
     1561 atcgaggtgc actgtttctg caacatgcag gctgggtttc tggcagtgca ggagaataaa
     1621 attgcatgga ctttgaaatt ttgatgtgtt tgtgaggatg aaatttgaag cactgaatta
     1681 aagcaaaatg catcaaatga aaaaaaaa
//
