LOCUS       NM_033541               2286 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus 2'-5' oligoadenylate synthetase 1C (Oas1c), mRNA.
ACCESSION   NM_033541
VERSION     NM_033541.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2286)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2286)
  AUTHORS   Kristiansen,H., Gad,H.H., Eskildsen-Larsen,S., Despres,P. and
            Hartmann,R.
  TITLE     The oligoadenylate synthetase family: an ancient protein family
            with multiple antiviral activities
  JOURNAL   J Interferon Cytokine Res 31 (1), 41-47 (2011)
   PUBMED   21142819
  REMARK    Review article
REFERENCE   3  (bases 1 to 2286)
  AUTHORS   Mashimo,T., Glaser,P., Lucas,M., Simon-Chazottes,D., Ceccaldi,P.E.,
            Montagutelli,X., Despres,P. and Guenet,J.L.
  TITLE     Structural and functional genomics and evolutionary relationships
            in the cluster of genes encoding murine 2',5'-oligoadenylate
            synthetases
  JOURNAL   Genomics 82 (5), 537-552 (2003)
   PUBMED   14559211
REFERENCE   4  (bases 1 to 2286)
  AUTHORS   Zeng,F. and Schultz,R.M.
  TITLE     Gene expression in mouse oocytes and preimplantation embryos: use
            of suppression subtractive hybridization to identify oocyte- and
            embryo-specific genes
  JOURNAL   Biol Reprod 68 (1), 31-39 (2003)
   PUBMED   12493692
REFERENCE   5  (bases 1 to 2286)
  AUTHORS   Perelygin,A.A., Scherbik,S.V., Zhulin,I.B., Stockman,B.M., Li,Y.
            and Brinton,M.A.
  TITLE     Positional cloning of the murine flavivirus resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9322-9327 (2002)
   PUBMED   12080145
REFERENCE   6  (bases 1 to 2286)
  AUTHORS   Eskildsen,S., Hartmann,R., Kjeldgaard,N.O. and Justesen,J.
  TITLE     Gene structure of the murine 2'-5'-oligoadenylate synthetase family
  JOURNAL   Cell Mol Life Sci 59 (7), 1212-1222 (2002)
   PUBMED   12222967
REFERENCE   7  (bases 1 to 2286)
  AUTHORS   Shibata,S., Kakuta,S., Hamada,K., Sokawa,Y. and Iwakura,Y.
  TITLE     Cloning of a novel 2',5'-oligoadenylate synthetase-like molecule,
            Oasl5 in mice
  JOURNAL   Gene 271 (2), 261-271 (2001)
   PUBMED   11418248
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC115937.14.
            
            On May 1, 2007 this sequence version replaced NM_033541.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028986.1, SRR13422598.1382772.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC115937.14        175796-175876       c
            82-545              AC115937.14        171943-172406       c
            546-834             AC115937.14        171322-171610       c
            835-1031            AC115937.14        168766-168962       c
            1032-1267           AC115937.14        166184-166419       c
            1268-1421           AC115937.14        165403-165556       c
            1422-2286           AC115937.14        163561-164425       c
FEATURES             Location/Qualifiers
     source          1..2286
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.64 cM"
     gene            1..2286
                     /gene="Oas1c"
                     /gene_synonym="Oasl2; Oasl5"
                     /note="2'-5' oligoadenylate synthetase 1C"
                     /db_xref="GeneID:114643"
                     /db_xref="MGI:MGI:2149633"
     exon            1..81
                     /gene="Oas1c"
                     /gene_synonym="Oasl2; Oasl5"
                     /inference="alignment:Splign:2.1.0"
     exon            82..545
                     /gene="Oas1c"
                     /gene_synonym="Oasl2; Oasl5"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..1451
                     /gene="Oas1c"
                     /gene_synonym="Oasl2; Oasl5"
                     /note="2'-5' oligoadenylate synthetase-like 2;
                     2',5'-oligoadenylate synthetase-like 5"
                     /codon_start=1
                     /product="inactive 2'-5' oligoadenylate synthetase 1C"
                     /protein_id="NP_291019.1"
                     /db_xref="CCDS:CCDS19626.1"
                     /db_xref="GeneID:114643"
                     /db_xref="MGI:MGI:2149633"
                     /translation="MENGLCSIQARELDEFICDYLFPDTTFLTELRADIDSISAFLKE
                     RCFQGAAHPVRVSRVVMGGSYDEHTALKGKSEAKMVLFFNNLTSFEEQLKRRGEFVEE
                     IQKHLCQLQQEKPFKVKFEVQSSEEPNSRSLSFKLSSPELQQEVEFDVQPAYDVLYEL
                     RNNTYAEPQFYNKVYAQLIHECTTLEKEGDFSICFTDLHQNFMRYRAPKLWNLIRLVK
                     HWYQLCKEKLREPLPPQYALELLTVYVWEHSNKNQEKVTTAKNFRTFLELVAYYKNLR
                     IYWTWYYDFRHQEVCAYLCRQLKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWM
                     QSSCFRNCDMSFVPTWDLSPERQECAFQ"
     exon            546..834
                     /gene="Oas1c"
                     /gene_synonym="Oasl2; Oasl5"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1031
                     /gene="Oas1c"
                     /gene_synonym="Oasl2; Oasl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1267
                     /gene="Oas1c"
                     /gene_synonym="Oasl2; Oasl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1421
                     /gene="Oas1c"
                     /gene_synonym="Oasl2; Oasl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..2286
                     /gene="Oas1c"
                     /gene_synonym="Oasl2; Oasl5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2259..2264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oas1c"
                     /gene_synonym="Oasl2; Oasl5"
                     /note="hexamer: ATTAAA"
     polyA_site      2284
                     /gene="Oas1c"
                     /gene_synonym="Oasl2; Oasl5"
                     /note="major polyA site"
ORIGIN      
        1 aagatccggc ccagggaaga atgtgtaagg aaactgacct ggctttctcg ggatttcttc
       61 tggaaaaaag gctgttacac gtaacaattc aagatcaaga aggaggaaca acagaaacta
      121 tgtttaggat gcttcatgcc tcctggttca cagcctgctg tgatgagggt ttgacaatcc
      181 aaagaaatgc cagcaggtaa acagacccca gagggtcagg gagcccagga gccagaggtg
      241 gcctgtgcag aggtctgatt tgcatagccc cgcccttcct gggaagagaa agcagctatg
      301 gatataaggg gcagctgact catgaggcaa ggctgcagtc agcaaacact cctggcctca
      361 ggatggagaa tggtctctgc agcatccaag ccagggagct ggacgagttc atatgtgatt
      421 acctctttcc tgacaccacc ttccttactg agctcagagc agacatcgac tccataagtg
      481 ctttcctgaa ggagagatgc ttccaaggtg ccgcccatcc tgtgagggtc tccagggttg
      541 tgatgggcgg ctcctatgat gaacacactg cactcaaggg caagtcagag gccaaaatgg
      601 tgttgttctt taacaatctc accagctttg aggagcagtt aaagcgacgg ggagagttcg
      661 ttgaggaaat tcagaaacac ctgtgtcagc tgcagcaaga gaaaccattt aaagtgaagt
      721 ttgaggtgca gagctcagag gagcccaact ccaggtctct gagcttcaag ctgagctccc
      781 ccgagctcca gcaggaggtg gaatttgatg tgcagccagc ctatgatgtc ctatatgaac
      841 tgagaaacaa cacgtatgct gaaccccaat tctacaacaa agtctacgcc caactcatcc
      901 atgagtgcac caccctggag aaggagggcg atttctccat ctgcttcacc gacctccatc
      961 agaacttcat gaggtatcgt gcgcccaagc tctggaacct catccgtctg gtcaagcact
     1021 ggtatcaact gtgtaaggag aagctgaggg agccgctgcc cccacagtac gccctggagc
     1081 tgctcactgt ctatgtatgg gaacattcga ataaaaatca agaaaaagta accacagcca
     1141 agaacttccg gaccttctta gaactggtcg cctattacaa gaatcttcga atctactgga
     1201 catggtatta tgacttccga catcaagagg tctgtgccta cctgtgcaga cagctcaaaa
     1261 aagccaggcc tctgatcctg gatccagcag acccaacaag gaacgtggct ggttcagact
     1321 tacaggcatg ggacctgctg gcaaaggagg ctcagacctg gatgcagtcc tcttgcttta
     1381 gaaactgtga tatgtccttt gtgcccacct gggatttgtc gccagagaga caagaatgtg
     1441 ccttccagtg agcagtgcag cgcttgctct gaaggctcca gagtcagggg cataccttcc
     1501 tctgctgcaa gaccttgacc tagagaggac aggatggcac tcaaggctcc agtgaggggc
     1561 atccagcctg tgatcagact ccaggcttct gatccctgac tgcccatgga tagccttcct
     1621 cacaggctgc ttcatctgcc ttagcttcca acagtgttct ctgggagtca gactgtgatg
     1681 gacagagaag aacgcaagct cgacttccat ctgtccacct gttgggaggt tctgtccaac
     1741 agtggctgat tgtcatcaac aaaccacagc aagccatggg ggagggtgca ctctgagaga
     1801 aggaaccttt aagtacactt gtgtgtctgt gtgtttaagg atgtggtgtg tccatatgca
     1861 actagaaacc ttgagcacgt gttacaagct ccacatgggc ccaggtaatt gccagaaagg
     1921 ggtggacaga gaaaaaccaa actgttacac gtattgatgt tgggtagctt gggatccttc
     1981 tagatctctg atgcaagaaa cccagactag aatccatggc tcctgctgtc cattctcctg
     2041 tgacaaaatt ttaggccttc cccatcccac acagaaactg ttctccaacc acacatgacc
     2101 ctggagccct gggaatctgg ccagcgtgca tcgtggtgca ctgattctgc agcatgcagg
     2161 ctgaggtcca cagcagtgtg ggaaactatg tgcaatttgt gaccagtgat gacttgaaag
     2221 cttagctgtc tgtgtgaggg tgagatttga agcactgaat taaatcacaa tgcactgact
     2281 cgaact
//
