LOCUS       NM_011852               2008 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 2'-5' oligoadenylate synthetase 1G (Oas1g), transcript
            variant 1, mRNA.
ACCESSION   NM_011852
VERSION     NM_011852.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2008)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2008)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2008)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 2008)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2008)
  AUTHORS   Kristiansen,H., Gad,H.H., Eskildsen-Larsen,S., Despres,P. and
            Hartmann,R.
  TITLE     The oligoadenylate synthetase family: an ancient protein family
            with multiple antiviral activities
  JOURNAL   J Interferon Cytokine Res 31 (1), 41-47 (2011)
   PUBMED   21142819
  REMARK    Review article
REFERENCE   6  (bases 1 to 2008)
  AUTHORS   Yoshida,H., Okabe,Y., Kawane,K., Fukuyama,H. and Nagata,S.
  TITLE     Lethal anemia caused by interferon-beta produced in mouse embryos
            carrying undigested DNA
  JOURNAL   Nat Immunol 6 (1), 49-56 (2005)
   PUBMED   15568025
REFERENCE   7  (bases 1 to 2008)
  AUTHORS   Sandberg,K., Kemper,P., Stalder,A., Zhang,J., Hobbs,M.V.,
            Whitton,J.L. and Campbell,I.L.
  TITLE     Altered tissue distribution of viral replication and T cell
            spreading is pivotal in the protection against fatal lymphocytic
            choriomeningitis in mice after neutralization of IFN-alpha/beta
  JOURNAL   J Immunol 153 (1), 220-231 (1994)
   PUBMED   8207238
REFERENCE   8  (bases 1 to 2008)
  AUTHORS   Sokawa,Y., Kitano,Y., Shimada,M., Okumura,M., Sokawa,J., Ueda,K.,
            Hamada,K. and Takeda,K.
  TITLE     Physiological expression of the 2',5'-oligoadenylate synthetase
            gene in mouse intestine
  JOURNAL   J Interferon Res 14 (3), 121-127 (1994)
   PUBMED   7930758
REFERENCE   9  (bases 1 to 2008)
  AUTHORS   Rutherford,M.N., Kumar,A., Nissim,A., Chebath,J. and Williams,B.R.
  TITLE     The murine 2-5A synthetase locus: three distinct transcripts from
            two linked genes
  JOURNAL   Nucleic Acids Res 19 (8), 1917-1924 (1991)
   PUBMED   1709495
REFERENCE   10 (bases 1 to 2008)
  AUTHORS   Cohen,B., Peretz,D., Vaiman,D., Benech,P. and Chebath,J.
  TITLE     Enhancer-like interferon responsive sequences of the human and
            murine (2'-5') oligoadenylate synthetase gene promoters
  JOURNAL   EMBO J 7 (5), 1411-1419 (1988)
   PUBMED   2457496
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015535.11 and AF480417.1.
            
            On Nov 25, 2014 this sequence version replaced NM_011852.2.
            
            Summary: This gene encodes a member of the oligoadenylate
            synthetase family of proteins. This gene and several other family
            members are present in a gene cluster on chromosome 5. These
            proteins are believed to function in antiviral immunity through
            binding to viral dsRNA and subsequent synthesis of
            2'-5'-oligoadenylates. The expression of this gene has been shown
            to be induced by interferon. Alternative splicing of this gene
            results in multiple transcript variants. [provided by RefSeq, Nov
            2014].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF480417.1, X58077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC015535.11        104232-104246       c
            16-2008             AF480417.1         1-1993
FEATURES             Location/Qualifiers
     source          1..2008
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.65 cM"
     gene            1..2008
                     /gene="Oas1g"
                     /gene_synonym="L2; Mmu-L; Mmu-L2; Oas1b; Oias-1; Oias1"
                     /note="2'-5' oligoadenylate synthetase 1G"
                     /db_xref="GeneID:23960"
                     /db_xref="MGI:MGI:97429"
     exon            1..234
                     /gene="Oas1g"
                     /gene_synonym="L2; Mmu-L; Mmu-L2; Oas1b; Oias-1; Oias1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1155
                     /gene="Oas1g"
                     /gene_synonym="L2; Mmu-L; Mmu-L2; Oas1b; Oias-1; Oias1"
                     /note="2'-5' oligoadenylate synthetase 1A;
                     2-5-oligoadenylate synthetase 1A ((2-5)oligo(A) synthetase
                     1A) (2-5A synthetase 1A) (p42 OAS); 2'-5'-oligoadenylate
                     synthase 1A; (2-5')oligo(A) synthase 1A; 2-5A synthase 1A"
                     /codon_start=1
                     /product="2'-5' oligoadenylate synthetase 1G"
                     /protein_id="NP_035982.2"
                     /db_xref="CCDS:CCDS39245.1"
                     /db_xref="GeneID:23960"
                     /db_xref="MGI:MGI:97429"
                     /translation="MEHGLRSIPAWTLDKFIEDYLLPDTTFGADVKSAVNVVCDFLKE
                     RCFQGAAHPVRVSKVVKGGSSGKGTTLKGRSDADLVVFLNNLTSFEDQLNRRGEFIKE
                     IKKQLYEVQHERRFRVKFEVQSSWWPNARSLSFKLSAPHLHQEVEFDVLPAFDVLGHG
                     SINKKPNPLIYTILIWECTSLGKDGEFSTCFTELQRNFLKQRPTKLKSLIRLVKHWYQ
                     LCKEKLGKPLPPQYALELLTVYAWEQGNGCNEFNTAQGFRTVLELVINYQHLRIYWTK
                     YYDFQHKEVSKYLHRQLRKARPVILDPADPTGNVAGGNPEGWRRLAEEADVWLWYPCF
                     MKNDGSRVSSWDVPTVVPVPFEQVEENWTCILL"
     exon            235..523
                     /gene="Oas1g"
                     /gene_synonym="L2; Mmu-L; Mmu-L2; Oas1b; Oias-1; Oias1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..708
                     /gene="Oas1g"
                     /gene_synonym="L2; Mmu-L; Mmu-L2; Oas1b; Oias-1; Oias1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..941
                     /gene="Oas1g"
                     /gene_synonym="L2; Mmu-L; Mmu-L2; Oas1b; Oias-1; Oias1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1095
                     /gene="Oas1g"
                     /gene_synonym="L2; Mmu-L; Mmu-L2; Oas1b; Oias-1; Oias1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1122
                     /gene="Oas1g"
                     /gene_synonym="L2; Mmu-L; Mmu-L2; Oas1b; Oias-1; Oias1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..2008
                     /gene="Oas1g"
                     /gene_synonym="L2; Mmu-L; Mmu-L2; Oas1b; Oias-1; Oias1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctacttccca tttcagccag gctgggagac ccaggaagct ccagacttag catggagcac
       61 ggactcagga gcatcccagc ctggacgctg gacaagttca tagaggatta cctccttccc
      121 gacaccacct ttggtgctga tgtcaaatca gccgtcaatg tcgtgtgtga tttcctgaag
      181 gagagatgct tccaaggtgc tgcccaccca gtgagggtct ccaaggtggt gaagggtggc
      241 tcctcaggca aaggcaccac actcaagggc aggtcagacg ctgacctggt ggtgttcctt
      301 aacaatctca ccagctttga ggatcagtta aaccgacggg gagagttcat caaggaaatt
      361 aagaaacagc tgtacgaggt tcagcatgag agacgtttta gagtcaagtt tgaggtccag
      421 agttcatggt ggcccaacgc ccggtctctg agcttcaagc tgagcgcccc ccatctgcat
      481 caggaggtgg agtttgatgt gcttccagcc tttgatgtcc tgggtcatgg tagtatcaat
      541 aagaagccta atcccttaat ctacaccatc ctcatctggg aatgtacctc cctggggaag
      601 gatggcgagt tctctacctg cttcacggag ctccagcgga acttcctgaa gcagcgccca
      661 accaagctga agagtctcat ccgcctggtc aaacactggt accaactgtg taaggagaag
      721 ctggggaagc cactgccccc acagtatgcc ctggagctac tcactgtcta tgcctgggaa
      781 caggggaatg gatgtaatga gttcaacaca gcccagggct tccggaccgt cttggaactg
      841 gtcatcaatt atcagcatct tcgaatctac tggacaaagt attatgactt tcaacacaag
      901 gaggtctcca aatacctgca cagacagctc agaaaagcca ggcctgtgat cctggaccca
      961 gctgacccga cagggaatgt ggctggtggg aacccagagg gctggaggcg gttggctgaa
     1021 gaggctgatg tgtggctgtg gtacccatgt tttatgaaaa atgatggttc ccgagtgagc
     1081 tcctgggatg tgccgacggt ggttcctgta ccttttgagc aggtggagga gaactggaca
     1141 tgtatcctgc tgtgagcaca gcagcacctg cccaggagac tgctggtcag gggcatttgc
     1201 tgctctgctg caggcccatg acccagtgag ggagggcccc acctggcatc agactccgtg
     1261 cttctgatgc ctgccagcca tgtttgactc ctgtccaatc acagccagcc ttcctcaaca
     1321 gattcagaag gagaggaaag aacacacgct tggtgtccat ctgtccacct gttggaaggt
     1381 tctgtctgac aaagtctgat caacaataaa ccacagcagg tgccgtcatg gtgtgtgaac
     1441 tctgaggagt gggccataca agaacagtgc aggtgtgtga gcgtgtgtgt gcccatgcac
     1501 atgcgtgtgt gtcttcacgg ttcaactaga tgcatttagt gagcacttac tacatatgct
     1561 acatgattca gatgttcagc agtggttaga gcaaagccta actgctaggc tttttgatgc
     1621 aagttggatt gggatccttc caggtctctt cttacacata cacacaagag aggaaccctt
     1681 ggtttcttct gcccatgacc ccaagacaag attctagccc tgccctatct gacacagaaa
     1741 cagttccctg gccacacatg gacatggaac actgagactg tggcctgtgc tctcagggtg
     1801 cccttgagtg gctacaacat gcaggctggg ggcccatagg tatgatgaaa ataaaaggta
     1861 cctggaattt ttgacacatg taactttgaa acagggtcat tggtagcaac gatcagcttt
     1921 atcacattta gttaaatcac aatgattgtg gtttcctttc tgagacatga atttgatgtg
     1981 acacacgctg tcgtggaact cacaggaa
//
